Month: October 2022

《Xanthates as Thiol Surrogates for Nucleophilic Substitution with Aryl Halides》 was written by Sokolov, Anatolii I.; Mikhaylov, Andrey A.; Baleeva, Nadezhda S.; Baranov, Mikhail S.. HPLC of Formula: 1129-28-8This research focused onxanthate aryl chloride nucleophilic aromatic substitution reaction; aryl thioalkane preparation. The article conveys some information:

An unprecedented xanthate-based protocol for the preparation of aryl-alkyl thioethers was reported. Heating xanthates with aryl halides and namely cesium carbonate in methanol provides the target thioethers in generally good yields within short reaction times. This method allowed one to avoid contact with odorous thiols and also to introduce substituents of which the corresponding thiols are virtually unavailable or inconvenient in use. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8HPLC of Formula: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. HPLC of Formula: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C24H12Br6On September 30, 1996 ,《Multinucleating ligands from multiple palladium(0)-catalyzed cross-coupling reactions – synthesis and characterization of a trinuclear cyclometalated ruthenium(II) complex and a hexanuclear EPR-active molybdenum complex》 was published in Inorganica Chimica Acta. The article was written by Cargill Thompson, Alexander M. W.; McCleverty, Jon A.; Ward, Michael D.. The article contains the following contents:

Two multinucleating ligands were prepared from 1,3,5-tris(3,5-dibromophenyl)benzene by multiple Pd(0)-catalyzed cross-coupling reactions. 1,3,5-Tris[3,5-bis(4-pyridylethenyl)phenyl]benzene (L1) has six remote pyridyl moieties, each of which can coordinate a 17 valence-electron {Mo(tp*)(NO)Cl} fragment (tp* = hydrotris(3,5-dimethylpyrazolyl)borate), affording hexanuclear [{Cl(NO)(tp*)Mo}6(L1)] (1). 1,3,5-Tris[3,5-bis(2-pyridyl)phenyl]benzene (L2) incorporates three potentially terdentate, cyclometalating N,C,N-donor sets, and can coordinate three {Ru(tpy)}2+ fragments (tpy = 2,2′:6′,2”-terpyridine) giving trinuclear [{(tpy)Ru}3(L2)][PF6]3 (2). Complex 1 is EPR active, with nearest-neighbor pairs of Mo centers displaying magnetic exchange interactions. Electrochem. studies of the two complexes suggest that there is little ground-state interaction between the metal centers in either case.3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8Synthetic Route of C24H12Br6) was used in this study.

3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C24H12Br6 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 403646-48-0On May 15, 2019 ,《Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Reed, Carson W.; Washecheck, Jordan P.; Quitlag, Marc C.; Jenkins, Matthew T.; Rodriguez, Alice L.; Engers, Darren W.; Blobaum, Anna L.; Jeffrey Conn, P.; Niswender, Colleen M.; Lindsley, Craig W.. The article conveys some information:

This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile amide moiety within a series of mGlu7 neg. allosteric modulators (NAMs). SAR rapidly honed in on either a 1,2,4- or 1,3,4-oxadizaole ring system as an effective bioisostere for the amide. Further optimization of the southern region of the mGlu7 NAM chemotype led to the discovery of VU6019278, a potent mGlu7 NAM (IC50 = 501 nM, 6.3% L-AP4 Min) with favorable plasma protein binding (rat fu = 0.10), low predicted hepatic clearance (rat CLhep = 27.7 mL/min/kg) and high CNS penetration (rat Kp = 4.9, Kp,uu = 0.65). In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0SDS of cas: 403646-48-0)

2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. SDS of cas: 403646-48-0 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acidOn October 15, 2022 ,《Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Reed, Carson W.; Rodriguez, Alice L.; Kalbfleisch, Jacob J.; Seto, Mabel; Jenkins, Matthew T.; Blobaum, Anna L.; Chang, Sichen; Lindsley, Craig W.; Niswender, Colleen M.. The article contains the following contents:

We describe here a series of metabotropic glutamate receptor 7 (mGlu7) neg. allosteric modulators (NAMs) with a saturable range of activity in inhibiting responses to an orthosteric agonist in two distinct in vitro pharmacol. assays. The range of inhibition among compounds in this scaffold provides highly structurally related ligands with differential degrees of receptor blockade that can be used to understand inhibitory efficacy profiles in native tissue or in vivo.2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acid) was used in this study.

2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acid Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 403646-48-0On November 30, 2001 ,《1,2-Didehydro-3- and -4-(trifluoromethoxy)benzene: the “”aryne”” route to 1- and 2-(trifluoromethoxy)naphthalenes》 appeared in European Journal of Organic Chemistry. The author of the article were Schlosser, Manfred; Castagnetti, E.. The article conveys some information:

Upon treatment of 1-bromo-2-(trifluoromethoxy)benzene with lithium diisopropylamide (LDA) at -100°C, 3-bromo-2-(trifluoromethoxy)phenyllithium is generated. It can be trapped as such, but isomerizes to afford 2-bromo-6-(trifluoromethoxy)phenyllithium when the temperature is raised to -75°C. The latter intermediate can be directly obtained from 1-bromo-3-(trifluoromethoxy)benzene. 1-Bromo-4-(trifluoromethoxy)benzene gives 5-bromo-2-(trifluoromethoxy)phenyllithium at -100°C, but at -75°C it slowly eliminates lithium bromide, thus setting free 1,2-dehydro-4-(trifluoromethoxy)benzene. In the same way, 1,2-dehydro-3-(trifluoromethoxy)benzene can be generated from 1-bromo-3-(trifluoromethoxy)benzene. Both arynes can be intercepted in situ with furan. The resulting [4+2] cycloadducts can be reduced with zinc powder, giving 1- and 2-(trifluoromethoxy)naphthalenes, they may be submitted to acid-catalyzed isomerization to produce trifluoromethoxy-1-naphthols, or they may be brominated to afford vic-dibromo derivatives Base-promoted dehydrobromination of the latter compounds produces 2- or 3-bromo-1,4-epoxy-1,4-dihydro-5- or -6-(trifluoromethoxy)naphthalenes, which undergo regioselective ring-opening in acidic media and halogen/metal exchange when treated with butyllithium. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0SDS of cas: 403646-48-0)

2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. SDS of cas: 403646-48-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C6H5BrO2On May 25, 2019, Sattar, Omar D. Abdul; Shneshil, Mustafa K.; Mohammed, Mustafa K.; Dheyab, Hiba B.; Alwan, Osama K.; Hussein, Suaad A.; Mahmood, Maha A. published an article in Journal of Physics: Conference Series. The article was 《Synthesis and anti-bacterial activity of some azo compounds》. The article mentions the following:

Some azo compounds were prepared as I (R = 4-hydroxyphenyl, 3-chloro-4-hydroxyphenyl, 4-hydroxy-2-nitrophenyl, etc.) by the reaction of 4-amino benzamide with benzoyl chloride forming N-benzoyl-4-amino benzamide, the later was diazotized to give N-benzoyl-4-((substituted phenyl)diazenyl)benzamide I. The azo derivatives I were tested for their antibacterial activity against (S. aureus, S. epidermidis, E. coli and P. aeruginosa) by using disk diffusion method. The min. inhibitory concentrations (MICs) of the compounds also calculated by agar streak dilution method. In the experiment, the researchers used many compounds, for example, 2-Bromobenzene-1,4-diol(cas: 583-69-7COA of Formula: C6H5BrO2)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C6H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 4,7-Bis(4-bromophenyl)-1,10-phenanthrolineOn November 27, 2002 ,《Divalent Osmium Complexes: Synthesis, Characterization, Strong Red Phosphorescence, and Electrophosphorescence》 appeared in Journal of the American Chemical Society. The author of the article were Carlson, Brenden; Phelan, Gregory D.; Kaminsky, Werner; Dalton, Larry; Jiang, Xuezhong; Liu, Sen; Jen, Alex K. Y.. The article conveys some information:

New divalent Os complexes are reported which feature strong red metal-to-ligand-charge-transfer (MLCT) phosphorescence and electrophosphorescence. The general formula of the complexes is Os(II)(N-N)2L-L, where N-N is either a bipyridine or a phenanthroline and L-L is either a phosphine or an arsine. New polypyridyl ligands synthesized are 4,4′-di(biphenyl)-2,2′-bipyridine (15) and 4,4′-di(di-Ph ether)-2,2′-bipyridine (16), and the 1,10-phenanthroline derivatives synthesized are 4,7-bis(p-methoxyphenyl)-1,10-phenanthroline (17), 4,7-bis(p-bromophenyl)-1,10-phenanthroline (18), 4,7-bis(4′-phenoxybiphen-4-yl)-1,10-phenanthroline (19), and 4,7-bis(4-naphth-2-ylphenyl)-1,10-phenanthroline (20). 4,4′-Diphenyl-2,2′-bipyridine (21) and 4,7-diphenyl-1,10-phenanthroline (22) were also used in these studies. Strong π-acid ligands used were 1,2-bis(diphenylarseno)ethane (23), cis-1,2-bis(diphenylphosphino)ethylene (24), and cis-1,2-vinylenebis(diphenylarsine) (25). 25 Was used for the 1st time in these types of luminescent Os complexes. These compounds feature strong MLCT absorption bands in the visible region and strong red phosphorescent emission ranging from 611 to 651 nm, with quantum efficiency up to 45% in EtOH solution at room temperature Red organic light-emitting diodes (OLEDs) were successfully fabricated by doping the Os(II) complexes into blend of poly(N-vinylcarbazole) (PVK) and 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazole (PBD). Brightness over 1400 cd/m2 for a double-layer device was reached, with a turn-on voltage of 8 V. The maximum external quantum efficiency was 0.64%. Commission Internationale de l’Eclairage (CIE) chromaticity coordinates (x, y) of the red electrophosphorescence from the complexes are (0.65, 0.34), which indicates pure red emission. The results came from multiple reactions, including the reaction of 4,7-Bis(4-bromophenyl)-1,10-phenanthroline(cas: 97802-08-9Quality Control of 4,7-Bis(4-bromophenyl)-1,10-phenanthroline)

4,7-Bis(4-bromophenyl)-1,10-phenanthroline(cas: 97802-08-9) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Quality Control of 4,7-Bis(4-bromophenyl)-1,10-phenanthroline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dutta, Shubham; Yang, Shengwen; Vanjari, Rajeshwer; Mallick, Rajendra K.; Gandon, Vincent; Sahoo, Akhila K. published an article in Angewandte Chemie, International Edition. The title of the article was 《Keteniminium-Driven Umpolung Difunctionalization of Ynamides》.Computed Properties of C6H5BBr2O2 The author mentioned the following in the article:

A three-component Pd-catalyzed coupling of ynamides, aryl diazonium salts, and aryl boronic acids for the synthesis of novel triaryl-substituted enamides is described. This transformation represents the first example of an umpolung regioselective unsym. syn-1,2-diarylation/aryl-olefination of ynamides. The aryl moieties of the diazonium salt (electrophile) and boronic acid (nucleophile) are explicitly incorporated in the electrophilic α- and nucleophilic β-position, resp., of the ynamide, resulting in a single isomer of the N-bearing tetrasubstituted olefin. The scope is broad (68 examples), showing excellent functional-group tolerance. DFT calculations substantiate the rationale of the mechanistic cycle and the regioselectivity. The chemoselectivity and synthetic potential of the enamide products were also studied.3,4-Dibromophenylboronic acid(cas: 1228180-83-3Computed Properties of C6H5BBr2O2) was used in this study.

3,4-Dibromophenylboronic acid(cas: 1228180-83-3) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Computed Properties of C6H5BBr2O2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fier, Patrick S.; Maloney, Kevin M. published an article on January 30 ,2019. The article was titled 《NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: 25195-52-2 The information in the text is summarized as follows:

Primary alkyl and aryl sulfonamides underwent chemoselective deamination reactions with benzaldehyde and K2CO3 in the presence of a pyrrolotriazolium chloride via N-benzylidenesulfonamides to yield sulfinate salts; the sulfinates were converted in situ to Me and aryl sulfones, sulfonic acids, and sulfonamides. Reaction of the sulfinates with MeI in DMF yielded Me sulfones, while oxidation with H2O2 in the presence of tungstic acid yielded sulfonic acids. Reaction of the sulfinate generated from celecoxib with 15NH4OH yielded the corresponding 15N-labeled sulfonamide; coupling reactions of the celecoxib-derived sulfinate with iodobenzene and a chloropyridine yielded aryl sulfones, while desulfonative coupling with Ph triflate yielded a biphenylpyrazole. The method tolerated nearly all common functional groups, including primary amines, and was used for the late-stage derivatization of several complex pharmaceutical compounds In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2Recommanded Product: 25195-52-2)

1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 25195-52-2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Muramatsu, Tatsuya; Okado, Yuji; Traeger, Hanna; Schrettl, Stephen; Tamaoki, Nobuyuki; Weder, Christoph; Sagara, Yoshimitsu published an article in Journal of the American Chemical Society. The title of the article was 《Rotaxane-Based Dual Function Mechanophores Exhibiting Reversible and Irreversible Responses》.Application of 583-69-7 The author mentioned the following in the article:

Mechanochromic mechanophores permit the design of polymers that indicate mech. events through optical signals. Here we report rotaxane-based supramol. mechanophores that display both reversible and irreversible fluorescence changes. These responses are triggered by different forces and are achieved by exploiting the mol. shuttling function and force-induced dethreading of rotaxanes. The new rotaxane mechanophores are composed of a ring featuring a luminophore, which is threaded onto an axle with a matching quencher and two stoppers. In the stress-free state, the luminophore is preferentially located in the proximity of the quencher, and the emission is quenched. The luminophore slides away from the quencher when a force is applied and the fluorescence is switched on. This effect is reversible, unless the force is so high that the luminophore-carrying ring slips past the stopper and dethreading occurs. We show that the combination of judiciously selected ring and stopper moieties is crucial to attain interlocked structures that display such a dual response. PU elastomers that contain such doubly responsive rotaxanes exhibit reversible fluorescence changes over multiple loading-unloading cycles due to the shuttling function, whereas permanent changes are observed upon repeated deformations to high strains due to breakage of the mech. bond upon dethreading of the ring from the axle. This response allows one, at least conceptually, to monitor the actual deformation of polymer materials and examine mech. damage that was inflicted in the past on the basis of an optical signal. In the experiment, the researchers used 2-Bromobenzene-1,4-diol(cas: 583-69-7Application of 583-69-7)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 583-69-7 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary