Month: October 2022

Wang, Bin; Yan, Zicong; Liu, Liyan; Wang, Jiawei; Zha, Zhenggen; Wang, Zhiyong published the artcile< TBN-mediated regio- and stereoselective sulfonylation & oximation (oximosulfonylation) of alkynes with sulfonyl hydrazines in EtOH/H2O>, Synthetic Route of 2725-82-8, the main research area is sulfonyl aryl ketoxime regioselective stereoselective preparation; tandem sulfonylation oximation terminal aryl alkyne arylsulfonylhydrazine butyl nitrite; byproduct radical inhibition tandem sulfonylation oximation alkyne arylsulfonylhydrazine; mechanism tandem sulfonylation oximation alkyne arylsulfonylhydrazine nitrite.

Terminal aryl alkynes such as phenylacetylene underwent regioselective and diastereoselective cascade sulfonylation and oximation reactions with arylsulfonyl hydrazides such as 4-MeC6H4SO2NHNH2 mediated by tert-Bu nitrite (TBN), hydrazine hydrate, and imidazole in 40:1 EtOH:H2O to yield (Z)-α-sulfonyl aryl Me ketoximes such as (Z)-4-MeC6H4SO2CH2C(:NOH)Ph. The mechanism was studied through identification of byproducts and radical inhibition and deuterium incorporation studies.

Green Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent) (terminal). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Synthetic Route of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ismael, Aya; Skrydstrup, Troels; Bayer, Annette published the artcile< Carbonylative Suzuki-Miyaura couplings of sterically hindered aryl halides: synthesis of 2-aroylbenzoate derivatives>, Application In Synthesis of 17100-65-1, the main research area is aroylbenzoate ester preparation; aryl halide boronic acid carbonylative Suzuki Miyaura.

A carbonylative approach to the synthesis of diversely substituted 2-aroylbenzoate esters ArC(O)R1 (Ar = 2-methoxyphenyl, thiophen-2-yl, 2-naphthyl, etc.; R1 = 2-methoxycarbonyl-6-methylphenyl, 2-methoxycarbonylphenyl, 2-methoxycarbonyl-4,5-dimethoxyphenyl, etc.) featuring a new protocol for the carbonylative coupling of aryl bromides R1Br with boronic acids ArB(OH)2 and a new strategy to favor carbonylative over non-carbonylative reactions were developed. Two different synthetic pathways – (i) the alkoxycarbonylation of 2-bromo benzophenones R2C6H4C(O)(2-BrC6H5) (R2 = 2-F, 4-F, 3-OMe, 4-OMe) and (ii) the carbonylative Suzuki-Miyaura coupling of 2-bromobenzoate esters – were evaluated. The latter approach provided a broader substrate tolerance, and thus it was the preferred pathway. Here observed that 2-substituted aryl bromides were challenging substrates for carbonylative chem. favoring the non-carbonylative pathway. However, it is found that carbonylative Suzuki-Miyaura couplings can be improved by slow addition of the boronic acid, suppressing the unwanted direct Suzuki coupling and, thus increasing the yield of the carbonylative reaction.

Organic & Biomolecular Chemistry published new progress about Alkoxycarbonylation. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Application In Synthesis of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yanagi, Kouichi; Komatsu, Toru; Ogihara, Shusuke; Okabe, Takayoshi; Kojima, Hirotatsu; Nagano, Tetsuo; Ueno, Tasuku; Hanaoka, Kenjiro; Urano, Yasuteru published the artcile< Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells>, Synthetic Route of 16426-64-5, the main research area is fluorescence imaging metabolic activity tumor cell glycolysis; chemical biology; coupled assays; fluorescent probes; glucolysis; glutaminolysis; metabolism.

In this study, we present a live-cell-based fluorometric coupled assay system to identify the compounds that can regulate the targeted metabolic pathways in live cells. The assay is established through targeting specific metabolic pathways and using “” input “” and “”output “” metabolite pairs. The changes in the extracellular output that are generated and released into the extracellular media from the input are assessed as the activity of the pathway. The screening for the glycolytic pathway and amino acid metabolism reveals the activities of the present drugs, 6-BIO and regorafenib, that regulate the metabolic fate of tumor cells.

Cell Reports published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Synthetic Route of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rueping, Magnus; Sugiono, Erli; Merino, Estibaliz published the artcile< Asymmetric organocatalysis: an efficient enantioselective access to benzopyrans and chromenes>, COA of Formula: C9H7BrO, the main research area is unsaturated aldehyde cycloalkanedione chiral diaryl prolinol ether; asym addition heterocyclization hydroxychromenone stereoselective preparation reduction oxidation aromatization; lactone oxadecalinone benzopyran stereoselective preparation; addition heterocyclization asym catalyst chiral diaryl prolinol ether.

Valuable, biol. active chromenones such as those depicted were synthesized based on a diaryl prolinol ether catalyzed, enantioselective reaction of diketones with α,β-unsaturated aldehydes. In these efficient addition-acetalization cascade reactions, diverse aliphatic and aromatic α,β-unsaturated aldehydes, as well as various diketones, can be successfully applied and the 2-hydroxychromenones can be isolated in good yields and with excellent enantioselectivities.

Chemistry – A European Journal published new progress about Acetalization catalysts (stereoselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moeckel, Robert; Babaoglu, Emre; Hilt, Gerhard published the artcile< Iodine(III)-Mediated Electrochemical Trifluoroethoxylactonisation: Rational Reaction Optimisation and Prediction of Mediator Activity>, COA of Formula: C8H6BrFO2, the main research area is iodine mediated electrochem trifluoroethoxylactonisation rational reaction optimization prediction mediator; electrochemistry; hypercoordinate iodine; iodine(III); iodoarenes; multivariate linear regression.

A new electrochem. I(III)-mediated cyclization reaction for the synthesis of 4-(2,2,2-trifluoroethoxy)isochroman-1-ones is presented. Based on this reaction design of experiments and multivariate linear regression anal. were used to demonstrate their 1st application in an electrochem. reaction. The broad applicability of these reaction conditions could be shown by a range of substrates and an extensive compatibility test.

Chemistry – A European Journal published new progress about Cyclic voltammetry. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Yang; Zhang, Cheng; Li, Zhuang; Gu, Peiyang; Wang, Zilong; Li, Hua; Lu, Jianmei; Zhang, Qichun published the artcile< Controlled deposition of large-area and highly-ordered thin films: effect of dip-coating-induced morphological evolution on resistive memory performance>, Reference of 20776-50-5, the main research area is resistive memory device dip coating morphol.

Developing a simple, versatile and efficient technique that enables both large-scale production and nano-scale control is highly desirable but very challenging for achieving high-performance organic-based memory electronic devices. Herein, the authors employed a dip-coating method to fabricate reliable and cost-effective organic memory devices (OMDs). This technique enables one to deposit high-quality, homogeneous and large-area nanopatterns on the surfaces of thin films and realize uniform OMD performances with a record reproducibility up to 96%. To the best of their knowledge, this is the first report on dip-coated OMDs with the highest reproducibility observed to date, which demonstrates the promising versatility of the dip-coating technique to fabricate organic memory devices and its suitability to scale-up for high-throughput solution processing.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Dip coating process. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Reference of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ahammed, Khondakar Sayef; Pal, Ritesh; Chakraborty, Jeet; Kanungo, Ajay; Purnima, Polnati Sravani; Dutta, Sanjay published the artcile< DNA Structural Alteration Leading to Antibacterial Properties of 6-Nitroquinoxaline Derivatives>, Reference of 3959-07-7, the main research area is DNA structure nitroquinoxaline derivative antibacterial activity.

Structural integrity of the bacterial genome plays an important role in bacterial survival. Cellular consequences of an intolerable amount of change in the DNA structure are not well understood in bacteria. We have stated that binding of synthetic 6-nitroquinoxaline derivatives with DNA led to change in its global structure, subsequently culminating with over-supercoiled form through in-path intermediates. This structural change results in induction of programmed cell death like physiol. hallmarks, which is dependent on substitution driven structural modulation properties of the scaffold. A sublethal dose of a representative derivative significantly inhibits DNA synthesis, produces fragmented nucleoids, and alters membrane architecture. We have also shown that exposure to the compound changes the native morphol. of Staphylococcus aureus cells and significantly disrupts preformed biofilms. Thus, our study gives new insight into bacterial responses to local or global DNA structural changes induced by 6-nitroquinoxaline small mols.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jimenez-Almarza, Alicia; Lopez-Magano, Alberto; Mas-Balleste, Ruben; Aleman, Jose published the artcile< Tuning the Activity-Stability Balance of Photocatalytic Organic Materials for Oxidative Coupling Reactions>, Quality Control of 3959-07-7, the main research area is imine preparation; amine oxidative coupling photocatalytic; amines; imines; organic materials; oxidative coupling; photocatalysis.

In the series of materials reported herein, the triazine-based material shows the optimal compromise between activity and stability when studied for the oxidative coupling of amines, achieving imine products. Accordingly, while significant leaching of mol. active fragments was ruled out for triazine-based polymers, other materials of the series show a significant chem. erosion as a result of the reaction with the amine substrates. Consequently, only a triazine-based material allowed performing several catalytic cycles (up to seven) with yields higher than 80%. The applicability of this heterogeneous catalyst had been proven with a variety of substrates, confirming its stability and obtaining diverse imine coupling products with excellent yields.

ACS Applied Materials & Interfaces published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Gui-Ling; Rios, Ramon; Vesely, Jan; Eriksson, Lars; Cordova, Armando published the artcile< Organocatalytic enantioselective aminosulfenylation of α,β-unsaturated aldehydes>, Formula: C9H7BrO, the main research area is unsaturated aldehyde alkylthio succinimide chiral organocatalyst aminosulfenylation; sucnimido mercaptoaldehyde stereoselective preparation.

A simple, highly enantioselective organocatalytic aminosulfenylation of α,β-unsaturated aldehydes affords orthogonally protected β-amino-α-mercaptoaldehydes in high yields and 93 to > 99% ee. Notably, the catalytic transformation shows that it is possible to efficiently employ all components of an electrophile, which includes a nucleofuge, in organocatalytic domino reactions of enals.

Angewandte Chemie, International Edition published new progress about Addition reaction (aminosulfenylation, stereoselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Chang; Zhang, Chao; Lu, Tong-Bu published the artcile< Graphdiyne anchored ultrafine Ag nanoparticles for highly efficient and solvent-free catalysis of CO2 cycloaddition>, Synthetic Route of 3959-07-7, the main research area is silver nanoparticle carbon dioxide cycloaddition graphdiyne.

Apart from photo-/electro-catalytic CO2 reduction, an important alternative route to CO2 utilization is to use this inert mol. as a C1 source to synthesize value-added chems.; however, the practical application is limited by the low conversion efficiency. Herein, we reported a composite catalyst of 3D sponge-like pyrenyl-graphdiyne (Pyr-GDY) anchored ultrafine Ag nanoparticles (Ag/Pyr-GDY), with the average size of Ag NPs of only 1.6 nm. The porous 3D Pyr-GDY component can not only anchor and stabilize the capping agent free ultrafine Ag NPs by virtue of the strong affinity between alkynyl groups and Ag, but also enhance the local concentration of CO2 due to the porous nature of 3D Pyr-GDY. As a result, the optimized Ag/Pyr-GDY catalyst displays a record-high activity towards the catalysis of CO2 cycloaddition with propargylamines under ambient temperature and pressure, with a TON of 20 488 and a yield of 83%, and is 15.3 times more active than the most efficient catalyst Ag27-MOF (TON = 1333, yield = 34%). Moreover, our catalysis was performed in a solvent-free system, which provides an economic, green and practical avenue for carbon capture, utilization and storage (CCUS).

Materials Chemistry Frontiers published new progress about Concentration (process). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary