Month: October 2022

Recommanded Product: Ethyl 4-bromobutyrateIn 2022 ,《Solvatochromic spiropyran – a facile method for visualized, sensitive and selective response of lead (Pb2+) ions in aqueous solution》 was published in Journal of Photochemistry and Photobiology, A: Chemistry. The article was written by Liu, Guojie; Li, Yiwei; Cui, Congcong; Wang, Min; Gao, He; Gao, Jun; Wang, Jingbo. The article contains the following contents:

1′-(4′-carboxybutyl) -3′, 3′-dimethyl-6-nitro-8-hydroxylspiro [chromene-2, 2′-indoline] (SPC) is a visual, selective, and sensitive detector to lead (Pb2+) ions. The presence of 8 -hydroxyl in pyran ring makes SPC have a remarkable solvatochromism in polar solvents (SPC can isomerize to the ring-opening body (Mcc) spontaneously under visible light conditions), ascribed to the formation of intramol. hydrogen bonds. The color and spectrum of the Mcc solution could be changed instantly and significantly by addition of Pb2+, and Mcc showed excellent selectivity to Pb2+ in the simulated lead-zinc ore leachate. The complex Mcc – Pb2+, with a stoichiometry ratio of 1:1, can stably exist under visible light conditions, which is attributed to the interaction between Pb2+ and the deprotonated carboxy (-COO-), phenolic oxygen atom and 8-hydroxyl of the Mcc, and the whole process does not need UV irradiation, avoiding the serious photo-degradation of spiropyran derivatives The low limit of detection (0.61 μM) and the established test strips indicate that SPC has the potential to be applied in the quant. detection of Pb2+ in real samples.Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 3,5-DibromoanilineIn 2020 ,《Structurally Informative Isotopic Shifts in Ion Mobility Spectra for Heavier Species》 was published in Journal of the American Society for Mass Spectrometry. The article was written by Pathak, Pratima; Baird, Matthew A.; Shvartsburg, Alexandre A.. The article contains the following contents:

The isotopic mol. envelopes due to stable isotopes for most elements were a staple of mass spectrometry since its origins, often leveraged to identify and quantify compounds However, all isomers share one MS envelope. As the mol. motion in media also depends on the isotopic composition, separations such as liquid chromatog. (LC) and ion mobility spectrometry (IMS) must also feature isotopic envelopes. These were largely not observed because of limited resolution, except for the (structurally uninformative) shifts in LC upon H/D exchange. We recently found the isotopic shifts in FAIMS for small haloanilines (∼130-170 Da) to hinge on the halogen position, opening a novel route to isomer characterization. Here, we extend the capability to heavier species: dibromoanilines (DBAs, ∼250 Da) and tribromoanilines (TBAs, ∼330 Da). The 13C shifts for DBAs and TBAs vary across isomers, some changing sign. While 81Br shifts are less specific, the 2-D 13C/81Br shifts unequivocally differentiate all isomers. The trends for DBAs track those for dichloroanilines, with the 13C shift order preserved for most isomers. The peak broadening due to merged isotopomers is also isomer-specific. The absolute shifts for TBAs are smaller than those for lighter haloanilines, but differentiate isomers as well because of compressed uncertainties. These results showcase the feasibility of broadly distinguishing isomers in the more topical ∼200-300 Da range using the isotopic shifts in IMS spectra. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of Benzyl 2-bromoacetateIn 2020 ,《E- and chemoselective thia-Michael addition to benzyl allenoate》 was published in Phosphorus, Sulfur and Silicon and the Related Elements. The article was written by Bibi, Rifhat; Murtaza, Amna; Khan, Khalid Mohammed; Rehman, Zia ur; Saeed, Aamer; Tahir, Muhammad Nawaz; Hassan, Abbas. The article contains the following contents:

Different thiols were successfully reacted with benzyl allenoate resulting in E-selective thia-Michael addition product with α,β-unsaturation as confirmed by single crystal x-ray crystallog. anal. The thia-Michael addition was chemoselective and free amine and alc. groups were well tolerated. Catalytic triethylamine was required for high conversion. Fair to excellent yields were obtained for a variety of aliphatic, aryl and heteroaryl thiols. After reading the article, we found that the author used Benzyl 2-bromoacetate(cas: 5437-45-6Application In Synthesis of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application In Synthesis of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A simple regioselective nuclear bromination of alkyl phenyl ethers》 was written by Yakabe, Shigetaka; Hirano, Masao; Morimoto, Takashi. SDS of cas: 30752-31-9 And the article was included in Organic Preparations and Procedures International on April 30 ,1998. The article conveys some information:

The regioselective bromination of alkyl Ph ethers was carried out with sodium perchlorate/sodium bromide/tris(acetylacetonato)manganese/moist alumina. In the experimental materials used by the author, we found 1-Bromo-4-(cyclohexyloxy)benzene(cas: 30752-31-9SDS of cas: 30752-31-9)

1-Bromo-4-(cyclohexyloxy)benzene(cas: 30752-31-9) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 30752-31-9 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Sharma, Vivekanand; De, Dinesh; Saha, Ranajit; Das, Ranjita; Chattaraj, Pratim Kumar; Bharadwaj, Parimal K. published 《A Cu(II)-MOF capable of fixing CO2 from air and showing high capacity H2 and CO2 adsorption》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 3,5-Dibromoaniline The information in the text is summarized as follows:

A porous Cu(II)-MOF shows an adsorption of 6.6 wt% of H2 at 77 K and 62 bar and a very high 60 wt% of CO2 at 298 K and 32 bar. When air is bubbled into a suspension of the activated MOF in the presence of different epoxides at room temperature, the CO2 in air is readily converted into the corresponding cyclic carbonates. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Mondal, Mukulesh; Panda, Manashi; Davis, Nicholas W.; McKee, Vickie; Kerrigan, Nessan J.. Application In Synthesis of Indium(III) bromide. The article was titled 《Asymmetric synthesis of cyclopentanones through dual Lewis acid-catalysed [3+2]-cycloaddition of donor-acceptor cyclopropanes with ketenes》. The information in the text is summarized as follows:

When InBr3-EtAlCl2 (15-30 mol%) was used as a dual Lewis acid system to promote the formal [3+2]-cycloaddition of enantioenriched donor-acceptor cyclopropanes I (R1 = C2H3, Ph, C2H2C6H4; R2 = 2-methoxy-2-oxoethyl, 2-ethoxy-2-oxoethyl, 2-(benzyloxy)-2-oxoethyl) with ketenes (O)CC(R3)(R4) (R3 = 4-methylphenyl, 4-(trifluoromethyl)phenyl, cyclohexyl, etc.; R4 = Et, Ph, Me, n-butyl), cyclopentanones II were formed in good to excellent yields (84-99%, 18 examples), and with excellent transfer of chirality (15 examples, 90% ee to >99% ee). In addition to this study using Indium(III) bromide, there are many other studies that have used Indium(III) bromide(cas: 13465-09-3Application In Synthesis of Indium(III) bromide) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Application In Synthesis of Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Manganese complex-catalysed α-alkylation of ketones with secondary alcohols enables the synthesis of β-branched carbonyl compounds》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Waiba, Satyadeep; Jana, Sayan K.; Jati, Ayan; Jana, Akash; Maji, Biplab. Recommanded Product: Bromopentacarbonylmanganese(I) The article mentions the following:

Herein, β-branched carbonyl compounds were synthesized via the α-alkylation of ketones with secondary alcs. under “”borrowing hydrogen”” catalysis. A wide range of secondary alcs., including various cyclic, acyclic, sym., and unsym. alcs., was successfully applied under the developed reaction conditions. A manganese(I) complex bearing a phosphine-free multifunctional ligand catalyzed the reaction and produced water as the sole byproduct. In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: Bromopentacarbonylmanganese(I)) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Naranjo, Cristina; Dorca, Yeray; Ghosh, Goutam; Gomez, Rafael; Fernandez, Gustavo; Sanchez, Luis published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Chain-capper effect to bias the amplification of asymmetry in supramolecular polymers》.Product Details of 4316-58-9 The article contains the following contents:

The kinetically controlled amplification of asymmetry experienced in the co-assembly of chiral tribiphenylaminetricarboxamides (S)-1 and (R)-1 is investigated (I, (R) or (S) at indicated center *). The formation of metastable monomeric species through intramol. H-bonds retards the efficient amplification of asymmetry due to a chain-capper effect. In addition to this study using Tris(4-bromophenyl)amine, there are many other studies that have used Tris(4-bromophenyl)amine(cas: 4316-58-9Product Details of 4316-58-9) was used in this study.

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Product Details of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Forlani, Giuseppe; Sabbioni, Giuseppe; Ragno, Daniele; Petrollino, Davide; Borgatti, Monica published an article in 2021. The article was titled 《Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumor cells》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Quality Control of 3,5-Dibromoaniline The information in the text is summarized as follows:

In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalyzing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. This leads to a higher proline content that exacerbates the effects of the so-called proline-P5C cycle, with tumor cells effectively using this method to increase cell survival. If a method of reducing or inhibiting P5C reductase could be discovered, it would provide new means of treating cancer. To address this point, the effect of some phenyl-substituted derivatives of aminomethylene-bisphosphonic acid, previously found to interfere with the catalytic activity of plant and bacterial P5C reductases, was evaluated in vitro on the human isoform 1 (PYCR1), expressed in E. coli and affinity purified. The 3.5-dibromophenyl- and 3.5-dichlorophenyl-derivatives showed a remarkable effectiveness, with IC50 values lower than 1μM and a mechanism of competitive type against both P5C and NADPH. The actual occurrence in vivo of enzyme inhibition was assessed on myelogenous erythroleukemic K562 and epithelial breast cancer MDA-MB-231 cell lines, whose growth was progressively impaired by concentrations of the dibromo derivative ranging from 10-6 to 10-4 M. Interestingly, growth inhibition was not relieved by the exogenous supply of proline, suggesting that the effect relies on the interference with the proline-P5C cycle, and not on proline starvation. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Quality Control of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Varakala, Saiprasad Dasugari; Reshma, Rudraraju Srilakshmi; Schnell, Robert; Dharmarajan, Sriram published an article in European Journal of Medicinal Chemistry. The title of the article was 《Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens》.Reference of 3-Bromo-2-methylbenzoic acid The author mentioned the following in the article:

Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and Et 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit mols. which ended up with forty-three analogs (twenty-nine analogs from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound I (effective against EcFabG, AbFabG, StFabG, MtFabG1) and II (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 3-Bromo-2-methylbenzoic acid Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary