Month: October 2022

Wu, Xiaoyu; Dai, Xiaoyang; Nie, Linlin; Fang, Huihui; Chen, Jie; Ren, Zhongjiao; Cao, Weiguo; Zhao, Gang published the artcile< Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition-Pictet-Spengler sequence>, Product Details of C9H7BrO, the main research area is ketoester unsaturated aldehyde tryptamine enantioselective three component coupling; indoloquinolizidine stereoselective preparation; Michael addition Pictet Spengler cyclocondensation diarylmethylhydropyrrole catalyst.

The enantioselective three-component Michael addition-Pictet-Spengler sequence of β-ketoesters, α,β-unsaturated aldehydes and tryptamines represents a facile and rapid one-pot access to highly substituted indoloquinolizidines, e.g. I, in moderate to excellent yields and good to excellent enantioselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mu, Xingye; Yu, Hanxiao; Peng, Henian; Xiong, Wenrui; Wu, Ting; Tang, Wenjun published the artcile< Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization>, Recommanded Product: 4-Bromo-3-formylbenzonitrile, the main research area is tetracyclic arene chemoselective enantioselective preparation; aspernomine strychnochromine core ring system preparation; dracaenone analog preparation; palladium benzoxaphospholane catalyst dearomatization cyclization bromoaryl bicycle; enantioselective desymmetrization bromophenyl bromobenzyl bicycle palladium benzoxaphospholane catalyst; bridged tetracyclic systems; dearomative cyclization; homogeneous catalysis; monophosphorus ligands; palladium.

In the presence of [Pd(cinnamyl)Cl]2, an arylbenzoxaphospholane ligand, and K2CO3 in toluene, bromoaryl-substituted bicyclic phenols such as I underwent dearomative cyclization reactions to yield tetracyclic arenes such as II; a variety of ring systems with differing bridging patterns and carbocyclic and heterocyclic linkers were prepared using the method. The method was used to prepare partial ring systems for the alkaloids aspernomine and strychnochromine and to prepare dracaenone analogs. Bis(bromophenyl)- and bis(bromobenzyl)-substituted bicycles underwent enantioselective desymmetrization by dearomative cyclization using [Pd(cinnamyl)Cl]2 and nonracemic arylbenzoxaphospholane ligands to give bromoaryl- and bromobenzyl-substituted tetracycles in 33-99% ee (absolute configuration undetermined).

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Recommanded Product: 4-Bromo-3-formylbenzonitrile.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mori, Mattia; Dasso Lang, Maria Chiara; Saladini, Francesco; Palombi, Nastasja; Kovalenko, Lesia; De Forni, Davide; Poddesu, Barbara; Friggeri, Laura; Giannini, Alessia; Malancona, Savina; Summa, Vincenzo; Zazzi, Maurizio; Mely, Yves; Botta, Maurizio published the artcile< Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein>, Application In Synthesis of 20099-90-5, the main research area is aminothiazole preparation antiretroviral HIV 1 nucleocapsid protein inhibitor; structure activity aminothiazole antiretroviral nucleocapsid protein inhibitor.

Small mol. inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the mol. is designed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by mol. dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds, I and II, showed no cytotoxicity, thus becoming valuable leads for further investigations.

ACS Medicinal Chemistry Letters published new progress about Anti-HIV agents. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Application In Synthesis of 20099-90-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shon, Jong-Hwa; Kim, Dooyoung; Rathnayake, Manjula D.; Sittel, Steven; Weaver, Jimmie; Teets, Thomas S. published the artcile< Photoredox catalysis on unactivated substrates with strongly reducing iridium photosensitizers>, HPLC of Formula: 576-83-0, the main research area is aryl halide alkyl hydrodehalogenation iridium photocatalyst.

In this work, the strong bis-cyclometalated iridium photoreductants with electron-rich β-diketiminate (NacNac) ancillary ligands enable high-yielding photoredox transformations of challenging substrates with very simple reaction conditions that require only a single sacrificial reagent. Using blue or green visible-light activation a variety of reactions, which include hydrodehalogenation, cyclization, intramol. radical addition, and prenylation via radical-mediated pathways, with optimized conditions that only require the photocatalyst and a sacrificial reductant/hydrogen atom donor were demonstrated. Many of these reactions involve organobromide and organochloride substrates RX (R = 3-methoxyphenyl, 4-cyanophenyl, {1-[(benzyloxy)carbonyl]piperidin-4-yl}, etc.; X = Br, Cl) which in the past have had limited utility in photoredox catalysis. This work paves the way for the continued expansion of the substrate scope in photoredox catalysis.

Chemical Science published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, HPLC of Formula: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Aberkane, Sabrina Messaoud; Palleschi, Vincenzo published the artcile< Comment on: ''Measurement of deviations of transition probability of the neutral silver lines at 827.35 and 768.77 nm using OES-technique"" by Alhijry et al. [JQSRT (2020) 106922]>, Reference of 82-73-5, the main research area is polemic neutral silver line transition probability OES technique.

A polemic in response to Alhijry et al. In this comment we pointed out an error in the identification of the neutral silver line at 768.77 that invalidates some of the results reported in the paper ”Measurement of deviations of transition probability of the neutral silver lines at 827.35 and 768.77 nm using OES-technique” by Alhijry et al., recently published on JQSRT.

Journal of Quantitative Spectroscopy & Radiative Transfer published new progress about Emission spectroscopy. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Reference of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Zi-Yuan; Dai, Ya-Zhong; Ding, Li; Dong, Bo-Wei; Jiang, Shang-Da; Wang, Jie-Yu; Pei, Jian published the artcile< A Stable Triplet-Ground-State Conjugated Diradical Based on a Diindenopyrazine Skeleton>, Formula: C9H11Br, the main research area is indenopyrazine stable triplet ground state conjugated diradical; conjugated radicals; high-spin; pyrazine; singlet-triplet gap; stable radicals.

High-spin conjugated radicals have great potential in magnetic materials and organic spintronics. However, to obtain high-spin conjugated radicals is still quite challenging due to their poor stability. We report the successful synthesis and isolation of a stable triplet conjugated diradical, 10,12-diaryldiindeno[1,2-b:2′,1′-e]pyrazine (m-DIP, I, Ar = mesityl, substituted 9-anthryl). With the m-xylylene analog skeleton containing electron-deficient sp2-nitrogen atoms, m-DIP displays significant aromatic character within its pyrazine ring and its spin d. mainly delocalizes on the meta-pyrazine unit, making it a triplet ground state conjugated diradical. Our work provides an effective “”spin d. tuning”” strategy for stable high-spin conjugated radicals.

Angewandte Chemie, International Edition published new progress about Amphoteric materials. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Formula: C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tashiro, Masashi; Nakayama, Kouji published the artcile< Preparation of bromobenzoic acids from the corresponding bromotoluenes via the Krohnke method>, Recommanded Product: 2,3-Dibromobenzoic acid, the main research area is benzoic acid dibromo; bromobenzoic acid; bromotoluene conversion bromobenzoic acid.

Bromotoluenes were converted to acids I (n = 2, 3) via N-benzylpyridinium salts II. Thus, 2,3-Br2C6H3Me was brominated to 2,3-Br2C6H3CH2Br, the latter and pyridine gave II (Brn = 2,3-Br2), the product was treated with 4-Me2NC6H4NO and then with HCl to yield 2,3-Br2C6H3CHO, and the aldehyde was oxidized by KMnO4 to give 2,3-Br2C6H3CO2H.

Organic Preparations and Procedures International published new progress about 603-78-1. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Recommanded Product: 2,3-Dibromobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Larsen, Matthew A.; Oeschger, Raphael J.; Hartwig, John F. published the artcile< Effect of Ligand Structure on the Electron Density and Activity of Iridium Catalysts for the Borylation of Alkanes>, Recommanded Product: 2,4,6-Trimethylbromobenzene, the main research area is phenanthroline ligand iridium catalyst electron density borylation alkane; C–H borylation; alkane functionalization; catalyst design; iridium; phenanthrolines; reaction kinetics.

An in-depth study of iridium catalysts for the borylation of alkyl C-H bonds is reported. Although the borylation of aryl C-H bonds can be catalyzed by iridium complexes containing phen or bpy ligands at mild temperatures and with limiting arene, the borylation of alkyl C-H bonds remains underdeveloped. We prepared a library of phenanthrolines that contain varying substitution patterns. The corresponding phen-Ir trisboryl carbon monoxide complexes were synthesized to determine the electron-donating ability of these ligands, and the initial rates for the borylation of the C-H bonds in THF and diethoxyethane β to oxygen catalyzed by Ir complexes containing these ligands were measured. For some subsets of these ligands, the donor ability correlated pos. with the rate of C-H borylation catalyzed by the complexes containing ligands within a given subset. However, across subsets, ligands possessing similar donor properties to one another form catalysts for the borylation of alkyl C-H bonds with widely varying activity. This phenomenon was investigated computationally, and it was discovered that the stabilizing interactions between the phenanthroline ligand and the boryl ligands attached to Ir in the transition state for C-H oxidative addition could account for the differences in the activity of the catalysts that possess similar electron densities at Ir. The effect of these interactions on the borylation of secondary alkyl C-H bonds is larger than it is on the borylation of primary alkyl C-H bonds.

ACS Catalysis published new progress about Alkanes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Recommanded Product: 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yue; Dai, Gaole; Chen, Yuanyuan; Wang, Ru; Li, Huamei; Shi, Xueliang; Zhang, Xiaohong; Xu, Yang; Zhao, Yu published the artcile< Effective Design Strategy of Small Bipolar Molecules through Fused Conjugation toward 2.5 V Based Redox Flow Batteries>, COA of Formula: C8H6BrFO2, the main research area is sym redox flow battery bipolar redox active mol design.

Using bipolar redox-active mols. (BRMs) as active materials is a practical way to address electrolyte crossover and resultant unpredictable side reactions in redox-flow batteries. However, the development of BRMs is greatly hindered by difficulties in finding new mols. from limited redox-active moieties and in achieving high cell voltage to compete with existing flow battery chemistries. This study proposes a strategy for design of high-voltage BRMs using fused conjugation that regulates the redox potential of integrated redox-active moieties. As a demonstration, quaternary N and ketone redox moieties are used to construct a new BRM that shows a prominent voltage gap with good electrochem. stability. A sym. redox-flow cell based on this mol. exhibits a high voltage of 2.5 V and decent cycling stability. This study provides a general strategy for designing new BRMs that may enrich the cell chemistries of organic redox-flow batteries.

ACS Energy Letters published new progress about Atomic charge. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Darensbourg, Donald J.; Mueller, Brian L.; Bischoff, Christopher J.; Reibenspies, Joseph H. published the artcile< Chemistry of zerovalent tungsten alkoxides. Synthesis, x-ray structure and reactivity toward carbon dioxide>, Computed Properties of 82-73-5, the main research area is crystal structure tungstate carbonyl fluoropropoxo; tungstate carbonyl fluoropropoxo fluoropropyl carbonate complex; propoxo tungstate carbonyl complex; carbon dioxide reaction tungstate carbonyl fluoropropoxo.

[PPN][W(CO)5(OCH2CF3)] and [PPN]2[W2(CO)8(OCH2CF3)2] (PPN = (Ph3P)2N+) have been synthesized and characterized. [PPN][W(CO)5(OCH2CF3)] reacted rapidly and reversibly with CO2 to afford [PPN][W(CO)2[OC(O)OCH2CF3]]. The x-rya crystal structure of [PPN]2[W2(CO)8(OCH2CF3)2] has been determined The complex crystallizes in the triclinic space group P1̅, a 13.460(11), b 12.318(5), c 13.842(10) Å, α 82.73(5), β 59.11(5), γ 80.09(5)°, and Z = 1.

Inorganic Chemistry published new progress about Crystal structure. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary