Month: October 2022

In 2022,Lenis-Rojas, Oscar A.; Carvalho, Beatriz; Cabral, Rui; Silva, Margarida; Friaes, Sofia; Roma-Rodrigues, Catarina; Meireles, Marta S. H.; Gomes, Clara S. B.; Fernandez, Jhonathan A. A.; Vila, Sabela F.; Rubiolo, Juan A.; Sanchez, Laura; Baptista, Pedro V.; Fernandes, Alexandra R.; Royo, Beatriz published an article in JBIC, Journal of Biological Inorganic Chemistry. The title of the article was 《Manganese(I) tricarbonyl complexes as potential anticancer agents》.COA of Formula: C5BrMnO5 The author mentioned the following in the article:

The antiproliferative activity of [Mn(CO)3(NN)Br] (NN = phendione 1, bipy 3) and of the two newly synthesized Mn complexes [Mn(CO)3(acridine)(phendione)]OTf (2) and [Mn(CO)3(di-triazole)Br] (4) has been evaluated by MTS against three tumor cell lines A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), HCT116doxR (colorectal carcinoma resistant to doxorubicin), and in human dermal fibroblasts. The antiproliferative assay showed a dose-dependent effect higher in complex 1 and 2 with a selectivity toward ovarian carcinoma cell line 21 times higher than in human fibroblasts. Exposure of A2780 cells to IC50 concentrations of complex 1 and 2 led to an increase of reactive oxygen species that led to the activation of cell death mechanisms, namely via intrinsic apoptosis for 2 and autophagy and extrinsic apoptosis for 1. Both complexes do not target DNA or interfere with cell cycle progression but are able to potentiate cell migration and neovascularization (for 2) an indicative that their application might be directed for initial tumor stages to avoid tumor invasion and metastization and opening a new avenue for complex 2 application in regenerative medicine. Interestingly, both complexes do not show toxicity in both in vivo models (CAM and zebrafish). In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2COA of Formula: C5BrMnO5) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.COA of Formula: C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C7H5BrOIn 2019 ,《Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst》 appeared in Progress in Chemical and Biochemical Research. The author of the article were Moosavi-Zare, Ahmad Reza; Goudarziafshar, Hamid; Jalilian, Zahra. The article conveys some information:

Preparation of pyrano[2,3-d]pyrimidine dione derivatives I (R = H, Me; R1 = C6H5, 4-BrC6H4, 2,3-(Cl2)C6H3, etc.) by the tandem Knoevenagel-Michaelcyclocondensation reaction of malononitrile, various aldehydes R1CHO and barbituric acid derivatives like barbituric acid and 1,3-dimethylbarbituric acid in the presence of isonicotinic acid as an efficient organocatalyst has been described. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Computed Properties of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Computed Properties of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2004,Chemical Communications (Cambridge, United Kingdom) included an article by Moss, Rebecca J.; Wadsworth, Kelly J.; Chapman, Christopher J.; Frost, Christopher G.. Formula: C6H4BBrF3K. The article was titled 《Rhodium-catalyzed tandem conjugate addition-protonation: an enantioselective synthesis of 2-substituted succinic esters》. The information in the text is summarized as follows:

The rhodium-catalyzed addition of potassium trifluoro(organo)borates to di-Me itaconate generated an intermediate complex which on protonation provided enantioenriched succinic esters, e.g., I. After reading the article, we found that the author used potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Formula: C6H4BBrF3K)

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Formula: C6H4BBrF3K

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover》 were Dhungana, Roshan K.; Granados, Albert; Sharique, Mohammed; Majhi, Jadab; Molander, Gary A.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2022. Application of 401-55-8 The author mentioned the following in the article:

Herein, a three-component organophotoredox coupling of N-alkenyl amides I [R1 = Me, R2 = H, Me; R1R2 = (CH2)3, (CH2)5; R3 = H, Me] with α-bromocarbonyls II (R4 = F, Me; R5 = EtO, Et2N) and various nucleophiles NuH (Nu = OH, 4-ClC6H4S, 2-pyrimidinylthio, EtO, N3, etc.) to give the corresponding compounds III is reported. This transition metal-free difunctionalization protocol installs sequential C-C and C-Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Application of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Kosikowska, Paulina; Bochno, Marta; Macegoniuk, Katarzyna; Forlani, Giuseppe; Kafarski, Pawel; Berlicki, Lukasz published 《Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase》.Journal of Enzyme Inhibition and Medicinal Chemistry published the findings.Synthetic Route of C6H5Br2N The information in the text is summarized as follows:

Inhibition of glutamine synthetase (GS) is one of the most promising strategies for the discovery of novel drugs against tuberculosis. Forty-three bisphosphonic and bis-H-phosphinic acids of various scaffolds, bearing aromatic substituents, were screened against recombinant GS from Mycobacterium tuberculosis. Most of the studied compounds exhibited activities in micromolar range, with N-(3,5-dichlorophenyl)-2-aminoethylidenebisphoshonic acid, N-(3,5-difluorophenyl)-2-aminoethylidene-bisphoshonic acid, and N-(3,4-dichlorophenyl)-1-hydroxy-1,1-ethanebisphosphonic acid showing the highest potency with kinetic parameters similar to the reference compound, L-methionine-S-sulfoximine. Moreover, these inhibitors were found to be much more effective against the pathogenic enzyme than against the human ortholog. Thus, with the bone-targeting properties of the bisphosphonate compounds in mind, this activity/selectivity profile makes these compounds attractive agents for the treatment of bone tuberculosis. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Kawano, Shin-ichiro; Kawada, Sae; Kitagawa, Yasutaka; Teramoto, Rena; Nakano, Masayoshi; Tanaka, Kentaro. Quality Control of 3,6-Dibromo-9H-carbazole. The article was titled 《Near-infrared absorption by intramolecular charge-transfer transition in 5,10,15,20-tetra(N-carbazolyl)porphyrin through protonation》. The information in the text is summarized as follows:

A porphyrin coupled quadruply with N-carbazolyl groups at the meso positions was synthesized. Because of the electron-withdrawing nature of the carbazole units at the porphyrin center, the tetra(N-carbazolyl)porphyrin and the protonated derivative display unique absorption bands derived from intramol. charge-transfer transition from the carbazoles to the porphyrin moiety. After reading the article, we found that the author used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Quality Control of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Quality Control of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells》 was written by Uchinomiya, Shohei; Matsunaga, Naoya; Kamoda, Koichiro; Kawagoe, Ryosuke; Tsuruta, Akito; Ohdo, Shigehiro; Ojida, Akio. Application In Synthesis of 8-Bromooctanoic acid And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, the authors report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application In Synthesis of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Bi- and poly(carbyne) functionalised polycyclic aromatics》 was written by Frogley, Benjamin J.; Hill, Anthony F.; Seitz, Antonia. SDS of cas: 523-27-3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Complexes where a central polyaromatic ring system is substituted with one to four W carbynes were prepared by Pd0/Au(I)-mediated coupling between a W stannylcarbyne and aryl halides. This strategy enables preparation of complexes with one to three carbynes substituted onto a single Ph ring, the 1st anthracenyl mono- and bis-carbynes, and a tetra(carbyne) complex constructed about a central pyrene ring system. The experimental part of the paper was very detailed, including the reaction process of 9,10-Dibromoanthracene(cas: 523-27-3SDS of cas: 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.SDS of cas: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bera, Sourav Sekhar; Bahukhandi, Srishti Ballabh; Empel, Claire; Koenigs, Rene M. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Catalyst-controlled site-selective N-H and C3-arylation of carbazole via carbene transfer reactions》.Application In Synthesis of 3,6-Dibromo-9H-carbazole The article contains the following contents:

A site-selective direct arylation reaction of carbazole and other N-heterocycles with diazo-naphthalen-2(1H)-ones was developed. While Au(I)-NHC catalysts led to selective C3-arylation, palladium acetate allowed for selective N-H arylation, displaying complete site-selectivity each. To show the applicability of these arylation reactions, one-pot, two-fold diarylation reactions of carbazole were demonstrated. In the experiment, the researchers used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Application In Synthesis of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Application In Synthesis of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamashiro, Toshiki; Abe, Takumi; Tanioka, Masaru; Kamino, Shinichiro; Sawada, Daisuke published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Cis-3-Azido-2-methoxyindolines as safe and stable precursors to overcome the instability of fleeting 3-azidoindoles》.Reference of Indium(III) bromide The article contains the following contents:

A general and concise approach for tackling this problem by using 3-azidoindole surrogated. The surrogated was bench-stable, presumably due to the observed intramol. O-Nβ bonding. The resultant fleeting intermediates underwent capturing in-situ to afford 3-substitued indoles through formal ipso-substitution of the azide group by nucleophiles. In these investigations, the fleeting 3-azidoindoles showed a C3-electrophilic character for the first time. In the experiment, the researchers used Indium(III) bromide(cas: 13465-09-3Reference of Indium(III) bromide)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Reference of Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary