Month: October 2022

Ranjini, P.; Shilpa, Chaitramallu M.; Kesagodu, Devaraju; Basavaraju, Y. B. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2021. The article was titled 《Synthesis of substituted 6,7-dimethoxy-4-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one and their apoptosis study》.SDS of cas: 2675-79-8 The article contains the following contents:

The field of biomedical analogs of podophyllotoxin is more in its infancy, but the explosion of interest in these mols. as inherently active therapeutic agents is increasing. There is growing interest in the design and synthesis of novel biocompatible analogs. The series of novel substituted podophyllotoxin derivatives I (R1 = H, OCH3; R2 = H, OCH3, Cl, etc.) were synthesized under mild conditions with satisfactory yield. Auto dock server anal. of the these analogs structure showed that the compounds were shown to interact with the proteins involved in Bcl-xL mediated pathway with inhibition constant of 0.000149 and 0.000584 for I (R1 = H; R2 = NH2) and I (R1 = H; R2 = CH3) resp. The recorded results of lipid peroxidation with treated samples were increased with increasing concentration In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8SDS of cas: 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.SDS of cas: 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Kaixuan; Xu, Chaoran; Hu, Xinyue; Zhou, Yuqiao; Lin, Lili; Feng, Xiaoming published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Catalytic asymmetric [3+2] cycloaddition of isomunchnones with methyleneindolinones》.Quality Control of Benzyl 2-bromoacetate The article contains the following contents:

An efficient enantioselective [3+2] cycloaddition of isomunchnones with methyleneindolinones that are generated by an in situ intramol. addition of the carbonyl group to rhodium carbenes is realized with a chiral N,N’-dioxide/Zn(II) complex as a Lewis acid. A series of chiral oxa-bridged 3-spiropiperidines are obtained in high yields with excellent dr and excellent ee values. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Qing-Hua; Jiang, Wei; Liang, Ru-Ping; Lin, Sen; Qiu, Jian-Ding published an article in 2021. The article was titled 《Synthesis of imidazolium-based cationic organic polymer for highly efficient and selective removal of ReO-4/TcO-4》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).HPLC of Formula: 623-24-5 The information in the text is summarized as follows:

Rational design of anion-scavenging materials with high selectivity and stability under high acid/base extreme conditions for removing 99TcO4- is still a significant challenge. Herein, we put forward an anion exchange strategy that utilized an imidazolium-based cationic organic polymer (named ImCOP) for efficient capture of perrhenate (ReO4-), a surrogate for TcO4- with nonradioactive. ImCOP was synthesized via the quaternization reaction using tris (4-(1H-imidazol-1-yl) phenyl) amine, a tripodal flexible ligand, and 1,4-bis (bromomethyl) benzene to forming a semi-rigid structure. ImCOP exhibited high chem. stability even under 3 M HNO3 and 3 M NaOH, which was superior to those of most materials. Attributed to the charged imidazolium moieties and tertiary amine groups that produced rich adsorption sites, ImCOP can produce electrostatic interactions with ReO4-, thereby leading to a record uptake capability (1162 mg g-1) of ReO4-. Furthermore, ImCOP exhibited high selectivity for removing ReO4- in the presence of large excess of competitive anions, which was attributed to the hydrophobic surface of ImCOP. These excellent features endowed ImCOP successfully separated ReO4- from simulated Hanford waste with a high adsorption removal of 93.4%. The excellent performance suggested ImCOP would be a promising material for TcO4-/ReO4-removal, which provided a feasible pathway for designing a high-efficiency and durable material for nuclear-related environmental remediation. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5HPLC of Formula: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. HPLC of Formula: 623-24-5 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hess, Andreas; Alandini, Nurtalya; Guelen, Hasret C.; Prohaska, Jan P.; Knochel, Paul published an article in 2022. The article was titled 《Regioselective magnesiations of functionalized arenes and heteroarenes using TMP2Mg in hydrocarbons》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Electric Literature of C7H5BrO2 The information in the text is summarized as follows:

The preparation of a new hydrocarbon-soluble magnesium amide TMP2Mg (TMP = 2,2,6,6-tetramethylpiperidyl) was report . This base showed excellent properties for the regioselective magnesiation of various arenes and heteroarenes bearing Et esters and carbamates under very mild reaction conditions. Subsequent trapping with aryl iodides (Negishi cross-coupling) gave access to a range of highly functionalized valuable building blocks such as I [R = 2-F,6-C(O)OEt, 2-F,6-C(O)Ot-Bu, 2-C(O)OEt, etc. R1 = I, 2-thienyl, 3-MeOC6H4, etc.]. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Electric Literature of C7H5BrO2)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Electric Literature of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Mohamed, Mohamed Gamal; Sharma, Santosh U.; Liu, Ni-Yun; Mansoure, Tharwat Hassan; Samy, Maha Mohamed; Chaganti, Swetha V.; Chang, Yu-Lung; Lee, Jyh-Tsung; Kuo, Shiao-Wei published an article in International Journal of Molecular Sciences. The title of the article was 《Ultrastable Covalent Triazine Organic Framework Based on Anthracene Moiety as Platform for High-Performance Carbon Dioxide Adsorption and Supercapacitors》.Application In Synthesis of 9,10-Dibromoanthracene The author mentioned the following in the article:

Conductive and porous nitrogen-rich materials have great potential as supercapacitor electrode materials. The exceptional efficiency of such compounds, however, is dependent on their larger surface area and the level of nitrogen doping. To address these issues, we synthesized a porous covalent triazine framework (An-CTFs) based on 9,10-dicyanoanthracene (An-CN) units through an ionothermal reaction in the presence of different molar ratios of molten zinc chloride (ZnCl2) at 400 and 500 °C, yielding An-CTF-10-400, An-CTF-20-400, An-CTF-10-500, and An-CTF-20-500 microporous materials. According to N2 adsorption-desorption analyses (BET), these An-CTFs produced exceptionally high sp. surface areas ranging from 406-751 m2·g-1. Furthermore, An-CTF-10-500 had a capacitance of 589 F·g-1, remarkable cycle stability up to 5000 cycles, up to 95% capacity retention, and strong CO2 adsorption capacity up to 5.65 mmol·g-1 at 273 K. As a result, our An-CTFs are a good alternative for both electrochem. energy storage and CO2 uptake. In the experimental materials used by the author, we found 9,10-Dibromoanthracene(cas: 523-27-3Application In Synthesis of 9,10-Dibromoanthracene)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Application In Synthesis of 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wu, Qianqian; Li, Minghong; He, Shuanglin; Xiong, Ying; Zhang, Ping; Huang, Heyan; Chen, Lin; Huang, Fang; Li, Fei published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Hangman effect boosts hydrogen production by manganese terpyridine complex》.Recommanded Product: Bromopentacarbonylmanganese(I) The author mentioned the following in the article:

The manganese terpyridine complex 1 with a coordinated carboxylate in the axial position was obtained in situ. By virtue of a hangman effect, complex 1 catalyzes electrochem. hydrogen evolution from phenol in acetonitrile solution with a turnover frequency of 525 s-1 at a low overpotential of ca. 230 mV. After reading the article, we found that the author used Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of Br3InIn 2018 ,《A five-component Biginelli-Diels-Alder cascade reaction》 appeared in Frontiers in Chemistry (Lausanne, Switzerland). The author of the article were Maskrey, Taber S.; Frischling, Madeline C.; Rice, Mikhaila L.; Wipf, Peter. The article conveys some information:

A new multi-component condensation was discovered during the reaction of urea, β-keto ester and formaldehyde. In the presence of catalytic indium bromide, a Biginelli dihydropyrimidinone intermediate such as I [R1 = Et, Me, Bn; X = O, S] was further converted to a five-component condensation product such as II [R1 = Me, Et, allyl, Bn; X = O, S] through a formal hetero Diels-Alder reaction. The product structure was confirmed by NMR and NOE anal. and the proposed stepwise mechanism was supported by the reaction of the Biginelli intermediate with Et 2-methylene-3-oxobutanoate. In the part of experimental materials, we found many familiar compounds, such as Indium(III) bromide(cas: 13465-09-3Computed Properties of Br3In)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Computed Properties of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: Methyl 3-(bromomethyl)benzoateIn 2018 ,《A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry. The article was written by Xu, Guangwei; Wang, Tianqi; Li, Yongtao; Huang, Zhi; Wang, Xin; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong. The article contains the following contents:

Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clin. IDO1 drugs show marginal efficacy as single agents. On basis of mol. docking and pharmacophore modeling, a novel inhibitor Roxyl-WL was discovered with a half maximal inhibitory concentration (IC50) value of 1 nM against IDO1 and 10-100-fold increased potent activity compared with IDO1 drugs in clin. trials. Roxyl-WL displayed excellent kinase spectrum selectivity with no activity out of the 337 protein kinases. In vitro, Roxyl-WL effectively augmented the proliferation of T cells and reduced the number of regulatory T cell (Tregs). When administered to melanoma (B16F10) tumor-bearing mice orally, Roxyl-WL significantly suppressed tumor growth and induced immune response. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Name: Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Optimization of Thermoelectric Properties of Polymers by Incorporating Oligoethylene Glycol Side Chains and Sequential Solution Doping with Preannealing Treatment》 was written by Tripathi, Ayushi; Ko, Youngjun; Kim, Miso; Lee, Yeran; Lee, Soonyong; Park, Juhyung; Kwon, Young-Wan; Kwak, Jeonghun; Woo, Han Young. Related Products of 111865-47-5 And the article was included in Macromolecules (Washington, DC, United States) on August 25 ,2020. The article conveys some information:

Two types of p-type thermoelec. (TE) polymers with alkyl (PCPDTSBT) and oligoethylene glycol (OEG) side chains (PCPDTSBT-A) on an sp2-hybridized olefinic bis(alkylsulfanyl)methylene-substituted cyclopentadithiophene backbone are synthesized. Interestingly, the OEG-substituted polymer, PCPDTSBT-A, exhibits significant self-doping compared to PCPDTSBT, where the polaron d. of the former is 2.3 × 1016 mm-3 (vs. 7.9 × 1014 mm-3 for PCPDTSBT) without external doping. Changing the side chains also induces a completely different polymer chain orientation in the PCPDTSBT-A (face-on) and PCPDTSBT (edge-on) films. The effect of doping with 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ) on the morphol. and TE properties of the polymers with different side chains is studied. Sequential solution doping (SQD) is performed by overcoating the preannealed polymer films with F4TCNQ solution, which affords highly effective doping without disrupting the morphol. of the crystalline films, especially for PCPDTSBT-A with OEG side chains. Resulting from the synergistic effect of the OEG side chains and SQD, PCPDTSBT-A exhibits remarkably improved elec. conductivity (53.8 S cm-1) with a higher power factor (40.4μW m-1 K-2), compared to PCPDTSBT, for which the maximum elec. conductivity is 1.4 S cm-1 and the power factor is 1.8μW m-1 K-2. In addition, the transport coefficient of PCPDTSBT-A, determined by applying the Kang-Snyder model (2.40 × 10-2 S cm-1), is superior to that of PCPDTSBT (3.59 × 10-3 S cm-1), thereby showing the excellence of the developed strategy for improving the performance of TE polymers. The experimental process involved the reaction of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5Related Products of 111865-47-5)

Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide(cas: 111865-47-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Related Products of 111865-47-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Xu, Bingying; Zhou, Haibo; Mei, Qingsong; Tang, Wei; Sun, Yilun; Gao, Mengping; Zhang, Cuilan; Deng, Shengsong; Zhang, Yong published 《Real-Time Visualization of Cysteine Metabolism in Living Cells with Ratiometric Fluorescence Probes》.Analytical Chemistry (Washington, DC, United States) published the findings.Name: 8-Bromooctanoic acid The information in the text is summarized as follows:

Sulfite from cysteine metabolism in living cells plays a crucial role in improving the water solubility of metabolic xenobiotics for their easier excretion in urine or bile. However, an imbalance of sulfite in vivo would lead to oxidative stress or age-related diseases, and an effective strategy for real-time imaging of cysteine metabolism in living cells is still lacking due to its low metabolite concentration and rapid reaction kinetics. Herein, a cyanine moiety based ratiometric fluorescence probe (I) was developed for highly selective and sensitive detection of sulfite in aqueous solution and living cells. The free probe exhibited an orange emission color, and the fluorescence color would gradually change to blue once sulfite anions selectively reacted with the unsaturated carbon double bonds in the probe mol. This ratiometric fluorescence manner endowed the probe excellent sensitivity with a detection limit of 0.78 nM, which was then explored to image the kinetic process of sulfite release in hepatic BRL cells after incubating with an excess amount of cysteine. This strategy opens new opportunities for revealing thiol-containing species metabolism and even quant. tracking their distributions in live cells or organelles. In the experimental materials used by the author, we found 8-Bromooctanoic acid(cas: 17696-11-6Name: 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Name: 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary