Month: October 2022

Application of 17696-11-6In 2021 ,《Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein》 appeared in Journal of the American Chemical Society. The author of the article were Besten, Willem den; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M.; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J.; Wertz, Ingrid; Yu, Kebing; Staben, Steven T.. The article conveys some information:

We hypothesized that the proximity-driven ubiquitylation of E3-interacting small mols. could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small mols. was modified to append a nucleophilic primary amine. This modification transforms XIAP binders into inducers of XIAP degradation The degradation of XIAP is E1- and proteasome-dependent, dependent on the ligase function of XIAP, and is rescued by subtle modifications of the small mol. that would obviate ubiquitylation. We demonstrate in vitro ubiquitylation of the small mol. that is dependent on its interaction with XIAP. Taken together, these results demonstrate the designed ubiquitylation of an engineered small mol. and a novel approach for the degradation of E3 ubiquitin ligases. In the part of experimental materials, we found many familiar compounds, such as 8-Bromooctanoic acid(cas: 17696-11-6Application of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 2969-81-5In 2022 ,《Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids》 appeared in Beilstein Journal of Organic Chemistry. The author of the article were Jakubkiene, Virginija; Valiulis, Gabrielius Ernis; Schweipert, Markus; Zubriene, Asta; Matulis, Daumantas; Meyer-Almes, Franz-Josef; Tumkevicius, Sigitas. The article conveys some information:

Here, the synthesis of new compounds in which a hydroxamic acid residue was attached to differently substituted pyrimidine rings via a methylene group bridge of varying length as potential HDAC inhibitors was described. The target compounds were obtained by alkylation of 2-(alkylthio)pyrimidin-4(3H)-ones with Et 2-bromoethanoate, Et 4-bromobutanoate, or Me 6-bromohexanoate followed by aminolysis of the obtained esters with hydroxylamine. Oxidation of the 2-methylthio group to the methylsulfonyl group and following treatment with amines resulted in the formation of the corresponding 2-amino-substituted derivatives, the ester group of which reacted with hydroxylamine to give the corresponding hydroxamic acids. The synthesized hydroxamic acids were tested as inhibitors of the HDAC4 and HDAC8 isoforms. Among the synthesized pyrimidine-based hydroxamic acids -hydroxy-6-[6-methyl-2-(methylthio)-5-propylpyrimidin-4-yloxy]hexanamide was found to be the most potent inhibitor of both the HDAC4 and HDAC8 isoforms, with an IC50 of 16.6μM and 1.2μM, resp. The results came from multiple reactions, including the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Benzyl 2-bromoacetateIn 2022 ,《Photocatalytic 1,2-oxo-alkylation reaction of styrenes with diazoacetates》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Li, Fang; Zhu, Siqi; Koenigs, Rene M.. The article contains the following contents:

The photocatalytic 1,2-difunctionalization reaction of styrenes with acceptor-only diazoalkanes are reported. In the presence of DABCO and tBuOOH, the carbene reactivity of diazoalkanes can be suppressed and a 1,2 oxo-alkylation reaction can be achieved (32 examples, up to 94% yield) without the formation of cyclopropane byproducts via the formation of radical intermediates from Et diazoacetate. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Methyl 3-bromopropanoateIn 2018 ,《A Sulfoxide-Based Isobaric Labeling Reagent for Accurate Quantitative Mass Spectrometry》 was published in Angewandte Chemie, International Edition. The article was written by Stadlmeier, Michael; Bogena, Jana; Wallner, Miriam; Wuehr, Martin; Carell, Thomas. The article contains the following contents:

Modern proteomics requires reagents for exact quantification of peptides in complex mixtures Peptide labeling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that sep. in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical mol. weight but a different mass of the reporter groups, allowing relative quantification of multiple samples in one measurement. Here the authors report a new isobaric labeling reagent, where the balancer and the reporter are linked by a sulfoxide group, which, based on the sulfoxide pyrolysis, leads to easy and asym. cleavage at low fragmentation energy. The fragmentation of the new design is significantly improved, yielding more intense complementary ion signals, allowing complementary ion cluster anal. as well. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2019 ,《Thinking Outside the “”Blue Box””: Induced Fit within a Unique Self-Assembled Polycationic Cyclophane》 was published in Journal of the American Chemical Society. The article was written by Blanco-Gomez, Arturo; Fernandez-Blanco, Angel; Blanco, Victor; Rodriguez, Jaime; Peinador, Carlos; Garcia, Marcos D.. The article contains the following contents:

We present herein the development of a new polycationic mol. receptor, inspired by the ubiquitous cyclobis(paraquat-p-phenylene)cyclophane (“”blue box””). Our analog, the “”white box””, has been easily self-assembled on a preparative scale in water, using a template-assisted process by acyl hydrazone bonding of complementary bis(pyridinium)xylylene tweezers, followed by kinetic trapping of the empty receptor. The obtained macrocycle was found to display a marked pH responsiveness in water, because of an abnormal acidity of the amide protons within its structure. Consequently, and because of the concurrence of rotational isomerism under acidic conditions (fixed at higher pH values), the compound was found to display a dual behavior as a conformationally locked/flexible mol. host, being able to recognize appropriate aromatic substrates, in a lock and key or induced fit fashion, by a conjunction of π-π, C-H···π, and, crucially, the hydrophobic effect. In addition to this study using 1,4-Bis(bromomethyl)benzene, there are many other studies that have used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1,4-Bis(bromomethyl)benzeneIn 2020 ,《Tetraphenylethene-based tetracationic dicyclophanes: synthesis, mechanochromic luminescence, and photochemical reactions》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Nian, Hao; Li, Aisen; Li, Yawen; Cheng, Lin; Wang, Ling; Xu, Weiqing; Cao, Liping. The article contains the following contents:

Two tetraphenylethene-based tetracationic dicyclophanes 1 and 2 were synthesized via a one-step SN2 reaction. Based on the central TPE unit and the slight difference of the outer linkers, 1 and 2 exhibited a classic aggregation-induced emission but contrasting mechanochromic luminescence under grinding, vaporing, or hydrostatic pressure in the solid state, and photochem. reactions with various emitting colors induced by photoirradiation in the solution state.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Reference of 1,4-Bis(bromomethyl)benzene) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 1,4-Bis(bromomethyl)benzene Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Dual character of peroxymonosulfate oxidation process to treat salty wastewater containing 2,4,6-tribromophenol》 was written by Fang, Changling; Lou, Xiaoyi; Tang, Yunyu; Tian, Liangliang; Cai, Youqiong; Xiao, Dongxue; Guo, Yaoguang; Liu, Jianshe. Name: 2-Bromobenzene-1,4-diol And the article was included in Journal of Environmental Chemical Engineering on August 31 ,2020. The article conveys some information:

Nowadays, increasing attention has been paid on the peroxymonosulfate (PMS) in situ oxidation for environmental decontamination. Chloride ion (Cl-) could directly react with PMS to produce some reactive halogen agents via non-radical pathways. In present study, the degradation kinetics of 2,4,6-tribromophenol (TBP) and the total organic carbon (TOC) removal by adding PMS in salty wastewater were inspected. TBP could effectively degraded by PMS in salty wastewater over the pH range of 3.0-7.0, and the degradation ratio increased with the pH of reaction solution Pos. effects of Cl- concentration (1-100 mM) on TBP degradation kinetics were also examined Moreover, the oxidation products and their evolution with reaction time were conducted in order to further evaluate the environmental benefits with co-existence of PMS and Cl-. Instead of complete mineralization, TBP was mainly transformed to new halogenated products which also have long half-lives. The chlorination of TBP is the dominant pathway in the presence of Cl-, since the main oxidant (HOCl) played an important role. The formation of undesirable halogenated products provides that adding PMS into salty wastewater might not be an unexpected proposal for TBP depletion involving of the attendance of chloride. The experimental process involved the reaction of 2-Bromobenzene-1,4-diol(cas: 583-69-7Name: 2-Bromobenzene-1,4-diol)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: 2-Bromobenzene-1,4-diol The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Li, Lixin; Zhao, Zhengguang; Xu, Jing; Luo, Haotian; Li, Yong; Ma, Xiantao; Tang, Lin; Ren, Bo; Cao, Xinhua; Ma, Yan-Na. HPLC of Formula: 401-55-8 The article mentions the following:

Palladium-catalyzed relay Heck-type reaction of fluoroalkyl bromide and terminal alkenes was reported. The reaction involved fluoroalkylation of alkenes and migration of double bonds via a 1,5-hydrogen atom transfer strategy. Through this method, a series of remote fluoroalkylated alkenes was obtained under mild conditions.Ethylbromofluoroacetate(cas: 401-55-8HPLC of Formula: 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.HPLC of Formula: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Tetramer of triphenylamine and similar derivatives with bromine atoms as hole injecting/transporting materials for efficient red phosphorescent OLEDs》 was written by Krucaite, Gintare; Blazevicius, Dovydas; Tavgeniene, Daiva; Grigalevicius, Saulius; Lin, Chun-Han; Shao, Chang-Min; Chang, Chih-Hao. Related Products of 4316-58-9This research focused ontriphenylamine derivative bromine red phosphorescent oraganic light emitting diode. The article conveys some information:

Tetramer of triphenylamine and similar compounds having bromine atoms have been synthesized, characterized and tested as hole injecting/transporting layers of organic light-emitting diodes (OLEDs). Rather high glass transition temperatures of the derivatives were determined to be in a range of 99-163°C. Some of the materials have suitable ionization potentials and adequate triplet state energies, which make them useful hole injecting/transporting layer materials for application in red phosphorescent devices. A simplified tri-layer device architectures of red OLEDs were prepared by adopting N-(1-diphenylamino[4,4-biphenyl])-N,N-bis(4-bromophenyl)amine (1) or N,N-bis (1-diphenylamino[4,4-biphenyl])-N-(4-bromophenyl)amine (2) as hole transporting layer (HTL) material. Tris(1-diphenylamino[4,4-biphenyl])amine (3) was selected for the hole injecting layer (HIL) to combine with 1 or 2 to construct step-wise hole injection in the devices. Peak efficiencies of the device with a single 1-based HTL were 12.5%, 18.6 cd/A, and 13.1 lm/W, all of which were slightly lower than those of a step-wise device having an addnl. 3-based HIL (i.e. 14.0%, 22.8 cd/A, and 17.8 lm/W). Similarly, the device with 2-based HTL exhibited peak efficiencies up to 13.5%, 21.3 cd/A, and 17.6 lm/W; while those of the device with an addnl. 3-based HIL achieved higher values of 13.8%, 22.6 cd/A, and 18.4 lm/W. The results indicate a high potential of these newly synthesized hole injecting/transporting materials. In the experimental materials used by the author, we found Tris(4-bromophenyl)amine(cas: 4316-58-9Related Products of 4316-58-9)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Related Products of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Thermotropic Columnar Liquid Crystals Based on Wedge-Shaped Phenylphosphonic Acids》 was written by Kumar, K. R. Sunil; Gupta, Monika; Sakamoto, Takeshi; Kato, Takashi. Quality Control of 1-Bromo-3,4,5-trimethoxybenzeneThis research focused onwedge shaped phenylphosphonic acid thermotropic columnar liquid crystal. The article conveys some information:

Wedge-shaped phenylphosphonic acids with variation in the peripheral alkoxy chains have been synthesized. These derivatives show a hexagonal columnar liquid-crystalline behavior upon thermal treatment. These materials have potential to be used as efficient anisotropic proton conductors. In addition to this study using 1-Bromo-3,4,5-trimethoxybenzene, there are many other studies that have used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Quality Control of 1-Bromo-3,4,5-trimethoxybenzene) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Quality Control of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary