Month: October 2022

Organic compounds having carbon bonded to bromine are called organic bromides. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of 244205-40-1.

Planas, Oriol;Peciukenas, Vytautas;Cornella, Josep research published 《 Bismuth-Catalyzed Oxidative Coupling of Arylboronic Acids with Triflate and Nonaflate Salts》, the research content is summarized as follows. Herein, a Bi-catalyzed cross-coupling of arylboronic acids with perfluoroalkyl sulfonate salts based on a Bi(III)/Bi(V) redox cycle is presented. An electron-deficient sulfone ligand proved to be key for the successful implementation of this protocol, which allows the unusual construction of C(sp²)-O bonds using com. available NaOTf and KONf as coupling partners. Preliminary mechanistic studies as well as theor. investigations reveal the intermediacy of a highly electrophilic Bi(V) species, which rapidly eliminates Ph triflate.

Synthetic Route of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C7H6Br2.

Pla-Lopez, Alberto;Castillo, Raquel;Cejudo-Marin, Rocio;Garcia-Pedrero, Olaya;Bakir-Laso, Mariam;Falomir, Eva;Carda, Miguel research published 《 Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents》, the research content is summarized as follows. Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthesized and biol. evaluated as multitarget inhibitors of VEGFR-2, PD-L1 and c-Myc proteins. The antiproliferative activity of these mols. on several tumor cell lines (HT-29, A-549, and MCF-7) and on the non-tumor cell line HEK-293 was determined The effects on the abovementioned biol. targets were evaluated for some selected compounds Compound I, bearing a p-chlorophenyl group, showed better results than sorafenib in regard to the downregulation of VEGFR-2 and a similar effect to BMS-8 on both PD-L1 and c-Myc proteins. The antiangiogenic and antivascular activities of chloro derivatives were also established by endothelial microtube formation assay on Matrigel.

COA of Formula: C7H6Br2, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application of C9H9BrO3.

Pizova, Hana;Malanik, Milan;Smejkal, Karel;Oravec, Michal;Bobal, Pavel research published 《 Synthesis of C-prenylated analogues of stilbenoid methyl ethers and their cyclic dihydrobenzopyranyl derivatives as potential anti-inflammatory agents》, the research content is summarized as follows. An efficient and versatile synthesis of the naturally occurring C-prenylated stilbenoid Me ethers and their synthetic analogs is presented. The synthesis represents a six step convergent process including an optimized C-prenylation method. Furthermore, during the demethylation process, six new dihydro-benzopyranyl derivatives were obtained and isolated.

Application of C9H9BrO3, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C8H6BrF3.

PipaonFernandez, Nahiane;Gaube, Gregory;Woelk, Kyla J.;Burns, Mathias;Hruszkewycz, Damian P.;Leitch, David C. research published 《 Palladium-Catalyzed Direct C-H Alkenylation with Enol Pivalates Proceeds via Reversible C-O Oxidative Addition to Pd(0)》, the research content is summarized as follows. A direct tandem C-O/C-H activation approach to C-C bond formation using palladium catalysis was reported. This reaction combines C-O oxidative addition at enol pivalates e.g., I with concerted metalation-deprotonation of functionalized heterocycles e.g., II to achieve base-free direct C-H alkenylation. Preliminary mechanistic studies revealed that the C-O oxidative addition to Pd(0) is reversible under these conditions and C-H activation occurs directly from the Pd(II) C-O oxidative addition products e.g., III. In situ ³¹P NMR spectroscopy further revealed that the (Cy₃P)₂Pd-(alkenyl)(OPiv) species is a major catalyst resting state during the reactions.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Formula: C8H6BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Pinchaipat, Bussaba;Khudkham, Teerawat;Wongsuwan, Sutthida;Chotima, Ratanon;Chainok, Kittipong;Pila, Taweesak research published 《 The novel zinc(II) complex with dibromo substituted Schiff base and its biological activity》, the research content is summarized as follows. Schiff base 3,5-dibromo-N-(8-quinolyl)salicylaldimine (HqsalBr₂) and its zinc(II) complex, [Zn(qsalBr₂)₂], have been synthesized and characterized using spectroscopic techniques and single crystal X-Ray crystallog. The interaction of the complex with calf thymus DNA (CT-DNA) was investigated by electronic absorption and luminescence titration methods. The results reveal the intercalative mode of binding between the synthesized complex and CT-DNA with binding constant (K_b) of 2.00 x 10⁶ M^-1. The complex also exhibits capability in the competitive reaction with the standard ethidium bromide (EB) and provides favorable quenching constant value (K_q) of 7.91 x 10¹¹ M^-1s^-1. Anti-lung cancer activity against A549 cell line was examined and zinc(II) complex performed the ability in the inhibition of this cancer cell growing.

Category: bromides-buliding-blocks, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5392-10-9, formula is C9H9BrO3, The most pervasive is the naturally produced bromomethane. Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde

Pimparkar, Sandeep;Bhattacharya, Trisha;Maji, Arun;Saha, Argha;Jayarajan, Ramasamy;Dutta, Uttam;Lu, Gang;Lupton, David W.;Maiti, Debabrata research published 《 Para-Selective Cyanation of Arenes by H-Bonded Template》, the research content is summarized as follows. In this work, the para-selective introduction of versatile nitrile moieties RSi(CH(CH₃)₂)₂O(4-R¹C₆H₄) (R = 4-cyanophenoxy, (4-cyanonaphthalen-1-yl)methyl, 2-cyano-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl, etc.; R¹ = 6-cyano-2H-1,3-benzodioxol-5-yl, 2-(pyridin-3-yl)benzen-1-yl, 2-cyano-4,5-dimethoxybenzen-1-yl, etc.), enabled by a detachable and reusable H-bonded auxiliary was demonstrated. The methodol. holds its efficiency irresp. of substrate electronic bias. The conspicuous shift in the step energetics was probed by both exptl. and computational mechanistic tools, which heralds the inception of para-deuteration. The synthetic impact of the methodol. was highlighted with reusability of directing group and post synthetic modifications.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., HPLC of Formula: 70-23-5.

Piltan, Mohammad research published 《 Syntheses of Novel Tetrasubstituted Thiophenes from Benzene-1,2-Diamines, Ethyl Bromopyruvate, Malononitrile, and Aryl Isothiocyanates》, the research content is summarized as follows. Synthesis of amino(oxo-dihydroquinoxalinyl)(phenylamino)thiophene-carbonitrile derivatives I [R = H, Me, Cl; R¹ = 2-MeOC₆H₄, 4-NO₂C₆H₄, Et, Ph] was reported via sequential base mediated condensation of malononitrile with aryl isothiocyanates followed by S-alkylation with 3-(bromomethyl)quinoxalin-2(1H)-one compounds and concurrent intramol. enamine type condensation of S-alkylated compounds in excellent yields.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., HPLC of Formula: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 629-04-9, formula is C7H15Br, The most pervasive is the naturally produced bromomethane. Name: 1-Bromoheptane

Pilicode, Naveenchandra;Naik, Praveen;Nimith, K. M.;Acharya, Madhukara;Satyanarayan, M. N.;Adhikari, Airody Vasudeva research published 《 New cyanopyridine-based π-conjugative poly(azomethine)s: Synthesis, characterization and electroluminescence studies》, the research content is summarized as follows. Four new Schiff-base type conjugative polymers (CPs), i.e., Py_1-4 carrying a strong electron-withdrawing cyanopyridine scaffold coupled with different electron-donating aromatic/heteroaromatic moieties were synthesized from their resp. co-monomers by simple poly-condensation route. They were subjected to structural, thermal, photophys., and electrochem. characterizations and theor. investigations in order to identify their suitability in polymer light-emitting diode (PLED) application. All these polymers showed good film-forming ability and exhibited favorable photophys. behaviors with an optical bandgap in the order of 2.54-2.68 eV. Further, their electrochem. data were used to evaluate HOMO and LUMO levels. Finally, Py_1-4 were successfully employed as blue-light emitter in the construction of new ITO/PEDOT:PSS/ Py_1-4/Al configured light-emitting diodes (LED), and the fabricated devices demonstrated stable blue electroluminescence behavior endorsing an effective electrons injection in the PLEDs.

Name: 1-Bromoheptane, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 6911-87-1, formula is C7H8BrN, The most pervasive is the naturally produced bromomethane. Product Details of C7H8BrN

Piehl, Patrick;Amuso, Roberta;Spannenberg, Anke;Gabriele, Bartolo;Neumann, Helfried;Beller, Matthias research published 《 Efficient methylation of anilines with methanol catalysed by cyclometalated ruthenium complexes》, the research content is summarized as follows. Cyclometalated ruthenium complexes, e.g., I, allow the effective methylation of anilines (R = 4-bromophenyl, 2-methylphenyl, 4-carbamoylphenyl, etc.) with methanol to selectively give N-methylanilines RNHCH₃. This hydrogen autotransfer procedure proceeds under mild conditions (60°C) in a practical manner (NaOH as base). Mechanistic investigations suggest an active homogenous ruthenium complex and β-hydride elimination of methanol as the rate determining step.

Product Details of C7H8BrN, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Formula: C5H9BrO2

Picconi, Pietro;Hind, Charlotte K.;Nahar, Kazi S.;Jamshidi, Shirin;Di Maggio, Lucia;Saeed, Naima;Evans, Bonnie;Solomons, Jessica;Wand, Matthew E.;Sutton, J. Mark;Rahman, Khondaker Miraz research published 《 New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria》, the research content is summarized as follows. It is urgent to find new antibiotic classes with activity against multidrug-resistant (MDR) Gram-neg. pathogens as the pipeline of antibiotics is essentially empty. Modified pyrrolobenzodiazepines with a C8-linked aliphatic heterocycle provide a new class of broad-spectrum antibacterial agents with activity against MDR Gram-neg. bacteria, including WHO priority pathogens. The structure-activity relationship established that the third ring was particularly important for Gram-neg. activity. Min. inhibitory concentrations for the lead compounds ranged from 0.125 to 2 mg/L for MDR Gram-neg., excluding Pseudomonas aeruginosa, and between 0.03 and 1 mg/L for MDR Gram-pos. species. The lead compounds were rapidly bactericidal with >5 log reduction in viable count within 4 h for Acinetobacter baumannii and Klebsiella pneumoniae. The lead compound inhibited DNA gyrase in gel-based assays, with an IC₅₀ of 3.16 ± 1.36 mg/L. This study provides a new chem. scaffold for developing novel broad-spectrum antibiotics which can help replenish the pipeline of antibiotics.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary