Month: October 2022

Synthetic Route of Br3InIn 2022 ,《Introducing the Catalytic Amination of Silanes via Nitrene Insertion》 was published in Journal of the American Chemical Society. The article was written by Rodriguez, Anabel M.; Perez-Ruiz, Jorge; Molina, Francisco; Poveda, Ana; Perez-Soto, Raul; Maseras, Feliu; Diaz-Requejo, M. Mar; Perez, Pedro J.. The article contains the following contents:

The direct functionalization of Si-H bonds by the nitrene insertion methodol. is described. A Cu(I) complex bearing a trispyrazolylborate ligand catalyzes the transfer of a nitrene group from PhI:NTs to the Si-H bond of silanes, disilanes, and siloxanes, leading to the exclusive formation of Si-NH moieties in the 1st example of this transformation. The process tolerates other functionalities in the substrate such as several C-H bonds and alkyne and alkene moieties directly bonded to the Si center. D. functional theory (DFT) calculations provide a mechanistic interpretation consisting of a Si-H homolytic cleavage and subsequent rebound to the Si-centered radical. In the experiment, the researchers used Indium(III) bromide(cas: 13465-09-3Synthetic Route of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Synthetic Route of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of (Bromomethyl)cyclopropaneIn 2019 ,《Dual nickel- and photoredox-catalyzed reductive cross-coupling of aryl vinyl halides and unactivated tertiary alkyl bromides》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Yu, Weijie; Chen, Long; Tao, Jiasi; Wang, Tao; Fu, Junkai. The article contains the following contents:

A novel reductive cross-coupling of aryl vinyl halides and unactivated tertiary alkyl bromides was realized via photoredox/nickel dual catalysis to produce vinyl arene derivatives bearing all-carbon quaternary centers with excellent E-selectivity. A stoichiometric metal reductant was avoided by employing com. available N,N,N’,N’-tetramethylethylenediamine (TMEDA) as the terminal reductant. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 3395-91-3In 2020 ,《Thermally Activated Delayed Fluorescence Benzyl Cellulose Derivatives for Nondoped Organic Light-Emitting Diodes》 was published in Macromolecules (Washington, DC, United States). The article was written by Shibano, Masaya; Ochiai, Hiroki; Suzuki, Katsuaki; Kamitakahara, Hiroshi; Kaji, Hironori; Takano, Toshiyuki. The article contains the following contents:

Thermally activated delayed fluorescence (TADF)-benzyl cellulose derivatives (TBC-X), which contained both carbazole (host) and phthalimide-based TADF dye (guest) moieties, were prepared from 2,3-di-O-benzyl cellulose in high yields. The TBC-X samples were soluble in common organic solvents such as CH2Cl2, CHCl3, THF, and toluene. The photoluminescence spectra of TBC-X spin-coated films had a single emission peak derived only from guest moieties, which indicated efficient energy transfer from the host to guest moieties. The TBC-10 (with a content of host and guest moieties of 93 and 7, resp.) in a spin-coated film had the highest photoluminescence quantum yield of 55.3% and TADF characteristics. A nondoped organic light emitting diode with TBC-10 as the emitting layer showed green emission (λEL = 517 nm) and achieved a maximum external quantum efficiency of 5.9%. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A highly stable amino-coordinated MOF for unprecedented block off N2 adsorption and extraordinary CO2/N2 separation》 was written by Zhang, Ling; Jiang, Ke; Jiang, Mengdie; Yue, Dan; Wan, Yating; Xing, Huabin; Yang, Yu; Cui, Yuanjing; Chen, Banglin; Qian, Guodong. Synthetic Route of C6H5Br2NThis research focused onzinc aminophenylenediacrylate coordination polymer preparation gas adsorption; crystal structure zinc aminophenylenediacrylate coordination polymer. The article conveys some information:

A highly stable amino-coordinated metal-organic framework ZJU-198 from (2E,2E0)-3,30-(5-amino-1,3-phenylene) diacrylic acid, was synthesized and structurally characterized, exhibiting high CO2 uptake of 105.8 cm3 cm-3 while blocking off N2 adsorption at 1.0 bar and 298 K, attributed to the unique pore window sizes. In addition to this study using 3,5-Dibromoaniline, there are many other studies that have used 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Transition metal- and light-free radical borylation of alkyl bromides and iodides using silane》 was written by Sun, Beiqi; Zheng, Sihan; Mo, Fanyang. Recommanded Product: 7051-34-5This research focused ontransition metal light free radical borylation alkyl bromide iodide; crystal structure mol structure optimized boronic ester alkyl preparation; radical borylation alkyl bromide iodide silane mechanism DFT. The article conveys some information:

We report operationally simple and neutral conditions for borylation of alkyl bromides and iodides to alkyl boronic esters under transition metal- and light-free conditions. A series of substrates with a wide range of functional groups were effectively transformed into the borylation products in moderate to good yields. Mechanistic studies, including radical clock experiments and DFT calculations, gave detailed insight into the radical borylation process. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 76283-09-5On March 15, 2019, Ndikuryayo, Ferdinand; Kang, Wei-Ming; Wu, Feng-Xu; Yang, Wen-Chao; Yang, Guang-Fu published an article in European Journal of Medicinal Chemistry. The article was 《Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors》. The article mentions the following:

Involved in the tyrosine degradation pathway, 4-hydroxyphenylpyruvate dioxygenase (HPPD) is an important target for treating type I tyrosinemia. To discover novel HPPD inhibitors, we proposed a hydrophobicity-oriented drug design (HODD) strategy based on the interactions between HPPD and the com. drug NTBC. Most of the new compounds showed improved activity, compound d23 being the most active candidate (IC50 = 0.047 μM) with about 2-fold more potent than NTBC (IC50 = 0.085 μM). Therefore, compound d23 is a potential drug candidate to treat type I tyrosinemia. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Product Details of 76283-09-5)

4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Product Details of 76283-09-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dankwardt, Sharon M.; Ferla, Steven; Krstenansky, John L.; Bhakta, Sunil; Ostrelich, Helene; Jarnagin, Kurt published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Nonpeptide bradykinin antagonist analogs based on a model of a Sterling-Winthrop nonpeptide bradykinin antagonist overlapped with cyclic hexapeptide bradykinin antagonist peptide》.Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate The author mentioned the following in the article:

A proposed overlap between cyclic hexapeptide bradykinin antagonist and nonpeptide bradykinin antagonists D- and L-3-(2-naphthyl)alanines I [R1 = Bu3P+, Bu3N+, H2N, HO, H2NC(:NH)NH, EtNHC(:NEt)NH, H-L-Arg-NH, H-D-Arg-NH, aca-D-Arg-NH; aca = 1-adamantylcarbonyl; R2 = H, CO2H; R3 = H, CH2CH2CO2H; X = cyclohexylimino, O] is discussed. Synthetic procedures for both enantiomers of I are given. Structural variations on both the peptides and nonpeptides support the proposed overlap based on an increase or decrease in the biol. activities of the antagonists. The experimental process involved the reaction of Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate)

Methyl 5-(bromomethyl)-2-nitrobenzoate(cas: 88071-91-4) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Reference of Methyl 5-(bromomethyl)-2-nitrobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitchell, T. Andrew; Bode, Jeffrey W. published their research in Journal of the American Chemical Society on December 23 ,2009. The article was titled 《Synthesis of Dialkyl Ethers from Organotrifluoroborates and Acetals》.Formula: C6H4BBrF3K The article contains the following contents:

The formation of ethers by C-O bond formation under harsh basic or acidic conditions is an entrenched synthetic disconnection in organic chem. We report a strategic alternative that involves the BF3·OEt2-promoted coupling of stable, easily prepared acetals with widely available potassium aryl-, alkenyl-, and alkynyltrifluoroborates. This fast, operationally simple process offers straightforward access to dialkyl ethers, many of which would be difficult to prepare using classical methods. The use of MOM-protected alcs. and acetal-protected aldehydes enables ether formation without recourse to protecting-group manipulations or strong bases. In addition to this study using potassium (3-bromophenyl)trifluoroborate, there are many other studies that have used potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Formula: C6H4BBrF3K) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C6H4BBrF3K

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Conjugated microporous polymer networks with adjustable microstructures for high CO2 uptake capacity and selectivity》 were Qin, Long; Xu, Guang-juan; Yao, Chan; Xu, Yan-hong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2016. Reference of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl The author mentioned the following in the article:

A series of phenylene-based conjugated microporous polymers (CMPs) of the A6 + Mx (x = 2, 3, 4, 6) type were synthesized. By tuning the monomer length and geometry, the BET surface area of CMPs can be tuned from 571 to 1115 M2 g-1. Amongst the synthesized CMPs, A6CMP-1 exhibits the highest CO2 adsorption capacity of 1218 mg g-1 at 318 K and 60 bar pressure. In addition, A6CMP-4 shows a high selectivity ratio of 47 for CO2/N2. In the experimental materials used by the author, we found 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8Reference of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl)

3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Reference of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Oxidative C-O bond cleavage of dihydroxybenzenes and conversion of coordinated cyanide to carbon monoxide using a luminescent Os(VI) cyanonitrido complex》 were Xiang, Jing; Zhu, Jiang; Zhou, Miaomiao; Liu, Lu-Lu; Wang, Li-Xin; Peng, Min; Hou, Bi-Shun; Yiu, Shek-Man; To, Wai-Pong; Che, Chi-Ming; Lau, Kai-Chung; Lau, Tai-Chu. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2022. Category: bromides-buliding-blocks The author mentioned the following in the article:

The photoreactions of a luminescent osmium(VI) nitrido complex, [OsVI(N)(L)(CN)3]- (OsN, HL = 2-(2-hydroxy-5-nitrophenyl)benzoxazole), with catechol (H2Cat) and hydroquinone (H2Q) lead to the cleavage of strong C-OH bonds (∼120 kcal mol-1) of the dihydroxybenzenes with concomitant conversion of the coordinated cyanide to carbon monoxide. The results came from multiple reactions, including the reaction of 2-Bromobenzene-1,4-diol(cas: 583-69-7Category: bromides-buliding-blocks)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary