Month: October 2022

Lu, Shu-Ning; Sun, Yue; Zhang, Jiajun; Chen, Zhengkai; Wu, Xiao-Feng published the artcile< Metal-free Synthesis of 5-Trifluoromethyl-1,2,4-triazoles via elemental sulfur promoted oxidative cyclization of trifluoroacetimidohydrazides with benzylic and aliphatic amines>, Category: bromides-buliding-blocks, the main research area is trifluoromethyl triazole preparation glycine transporter 1 inhibitor; aralkyl amine trifluoroacetimidohydrazide oxidative cyclization elemental sulfur promoter.

An elemental sulfur-mediated oxidative cyclization of readily available trifluoroacetimidohydrazides and aliphatic amines has been achieved, which provided a direct avenue to structurally diverse 5-trifluoromethyl-1,2,4-triazoles. In this transformation, sulfur acts as a traceless oxidizing agent. A myriad of benzyl amines and tertiary aliphatic amines were tolerated in this protocol. The reaction can be scaled up easily and also been applied to build GlyT1 inhibitor as an example of bio-active mol.

Molecular Catalysis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhi-Yun; Cook, Silas P. published the artcile< Directed Ni-Catalyzed Reductive Arylation of Aliphatic C-H Bonds>, Quality Control of 401-78-5, the main research area is amidyl oxalate hydroxamic ester aryl halide reductive arylation nickel.

Herein, authors describe a nickel-catalyzed reductive arylation of remote C(sp3)-H bonds with aryl electrophiles. The reaction targets secondary and tertiary C(sp3)-H bonds to deliver all-carbon quaternary centers. The success of this method relies on a novel amidyl radical precursor that tolerates reducing conditions-O-oxalate hydroxamic acid esters.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Caspers, Lucien D.; Spils, Julian; Damrath, Mattis; Lork, Enno; Nachtsheim, Boris J. published the artcile< One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts>, Product Details of C7H6BrNO2, the main research area is iodobenzyl alc Friedel Crafts oxidation cyclization one pot conformation; diaryliodonium salt preparation.

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates, e.g., I, are described. Strong Bronsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alc. derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and d. functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-iodo). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Product Details of C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liao, Xudong; Zhou, Yi; Ai, Chengmei; Ye, Cuijiao; Chen, Guanghui; Yan, Zhaohua; Lin, Sen published the artcile< SO2F2-mediated oxidation of primary and tertiary amines with 30% aqueous H2O2 solution>, Recommanded Product: 4-Bromobenzylamine, the main research area is azoxybenzene green preparation; aniline oxidation catalyst sulfuryl fluoride; aryl nitrile green preparation; amide green preparation; amine oxidation catalyst sulfuryl fluoride; oxide quinoline isoquinoline pyridine green preparation.

A highly efficient and selective oxidation of primary and tertiary amines employing SO2F2/H2O2/base system was described. Anilines were converted to the corresponding azoxybenzenes I [R = H, 4-Me, 3-Cl-4-Me, etc.], while primary benzylamines were transformed into nitriles ArC≡N [Ar = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] and secondary benzylamines were rearranged to amides ArNHC(O)R1 [Ar = Ph; R1 = Me, Et]. For tertiary amine substrates quinolines, isoquinolines and pyridines, their oxidation products were the corresponding N-oxides II [R1 = R2 = Me; R3 = Me, Ph], III [R4 = H, 7-Me, 6-NO2; R5 = 2-Me, 3-Me, 4-Me], IV [R6 = H, 8-Cl, 6-Br] and V [R7 = H, 2,6-di-Me, 4-MeO, 2-Br, 4-oxiran-2-yl]. The reaction conditions were very mild and just involve SO2F2, amines, 30% aqueous H2O2 solution, and inorganic base at room temperature One unique advantage was that this oxidation system was just composed of inexpensive inorganic compounds without the use of any metal and organic compounds

Tetrahedron Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cui, Penglei; Li, Sida; Wang, Xianjin; Li, Ming; Wang, Chun; Wu, Lipeng published the artcile< Visible-Light-Promoted Unsymmetrical Phosphine Synthesis from Benzylamines>, SDS of cas: 3959-07-7, the main research area is photochem deaminative alkylation reaction benzylamine Katritzky salt phenylphosphine; unsym tertiary phosphine preparation electrochem fluorescence.

Herein, by applying visible-light photoredox catalysis, the authors have achieved the catalytic deaminative alkylation of diphenylphosphine and Ph phosphine with benzylamine-derived Katritzky salts at room temperature The use of Eosin Y as photoredox catalyst and visible light can largely promote the reaction. Unsym. tertiary phosphines were successfully synthesized, including phosphines with three different substituents that are otherwise difficult to obtain.

Organic Letters published new progress about Alkylation (photochem. deaminative alkylation reaction). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhu, Xiaoming; Zhou, Fengru; Yang, Yuan; Deng, Guobo; Liang, Yun published the artcile< Catalyst- and Additive-Free Method for the Synthesis of 2-Substituted Benzothiazoles from Aromatic Amines, Aliphatic Amines, and Elemental Sulfur>, Reference of 3959-07-7, the main research area is benzothiazole green preparation cyclization aromatic amine sulfur; naphthothiazole green preparation cyclization aromatic amine sulfur.

Under catalyst- and additive-free conditions, a novel, convenient, environmentally friendly method was developed for the synthesis of 2-substituted benzothiazoles via the three-component one pot reaction from aromatic amines, aliphatic amines, and elemental sulfur. The reaction achieves double C-S and one C-N bond formations via cleavage of two C-N bonds and multiple C-H bonds. Furthermore, the mechanism research shows that DMSO acts as an oxidant in the cyclization reaction.

ACS Omega published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Parker, Ariel N.; France, Stefan published the artcile< Completion of the Set: Synthesis of the (6,X′)-Flubromazepam Positional Isomers as Standards for Forensic Analysis>, Computed Properties of 82-73-5, the main research area is forensic synthesis flubromazepam positional isomer standard.

Mounting concern among forensic examiners regarding the emergence of positional isomers as tech. legal alternatives to scheduled benzodiazepines has encouraged the preemptive synthesis of analogs as standards Recently, flubromazepam was identified by the Drug Enforcement Administration for future scheduling, and subsequently, 9 of the 12 possible flubromazepam isomers were synthesized. However, the three (6,X′)-isomers proved inaccessible via that approach. Herein, through a redesigned synthetic approach, the remaining three isomers were obtained, thus completing the set and enabling future forensic anal.

Journal of Organic Chemistry published new progress about Acylation. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Murugesan, Natesan; Gu, Zhengxiang; Fadnis, Leena; Tellew, John E.; Baska, Rose Ann F.; Yang, Yifan; Beyer, Sophie M.; Monshizadegan, Hossain; Dickinson, Kenneth E.; Valentine, Maria T.; Humphreys, W. Griffith; Lan, Shih-Jung; Ewing, William R.; Carlson, Kenneth E.; Kowala, Mark C.; Zahler, Robert; Macor, John E. published the artcile< Dual Angiotensin II and Endothelin A Receptor Antagonists: Synthesis of 2'-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and Pharmacokinetics>, Synthetic Route of 89003-95-2, the main research area is angiotensin endothelin antagonist isoxazolyl biphenylsulfonamide preparation pharmacokinetics; antihypertensive synergism angiotensin endothelin antagonist isoxazolyl biphenylsulfonamide preparation pharmacokinetics.

In a previous report its was demonstrated that merging together key structural elements present in an AT1 receptor antagonist (irbesartan) with key structural elements in a biphenylsulfonamide ETA receptor antagonist followed by addnl. optimization provided a product which is a dual-action receptor antagonist (DARA), which potently blocked both AT1 and ETA receptors. Described herein are our efforts directed toward improving both the pharmacokinetic profile as well as the AT1 and ETA receptor potency of 4′-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2′-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl][1,1′-biphenyl]-2-sulfonamide (I). Efforts centered on modifying the 2′-side chain of I and examining the (isoxazolyl)sulfonamide moiety in I. This effort resulted in the discovery of 4′-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2′-(ethoxymethyl)[1,1′-biphenyl]-2-sulfonamide (II) as a highly potent second-generation DARA. This compound also showed substantially improved pharmacokinetic properties compared to I. In rats, DARA II reduced blood pressure elevations caused by i.v. infusion of Ang II or big ET-1 to a greater extent and with longer duration than DARA I or AT1 or ETA receptor antagonists alone. II clearly demonstrated superiority over irbesartan (an AT1 receptor antagonist) in the normal SHR model of hypertension in a dose-dependent manner, demonstrating the synergy of AT1 and ETA receptor blockade in a single mol. The crystal and mol. structures of II were reported.

Journal of Medicinal Chemistry published new progress about Angiotensin II receptor antagonists. 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Synthetic Route of 89003-95-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miyamoto, Shoto; Matsuoka, Aki; Yamada, Yuji; Ishikawa, Ryuta; Hayashida, Osamu published the artcile< Benzoxaborole Catalyst for Site-Selective Modification of Polyols>, Application In Synthesis of 6942-39-8, the main research area is benzoxaborole catalyst preparation; site selective protecting group free modification polyol; benzoylation tosylation benzylation glycosylation cis diol benzoxaborole catalyst.

The site-selective modification of polyols bearing several hydroxyl groups without the use of protecting groups remains a significant challenge in synthetic chem. To address this problem, novel benzoxaborole derivatives were designed as efficient catalysts for the highly site-selective and protecting-group-free modification of polyols. To identify the effective substituent groups enhancing the catalytic activity and selectivity, a series of benzoxaborole catalysts were synthesized. In-depth anal. for the substituent effect revealed that I [R = 4-F, 4-CF3, 3,5-(CF3)2], bearing multiple electron-withdrawing fluoro- and trifluoromethyl groups, exhibited the greatest catalytic activity and selectivity. Moreover, I [R = 4-F]-catalyzed benzoylation, tosylation, benzylation, and glycosylation of various cis-1,2-diol derivatives proceeded with good yield and site-selective manner.

European Journal of Organic Chemistry published new progress about Benzoxaboroles Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Application In Synthesis of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Friis, Stig D.; Pirnot, Michael T.; Dupuis, Lauren N.; Buchwald, Stephen L. published the artcile< A Dual Palladium and Copper Hydride Catalyzed Approach for Alkyl-Aryl Cross-Coupling of Aryl Halides and Olefins>, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is palladium copper hydride catalyzed cross coupling aryl halide olefin; alkenes; copper; cross-coupling; homogeneous catalysis; palladium.

We report an efficient means of sp2-sp3 cross coupling for a variety of terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis [e.g., 4-bromoanisole + 4-phenyl-1-butene → MeOC6H4-4-(CH2)4Ph in presence of [Pd(cinnamyl)Cl]2, BrettPhos, CuCl.(R)-DTBM-SEGPHOS and Me2PhSiH]. In addition to its applicability to a range of aryl bromide substrates, this process was also suitable for electron-deficient aryl chlorides, furnishing higher yields than the corresponding aryl bromides in these cases. The optimized protocol does not require the use of a glove-box and employs air-stable Cu and Pd complexes as precatalysts. A reaction on 10 mmol scale further highlighted the practical utility of this protocol. Employing a similar protocol, a series of cyclic alkenes were also examined Cyclopentene was shown to undergo efficient coupling under these conditions. Lastly, deuterium-labeling studies indicate that deuterium scrambling does not take place in this sp2-sp3 cross coupling, implying that β-hydride elimination is not a significant process in this transformation.

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary