Month: October 2022

Barman, Soumitra; Singh, Ashish; Rahimi, Faruk Ahamed; Maji, Tapas Kumar published an article in 2021. The article was titled 《Metal-free catalysis: A redox-active donor-acceptor conjugated microporous polymer for selective visible-light-driven CO2 reduction to CH4》, and you may find the article in Journal of the American Chemical Society.Product Details of 4316-58-9 The information in the text is summarized as follows:

Achieving more than a two-electron photochem. CO2 reduction process using a metal-free system is quite exciting and challenging, as it needs proper channeling of electrons. In the present study, we report the rational design and synthesis of a redox-active conjugated microporous polymer (CMP), TPA-PQ, by assimilating an electron donor, tris(4-ethynylphenyl)amine (TPA), with an acceptor, phenanthraquinone (PQ). The TPA-PQ shows intramol. charge-transfer (ICT)-assisted catalytic activity for visible-light-driven photoreduction of CO2 to CH4 (yield = 32.2 mmol g-1) with an impressive rate (2.15 mmol h-1 g-1) and high selectivity (>97%). Mechanistic anal. based on exptl. results, in situ DRIFTS, and computational studies reveals that the potential of TPA-PQ for catalyzing photoreduction of CO2 to CH4 was energetically driven by photoactivated ICT upon surface adsorption of CO2, wherein adjacent keto groups of PQ unit play a pivotal role. The critical role of ICT for stimulating photocatalysis is further illustrated by synthesizing another redox-active CMP (TEB-PQ), bearing triethynylbenzene (TEB) and PQ, that shows 8-fold lesser activity for photoreduction toward CO2 to CH4 (yield = 4.4 mmol g-1) as compared to TPA-PQ. The results demonstrate a novel concept for CO2 photoreduction to CH4 using an efficient, sustainable, and recyclable metal-free robust organic photocatalyst. In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9Product Details of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Product Details of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Cao, Lixin; Cai, Zhengguo; Li, Mingyuan published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Phosphinobenzenamine Nickel Catalyzed Efficient Copolymerization of Methyl Acrylate with Ethylene and Norbornene》.Related Products of 7073-94-1 The author mentioned the following in the article:

A series of phosphinobenzenamine-based nickel complexes bearing substituted phenylphosphine ligands were synthesized and characterized. These nickel complexes combined with methylaluminoxane (MAO) exhibited very high activity (~106 g mol-1 h-1) and good thermal stability for norbornene polymerization The nickel catalysts were able to conduct copolymerization of norbornene and Me acrylate (MA) with high activity (3.76 x 105 g mol-1 h-1) to give high-mol.-weight functionalized cyclic olefin copolymer (COC) with reasonable MA incorporation (2.39-6.47 mol %). Moreover, the nickel catalysts also promote the copolymerization of ethylene and MA with moderate activity (~104 g mol-1 h-1) to produce semicrystalline high-mol.-weight polar functionalized polyethylene (PE). The MA incorporation in the copolymer was controlled in a wide range (up to 15.5 mol %). These complexes without any sterically bulky substituent on the ligand are distinctive examples of earth-abundant nickel complexes toward the direct copolymerization of ethylene or norbornene with the challenging vinyl polar monomer MA. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Related Products of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Related Products of 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Kreisel, Tatjana; Mendel, Marvin; Queen, Adele E.; Deckers, Kristina; Hupperich, Daniel; Riegger, Julian; Fricke, Christoph; Schoenebeck, Franziska published an article in Angewandte Chemie, International Edition. The title of the article was 《Modular Generation of (Iodinated) Polyarenes Using Triethylgermane as Orthogonal Masking Group》.Quality Control of 2,5-Dibromothiophene The author mentioned the following in the article:

Herein, a complementary modular coupling approach to the widely employed Suzuki coupling strategy of boron containing precursors, which relied on organogermane containing building blocks as key orthogonal functionality and an electrophilic (rather than nucleophilic) unmasking event paired with air-stable PdI dimer based bond construction was disclosed. This allowed to significantly shorten the reaction times for the iterative coupling steps and/or to close gaps in the accessible compound space, enabling straightforward access also to iodinated compounds In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Quality Control of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Quality Control of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 623-24-5In 2022 ,《Rationally designed Ru(II) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Tu, Le; Li, Chonglu; Liu, Chang; Bai, Suya; Yang, Jingfang; Zhang, Xian; Xu, Liying; Xiong, Xiaoxing; Sun, Yao. The article conveys some information:

Herein, we construct a series of Ru(II) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(II) metallacycles in biomedicine. The experimental process involved the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5HPLC of Formula: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.HPLC of Formula: 623-24-5 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C7H4BrF3In 2021 ,《The Application of Pulse Radiolysis to the Study of Ni(I) Intermediates in Ni-Catalyzed Cross-Coupling Reactions》 appeared in Journal of the American Chemical Society. The author of the article were Till, Nicholas A.; Oh, Seokjoon; MacMillan, David W. C.; Bird, Matthew J.. The article conveys some information:

Here we report the use of pulse radiolysis and spectroelectrochem. to generate low-valent nickel intermediates relevant to synthetically important Ni-catalyzed cross-coupling reactions and interrogate their reactivities toward comproportionation and oxidative addition processes. Pulse radiolysis provided a direct means to generate singly reduced [(dtbbpy)NiBr], enabling the identification of a rapid Ni(0)/Ni(II) comproportionation process taking place under synthetically relevant electrolysis conditions. This approach also permitted the direct measurement of Ni(I) oxidative addition rates with electronically differentiated aryl iodide electrophiles (kOA = 1.3 x 104-2.4 x 105 M-1 s-1), an elementary organometallic step often proposed in nickel-catalyzed cross-coupling reactions. Together, these results hold implications for a number of Ni-catalyzed cross-coupling processes. In the experimental materials used by the author, we found 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Formula: C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Formula: C7H4BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 1129-28-8In 2022 ,《Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives as gut-selective NaPi2b inhibitors》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Ushiki, Yasunobu; Kawabe, Kenichi; Yamamoto-Okada, Kumiko; Uneuchi, Fumito; Asanuma, Yuta; Yamaguchi, Chitose; Ohta, Hiroshi; Shibata, Tsuyoshi; Abe, Tomohiro; Okumura-Kitajima, Lisa; Kosai, Yuki; Endo, Mayumi; Otake, Katsumasa; Munetomo, Eiji; Takahashi, Teisuke; Kakinuma, Hiroyuki. The article conveys some information:

Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the lung and testis has been reported. To identify gut-selective (minimally systemic) NaPi2b inhibitors, authors prepared and evaluated 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives with highly polar functional groups to reduce systemic exposure. As a result, compounds I (R = NH(CH)2O(CH2)2O(CH2)2O(CH2)2OH) and I (R = NHC(Me)2C(O)NH(CH2)2N(Me)2) showed a good activity in vitro and a low bioavailability in Sprague-Dawley (SD) rats. However, these compounds did not suppress phosphate absorption in SD rats. This lack of in vivo efficacy could be due to the high hydrophobicity of these compounds The results of further investigations of other classes of compounds with appropriate phys. properties will be reported in due course. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Recommanded Product: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C7H13BrO2In 2022 ,《Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells》 appeared in European Journal of Medicinal Chemistry. The author of the article were Barreca, Marilia; Ingarra, Angela Maria; Raimondi, Maria Valeria; Spano, Virginia; De Franco, Michele; Menilli, Luca; Gandin, Valentina; Miolo, Giorgia; Barraja, Paola; Montalbano, Alessandra. The article conveys some information:

Searching for new small mols. as photosensitizing agents, the authors have developed a class of twenty-five pyrimido[5,4-g]indolizines I (R = H, COOEt, COOiPr, R1 = H, Ph, COMe, cyclohexyl, cyclopentyl, n = 1) and pyrimido[4,5-c]pyrrolo[1,2-a]azepines I (R = COOEt, COOiPr, R1 = H, Ph, cyclohexyl, cyclopentyl, n = 2) with a good substitution pattern defining a versatile synthetic pathway to approach the title ring systems. All compounds were evaluated for their photocytotoxicity on a triple neg. human breast cancer cell line (MDA-MB-231) in the dark and under UVA light (2.0 J/cm2). The most effective compounds exhibited a photoantiproliferative activity with IC50 values up to nanomolar ranges. Interestingly, these newly developed compounds showed high selectivity towards cancerous cells with respect to non-cancerous ones. Moreover, four representative derivatives were also phototoxic against an addnl. human HER2 pos. breast cancer cell line (HCC1954) and against the HER2 pos. vesical cancer cell line (T24) harboring Hras mutation. Mechanistic studies performed in triple neg. MDA-MB-231 cancer cells revealed the ability of the compounds to increase reactive oxygen species (ROS) production and to induce a thiol redox stress, thus triggering cancer cell death through apoptosis. Apoptotic cell death was also induced in highly aggressive and metastatic HER2 pos. Hras mutated T24-treated bladder cancer cells. Overall, data confirm that these new small photosensitizing agents may represent very promising candidates for phototherapy application against highly aggressive and resistant cancers. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5437-45-6In 2020 ,《Optimization of a Chemical Synthesis for Single-Chain Rhamnolipids》 was published in ACS Sustainable Chemistry & Engineering. The article was written by Compton, Avery A.; Deodhar, Bhushan S.; Fathi, Amir; Pemberton, Jeanne E.. The article contains the following contents:

This work reports efforts to improve the efficiency and green metrics associated with the chem. synthesis of single-tailed monorhamnolipids. Scaling of synthetic schemes for monorhamnolipids recently reported from this laboratory has been challenging, as large-scale production typically requires high-pressure equipment and an inert atm. due to the pyrophoric nature of a palladium/carbon (Pd/C) catalyst used for a key deprotection step. Furthermore, using Reformatsky condensation in conjunction with a Me ester carboxylic acid protecting group, a safer, simpler, and “”greener”” synthetic pathway to 3-hydroxyalkanoic acid lipid tails is achieved. The two diastereomers of the resulting single-tail rhamnolipids from both 3-hydroxydecanoic acid and 3-hydroxytetradecanoic acid lipid chains are separated and independently characterized. Surface tensiometry was performed on these materials at pH 4 (acid neutral state) and 8 (acid anionic state). All rhamnolipids exhibit min. surface tension values of 30-36 mN/m. Large differences in critical micelle concentration (CMC) values are observed between diastereomers for α-rhamnose 3-hydroxydecanoic acid at pH 4, with α-rhamnose (R)-3-hydroxydecanoic acid having a CMC of ~380μM compared to 1.7 mM for α-rhamnose (S)-3-hydroxydecanoic acid. For α-rhamnose 3-hydroxydecanoic acid diastereomers at pH 8, the CMC values differ slightly for the two diastereomers, with α-rhamnose (R)-3-hydroxydecanoic acid at 13 mM and α-rhamnose (R)-3-hydroxydecanoic acid at 21 mM. Similarly, CMC values of the two α-rhamnose 3-hydroxytetradecanoic acid diastereomers at pH 4 are similar at ~100μM but exhibit large differences at pH 8, with the racemic and α-rhamnose (R)-3-hydroxytetradecanoic acid with a CMC value of ~500μM and the α-rhamnose (S)-3-hydroxytetradecanoic acid exhibiting a CMC value of 1.8 mM. A synthetic scheme with increased efficiency and improved green metrics for single-tail monorhamnolipid surfactants from rhamnose and 3-hydroxyacids. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1530-32-1In 2022 ,《Catalytic, contra-Thermodynamic Positional Alkene Isomerization》 was published in Journal of the American Chemical Society. The article was written by Occhialini, Gino; Palani, Vignesh; Wendlandt, Alison E.. The article contains the following contents:

The discovery of a dual catalyst system that promotes contra-thermodn. positional alkene isomerization under photochem. irradiation, providing access to terminal alkene isomers, e.g., (2-methylallyl)benzene directly from conjugated, internal alkene, e.g., (2-methylpropenyl)benzene starting materials was reported. The utility of the method is demonstrated in the deconjugation of diverse electron-rich/electron-poor alkenes and through strategic application to natural product synthesis, e.g., (-)-nopinone. Mechanistic studies are consistent with a regiospecific bimol. homolytic substitution (SH2′) mechanism proceeding through an allyl-cobaloxime intermediate. The experimental process involved the reaction of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 1129-28-8In 2022 ,《BF3 Mediated [1,5]-Hydride Shift Triggered Cyclization: Thioethers Join the Game》 was published in European Journal of Organic Chemistry. The article was written by Zaitseva, Elvira R.; Smirnov, Alexander Yu.; Timashev, Vladimir I.; Malyshev, Vadim I.; Zhigileva, Ekaterina A.; Mikhaylov, Andrey A.; Medvedev, Michael G.; Baleeva, Nadezhda S.; Baranov, Mikhail S.. The article contains the following contents:

2-(2-(Benzylthio)benzylidene)malonates can underwent the 1,5-hydride shift triggered cyclization resulting in thiachromanes in 45-84% yield. Boron trifluoride as a reaction promotor is the key to success. DFT calculations revealed that the reaction proceeds via a chelate BF2 complex, which was confirmed by NMR-anal. Exptl. and theor. comparison of nitrogen, sulfur and carbon analogs revealed that sulfur derivatives have the highest activation barrier for the hydride transfer due to the unfavorable transition state geometry, which explains the lack of previous reports on 1,5-hydride shifts in (alkylthio)styrenes. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8HPLC of Formula: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. HPLC of Formula: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary