Month: October 2022

《Orthogonal Stability and Reactivity of Aryl Germanes Enables Rapid and Selective (Multi)Halogenations》 was written by Fricke, Christoph; Deckers, Kristina; Schoenebeck, Franziska. Related Products of 2675-79-8 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

While halogenation is of key importance in synthesis and radio-imaging, the currently available repertoire is largely designed to introduce a single halogen per mol. This report makes the selective introduction of several different halogens accessible. Showcased here is the privileged stability of nontoxic aryl germanes under harsh fluorination conditions (that allow selective fluorination in their presence), while displaying superior reactivity and functional-group tolerance in electrophilic iodinations and brominations, out-competing silanes or boronic esters under rapid and additive-free conditions. Mechanistic experiments and computational studies suggest a concerted electrophilic aromatic substitution as the underlying mechanism. The results came from multiple reactions, including the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging》 was written by Morozumi, Akihiko; Kamiya, Mako; Uno, Shin-nosuke; Umezawa, Keitaro; Kojima, Ryosuke; Yoshihara, Toshitada; Tobita, Seiji; Urano, Yasuteru. Recommanded Product: 2623-87-2 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Single-mol. localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. The authors previously introduced a spontaneously blinking rhodamine fluorophore based on an intramol. spirocyclization reaction for live-cell SMLM under physiol. conditions. Here, the authors report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-IR (NIR) and green ranges, the authors succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Molecular Diffusion in a Flexible Mesoporous Metal-Organic Framework over the Course of Structural Contraction》 was written by Walenszus, Francesco; Bon, Volodymyr; Evans, Jack D.; Kaskel, Stefan; Dvoyashkin, Muslim. SDS of cas: 6825-20-3 And the article was included in Journal of Physical Chemistry Letters in 2020. The article conveys some information:

In situ 1H pulsed field gradient (PFG) NMR was used to investigate the mol. diffusion of n-butane in the pores of the flexible metal-organic framework DUT-49(Cu) at 298 K at different pore loadings, including pressure ranges below and above the neg. gas adsorption (NGA) transition caused by structural contraction of the material. Supported by mol. dynamics simulations, the investigation provided crucial insight into confined diffusion within a highly flexible pore environment. The self-diffusion coefficients were derived from the experiment and compared with simulations, capturing the diffusion during n-butane adsorption and desorption. This complementary approach has yielded exptl. characterization of mol. diffusion mechanisms during the unique process of NGA. This includes the observation of a 4-fold decrease of diffusivity within a less than 2 kPa gas pressure variation, corresponding to the NGA transition point. In addition to this study using 3,6-Dibromo-9H-carbazole, there are many other studies that have used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3SDS of cas: 6825-20-3) was used in this study.

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.SDS of cas: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A dual light-driven palladium catalyst: Breaking the barriers in carbonylation reactions》 was written by Torres, Gerardo M.; Liu, Yi; Arndtsen, Bruce A.. Recommanded Product: Ethyl 4-bromobutyrate And the article was included in Science (Washington, DC, United States) in 2020. The article conveys some information:

Transition metal-catalyzed coupling reactions have become one of the most important tools in modern synthesis. However, an inherent limitation to these reactions is the need to balance operations, because the factors that favor bond cleavage via oxidative addition ultimately inhibit bond formation via reductive elimination. Here, we describe an alternative strategy that exploits simple visible-light excitation of palladium to drive both oxidative addition and reductive elimination with low barriers. Palladium-catalyzed carbonylations can thereby proceed under ambient conditions, with challenging aryl or alkyl halides and difficult nucleophiles, and generate valuable carbonyl derivatives such as acid chlorides, esters, amides, or ketones in a now-versatile fashion. Mechanistic studies suggest that concurrent excitation of palladium(0) and palladium(II) intermediates is responsible for this activity. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Photon Equivalents as a Parameter for Scaling Photoredox Reactions in Flow: Translation of Photocatalytic C-N Cross-Coupling from Lab Scale to Multikilogram Scale》 was written by Corcoran, Emily B.; McMullen, Jonathan P.; Levesque, Francois; Wismer, Michael K.; Naber, John R.. COA of Formula: C7H4BrF3 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

With the development of new photocatalytic methods over recent decades, the translation of these chem. reactions to industrial-production scales using continuous-flow reactors has become a topic of increasing interest. In this context, we describe our studies toward elucidating an empirically derived parameter for scaling photocatalytic reactions in flow. By evaluating the performance of a photocatalytic C-N cross-coupling reaction across multiple reactor sizes and geometries, it was demonstrated that expressing product yield as a function of the absorbed photon equivalent provides a predictive, empirical scaling parameter. Through the use of this scaling factor and characterization of the photonic flux within each reactor, the cross-coupling was scaled successfully from the milligram scale in batch to a multi-kilogram reaction in flow. After reading the article, we found that the author used 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7COA of Formula: C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.COA of Formula: C7H4BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nguyen, Suong T.; McLoughlin, Elizabeth A.; Cox, James H.; Fors, Brett P.; Knowles, Robert R. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage》.COA of Formula: C8H15BrO2 The article contains the following contents:

The accumulation of persistent plastic waste in the environment is widely recognized as an ecol. crisis. New chem. technologies are necessary both to recycle existing plastic waste streams into high-value chem. feedstocks and to develop next-generation materials that are degradable by design. Here, we report a catalytic methodol. for the depolymerization of a com. phenoxy resin and high mol. weight hydroxylated polyolefin derivatives upon visible light irradiation near ambient temperature Proton-coupled electron transfer (PCET) activation of hydroxyl groups periodically spaced along the polymer backbone furnishes reactive alkoxy radicals that promote chain fragmentation through C-C bond β-scission. The depolymerization produces well-defined and isolable product mixtures that are readily diversified to polycondensation monomers. In addition to controlling depolymerization, the hydroxyl group modulates the thermomech. properties of these polyolefin derivatives, yielding materials with diverse properties. These results demonstrate a new approach to polymer recycling based on light-driven C-C bond cleavage that has the potential to establish new links within a circular polymer economy and influence the development of new degradable-by-design polyolefin materials. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6COA of Formula: C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.COA of Formula: C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bhukya, Balakishan; Kaushal, Tanu; Kumar, Deepak; Singh, Diksha; Parveen, Shahnaz; Khan, Sana; Luqman, Suaib; Konwar, Rituraj; Chanda, Debabrata; Khan, Feroz; Kumar, Shailesh; Meena, Abha; Negi, Arvind S. published their research in Indian Journal of Heterocyclic Chemistry in 2021. The article was titled 《Antiproliferative activity of diarylnaphthofurans through microtubule destabilization》.Quality Control of Ethyl 3-bromopropanoate The article contains the following contents:

The present communication deals with pharmacophore designing based on ”Fragment-Based Drug Discovery” approach. Two series of compounds diaryl naphthofurans I (R = (3-nitrophenyl)carbonyl, 4-fluorophenyl, 5-formylfuran-2-yl, etc.) and II (R1 = H, 2-ethoxy-2-oxoethyl, 3-ethoxy-3-oxopropyl, 4-ethoxy-4-oxobut-2-en-1-yl, etc.) were synthesized and evaluated against human cancer cell lines by sulforhodamine assay, target studies through tubulin kinetics, in silico predictions of binding pocket, and drugability and safety studies by acute oral toxicity in mice model. Out of 24 varied analogs, seven compounds exhibited significant antiproliferative activity against both hormone-dependent and hormone-independent breast cancer cell lines. Among these, two of the most active representative compounds I (R = 3-carboxyphenyl) and II (R1 = H) showed potential antiproliferative activity against MDA-MB-231 with IC50 at 10.04μM and 10.70μM and significant anti-tubulin effect at their half IC50 and IC50. In mol. docking studies, both the compounds occupied colchicine binding pocket at β-tubulin with high binding energies of -8.3 Kcal/mol and -7.9 Kcal/mol, resp. Both the identified investigational leads were found to be safe and non-toxic in rodent model up to 1000 mg/kg oral dose. Optimization of these lead compounds may yield some better candidates in future. In the experimental materials used by the author, we found Ethyl 3-bromopropanoate(cas: 539-74-2Quality Control of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Quality Control of Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Akash; Verma, Shruti; Pathak, Devendra Deo published an article in 2021. The article was titled 《Synthesis and characterization of a recyclable graphene oxide-surface- engineered copper(II) Schiff base complex: Catalytic application in synthesis of 1,2,3-triazoles and 2H-indazoles》, and you may find the article in Journal of Environmental Chemical Engineering.Related Products of 6630-33-7 The information in the text is summarized as follows:

A new graphene oxide (GO) supported Cu(II) Schiff base complex (GO-SB-Cu) was synthesized by utilizing Schiff base functionalized GO (GO-SB) and copper acetate in ethanol under reflux. The synthesized complex was characterized using several techniques such as fourier transform IR spectroscopy (FTIR), powd. X-ray diffraction (PXRD), fourier transform (FT-Raman), thermo gravimetric anal. (TGA), field emission SEM (FESEM), high resolution transition electron microscopy (HRTEM), elemental dispersive X-ray anal. (EDX), elemental mapping, X-ray photo electron spectroscopy (XPS) and at. absorption spectroscopy (AAS) anal. The complex was found to be highly efficient in the click reaction for synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature and an operationally simple and efficient one-pot synthesis of 2H-indazoles from com. accessible reactants at ambient temperature, without using any base, additive or co-catalyst. A variety of electron donating/withdrawing groups were employed to explore the scope of the reactions. Interestingly, aliphatic and heterocyclic amines were also tested and found active in the synthesis of 2H-indazoles. The results demonstrated that the reaction could be scaled up conveniently and the catalyst could be easily recycled up to successive four times without any noteworthy loss in the catalytic action. High yield of the products, easy workup, environmentally benign, high stability of the catalyst and mild reaction conditions are the key points of this catalyst. All the synthesized organic products were identified by 1H and 13C NMR spectroscopy. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Related Products of 6630-33-7) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Related Products of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bhattacharya, Aditya; mani Shukla, Pushpendra; Maji, Biswajit published an article in 2021. The article was titled 《””Haliranium Ion””-Induced Intermolecular Friedel-Crafts Alkylation in HFIP: Synthesis of β,β-Diaryl α-Halo carbonyl Compounds》, and you may find the article in European Journal of Organic Chemistry.Application of 2675-79-8 The information in the text is summarized as follows:

Herein, a highly regio- and diastereoselective haliranium ion-induced intermol. Friedel-Crafts reaction of α,β-unsaturated carbonyl compounds in HFIP is reported. The operationally simple and mild method affords the synthetically useful β,β-diarylated α-halo carbonyl compounds in good yields after a very short reaction time. As an application, a few examples of β,β-diarylated olefins are prepared in excellent yields. Based on the exptl. results and a qual. study of 1D-NMR-experiments, a plausible reaction mechanism is proposed. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Duarte de Almeida, Leandro; Bourriquen, Florian; Junge, Kathrin; Beller, Matthias published an article in 2021. The article was titled 《Catalytic Formal Hydroamination of Allylic Alcohols Using Manganese PNP-Pincer Complexes》, and you may find the article in Advanced Synthesis & Catalysis.Synthetic Route of C5BrMnO5 The information in the text is summarized as follows:

Several manganese-PNP pincer catalysts for the formal hydroamination of allylic alcs. were presented. The resulting γ-amino alcs. were selectively obtained in high yields applying compound I in a tandem process under mild conditions.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Synthetic Route of C5BrMnO5) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Synthetic Route of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary