Month: October 2022

In 2018,Tang, Qianyun; Xiao, Wanyue; Li, Jiewei; Chen, Dapeng; Zhang, Yewei; Shao, Jinjun; Dong, Xiaochen published 《A fullerene-rhodamine B photosensitizer with pH-activated visible-light absorbance/fluorescence/photodynamic therapy》.Journal of Materials Chemistry B: Materials for Biology and Medicine published the findings.Application of 1129-28-8 The information in the text is summarized as follows:

The development of smart photosensitizers with tumor microenvironment-activable fluorescence turn-on and singlet oxygen generation plays an important role in tumor bioimaging and photodynamic therapy. Herein, a pH-activable heavy-atom-free photosensitizer (C60-RB) has been successfully synthesized through introducing a fullerene unit onto rhodamine B hydrazide. Under acidic conditions, C60-RB, having a spirolactam structure, can be activated to its ring-opened structure C60-RB-H and thus, visible-light absorbance enhancement, fluorescence turn-on and triplet excited state generation can be accomplished. In the presence of hydrion, the fullerene unit in C60-RB C60-RB-H acting as an intramol. spin converter can cause good intersystem crossing, and the energy gap between S1 and T1 (ΔEST) is lowered to 0.017 eV. Through encapsulation with amphiphilic DSPE-mPEG2000, water-soluble nanoparticles (NPs) of C60-RB are obtained. In vitro experiments indicate that C60-RB NPs are capable of universal cellular uptake and lysosomal activation (pH 4.5-5.0), and they also exhibit excellent photodynamic therapeutic effect. The fluorescence turn-on and efficient singlet oxygen generation enabled by pH-activated C60-RB NPs testify their great potential applications for cancer diagnosis and treatment. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Application of 1129-28-8 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Xu, Yin-Xiang; Song, Yu-Meng; Chen, Chao-Yan; Shen, Jia-Wen; Zhu, Hai-Liang published an article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The title of the article was 《A pH-applicative fluorescent probe with long measuring range for monitoring hydrazine in water samples and Arabidopsis thaliana》.Reference of 4-Bromobutanoic acid The author mentioned the following in the article:

In this work, a fluorescent probe, RhodCl-Hz, with pH-applicative capability and long measuring range, was developed to serve the topic on the enrichment process of hydrazine. It was practical due to the clear acid-base boundary and the sectioned linear ranges. With the excitation wavelength of 515 nm and the emission peak at 565 nm, the detecting system was steady. It exhibited a clear cut-off point at pH 7.0 and steady fluorescence signals within the range of 7.0-10.0. As a whole, the linear range of 10.0-500 μM (1.0-50.0 equiv) was long. The limit of detection value was calculated as 0.64 μM. With high selectivity, RhodCl-Hz was applied to suit water samples and biol. imaging in both Arabidopsis Thaliana root tips and living MCF-7 cells. The information here might be helpful for revealing the enrichment process of hydrazine. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 3395-91-3In 2019 ,《Quantitative structure-activity and quantitative structure-property relationship approaches as alternative skin sensitization risk assessment methods》 was published in Journal of Toxicology and Environmental Health, Part A: Current Issues. The article was written by Kim, Ji Yun; Kim, Min Kook; Kim, Kyu-Bong; Kim, Hyung Sik; Lee, Byung-Mu. The article contains the following contents:

This study aimed to predict skin sensitization potency of selected chems. by quant. analyzing their physicochem. properties by employing quant. structure-activity relationship (QSAR) and quant. structure-property relationship (QSPR) approaches as alternative risk assessment methods to animal testing. Correlations between effective concentration for a stimulation index of 3 (EC3) (%), the amount of a chem. required to elicit a threefold increase in lymph node cell proliferative activity (stimulation index, ≥3), were calculated using local lymph node assay (LLNA) and physicochem. properties of 212 skin sensitizers and 38 non-sensitizers were investigated. The correlation coefficients between m.p. (MP) and EC3 and between surface tension (ST) and EC3 were 0.65 and 0.69, resp. Thus, correlation coefficients between EC3 and MP, ST, and MP + ST reliably predicted the skin sensitization potential of the chems. with sensitivities of 72% (126/175), 70% (122/174), and 73% (116/158); specificities of 77% (27/35), 69% (22/32), and 81% (26/32); and accuracies of 73% (153/210), 70% (144/206), and 75% (142/190), resp. Our findings suggest that the EC3 value may be more accurately predicted using the ST values of chems. as opposed to MP values. Thus, information on MP and ST parameters of chems. might be useful for predicting the EC3 values as not only an alternative approach to animal testing, but as a risk assessment method for skin sensitization. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3SDS of cas: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 2,5-DibromothiopheneIn 2022 ,《Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy》 was published in Journal of Materials Chemistry B: Materials for Biology and Medicine. The article was written by Guo, Mengying; Zhou, Kun; Ding, Rui; Zhao, Xiaodan; Zhang, Yueyan; Zhang, Zixi; He, Gang. The article contains the following contents:

A series of water-soluble cationic thienoviologen derivative photosensitizers (nTPy-Rs) for photodynamic therapy (PDT) is reported. Cationic pyridine groups were introduced into the thiophene framework to enhance solubility and bacteria-binding ability, which effectively improved bacteriol. imaging and antibacterial activity. The optoelectronic properties of nTPy-Rs were regulated by adjusting the number of thiophene groups, and the differences in antibacterial activity due to the functional scaffolds were compared. The results showed that nTPy-Rs could generate reactive oxygen species (ROS, including macroscopic free radicals), efficiently inhibit bacterial growth, and achieve the min. inhibitory concentration (MIC) to the ng mL-1 level. Remarkably, 2TPyC6, containing two thiophene groups and modified by alkyl side chains, showed the best bacteriostatic performance, with the MIC of 20 ng mL-1 and 4.5 ng mL-1 for E. coli and S. aureus, resp., which are the lowest photosensitizer concentrations used in PDT to date. The low cell cytotoxicity and excellent antibacterial performance give nTPy-Rs great potential as PDT agents in vivo. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Safety of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Exploiting Hansen solubility parameters to tune porosity and function in conjugated microporous polymers》 was written by Chen, Jie; Qiu, Ting; Yan, Wei; Faul, Charl F. J.. Application of 4316-58-9 And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2020. The article conveys some information:

Here we expand our recently reported Bristol-Xi’an Jiaotong (BXJ) approach using simple salts to fine-tune the porosity of conjugated microporous materials synthesized by various reaction approaches, including Buchwald-Hartwig (BH), Sonogashira-Hagihara, oxidative coupling and Suzuki cross-coupling. The surface area and the porosity of the produced conjugated microporous polyanilines (CMPAs) acquired from the non-salt-added BH coupling are optimized by the addition of inorganic salts. BXJ-salt addition provides a facile route to radically improve the BET surface area from 28 to 901 m2 g-1 for PTAPA and from 723 m2 g-1 to 1378 m2 g-1 for PAPA in a controllable manner. In addition, the surface area shows a gradual decrease with an increase in the ionic radius of salts. We furthermore show high compatibility of this approach in the synthesis of typical CMPs, further increasing the surface area from 886 to 1148 m2 g-1, 981 to 1263 m2 g-1, and 35 to 215 m2 g-1 for CMP-1, PTCT and p-PPF, resp. More importantly, the BXJ approach also allows the broad PSD of the CMPs to be narrowed to the microporous range only, mimicking COFs and MOFs. With the porosity optimized, CO2 uptakes are dramatically improved by >300% from 0.75 mmol g-1 to 2.59 mmol g-1 for PTAPA and from 2.41 mmol g-1 to 2.93 mmol g-1 for PAPA. Careful addressing of Hansen solubility parameters (HSPs) of solvents and resulting polymers through salt addition has the potential to become an important design tool for the preparation of fully tuneable porous materials. We are currently exploring further methods to tune both structure and function in a wide range of organic porous materials. In the part of experimental materials, we found many familiar compounds, such as Tris(4-bromophenyl)amine(cas: 4316-58-9Application of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Chen, Xin; Wang, Yubing; Wang, Jianan; Liu, Jianwei; Sun, Shiyi; Zhu, Lei; Ma, Qianyue; Zhu, Ningrui; Wang, Xi; Chen, Jie; Yan, Wei published an article in Journal of Materials Chemistry A: Materials for Energy and Sustainability. The title of the article was 《A COF-like conductive conjugated microporous poly(aniline) serving as a current collector modifier for high-performance Li-S batteries》.Recommanded Product: 4316-58-9 The author mentioned the following in the article:

Conducting polymers such as polyaniline have demonstrated their considerable superiorities when serving as promising sulfur host materials for Li-S batteries, owing to their strong affinity for lithium polysulfides (LiPSs) and excellent conductivity However, less polar groups, an unstable frame structure and low sp. surface area limited their electrochem. performance. Herein, a covalent organic framework (COF)-like conjugated microporous polyaniline (CMPA) with an extended π-conjugated system and permanent 3D microporosity was developed as a modified material for use in the current collector of the sulfur cathode for highly efficient Li-S batteries. This multifunctional CMPA shows the integrated nature of conjugated microporous polymers (CMPs) and PANi, ensuring exceptionally sp. surface area, nitrogen-rich character, stable framework and high conductivity Owing to these superiorities, the current collector modified by CMPA delivers a high areal capacity (7.42 mA h cm-2) and high energy d. (202.8 W h kgcell-1) even under a sulfur loading of 8.72 mg cm-2. These outcomes present a new strategy for designing advanced cathodes and also demonstrate the potential of CMPs in energy storage batteries. In addition to this study using Tris(4-bromophenyl)amine, there are many other studies that have used Tris(4-bromophenyl)amine(cas: 4316-58-9Recommanded Product: 4316-58-9) was used in this study.

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Recommanded Product: 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ultrafine silver nanoparticles supported on a covalent carbazole framework as high-efficiency nanocatalysts for nitrophenol reduction》 was written by Gong, Wei; Wu, Qianqian; Jiang, Guoxing; Li, Guangji. Related Products of 6825-20-3This research focused onultrafine silver nanoparticle covalent carbazole framework support; nanocatalyst nitrophenol reduction. The article conveys some information:

A novel conjugated microporous polymer (CMP) material CZ-TEB was synthesized with a carbazole analog and 1,3,5-triethynylbenzene. It possessed a high sp. surface area, excellent thermal stability and layered-sheet morphol. Furthermore, ultrafine silver nanoparticles were successfully immobilized on CZ-TEB, thus preparing a nanocatalyst Ag0@CZ-TEB. To evaluate its catalytic performance, Ag0@CZ-TEB was exploited in the reduction reaction of nitrophenols, a family of priority pollutants. Ag0@CZ-TEB exhibited high catalytic ability, convenient recovery and excellent reusability. Strikingly, the normalized rate constant (knor) of the reduction reaction of 4-NP to 4-AP is as high as 21.49 mmol-1 s-1. This result shows a significant improvement over all previously reported work. We purposed to use a “”capture-release”” model to explain the high catalytic ability of Ag0@CZ-TEB. This explanation is supported by further exptl. results that agree well with the “”capture-release”” model. The experimental process involved the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Related Products of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Related Products of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doufene, Koceila; Malki, Yohan; Vincent, Laure-Anais; Cuq, Pierre; Devoisselle, Jean-Marie; Masurier, Nicolas; Aubert-Pouessel, Anne published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021. The article was titled 《Vegetable Oil-based Hybrid Submicron Particles Loaded with JMV5038: A Promising Formulation against Melanoma》.Related Products of 586-76-5 The article contains the following contents:

The aim of this work was to carry out a preformulation study on JMV5038 as a new potent cytotoxic agent, and to develop its formulation within vegetable oil-based hybrid submicron particles (HNP) in order to obtain a versatile dosage form against melanoma. JMV5038 was first characterized through physico-chem. tests and it exhibited high m.p. and logP value, an important pH-sensitivity that led to the formation of well-identified degradation products at low pH, as well as a substantial solubility value in silylated castor oil (ICO). Then, JMV5038-loaded HNP were formulated through a thermostabilized emulsion process based on the sol-gel crosslinking of ICO. They showed high loading efficiency and their in vitro release kinetic assessed in a biorelevant PBS/octanol biphasic system showed a constant sustained release over one month. The cytotoxic activity and cytocompatibility of HNP were evaluated on A375 melanoma cells and NIH 3T3 cells, resp. JMV5038-loaded HNP exhibited a slightly enhanced cytotoxic activity of JMV5038 on melanoma cells while demonstrating their safety on NIH 3T3 cells. In conclusion, JMV5038-loaded HNP proved to be an efficient and safe drug s.c. delivery system that will be interesting to evaluate through preclin. studies. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Yu-Cheng; Kegel, Laurel L.; Knoff, David S.; Deodhar, Bhushan S.; Astashkin, Andrei V.; Kim, Minkyu; Pemberton, Jeanne E. published an article in Journal of Materials Chemistry B: Materials for Biology and Medicine. The title of the article was 《Layered supramolecular hydrogels from thioglycosides》.Reference of Indium(III) bromide The author mentioned the following in the article:

Low mol. weight hydrogels are made of small mols. that aggregate via noncovalent interactions. Here, comprehensive characterization of the phys. and chem. properties of hydrogels made from thioglycolipids of the disaccharides lactose and cellobiose with simple alkyl chains is reported. While thiolactoside hydrogels are robust, thiocellobioside gels are metastable, precipitating over time into fibrous crystals that can be entangled to create pseudo-hydrogels. Rheol. confirms the viscoelastic solid nature of these hydrogels with storage moduli ranging from 10-600 kPa. Addnl., thiolactoside hydrogels are thixotropic which is a desirable property for many potential applications. Freeze-fracture electron microscopy of xerogels shows layers of stacked sheets that are entangled into networks. These structures are unique compared to the fibers or ribbons typically reported for hydrogels. Differential scanning calorimetry provides gel-to-liquid phase transition temperatures ranging from 30 to 80°C. Prodan fluorescence spectroscopy allows assignment of phase transitions in the gels and other lyotropic phases of high concentration samples. Phase diagrams are estimated for all hydrogels at 1-10 wt% from 5 to ≥ 80°C. These hydrogels represent a series of interesting materials with unique properties that make them attractive for numerous potential applications. In the experiment, the researchers used many compounds, for example, Indium(III) bromide(cas: 13465-09-3Reference of Indium(III) bromide)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Reference of Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Phosphine-based porous aromatic frameworks for gold nanoparticle immobilization with superior catalytic activities》 were Yang, Yuting; Wang, Tienan; Jing, Xiaofei; Zhu, Guangshan. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. Related Products of 623-24-5 The author mentioned the following in the article:

Triphenylphosphine (PPh3) and diphenyl-2-pyridylphosphine (PPh2Py), which are usually used as ligands to protect gold nanoparticles (AuNPs), were selected as monomers to build up porous aromatic frameworks (PAFs) with high surface areas for AuNPs immobilization. Using the cost-effective Friedel-Crafts alkylation reaction, phosphine-based PAFs (PAF-93 and PAF-94) were successfully synthesized, and they possessed high stabilities as well as high surface areas. AuNPs with sizes of smaller than 2 nm in Au@PAF-94 were obtained owing to the stronger interactions with P and N donors in PAF skeletons, thus leading to high catalytic activities. According to the pseudo-first-order kinetics, the kapp (apparent rate constant) value for Au@PAF-94 in the reduction reaction of 4-nitrophenol is 2.2 × 10-2 s-1, which is superior to most of the presently reported AuNP catalysts with solid supports under similar conditions. Addnl., Au@PAFs exhibited excellent recyclability and retained their high catalytic activities after five successful cycles.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Related Products of 623-24-5) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Related Products of 623-24-5 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary