Month: October 2022

The author of 《Hydrazone linkage based Schiff base: synthesis, characterization and their biological applications》 were Pradhan, Alka Prof.; Koshal, Anil Kumar; Khichi, Dharmendra Singh. And the article was published in World Journal of Pharmaceutical Research in 2019. Product Details of 6630-33-7 The author mentioned the following in the article:

Synthesis of hydrazone linkage based Schiff base derivatives I [X = H, OH, Cl, Br; Y = H, 4-NO2, 4-NH2] via condensation of 2-[1-(4-aminophenyl)ethylidene]-hydrazine-1-carbothioamide intermediate II with benzaldehydes was described. Thiosemicarbazide intermediate II was obtained from reaction of 1-(4-aminophenyl)ethan-1-one and thiosemicarbazide. All synthesized compounds were screened for their antibacterial and antifungal activity by using agar well diffusion method. The results revealed that the compound I [X = H, OH, Y = H, 4-NH2] showed excellent activity against E. coli and moderate show against P. aerugenosaand and S.aureus. compound I [X = OH, Cl, Br; Y = H] were showed excellent against S.aureus. All compounds showed moderate anti-fungal activity against A. flavus and A. fumigates and show excellent against Candida albicans. In the experiment, the researchers used o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Catalyst-Controlled 1,2- and 1,1-Arylboration of α-Alkyl Alkenyl Arenes》 were Bergmann, Allison M.; Dorn, Stanna K.; Smith, Kevin B.; Logan, Kaitlyn M.; Brown, M. Kevin. And the article was published in Angewandte Chemie, International Edition in 2019. Product Details of 402-43-7 The author mentioned the following in the article:

Two methods are reported for the 1,2- and 1,1-arylboration of α-Me vinyl arenes. In the case of 1,2-arylboration, the formation of a quaternary center occurred through a rare cross-coupling reaction of a tertiary organometallic complex. 1,1-Arylboration was enabled by catalyst optimization and occurred through a β-hydride elimination/reinsertion cascade. Enantioselective variants of both processes are presented as well as mechanistic investigations.1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Product Details of 402-43-7) was used in this study.

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Product Details of 402-43-7 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of novel 2-(piperazin-1-yl-alkyl)-1H-benzimidazole derivatives and assessment of their interactions with the D2 dopamine receptor》 were Penjisevic, Jelena Z.; Andric, Deana B.; Sukalovic, Vladimir B.; Roglic, Goran M.; Soskic, Vukic; Kostic-Rajacic, Sladana. And the article was published in Journal of the Serbian Chemical Society in 2019. Formula: C5H9BrO2 The author mentioned the following in the article:

A total of 14 novel arylpiperazines were synthesized, and pharmacol. evaluated by measuring their affinities towards the D2 dopamine receptor (DRD2) in a [3H]spiperone competition assay. All the herein described compounds consist of a benzimidazole moiety connected to N-(2-methoxyphenyl)piperazine via linkers of various lengths. Mol. docking anal. and mol. dynamics simulations were performed on the DRD2-arylpiperazine complexes with the objective of exploring the receptor-ligand interactions and properties of the receptor binding site. The recently published crystal structure of DRD2 was used throughout this study. The major finding is that high affinity arylpiperazines must interact with both the orthosteric binding site and the extended binding pocket of DRD2 and therefore should contain a linker of 5 or 6 methylene groups long. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-bromopropanoate(cas: 539-74-2Formula: C5H9BrO2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yang, Le; Zheng, Jing; Zou, Zhen; Cai, Haiyan; Qi, Peng; Qing, Zhihe; Yan, Qi; Qiu, Liping; Tan, Weihong; Yang, Ronghua. Product Details of 2969-81-5 The article mentions the following:

As the most abundant protein in blood, human serum albumin (HSA) is usually regarded as an interferent in clin. mol. diagnosis. Herein, the authors report that HSA is an endogenous signal amplifier for the detection of the prostate-specific antigen (PSA) in human plasma. This is the first study to use intrinsic biol. components as the signal amplifier in blood tests. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Product Details of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ni-catalyzed regioselective 1,2-dialkylation of alkenes enabled by the formation of two C(sp3)-C(sp3) bonds》 was published in Journal of the American Chemical Society in 2020. These research results belong to Dhungana, Roshan K.; Sapkota, Rishi R.; Wickham, Laura M.; Niroula, Doleshwar; Giri, Ramesh. Safety of Methyl 3-(bromomethyl)benzoate The article mentions the following:

The authors disclosed a Ni-catalyzed vicinal difunctionalization of alkenes with benzyl halides and alkylzinc reagents, which produces products with two new alkyl-alkyl bonds. This alkene dialkylation is effective in combining secondary benzyl halides and secondary alkylzinc reagents with internal alkenes, which furnishes products with three contiguous all-carbon secondary stereocenters. The products can be readily elaborated to access complex tetraene, benzosuberene, and bicyclodecene cores. The reaction also features as the most efficient alkene difunctionalization process to date with catalyst loadings down to 500 ppm and the catalytic turnover number (TON) and turnover frequency (TOF) registering up to 2 x 103 and 165 h-1 at rt, resp. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Jankowska, Agnieszka; Satala, Grzegorz; Kolaczkowski, Marcin; Bucki, Adam; Gluch-Lutwin, Monika; Swierczek, Artur; Pociecha, Krzysztof; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Lubelska, Annamaria; Latacz, Gniewomir; Gawalska, Alicja; Bojarski, Andrzej J.; Wyska, Elzbieta; Chlon-Rzepa, Grazyna. HPLC of Formula: 2969-81-5 The article mentions the following:

A library of novel anilide and benzylamide derivatives of ω-(4-(2-methoxyphenyl)piperazin-1-yl)alkanoic acids as combined 5-HT1A/5-HT7 receptor ligands and phosphodiesterase PDE4B/PDE7A inhibitors was designed using a structure-based drug design approach. The in vitro studies of 33 newly synthesized compounds (7-39) allowed us to identify 22 as the most promising multifunctional 5-HT1A/5-HT7 receptor antagonist (5-HT1AKi = 8 nM, Kb = 0.04 nM; 5-HT7Ki = 451 nM, Kb = 460 nM) with PDE4B/PDE7A inhibitory activity (PDE4B IC50 = 80.4μM; PDE7A IC50 = 151.3μM). Compound 22 exerted a very good ability to passively penetrate through biol. membranes and a high metabolic stability in vitro. Moreover, the pharmacol. evaluation of 22 showed its procognitive and antidepressant properties in rat behavioral tests. Compound 22 at a dose of 3 mg/kg (i.p.) significantly reversed MK-801-induced episodic memory deficits in the novel object recognition test, while at a dose of 10 mg/kg (i.p.) reduced the immobility time of animals (by about 34%) in the forced swimming test. The antidepressant-like effect produced by compound 22 was stronger than that of escitalopram used as a reference drug. This study opens a new perspective in the search for efficacious drugs for the treatment of cognitive and depressive disorders. In the part of experimental materials, we found many familiar compounds, such as Ethyl 4-bromobutyrate(cas: 2969-81-5HPLC of Formula: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and Cross-Linking of a Benzoxazine-Containing Anthracene Moiety: Thermally Stable Photoluminescent Benzoxazine Resin》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Goto, Masahide; Yajima, Tatsuo; Minami, Masaki; Sogawa, Hiromitsu; Sanda, Fumio. SDS of cas: 523-27-3 The article mentions the following:

A novel benzoxazine derivative, 9,10-bis(6-ethynyl-3-phenyl-3,4-dihydro-1,3-benzoxazine)anthracene (1a), was synthesized by the Sonogashira-Hagihara coupling reaction of 9,10-dibromoanthracene and 6-ethynyl-3-phenyl-3,4-dihydro-1,3-benzoxazine. A CH2Cl2 solution of 1a luminesced with a high quantum yield (Φ = 81%). Compound 1a afforded solvent-insoluble cross-linked polybenzoxazine 1b by the bulk polymerization at 250°C. Solution polymerization of a dilute solution of 1a at 200°C afforded solvent-soluble samples, accompanied by a decrease of photoluminescence intensity. The weight loss values of 1a and 1b were 81 and 87%, resp., under nitrogen at 500°C. We believe that the present study will lead to thermally stable curing resins whose degree of curing can be estimated with the naked eye by observing the decrease of photoluminescence. In the experiment, the researchers used many compounds, for example, 9,10-Dibromoanthracene(cas: 523-27-3SDS of cas: 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.SDS of cas: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Evidence for lactone formation during infrared multiple photon dissociation spectroscopy of bromoalkanoate doped salt clusters》 was written by Bersenkowitsch, Nina K.; Oncak, Milan; Heller, Jakob; Pascher, Tobias F.; van der Linde, Christian; Beyer, Martin K.. Category: bromides-buliding-blocks And the article was included in Physical Chemistry Chemical Physics in 2020. The article conveys some information:

Reaction mechanisms of organic mols. in a salt environment are of fundamental interest and are potentially relevant for atm. chem., in particular sea-salt aerosols. Here, the authors found evidence for lactone formation upon IR multiple photon dissociation (IRMPD) of noncovalent bromoalkanoate complexes as well as bromoalkanoate embedded in sodium iodide clusters. The mechanism of lactone formation from bromoalkanoates of different chain lengths was studied in the gas phase with and without salt environment by a combination of IRMPD and quantum chem. calculations IRMPD spectra are recorded in the 833-3846 cm-1 range by irradiating the clusters with tunable laser systems while they are stored in the cell of a Fourier transform ICR (FT-ICR) mass spectrometer. The measurements of the binary complex Br(CH2)mCOOH·Br(CH2)mCOO- for m = 4 indicate valerolactone formation without salt environment while lactone formation is hindered for longer chain lengths. When embedded in sodium iodide clusters, butyrolactone formation from 4-bromobutyrate seems to take place already during formation of the doped clusters in the electrospray process, evidenced by the IR signature of the lactone. In contrast, IRMPD spectra of sodium iodide clusters containing 5-bromovalerate contain signatures for both valerate as well as valerolactone. In both cases, however, a neutral fragment corresponding to the mass of valerolactone is eliminated, indicating that ring formation can be activated by IR light in the salt cluster. Quantum chem. calculations show that already complexation with one sodium ion significantly increases the barrier for lactone formation for all chain lengths. IRMPD of sodium iodide clusters doped with neutral bromoalkanoic acid mols. proceeds by elimination of HI or desorption of the intact acid mol. from the cluster. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Category: bromides-buliding-blocks)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Thermally Controlled On/Off Switch in a Living Anionic Polymerization of 1-Cyclopropylvinylbenzene with an Anion Migrated Ring-Opening Mechanism》 was written by Bai, Hongyuan; Leng, Xuefei; Han, Li; Yang, Lincan; Li, Chao; Shen, Heyu; Lei, Lan; Zhang, Songbo; Wang, Xuefei; Ma, Hongwei. HPLC of Formula: 1779-49-3 And the article was included in Macromolecules (Washington, DC, United States) in 2020. The article conveys some information:

A reversible on/off switch to control chain growth in a living anionic polymerization is a meaningful challenge for its profound potential in both polymerization mechanisms and the preparation of advanced materials. Herein, we report a thermally controlled on/off switch for chain propagation in an anionic polymerization that is realized with a 1-cyclopropylvinylbenzene (CPVB) monomer. Interestingly, the specific ring-opening manner and thermal sensitivity are shown in the addition reaction of CPVB with the initiator or living chains. The ring opening of the cyclopropyl group in CPVB is observed to be a possible anion migrated ring-opening mechanism in the addition reactions. Addnl., the polymerization of CPVB occurs only at high temperature, and the chain growth constant kCC is near 0 at 20°C, 0.0039 (L/mol)1/2 min-1 at 50°C, and 0.016 (L/mol)1/2 min-1 at 60°C. Thus, based on its unique characteristics, an ingenious design of “”heat (60°C)-cool (20°C)”” cycles is employed to achieve a thermally controlled on/off switch for chain growth in an anionic polymerization It is expected that this finding can provide new insights into both controlling the monomer or multiblock sequence and raise a novel technique to stage control the chain growth with temperatures in living anionic polymerization In addition to this study using Methyltriphenylphosphonium bromide, there are many other studies that have used Methyltriphenylphosphonium bromide(cas: 1779-49-3HPLC of Formula: 1779-49-3) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.HPLC of Formula: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dhungana, Roshan K.; Sapkota, Rishi R.; Wickham, Laura M.; Niroula, Doleshwar; Shrestha, Bijay; Giri, Ramesh published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Ni-Catalyzed Arylbenzylation of Alkenylarenes: Kinetic Studies Reveal Autocatalysis by ZnX2》.Category: bromides-buliding-blocks The article contains the following contents:

We report a Ni-catalyzed regioselective arylbenzylation of alkenylarenes with benzyl halides and arylzinc reagents. The reaction furnishes differently substituted 1,1,3-triarylpropyl structures that are reminiscent of the cores of oligoresveratrol natural products. The reaction is also compatible for the coupling of internal alkenes, secondary benzyl halides and variously substituted arylzinc reagents. Kinetic studies reveal that the reaction proceeds with a rate-limiting single-electron-transfer process and is autocatalyzed by in-situ-generated ZnX2. The reaction rate is amplified by a factor of three through autocatalysis upon addition of ZnX2. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Category: bromides-buliding-blocks)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary