Month: October 2022

Mohamed, Mohamed Gamal; Liu, Ni-Yun; El-Mahdy, Ahmed A. F.; Kuo, Shiao-Wei published an article in 2021. The article was titled 《Ultrastable luminescent hybrid microporous polymers based on polyhedral oligomeric silsesquioxane for CO2 uptake and metal ion sensing》, and you may find the article in Microporous and Mesoporous Materials.Safety of 9,10-Dibromoanthracene The information in the text is summarized as follows:

In this study we prepared four different fluorescent hybrid microporous polymers (HPPs) derived from cubic octavinylsilsesquioxane (OVS) through Heck coupling with brominated anthracene (An-Br2), triphenyltriazine (TPT-Br3), bicarbazole (Car-Br4) and tetraphenylethene (TPE-Br4). The chem. structures of these HPPs were confirmed using Fourier transform IR spectroscopy and solid-state NMR spectroscopy. Thermogravimetric anal. and N2 adsorption/desorption measurements revealed that each of these HPPs had outstanding thermal stability, a high surface area, and inherent porosity. The CO2 uptakes of TPT-HPP and Car-HPP at 273 and 298 K were higher than those of An-HPP and TPE-HPP. Furthermore, the luminescence of these HPPs could be quenched completely upon the addition of Fe2+, and Fe3+ metal cations. Thus, these HPP materials appear to be good candidates for CO2 adsorption and metal ion sensing. The experimental part of the paper was very detailed, including the reaction process of 9,10-Dibromoanthracene(cas: 523-27-3Safety of 9,10-Dibromoanthracene)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.Safety of 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mumford, Emily M.; Hemric, Brett N.; Denmark, Scott E. published an article in 2021. The article was titled 《Catalytic, Enantioselective Syn-Oxyamination of Alkenes》, and you may find the article in Journal of the American Chemical Society.Product Details of 1530-32-1 The information in the text is summarized as follows:

The chemo-, regio-, diastereo-, and enantioselective 1,2-oxyamination of alkenes R1CH=CHR2 (R1 = n-Pr, Ph, thiophen-3-yl, naphthalen-2-yl, etc.; R2 = i-Pr, (benzyloxy)methyl, (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl, etc.) using selenium(II/IV) catalysis with a chiral diselenides I (R = tert-Bu, Ph, adamantan-2-yl , naphthalen-2-yl) catalyst is reported. This method uses N-tosylamides R3C(O)NHTs (R3 = 2,6-dimethylphenyl, 2-bromophenyl, naphthalen-1-yl, etc.) to generate oxazoline products syn-II that are useful both as protected 1,2-amino alc. motifs and as chiral ligands. The reaction proceeds in good yields with excellent enantio- and diastereoselectivity for a variety of alkenes and pendant functional groups such as sulfonamides, alkyl halides, and glycol-protected ketones. Furthermore, the rapid generation of oxazoline products syn-II are demonstrated in the expeditious assembly of chiral PHOX ligands as well as diversely protected amino alcs. The results came from multiple reactions, including the reaction of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Product Details of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Product Details of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Angelucci, Francesco; Cirillo, Davide; Bjoersvik, Hans-Rene published an article in 2022. The article was titled 《Imidazole Backbone Functionalization with Olefin Cross-Metathesis》, and you may find the article in European Journal of Organic Chemistry.Related Products of 1530-32-1 The information in the text is summarized as follows:

A selective and high-rate Ru-catalyzed cross-metathesis reaction of alkenes with vinylimidazole was disclosed. Cross-metathesis was known to operate less efficiently on N-heterocycles, but through optimization by means of statistical exptl. design and multiple regression, optimal reaction conditions were identified that allowed for consistent high-yields without the need of overly complicated set-ups or additives. The method was tested on a series of terminal alkene reagents with a variety of different functional groups and it provides the corresponding target mols. in good to high yields. The results came from multiple reactions, including the reaction of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Related Products of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Related Products of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Hwang, Soon-Hyeok; Kang, Sung-Yun; Yang, Sanghee; Lee, Jaeho; Choi, Tae-Lim published an article in Journal of the American Chemical Society. The title of the article was 《Synchronous Preparation of Length-Controllable 1D Nanoparticles via Crystallization-Driven In Situ Nanoparticlization of Conjugated Polymers》.COA of Formula: C4H2Br2S The author mentioned the following in the article:

Precise size control of semiconducting nanomaterials from polymers is crucial for optoelectronic applications, but the low solubility of conjugated polymers makes this challenging. Herein, we prepared length-controlled semiconducting one-dimensional (1D) nanoparticles by synchronous self-assembly during polymerization First, we succeeded in unprecedented living polymerization of highly soluble conjugated poly(3,4-dihexylthiophene). Then, block copolymerization of poly(3,4-dihexylthiophene)-block-polythiophene spontaneously produced narrow-dispersed 1D nanoparticles with lengths from 15 to 282 nm according to the size of a crystalline polythiophene core. The key factors for high efficiency and length control are a highly solubilizing shell and slow polymerization of the core, thereby favoring nucleation elongation over isodesmic growth. Combining kinetics and high-resolution imaging analyses, we propose a unique mechanism called crystallization-driven in situ nanoparticlization of conjugated polymers (CD-INCP) where spontaneous nucleation creates seeds, followed by seeded growth in units of micelles. Also, we achieved “”living”” CD-INCP through a chain-extension experiment We further simplified CD-INCP by adding both monomers together in one-shot copolymerization but still producing length-controlled nanoparticles.2,5-Dibromothiophene(cas: 3141-27-3COA of Formula: C4H2Br2S) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.COA of Formula: C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4-Bromobutanoic acidIn 2021 ,《Remote C-H Pyridylation of Hydroxamates through Direct Photoexcitation of O-Aryl Oxime Pyridinium Intermediates》 appeared in Angewandte Chemie, International Edition. The author of the article were Kweon, Byeongseok; Kim, Changha; Kim, Seonyul; Hong, Sungwoo. The article conveys some information:

An efficient strategy for the remote C-H pyridylation of hydroxamates with excellent ortho-selectivity by designing a new class of photon-absorbing O-aryl oxime pyridinium salts generated in-situ from the corresponding pyridines and hydroxamates. When irradiated by visible light, the photoexcitation of oxime pyridinium intermediates generated iminyl radicals via the photolytic N-O bond cleavage, which does not require an external photocatalyst. The efficiency of light absorption and N-O bond cleavage of the oxime pyridinium salts was modulated through the electronic effect of substitution on the O-aryl ring. The resultant iminyl radicals enabled the installation of pyridyl rings at the γ-CN position, which yields synthetically valuable C2-substituted pyridyl derivatives This novel synthetic approach provided significant advantages in terms of both efficiency and simplicity and exhibits broad functional group tolerance in complex settings under mild and metal-free conditions. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Ethyl 4-bromobutyrateIn 2019 ,《Regioselective Alkylative Cross-Coupling of Remote Unactivated C(sp3)-H Bonds》 appeared in Journal of the American Chemical Society. The author of the article were Thullen, Scott M.; Treacy, Sean M.; Rovis, Tomislav. The article conveys some information:

The functionalization of unactivated C(sp3)-H bonds poses a significant challenge due to their ubiquity and relative similarity in most organic frameworks. Herein, we describe the use of a combined photoredox and nickel catalytic system for the regioselective C(sp3)-C(sp3) coupling of unactivated C(sp3)-H bonds and alkyl bromides. Positional selectivity is dictated by a 1,5-hydrogen atom transfer (HAT) reaction by a pendent amide. Interception of this radical by a Ni catalyst allows distal alkylation to occur in good yield and excellent selectivity. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Quality Control of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C9H9BrO2In 2021 ,《Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization》 was published in Journal of Medicinal Chemistry. The article was written by Zirimwabagabo, Jean-Olivier; Jailani, Ameera B. A.; Avgoustou, Paris; Tozer, Matthew J.; Gibson, Karl R.; Glossop, Paul A.; Mills, James E. J.; Porter, Roderick A.; Blaney, Paul; Wang, Ning; Skerry, Timothy M.; Richards, Gareth O.; Harrity, Joseph P. A.. The article contains the following contents:

Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) together with one of three accessory proteins known as receptor activity-modifying proteins (RAMPs). CLR/RAMP1 forms a CGRP receptor, CLR/RAMP2 forms an adrenomedullin-1 (AM1) receptor, and CLR/RAMP3 forms an adrenomedullin-2 (AM2) receptor. The CTR/RAMP complexes form three distinct amylin receptors. While the selective blockade of AM2 receptors would be therapeutically valuable, inhibition of AM1 receptors would cause clin. unacceptable increased blood pressure. We report here a systematic study of structure-activity relationships that has led to the development of first-in-class AM2 receptor antagonists such as I. These compounds exhibit therapeutically valuable properties with 1000-fold selectivity over the AM1 receptor. These results highlight the therapeutic potential of AM2 antagonists. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Computed Properties of C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 4-Bromobutanoic acidIn 2020 ,《Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release》 was published in Angewandte Chemie, International Edition. The article was written by Chakroun, Rami W.; Sneider, Alexandra; Anderson, Caleb F.; Wang, Feihu; Wu, Pei-Hsun; Wirtz, Denis; Cui, Honggang. The article contains the following contents:

Self-assembly of peptide-based building units into supramol. nanostructures creates an important class of biomaterials with robust mech. properties and improved resistance to premature degradation Yet, upon aggregation, substrate-enzyme interactions are often compromised because of the limited access of macromol. proteins to the peptide substrate, leading to either a reduction or loss of responsiveness to biomol. cues. Reported here is the supramol. design of unsym. reverse bolaamphiphiles (RBA) capable of exposing a matrix metalloproteinase (MMP) substrate on the surface of their filamentous assemblies. Upon addition of MMP-2, these filaments rapidly break into fragments prior to reassembling into spherical micelles. Using 3D cell culture, it is shown that drug release is commensurate with cell d., revealing more effective cell killing when more cancer cells are present. This design platform could serve as a cell-responsive therapeutic depot for local chemotherapy. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Safety of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Safety of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Development of 18F-labeled radiotracers for PET imaging of the adenosine A2A receptor: synthesis, radiolabeling and preliminary biological evaluation》 was published in International Journal of Molecular Sciences in 2021. These research results belong to Lai, Thu Hang; Schroder, Susann; Toussaint, Magali; Dukic-Stefanovic, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jorg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rares-Petru. Product Details of 76283-09-5 The article mentions the following:

The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomog. (PET) radiotracer to monitor changes of receptor d. and/or occupancy during the A2AR-tailored therapy, authors designed a library of fluorinated analogs based on a recently published lead compound (PPY). Among those, the highly affine 4-fluorobenzyl derivate (Ki(hA2AR) = 5.3 nM) and the 2-fluorobenzyl derivate (Ki(hA2AR) = 2.1 nM) were chosen for 18F-labeling via an alc. enhanced copper-mediated procedure starting from the corresponding boronic acid pinacol ester precursors. Investigations of the metabolic stability of compound I (R = p-18F, o-18F) in CD-1 mice by radio-HPLC anal. revealed parent fractions of more than 76% of total activity in the brain. Specific binding of I (R = o-18F)on mice brain slices was demonstrated by in vitro autoradiog. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance. After reading the article, we found that the author used 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Product Details of 76283-09-5)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Product Details of 76283-09-5Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The Tris(pentafluorophenyl)methylium Cation: Isolation and Reactivity》 was written by Hoffmann, Kurt F.; Battke, David; Golz, Paul; Rupf, Susanne M.; Malischewski, Moritz; Riedel, Sebastian. Application of 4316-58-9This research focused ontrispentafluorophenylmethylium cation isolation calculation reactivity electrochem; crystal structure mol trispentafluorophenylmethylium aluminate preparation optimized; High Hydride Affinity; Perfluorinated Trityl Cation; Strong Oxidizer; Superacids; Weakly Coordinating Anions. The article conveys some information:

Herein, we present two different routes for the synthesis of the perfluorinated trityl cation, which allowed the handling of the free, uncoordinated species in organic solvents for the first time. The usage of the weakly coordinating anion [Al(OTeF5)4]- and its derivatives allows the characterization of this species by NMR spectroscopy and most importantly by single-crystal X-ray diffraction. The high hydride ion affinity of the cation is shown by hydrogen abstraction from isobutane. Furthermore, cyclic voltammetry reveals its oxidative potential which is supported by the reaction with tris(4-bromophenyl)amine, giving rise to the formation of the ammoniumyl radical cation, also known as “”magic blue””. In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9Application of 4316-58-9)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary