Month: October 2022

Deng, Lanqing; Chen, Lang; Zhu, Liangdi; Li, Yang; Ou-Yang, Jie; Wu, Shaofeng; Chen, Peng; Shen, Sheng; Guo, Junkang; Zhou, Yongbo; Au, Chak-Tong; Yin, Shuang-Feng published the artcile< Green, versatile, and scale-up synthesis of amides by aerobic oxidative amination over Ag2O/P-C3N4 photocatalyst>, Reference of 3959-07-7, the main research area is green versatile scale amide aerobic oxidative amination photocatalyst.

Being extensively applied in various fields of chem. and chem. industry, the development of a green and versatile method for the synthesis of amides is in line with the demand of sustainable chem. Herein, a direct, highly selective, and scale-up (5-20 mmol) method for photocatalytic synthesis of amides through aerobic oxidative amination of alcs. with amines was developed under visible light, room temperature, using air as the oxidant. Benefiting from the adsorption of sodium hemiaminal on catalyst lengthens the C-H bond (1.148 Å), this novel process is feasible for a broad range of functionlized amides (69 examples), especially those for drug manufacture (e.g., moclobemide and pipobroman). Imines was almost prevented with excellent amide selectivity up to 99% could be ascribed to the low energy barrier for hemiaminal dehydrogenation while that for dehydration is high (2.13 eV). This green and efficient protocol represents an ideal alternative to the currently known methods.

Chemical Engineering Science published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kang, Seokwoo; Huh, Jin-Suk; Kim, Jang-Joo; Park, Jongwook published the artcile< Highly efficient deep-blue fluorescence OLEDs with excellent charge balance based on phenanthro[9,10-d]oxazole-anthracene derivatives>, Name: 4-Bromobenzylamine, the main research area is phenanthrooxazole anthracene derivative fluorescence organic light emitting diode.

Two blue fluorescent materials, m-PO-ABN and p-PO-ABN, are newly synthesized by controlling the conjugation length based on different linkages of the meta or para position between the phenanthro[9,10-d]oxazole (PO) moiety and anthracene substituted with a cyano group. The two materials emit deep-blue light with a high photoluminescence quantum yield (PLQY) in solution state. Non-doped devices fabricated using m-PO-ABN and p-PO-ABN show the EL peaks at 448 and 460 nm corresponding to the Commission Internationale de L’Eclairage (CIE) coordinates of (0.148, 0.099) and (0.150, 0.164), resp. The external quantum efficiency (EQE) values of the devices are 5.9% and 5.3% for m-PO-ABN and p-PO-ABN, resp. Transient EL measurements and optical calculation results reveal that both materials exhibit good charge balance and triplet-triplet annihilation in the devices, which may originate from enhanced bipolar characteristics due to the insertion of PO and cyano moieties.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Blue electroluminescence. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luo, Ziwei; Yang, Xinkan; Tsui, Gavin Chit published the artcile< Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides>, Formula: C7H4BrF3S, the main research area is perfluoroalkyl sulfide synthesis perfluoroalkylation thiosulfonate.

A practical synthesis of perfluoroalkyl sulfides is described. The method employs stable and readily accessible thiosulfonates as new electrophiles with com. nucleophilic perfluoroalkylating reagents. The mild reaction conditions allow access to a wide variety of both aryl- and alkyl-substituted perfluoroalkyl sulfides amenable to pharmaceutical development. Furthermore, the reaction operation is straightforward, odorless, does not produce toxic wastes, and, therefore should appeal to practitioners in industrial-scale productions.

Organic Letters published new progress about Fluorocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (as alternative perfluoroalkylation agents). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Formula: C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Ziyu; Wang, Ningning; Gao, Hang; Quan, Yiwu; Ju, Huangxian; Cheng, Yixiang published the artcile< Amplified electrochemiluminescence signals promoted by the AIE-active moiety of D-A type polymer dots for biosensing>, HPLC of Formula: 184239-35-8, the main research area is amplified electrochemiluminescence aggregation induced emission polymer dot biosensor.

Three-component conjugated polymers of a strong donor-acceptor (D-A) type could be synthesized by Pd-catalyzed Suzuki coupling polymerization reaction of 1,2-bis(4-bromophenyl)-1,2-diphenylethene (M-1) with 9-octyl-3,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole (M-2) and 4,6-bis((E)-4-bromostyryl)-2,2-difluoro-5-phenyl-2H-1|3,3,2|4-dioxaborinine (M-3). Among them, P-1 and P-2 with high TPE ratios at 0.95 and 0.9 showed obvious aggregation-induced emission (AIE) behavior; in contrast P-3 with a low TPE ratio at 0.8 showed an aggregation-caused quenching (ACQ) phenomenon. In particular, the three resulting polymer dots (P-1 to P-3 Pdots) exhibited a 200 mV lower electrochemiluminescence (ECL) potential due to their strong D-A electronic structure. Most importantly, the ECL signals of Pdots could be enhanced as high as 3 times by increasing their AIE-active TPE moiety ratios from 0.8 (P-3) to 0.95 (P-1) via the band gap emission process. Herein, P-1 Pdots with the strongest ECL signal were successfully used as ECL biosensors for the detection of catechol, epinephrine and dopamine with detection limits of 1, 7 and 3 nM, resp. This work provides a new strategy for developing highly sensitive ECL biosensors by the smart structure design of the AIE-active Pdots.

Analyst (Cambridge, United Kingdom) published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, HPLC of Formula: 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Haibo; Zhu, Jiangtao; Chen, Zixian; Li, Shan; Wu, Yongming published the artcile< Synthesis of 3-trifluoromethyl-1,4-dihydropyridazines by the PTSA-catalyzed reaction of α,β-unsaturated aldehydes with (E)-1-phenyl-2-(2,2,2-trifluoroethylidene)>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is fluoromethyl hydropyridazine preparation PTSA catalyzed condensation unsaturated aldehyde phenylfluoroethylidene.

A facile and efficient method for the synthesis 3-trifluoromethyl-1,4-dihydropyridazine from a variety of readily available α,β-unsaturated aldehyde and (E)-1-phenyl-2-(2,2,2-trifluoroethylidene)hydrazine was developed. The reaction proceeded under mild conditions and gave the expected 1,4-dihydropyridazine products in moderate to high yields.

Synlett published new progress about Condensation reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Avinash, Iruthayaraj; Parveen, Sabeeha; Anantharaman, Ganapathi published the artcile< Backbone Boron-Functionalized Imidazoles/Imidazolium Salts: Synthesis, Structure, Metalation Studies, and Fluoride Sensing Properties>, Application of C9H11Br, the main research area is boryl phosphino functionalized imidazole imidazolium salt preparation crystal structure; metalation fluoride sensing boryl phosphino functionalized imidazole imidazolium salt; copper boryl phosphino imidazole copper preparation photophys crystal structure.

Incorporation of a Lewis acidic BMes2 (Mes = mesityl) moiety at the backbone of the imidazole ring was achieved by metal-halogen exchange procedure. Among them, two isomeric boron-phosphine functionalized imidazoles (3 and 6), monoboron-functionalized imidazoles (4 and 5), and its corresponding imidazolium salts were synthesized and thoroughly characterized. The solid-state structure of 3 reveals a dimeric B-N adduct that possesses six-membered [C-B-N]2 ring, and 5 crystallizes as tetrameric B-N adduct that forms an interesting 16-membered macrocycle, whereas 4 and 6 were obtained as monomeric BMes2-substituted imidazoles. 6 Behaves as a P^N-type ligand upon the coordination with CuI to afford luminescent L2Cu4I4-type metal complexes (10 and 11) whose photophys. properties were also studied. The presence (in 10) and the absence (in 11) of BMes2 made a remarkable impact on fluorescence emission causing shift from the green (10) to orange (11) region. The fluoride sensing properties of BMes2-containing imidazoles (4 to 9) were studied using UV-vis and fluorescence spectroscopy. Various backbone boron-functionalized imidazoles were prepared conveniently from 4,5-diiodo-1-methylimidazole through metal-halogen exchange procedure, and the corresponding imidazolium salts were prepared by quaternization reaction. Fluoride sensing properties of six imidazol(ium)e-based boranes were evaluated. In addition, metalation studies of BMes2-substituted P^N-type imidazole ligand with CuI led to the formation of two luminescent [(P^N)2Cu4I4]-type copper clusters, and their photophys. studies illustrate the impact of the BMes2 group on their electronic/photophys. properties.

Inorganic Chemistry published new progress about Crystal structure. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Application of C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Inoa, Joan; Patel, Mansi; Dominici, Grecia; Eldabagh, Reem; Patel, Anjali; Lee, John; Xing, Yalan published the artcile< Benzylic Hydroperoxidation via Visible-light Induced Csp3-H activation>, Synthetic Route of 2725-82-8, the main research area is benzylic hydroperoxidn carbon hydrogen activation catalyst.

A highly efficient benzylic hydroperoxidn. e.g., C6H5CH2CH2C6H5 has been realized through a visible-light induced Csp3-H activation. It believe that this reaction undergoes a direct HAT mechanism catalyzed by eosin Y. This approach features the use of a metal-free catalyst (Eosin Y), an energy-economical light source (blue LED), and a sustainable oxidant (mol. oxygen). A variety of benzylic hydroperoxides e.g., C6H5CH(OOH)CH2C6H5 and several endoperoxides e.g., 4-NO2C6H4CH(CH3)OOC(O)CH3 was successfully prepared with good yields and excellent functional group compatibility.

Journal of Organic Chemistry published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Synthetic Route of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xiao-Qian; Han, Jia-Bin; Zhang, Cheng-Pan published the artcile< Cu-Mediated Trifluoromethylation of Aromatic α-Diazo Esters with the Yagupolskii-Umemoto Reagent>, Electric Literature of 14062-30-7, the main research area is aromatic diazo ester trifluoromethylation Yagupolskii Umemoto reagent copper; trifluoromethyl arylacetic ester preparation; copper trifluoromethylation catalyst.

Reductive trifluoromethylation of aromatic α-diazo esters at room temperature with the Yagupolskii-Umemoto reagent {[Ph2SCF3][OTf]; (I)} in DMF in the presence of excess CuCl gave a variety of α-trifluoromethyl arylacetates, e.g., II, in up to 93 % yield. The prior reaction of I with CuCl before the addition of the α-diazo esters was imperative for the conversion. This initial reaction might pregenerate the key [CuICF3] intermediate, according to the results of our control experiments When the long-chain perfluoroalkyl diphenylsulfonium triflates were used instead of I, the reaction of an aromatic α-diazo ester under the same conditions followed by treatment with NaHCO3 gave a series of fluorinated α,β-unsaturated esters in good yields. This protocol gives a facile, convenient, and practical access to α-trifluoromethyl arylacetates and their analogs, implying that the “”+Rfn”” reagents are compatible with α-diazo esters in the presence of an appropriate reductant.

European Journal of Organic Chemistry published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-diazo). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Electric Literature of 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Yong; Cao, Xinyi; Zhao, Leyao; Pi, Chao; Ji, Jingfei; Cui, Xiuling; Wu, Yangjie published the artcile< Generalized Chemoselective Transfer Hydrogenation/Hydrodeuteration>, COA of Formula: C8H9Br, the main research area is unsaturated compound palladium catalyst chemoselective transfer hydrogenation.

A generalized, simple and efficient transfer hydrogenation of unsaturated bonds was developed using HBPin and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, were all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H2 combination, were tolerated. The activity of the reactants was studied and the trends were as follows: styrene>diphenylmethanimine>benzaldehyde>azobenzene>nitrobenzene>quinoline>acetophenone>benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalyst in situ generated from Pd(OAc)2 and HBPin extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBPin via in situ HD generation and discrimination.

Advanced Synthesis & Catalysis published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, COA of Formula: C8H9Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P. published the artcile< Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides>, Reference of 6942-39-8, the main research area is melatonin receptor agonist methoxy fluorenylethyl propanamide preparation chronobiotic; structure activity melatonin receptor methoxy fluorenylethyl propanamide preparation chronobiotic; biol rhythm chronobiotic methoxy fluorenylethyl amide preparation human.

A series of fluoren-9-yl Et amides were synthesized and evaluated for human melatonin MT1 and MT2 receptor binding. N-[2-(2,7-dimethoxy-9H-fluoren-9-yl)ethyl]propanamide (I) was selected and evaluated in functional assays measuring intrinsic activity at the human MT1 and MT2 receptors and demonstrated full agonism at both receptors. The chronobiotic properties of I were demonstrated in both acute and chronic rat models where I produced an acute phase advance of 32 min at 1 mg/kg and chronically entrained free-running rats with a mean ED of 0.23 mg/kg. I is significantly less efficacious than melatonin in constricting human coronary artery.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Reference of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary