Month: October 2022

《General and selective syn-carboxylation-trifluoromethylation of terminal alkynes: application to the late-stage modification of dehydrocholic acid》 was written by Zhang, Song-Lin; Xiao, Chang; Wan, Hai-Xing; Zhang, Xiaoming. Formula: C7H5BrO2This research focused ontrifluoromethyl enol carboxylic ester preparation regioselective diastereoselective; terminal aryl alkyne carboxylic acid syn carboxylation trifluoromethylation. The article conveys some information:

A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(III)-CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochem. This method is broadly applicable to various carboxylic acids and terminal alkynes, producing a range of biol. active trifluoromethyl enol carboxylic esters I (Ar = 4-ClC6H4, 4-EtC6H4, Ph, etc.; R = tBu, Bu, 4-BrC6H4, etc.). The synthetic potential of this method is further demonstrated by the late-stage functionalization of a complex pharmaceutical compound dehydrocholic acid. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Pd(II)-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates under mild conditions》 was published in Chemical Communications (Cambridge, United Kingdom) in 2011. These research results belong to Li, Mingzong; Wang, Cong; Fang, Ping; Ge, Haibo. Quality Control of potassium (3-bromophenyl)trifluoroborate The article mentions the following:

A novel Pd-catalyzed decarboxylative cross-coupling of oxamic acids with potassium phenyltrifluoroborates has been realized under mild reaction conditions. This method provides an efficient access to N-mono- or N,N-disubstituted benzamides and benzoates.potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Quality Control of potassium (3-bromophenyl)trifluoroborate) was used in this study.

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Quality Control of potassium (3-bromophenyl)trifluoroborateSome of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Tris-NHC-propagated self-supported polymer-based Pd catalysts for heterogeneous C-H functionalization》 was written by Mandal, Tanmoy; Dutta, Tapas Kumar; Mohanty, Sunit; Choudhury, Joyanta. Reference of Tris(4-bromophenyl)amineThis research focused ontris NHC propagated self supported polymer palladium catalyst preparation; arene carbon hydrogen functionalization halogenation arylation catalyst. The article conveys some information:

Three-dimensionally propagated imidazolium-containing mesoporous coordination polymer and organic polymer-based platforms were successfully exploited to develop single-site heterogenized Pd-NHC catalysts for oxidative arene/heteroarene C-H functionalization reactions. The catalysts were efficient in directed arene halogenation, and nondirected arene and heteroarene arylation reactions. High catalytic activity, excellent heterogeneity and recyclability were offered by these systems making them promising candidates in the area of heterogeneous C-H functionalization, where efficient catalysts are still scarce. In addition to this study using Tris(4-bromophenyl)amine, there are many other studies that have used Tris(4-bromophenyl)amine(cas: 4316-58-9Reference of Tris(4-bromophenyl)amine) was used in this study.

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Reference of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Chemical Communications (Cambridge, United Kingdom) included an article by Deng, Zhixin; Han, Sheng; Ke, Miaolin; Ning, Yingtang; Chen, Fen-Er. Safety of Ethyl 3-(2-bromophenyl)propanoate. The article was titled 《Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters》. The information in the text is summarized as follows:

Palladium-catalyzed linear-selective hydroesterification of vinyl arenes with alcs. enabled by diphosphine ligands derived from bis[2-(diphenylphosphino)ethyl]amides has been developed. A variety of 3-arylpropanoate esters were obtained in high yields and regioselectivity. The robustness of this methodol. was further demonstrated by the efficient gram-scale synthesis of the Et 3-phenylpropanoate as a precursor to hydrocinnamic acid. After reading the article, we found that the author used Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Safety of Ethyl 3-(2-bromophenyl)propanoate)

Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of Ethyl 3-(2-bromophenyl)propanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Zhou, Quan-Quan; Dusel, Simon Josef Siegfried; Lu, Liang-Qiu; Konig, Burkhard; Xiao, Wen-Jing. Related Products of 7051-34-5. The article was titled 《Alkenylation of unactivated alkyl bromides through visible light photocatalysis》. The information in the text is summarized as follows:

Two visible-light driven alkenylation reactions of unactivated alkyl bromides, which were enabled by the use of Ir(dF(CF3)ppy)2(dtbbpy)PF6 as the photocatalyst and (TMS)3SiH as the atom transfer reagent to activate the alkyl bromides, were described for the first time. These protocols can be used to produce a variety of alkenes from easily available feedstock with good reaction efficiency and high chemoselectivity under mild reaction conditions. To further demonstrate the applicability of the present strategy, the alkenylation of bioactive mols. and glycosyl bromides, as well as the alkynylation of unactivated alkyl bromides, was proven to be feasible. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Related Products of 7051-34-5) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Related Products of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Murai, Masahito; Nishimura, Kengo; Takai, Kazuhiko. HPLC of Formula: 1530-32-1. The article was titled 《Palladium-catalyzed double-bond migration of unsaturated hydrocarbons accelerated by tantalum chloride》. The information in the text is summarized as follows:

The operationally simple palladium-catalyzed double-bond migration without heteroatom-containing coordinating functional groups was described. Addition of TaCl5 as a second catalyst greatly enhanced the migration efficiency to provided β-alkylstyrenes through migration of up to a five-carbon chain. Both catalysts were com. available and the reaction occurred without external ligands under neutral conditions. The reaction proceeded via generation of π-allyl palladium species, which enabled the chemoselective double-bond migration of hydrocarbons in the presence of allyl ethers. Remote functionalization through double-bond migration was also demonstrated using FeCl3 as a second catalyst. In the experiment, the researchers used Ethyltriphenylphosphonium bromide(cas: 1530-32-1HPLC of Formula: 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.HPLC of Formula: 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Tanini, Damiano; Lupori, Beatrice; Malevolti, Gianni; Ambrosi, Moira; Nostro, Pierandrea Lo; Capperucci, Antonella. Safety of Methyl 3-bromopropanoate. The article was titled 《Direct biocatalysed synthesis of first sulfur-, selenium- and tellurium- containing L-ascorbyl hybrid derivatives with radical trapping and GPx-like properties》. The information in the text is summarized as follows:

6-O-L-Ascorbyl selenoesters, thioesters and telluroesters, e.g., I, II, and III, resp., can be efficiently and directly prepared from L-ascorbic acid and suitable functionalized chalcogenoesters through lipase-catalyzed transesterification reactions. Novel synthesized L-ascorbyl derivatives exhibited remarkable chain breaking and glutathione peroxidase-like activities. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Indo American Journal of Pharmaceutical Research included an article by Joshi, Shrinivas D.; Kulkarni, V. H.; Kumar, S. R. Prem; Basha, Jeelan. COA of Formula: C7H5BrO2. The article was titled 《Synthesis, antitubercular and antibacterial activities of novel N’-(substituted)-(2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamide derivatives》. The information in the text is summarized as follows:

A series of substituted N-(2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides I (R = H, 4-Cl, 4-Br, 4-F, 4-NO2, 3-Cl) was synthesized by reacting different substituted aromatic acids RC6H4C(O)OH with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.COA of Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Zhang, Guodong; Gao, Yang published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Ru-catalyzed C(sp2)-H vinylation/annulation of benzoic acids and alkynes: rapid access to medium-sized lactones》.Formula: C8H7BrO2 The article contains the following contents:

An unprecedented ruthenium catalyzed [4+4] annulation of readily available benzoic acids and alkynes was reported. The carboxylate group acted as both a directing group and an internal nucleophilic reagent to facilitated a C(sp2)-H vinylation/annulation cascade. This reaction avoided the classically oxidative [4+2] annulation, allowed the efficient synthesis of a wide array of eight-membered lactones under oxidant-free conditions. Moreover, this catalytic system would be successfully extended to [4+3] and [4+5] annulations for the assembly of seven- and nine-membered lactones. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C8H7BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mondal, Anirban; Visser, Paco; Doze, Anna M.; Buter, Jeffrey; Feringa, Ben L. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Pd-catalyzed sp-sp3 cross-coupling of benzyl bromides using lithium acetylides》.COA of Formula: C9H9BrO2 The article contains the following contents:

An efficient method for the cross-coupling of benzyl bromides (sp3) with lithium acetylides (sp) was developed to obtain benzylic alkynes I [R = H, 3-MeO, 4-Me, etc.; R1 = Si(CH3)3, Si(i-Pr)3, Ph, 9-phenanthryl]. The reaction proceeded within 10 min at room temperature and could be performed in the presence of organolithium-sensitive functional groups such as esters, nitriles, amides and boronic esters. The potential application of the methodol. was demonstrated in the preparation of key intermediates used in pharmaceuticals, chem. biol. and natural products. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8COA of Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. COA of Formula: C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary