Month: October 2022

《Bi(OAc)3/chiral phosphoric acid catalyzed enantioselective allylation of isatins》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Wang, Jie; Zhang, Qingxia; Li, Yao; Liu, Xiangshuai; Li, Xin; Cheng, Jin-Pei. COA of Formula: Br3In The article mentions the following:

An efficient protocol for construction of chiral 3-allyl-3-hydroxyoxindoles I (R = 4-Cl, 5-Br, 6-F, etc.; R1 = Me, Ph, naphthalen-1-ylmethyl, etc.) via the enantioselective allylation reaction of isatins II and allylboronates CH2=CH(R2)C(R3)(R4)B(-OC(CH3)2C(CH3)2O-) (R2 = R3 = R4 = H, Me) catalyzed by a simple binary acid Bi(OAc)3/chiral phosphoric acid system under mild conditions was disclosed. The synthetic utility of this strategy has been demonstrated through the formal synthesis of ent-CPC-1. In the experiment, the researchers used many compounds, for example, Indium(III) bromide(cas: 13465-09-3COA of Formula: Br3In)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.COA of Formula: Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function》 was published in Biochemical Pharmacology (Amsterdam, Netherlands) in 2020. These research results belong to Li, Xaria X.; Lee, John D.; Massey, Nicholas L.; Guan, Carolyn; Robertson, Avril A. B.; Clark, Richard J.; Woodruff, Trent M.. Reference of Ethyl 4-bromobutyrate The article mentions the following:

The complement fragment C5a is a core effector of complement activation. C5a, acting through its major receptor C5aR1, exerts powerful pro-inflammatory and immunomodulatory functions. Dysregulation of the C5a-C5aR1 axis has been implicated in numerous immune disorders, and the therapeutic inhibition of this axis is therefore imperative for the treatment of these diseases. A myriad of small-mol. C5aR1 inhibitors have been developed and independently characterised over the past two decades, however the pharmacol. properties of these compounds has been difficult to directly compare due to the wide discrepancies in the model, read-out, ligand dose and instrumentation implemented across individual studies. Here, we performed a systematic characterization of the most commonly reported and clin. advanced small-mol. C5aR1 inhibitors (peptidic: PMX53, PMX205 and JPE1375; non-peptide: W545011, NDT9513727, DF2593A and CCX168). Through signalling assays measuring C5aR1-mediated cAMP and ERK1/2 signalling, and β-arrestin 2 recruitment, this study highlighted the signalling-pathway dependence of the rank order of potencies of the C5aR1 inhibitors. Functional experiments performed in primary human macrophages demonstrated the high insurmountable antagonistic potencies for the peptidic inhibitors as compared to the non-peptide compounds Finally, wash-out studies provided novel insights into the duration of inhibition of the C5aR1 inhibitors, and confirmed the long-lasting antagonistic properties of PMX53 and CCX168. Overall, this study revealed the potent and prolonged antagonistic activities of selected peptidic C5aR1 inhibitors and the unique pharmacol. profile of CCX168, which thus represent ideal candidates to fulfil diverse C5aR1 research and clin. therapeutic needs. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Reference of Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Carbocation inside the cage: a periodical DFT study on the interaction of the C4H7+ system with alkali metal ion-exchanged zeolite Y》 was published in ARKIVOC (Gainesville, FL, United States) in 2020. These research results belong to Rosenbach, Nilton Jr.; Mota, Claudio J. A.. Recommanded Product: 7051-34-5 The article mentions the following:

Periodic DFT calculations at GGA-PPBE level were carried out with the goal of achieving better understanding of the influence of the polarity of the zeolite cavity on the stability of carbocations intermediates inside these materials. The results show that local electrostatic interactions play the major role of stabilizing such species on the zeolite surface. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《High-performance Li-organic battery based on thiophene-containing porous organic polymers with different morphology and surface area as the anode materials》 was written by Xu, Ning; Mei, Shiwei; Chen, Zhangxin; Dong, Yujie; Li, Weijun; Zhang, Cheng. Application of 3141-27-3 And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2020. The article conveys some information:

It is the hot issue for Li-organic battery that whether the higher sp. surface area of the porous organic polymers as the electrode materials can benefit to the better battery performance. In this article, the conjugated polymer based on star-shaped benzene-thiophene structure (pBHT) and benzene-ethynyl-thiophene structure (pBAT and pBABT) were designed and successfully prepared The pBHT polymer exhibits the unique stacked hollow tube morphol. and possesses the high surface area (∼ 1139 m2/g), while the polymers pBAT and pBABT both display the macroporous morphol. with the low surface area (32.5 and 12.5 m2/g). Being explored for the battery performance as anode materials, the pBHT electrode exhibits a very low discharge capacity (< 100 mAh g-1) and poor cycle′s stability. In contrast, the pBABT electrode with very low surface area of only 12.5 m2/g displays the higher discharge capacity (442 mAh g-1 at 500 mA/g of the second cycle), excellent stability (401 mAh g-1 at 500 mA/g of the 1000 cycles) and higher rate capabilities. These uncommon electrochem. properties may be attributed to the unique hollow tube morphol. for the polymer pBHT, which limit the lithium ion released and might form ""dead lithium"", thus resulting in the collapse of polymer structures and difficult solid electrolyte interface formation, as well as the fast capacity fading and extremely low capacity according to the electrochem. behaviors and SEM measurements. EIS also confirm the uncommon electrochem. properties with the three polymer electrodes from the kinetics for charge carrier insertion/extraction the findings may offer a clue to explore the effect of sp. surface area and morphol. of polymer electrodes on the performance of LIBs when designing the high-performance electrode materials. In addition to this study using 2,5-Dibromothiophene, there are many other studies that have used 2,5-Dibromothiophene(cas: 3141-27-3Application of 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Application of 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Photo-regulated supramolecular star with a pillar[6]arene-coated metal-organic polyhedron (MOP) core》 was written by Hao, Xiang; Leng, Zejian; Sun, Dan; Peng, Feng; Yasin, Akram. SDS of cas: 6825-20-3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Authors herein report a 12-armed photo-responsive supramol. star centered by a pillar[6]arene-coated M6L12 metal-organic polyhedron (MOP) via a core-first approach. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3SDS of cas: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.SDS of cas: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kretschmer, Nadine; Hufner, Antje; Durchschein, Christin; Popodi, Katrin; Rinner, Beate; Lohberger, Birgit; Bauer, Rudolf published an article in 2021. The article was titled 《Synthesis and pharmacological in vitro investigations of novel shikonin derivatives with a special focus on cyclopropane bearing derivatives》, and you may find the article in International Journal of Molecular Sciences.Application of 2623-87-2 The information in the text is summarized as follows:

In previous studies, author’s showed that the constituents of the roots of Onosma paniculata as well as a synthetic derivative of the most active constituent showed promising results in metastatic melanoma cell lines. In the current study, author’s address the question whether author’s can generate further derivatives with optimized activity by synthesis. Therefore, author’s prepared 31, mainly novel shikonin derivatives and screened them in different melanoma cell lines (WM9, WM164, and MUG-Mel2 cells) using the XTT viability assay. Author’s identified (R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl 2-cyclopropyl-2-oxoacetate as a novel derivative with even higher activity. Furthermore, pharmacol. investigations including the ApoToxGloM Triplex assay, LDH assay, and cell cycle measurements revealed that this compound induced apoptosis and reduced cells in the G1 phase accompanied by an increase of cells in the G2/M phase. Moreover, it showed hardly any effects on the cell membrane integrity. However, it also exhibited cytotoxicity against non-tumorigenic cells. Nevertheless, in summary, author’s could show that shikonin derivatives might be promising drug leads in the treatment of melanoma. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Johnson, John Douglas; Teeples, Charles Reece; Akkawi, Nicholas Rajai; Wilkerson-Hill, Sidney M. published an article in Journal of the American Chemical Society. The title of the article was 《Efficient Synthesis of Orphaned Cyclopropanes Using Sulfones as Carbene Equivalents》.Formula: C4H7Br The author mentioned the following in the article:

Herein, a mechanistically distinct platform to transfer 1,1-dialkylcarbene units to olefins using carbometalation reactions of dialkyl sulfonyl anions was introduced. In presence of NaNH2 or n-BuLi in ethereal solvents, dialkyl sulfones reacted with styrenes and arylbutadienes between 23 and 70°C to produce corresponding 1,1-dialkylcyclopropanes, e.g., I [R1 = Me, Et, n-Bu, etc.; R2 = H, i-Bu, n-pentadecyl, etc.; R1R2 = (CH2)4, (CH2)5, (CH2)6]. Forty examples of this reactivity including 16 different styrenes (up to 89% isolated yield), 9 arylbutadienes (51-88% yield), and 13 different sulfones (46-80% yield) was reported. In addition, an example of a sequential cyclopropanation reaction using this method was reported. Preliminary mechanistic studies suggested a stepwise anionic process that was initiated by direct addition of sulfonyl anions to a carbon-carbon double bond. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Chao; Shi, Lei; Zhang, Jiaxu; Sun, Jianmin published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《One-pot synthesis of pyridine-based ionic hyper-cross-linked polymers with hierarchical pores for efficient CO2 capture and catalytic conversion》.Reference of 1,4-Bis(bromomethyl)benzene The author mentioned the following in the article:

A kind of pyridine-based ionic hyper-cross-linked polymers (Py-HCP-X, X = Cl, Br) with high surface area, plentiful hierarchical pores and abundant catalytic active units were prepared via a one-pot method. Adsorption measurements showed that the as-prepared Py-HCP-X exhibited high CO2 capture capacity (up to 1.72 mmol g-1, 273 K and 1 bar). Importantly, Py-HCP-Br displayed excellent catalytic activity for the cycloaddition of CO2 to epoxides under metal/cocatalyst/solvent-free conditions. And the propylene carbonate was produced in 97% yield with an excellent selectivity of 99% at 120°C and 2.0 MPa CO2 for 8 h. The high performance of the present catalyst is ascribable to synergistic contributions of plentiful hierarchical pores and abundant nucleophilic bromide ions and pyridine-based active units in the Py-HCP-Br catalyst. Addnl., the catalyst is able to be simply separated by centrifugation and reused for four runs without significant loss in the performance, furthermore, the catalyst exhibits great structural stability and substrate universality. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Reference of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Reference of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Qiu, Shuai; Gao, Zhao; Song, Xin; Hu, Xiao; Yuan, Hongxing; Tian, Wei published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Hierarchical self-assembly induced supramolecular polymer helical nanowires with white circularly polarized luminescence》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Novel CPL-active supramol. helical nanowires (SHNWs) were successfully constructed, via the hierarchical self-assembly of supramol. coordination polymers. The CPL colors of the resultant SHNWs were drastically regulated from blue to red, and pass through white. In the experimental materials used by the author, we found Tris(4-bromophenyl)amine(cas: 4316-58-9Category: bromides-buliding-blocks)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1779-49-3In 2019 ,《Rhodium(III) vs. cobalt(III): a mechanistically distinct three-component C-H bond addition cascade using a Cp*RhIII catalyst》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Li, Ruirui; Ju, Cheng-Wei; Zhao, Dongbing. The article conveys some information:

Three-component C-H bond additions across two different coupling partners remain underdeveloped. Herein, we report the first three-component RhIII-catalyzed C-H bond additions to a wide range of dienes and aldehydes. Our method constitutes a complementary access with Ellman’s CoIII-catalytic system to homoallylic alcs. The results came from multiple reactions, including the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Application of 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Application of 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary