Month: October 2022

Blackhall, Alexander; Brydon, Donald L.; Javaid, Khalid; Sagar, Anthony J. G.; Smith, David M. published the artcile< Substitution reactions of phenylated aza heterocycles. Part 2. Bromination of some 2,5-diaryl-1,3,4-oxadiazoles>, Application In Synthesis of 603-78-1, the main research area is aryloxadiazole bromination; bromination diaryloxadiazole; oxadiazole diaryl bromination; nitrophenylphenyloxadiazole bromination regiochem.

2,5-Diaryl-1,3,4-oxadiazoles were brominated by either Br in oleum or Br and KBrO3 in HOAc-H2SO4. E.g., treatment of 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole and Br in concentrated H2SO4-HOAc by dropwise addition of aqueous KBrO3 gave the corresponding 2-, 3-, and 4-bromophenyl and 2,3-, 2,5-, and 2,6-dibromophenyl derivatives in 16, 14, 26, 1, 6, and 2% yield, resp.

Journal of Chemical Research, Synopses published new progress about Bromination. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application In Synthesis of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Run-Duo; Shuler, Scott A.; Watson, Donald A. published the artcile< Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination>, Recommanded Product: 4-Bromobenzylamine, the main research area is hydroxamic ether arylboronic acid palladium catalyst tandem aza Heck; amine carbon monoxide hydroxamic ether tandem aza heck carbonylation; lactam preparation.

The palladium-catalyzed tandem aza-Heck-Suzuki and aza-Heck-carbonylation reactions of O-Ph hydroxamic ethers were reported. These formal alkene carboamination reactions provided highly versatile access to wide range complex, stereogenic secondary lactams and exhibited outstanding functional group tolerance and high diastereoselectivity.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yoshida, Suguru; Igawa, Kazunobu; Tomooka, Katsuhiko published the artcile< Nucleophilic Substitution Reaction at the Nitrogen of Arylsulfonamides with Phosphide Anion>, HPLC of Formula: 639520-70-0, the main research area is nucleophilic substitution arylsulfonamide phosphide anion; phosphamide preparation nucleophilic substitution arylsulfonamide phosphide anion; amine preparation nucleophilic substitution arylsulfonamide phosphide anion; protected amine preparation nucleophilic substitution arylsulfonamide phosphide anion.

A novel nucleophilic substitution reaction at the nitrogen of arylsulfonamides by means of phosphide anions has been described. This reaction allows for the efficient transformation of arylsulfonamides into synthetically valuable phosphamides, amines, and a variety of protected amines.

Journal of the American Chemical Society published new progress about Acid hydrolysis (of phosphinamide N-P bond). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, HPLC of Formula: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Choi, Young Lok; Kim, Joa Kyum; Choi, Sang-Un; Min, Yong-Ki; Bae, Myung-Ae; Kim, Bum Tae; Heo, Jung-Nyoung published the artcile< Synthesis of aristolactam analogues and evaluation of their antitumor activity>, Category: bromides-buliding-blocks, the main research area is aristolactam analog library preparation antitumor.

A series of natural aristolactams and their analogs have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-Me piperolactam A, and sauristolactam showed moderate antitumor activities in selected cell lines. However, several synthetic aristolactam derivatives (e.g. I) exhibited potent antitumor activities against a broad array of cancer cell lines with GI50 values in the submicromolar range.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhang; Deng, Chao; Su, Liwu; Wang, Dan; Jiang, Yongshi; Tsuboi, Taiju; Zhang, Qisheng published the artcile< Efficient Intramolecular Charge-Transfer Fluorophores Based on Substituted Triphenylphosphine Donors>, Computed Properties of 576-83-0, the main research area is efficient intramol charge transfer fluorophore substituted triphenylphosphine donor; intramolecular charge transfer; non-radiative decay; organic light emitting diodes; thermally activated delayed fluorescence; triphenylphosphine donor.

Triphenylphosphine (TPP)-based luminescent compounds are rarely investigated because of the low photoluminescence quantum yield (PLQY). Here, we demonstrate that introducing steric hindrance groups to the TPP moiety and separating the orbitals involved in the transition can drastically suppress the non-radiative decay induced by structural distortion of TPP in the excited state. High PLQY up to 0.89 as well as thermally activated delayed fluorescence are observed from the intramol. charge-transfer (ICT) mols. with substituted TPP donors (sTPPs) in doped films. The red organic light-emitting diodes employing these emitters achieve comparable external quantum efficiencies to the control device containing a classical phosphorescent dye, revealing the great potential of the ICT emitters based on electrochem. stable sTPPs.

Angewandte Chemie, International Edition published new progress about Band structure. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Computed Properties of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hong, Younggi; Goh, Munju published the artcile< Pressure Dependence on the Thermal Conductivity of H- and J-type Nanocomposites>, Recommanded Product: 1,2-Bis(4-bromophenyl)-1,2-diphenylethene, the main research area is biphenyl carbonitrile boron nitride epoxy nanocomposite thermal optical property.

The dependence of thermal conductivity on molding pressure in composites containing H- and J-type aggregation mols. is investigated for the first time. When mixed with hexagonal boron nitride (h-BN), small mols. capable of H- and J-aggregation significantly affect the orientation of h-BN under pressure, resulting in a substantial pressure dependence. For demonstration, 4′,4”’-(1,2-diphenylethylene-1,2-diyl)bis{(1,1′-biphenyl)-4-carbonitrile} (TPE-2CP) and 4′,4”’,4””’,4”””’-(ethene-1,1,2,2-tetrayl)tetrakis[{(1,1′-biphenyl)-4-carbonitrile}] (TPE-4CP) are synthesized, which exhibit H- and J-aggregation, resp. Furthermore, epoxy (EP) composites containing TPE-2CP or TPE-4CP are prepared, which show different aggregation states with changing pressure. As the pressure increases, the thermal conductivity gradually increases in the radial direction and decreases in the axial direction for TPE-4CP/EP (and vice versa for TPE-2CP/EP, but to a lesser extent). Consequently, the pressure dependence of composites with h-BN as a filler to TPE-4CP/EP is also examined The radial thermal conductivity of this h-BN/TPE-4CP/EP composite increases from 0.8888 W mK-1 at 10 MPa to 1.0062 W mK-1 at 50 MPa. The reasons for the appearance of aggregation states and changes in the thermal conductivity with increasing pressure are then discussed.

Advanced Materials Interfaces published new progress about Aggregation. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Recommanded Product: 1,2-Bis(4-bromophenyl)-1,2-diphenylethene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tran, Cong Chi; Kawaguchi, Shin-ichi; Sato, Fumiya; Nomoto, Akihiro; Ogawa, Akiya published the artcile< Photoinduced Cyclizations of o-Diisocyanoarenes with Organic Diselenides and Thiols that Afford Chalcogenated Quinoxalines>, Electric Literature of 401-78-5, the main research area is diselenide diisocyanoarene photoinduced cyclization light; bisselanyl quinoxaline preparation; thiol diisocyanoarene photoinduced cyclization light; thiolated quinoxaline preparation.

This study describes the syntheses of 2,3-bis(selanyl)quinoxalines via the photoinduced cyclizations of o-diisocyanoarenes with diaryl or dialkyl diselenides, in addition to providing a detailed discussion of the corresponding mechanism and revealing that the developed procedure can also be applied to prepare 2-thiolated quinoxaline derivatives from o-diisocyanoarenes and thiols. The developed technique does not need the use of additives or metal catalysts and features the advantages of a high conversion, a broad substrate scope, and mild reaction conditions, thereby rendering it a valuable addition to the quinoxaline synthesis toolbox.

Journal of Organic Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Electric Literature of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Leth, Lars A.; Glaus, Florian; Meazza, Marta; Fu, Liang; Thogersen, Mathias K.; Bitsch, Emma A.; Jorgensen, Karl Anker published the artcile< Decarboxylative [4+2] Cycloaddition by Synergistic Palladium and Organocatalysis>, Product Details of C9H7BrO, the main research area is vinyl tetrahydroquinoline preparation decarboxylative cycloaddition palladium organocatalyst; asymmetric catalysis; cycloaddition; decarboxylation; heterocycles; synergistic catalysis.

A novel reaction based on synergistic catalysis, combining palladium- and organocatalysis was developed. The palladium catalyst activates vinyl benzoxazinanones via a decarboxylation to undergo a [4+2] cycloaddition with iminium-ion activated α,β-unsaturated aldehydes. The reaction proceeds for a number of combinations of vinyl benzoxazinanones reacting with α,β-unsaturated aldehydes, providing highly substituted vinyl tetrahydroquinolines in good to high yields, and excellent enantio- and diastereoselectivities (>98% ee and >20:1 d.r.). The palladium catalyst used in the synergistic catalysis can be re-used in a one-pot sequential coupling reaction with an aromatic boronic acid forming the coupling product in 95% yield, >20:1 d.r. and 99% ee.

Angewandte Chemie, International Edition published new progress about [4+2] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Zhi-Qin; Gao, Zhong-Hua; Jia, Wen-Qiang; Ye, Song published the artcile< Bifunctional N-Heterocyclic Carbene Catalyzed [3+4] Annulation of Enals and Aurones>, HPLC of Formula: 3893-18-3, the main research area is benzofuran lactone fused preparation diastereoselective enantioselective; aurone enal annulation bifunctional heterocyclic carbene catalyst; N-heterocyclic carbenes; annulation; kinetic control; lactones; organocatalysis.

Bifunctional N-heterocyclic carbenes with a free hydroxy group were demonstrated as efficient catalysts for the [3+4] annulation of enals RHC:CHCHO (R = 4-H3CCO6H4, 2-ClC6H4, furan-2-yl, CH2CH2CH3, etc.) with aurones I [Ar = C6H5, naphthalen-1-yl, furan-2-yl, styryl, etc.] to give the corresponding benzofuran-fused ε-lactones II in good yields with good diastereoselectivities and excellent enantioselectivities. The control experiments reveals that the [3+4] cycloadducts are kinetically favored and could be transformed to the thermodynamically favored [3+2] cycloadducts with a non-bifunctional NHC catalyst.

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doyle, Amanda A.; Kramer, Tobias; Kavanagh, Kevin; Stephens, John C. published the artcile< Cinnamaldehydes: Synthesis, antibacterial evaluation, and the effect of molecular structure on antibacterial activity>, Computed Properties of 3893-18-3, the main research area is cinnamaldehyde synthesis mol structure antibacterial activity.

trans-Cinnamaldehyde is a major component of Cinnamomum cassia and has been reported to give rise to antimicrobial properties in cinnamon spice. In order to better understand the relationship between the structure of trans-cinnamaldehyde and its antimicrobial role, fifteen structurally different trans-cinnamaldehyde derivatives were selected for study based on their predicted electrophilicities. Both synthesized and com. trans-cinnamaldehyde derivatives were evaluated for their antibacterial activity, with modest mM activity levels found against both E. coli and S. aureus. An initial mechanism of action study, suggesting that the electrophilicity of the trans-cinnamaldehydes affects the antibacterial activity, was conducted as well as an exploration of their ability to alter bacterial cell wall integrity. In addition, in vivo toxicity levels were determined using the larvae of the greater wax moth, Galleria mellonella, with all derivatives tested showing low toxicity.

Results in Chemistry published new progress about Antibacterial agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary