Month: October 2022

Zhang, Hui; Li, Weishuang; Hu, Xu-Dong; Liu, Wen-Bo published the artcile< Enantioselective Synthesis of Fused Isocoumarins via Palladium-Catalyzed Annulation of Alkyne-Tethered Malononitriles>, Category: bromides-buliding-blocks, the main research area is isocoumarin preparation; phenylalkynyl malononitrile palladium catalyst enantioselective tandem oxypalladation intramol cycloaddition.

An enantioselective palladium-catalyzed annulation of alkyne-tethered malononitriles for the synthesis of 3,4-ring-fused isocoumarins were described. This cascade strategy involved oxypalladation of ortho-alkynylbenzoates and desymmetrizing addition onto one cyano group of the pendant malononitriles, which enabled the concurrent construction of two rings and an all-carbon quaternary stereocenter in a single operation.

Journal of Organic Chemistry published new progress about Aliphatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kan, Jian; Huang, Shijun; Lin, Jin; Zhang, Min; Su, Weiping published the artcile< Silver-Catalyzed Arylation of (Hetero)arenes by Oxidative Decarboxylation of Aromatic Carboxylic Acids>, Synthetic Route of 16426-64-5, the main research area is carboxylic acid aromatic oxidative decarboxylative coupling Minisci arene heteroarene; biaryl preparation; CH activation; heterocycles; oxidation; radicals; silver.

The silver-catalyzed intermol. Minisci-type reaction of aromatic carboxylic acids was developed. With an inexpensive silver salt as a catalyst, this new reaction enabled a variety of aromatic carboxylic acids R1CO2H (R1 = 4-NCC6H4, 3-BrC6H4, 2-Cl-4-MeSO2C6H3, 2-chloro-3-pyridyl, etc.) to undergo decarboxylative coupling with electron-deficient arenes or heteroarenes R2H (R2 = Ph, 2,5-F2C6H3, pyridyl, etc.) regardless of the position of the substituents on the aromatic carboxylic acid, thus eliminating the need for ortho-substituted aromatic carboxylic acids, which were a limitation of previously reported methods.

Angewandte Chemie, International Edition published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Synthetic Route of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gopalaiah, Kovuru; Tiwari, Ankit; Choudhary, Renu; Mahiya, Kuldeep published the artcile< Straightforward Access to 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides and Quinazolines via Iron-Catalyzed Aerobic Oxidative Condensation of Amines>, Application In Synthesis of 3959-07-7, the main research area is aminobenzenesulfonamide primary amine iron catalyst oxidative cyclocondensation; dihydrobenzothiadiazine dioxide preparation; aminobenzylamine primary amine iron catalyst oxidative cyclocondensation; quinazoline preparation.

A novel and straightforward approach for constructing 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides from 2-aminobenzenesulfonamide and benzylamines via oxidative condensation was explored. Abundant and cheap iron salt as a catalyst and air as an oxidant were employed, which makes the process more practical and economical. This reaction protocol was further applied to synthesize diverse functionalized quinazolines through oxidative condensation of 2-aminobenzylamines with benzylamines. Besides this, the use of amino acid such as phenylglycine as benzylamine surrogate was tested for the construction of 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide and quinazoline derivatives The proposed mechanistic pathway was validated by isolating the key intermediates.

ChemistrySelect published new progress about Benzothiadiazines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doobary, Sayad; Sedikides, Alexi T.; Caldora, Henry P.; Poole, Darren L.; Lennox, Alastair J. J. published the artcile< Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-rich Substrates>, Reference of 3959-07-7, the main research area is vicinal difluoroalkane preparation difluorination unactivated alkene hypervalent iodine mediator; electrochem difluorination unactivated alkene hypervalent iodine mediator; electrochemistry; fluorination; green chemistry; hypervalent iodine; oxidation.

Fluorinated alkyl groups are important motifs in bioactive compounds, pos. influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochem. generation of a hypervalent iodine mediator using an “”ex-cell”” approach, which avoids oxidative substrate decomposition The more sustainable conditions give good to excellent yields in up to decagram scales. Of note, when handling HF reagents, personal protection is of utmost importance.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (unactivated). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shah, Shalini; Goyal, Anju published the artcile< Synthesis and antimicrobial activity of some n'-(substituted benzylidene)-2-(7-bromo-phenylquinazolin-4-yloxy) acetohydrazide derivatives>, Related Products of 20776-50-5, the main research area is benzylidene bromophenylquinazolinyloxy acetohydrazide preparation antibacterial antifungal activity.

The title compounds were prepared by the reaction of bromoanthranilic acid with benzoyl chloride which gave 7-bromo-2-phenyl-4H-benzo(1,3)oxazin-4-one, further on reaction with formamide gave 7-bromo-2-phenylquinazolin-4(3H)-one. The esterification product of 7-bromo-2-phenylquinazolin-4(3H)-one reacted with hydrazine-hydrate gave (7-bromo-2-phenylquinazolin-4yloxy)acetohydrazide. The sub stituted benzaldehyde RCHO on reaction with (7-bromo-2-phenylquinazolin-4-yloxy)acetohydrazide yielded N’-(sub stituted benzylidene)-2-(7-bromo-2-phenylquinazolin-4-yloxy) acetohydrazide I (R = Cl, OH, NO2; R1 = MeO, NO2, Cl; R2 = Cl, MeO, F, OH, NO2; R3 = MeO). All synthesized derivative compounds I were evaluated for their in vitro antimicrobial activities using the disk diffusion technique. All the synthesized compounds exhibit antimicrobial activity and the compounds I (R = NO2; R1 = NO2; R2 = F, NO2) have a broad spectrum of activity at 50μg/mL.

International Journal of Pharmaceutical Sciences and Research published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nonami, Reina; Morimoto, Yusei; Kanemoto, Kazuya; Yamamoto, Yasunori; Shirai, Tomohiko published the artcile< Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes>, Product Details of C7H6BrNO2, the main research area is formylphenyl acetamide norbornene iridium catalyst enantioselective decarbonylation; norbornanyl phenyl acetamide preparation; C−H bond activation; asymmetric catalysis; cationic iridium; decarbonylation; decarbonylative arylation.

An unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asym. C-C bonds through the formation of an aryl-iridium intermediate. The decarbonylative aryl addition to bicyclic alkenes were fluidly performed without a stoichiometric aryl-metal reagent, such as aryl boronic acid, with a cationic iridium complex generated in-situ from Ir(cod)2(BArF4) and the sulfur-linked bis(phosphoramidite) ligand ((R,R)-S-Me-BIPAM). This reaction has broad functional group compatibility and no waste was generated, except carbon monoxide.

Chemistry – A European Journal published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Product Details of C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas published the artcile< Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis>, Quality Control of 188813-04-9, the main research area is palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Bioconjugate Chemistry published new progress about Carbonylation. 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Quality Control of 188813-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rueping, Magnus; Sugiono, Erli; Merino, Estibaliz published the artcile< Asymmetric iminium ion catalysis: an efficient enantioselective synthesis of pyranonaphthoquinones and β-lapachones>, Safety of 3-(4-Bromophenyl)acrylaldehyde, the main research area is asym synthesis pyranonaphthoquinone addition cyclization aliphatic aromatic aldehyde hydroxynaphthoquinone; lapachone derivative asym synthesis pyranonaphthoquinone.

An addition-cyclization reaction cascade triggered by an organocatalyst was used for the enantioselective preparation of a series of biol. active 1,2- and 1,4-pyranonaphthoquinones, e.g. I, from aliphatic and aromatic α,β-unsaturated aldehydes and 2-hydroxy-1-4-naphthoquinone. A trimethylsilyl-protected diarylprolinol serves as the Lewis base organocatalyst.

Angewandte Chemie, International Edition published new progress about Addition reaction catalysts. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Safety of 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Bin; Cheng, Yujun; Lei, Hui; Hu, Lin; Li, Zaifang; Huang, Xuexiang; Chen, Lie; Chen, Yiwang published the artcile< A novel AIE molecule as a hole transport layer enables efficient and stable perovskite solar cells>, SDS of cas: 184239-35-8, the main research area is perovskite solar cell hole transport layer aggregation induced emission.

A low-cost and efficient hole transport layer (HTL) material (TPE-CZ) with the aggregation-induced emission (AIE) effect has been synthesized. Due to the AIE effect, perovskite solar cells with TPE-CZ as the HTL deliver a higher power conversion efficiency (PCE) of 18% with better stability than those with the reference HTL (Spiro-OMeTAD).

Chemical Communications (Cambridge, United Kingdom) published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, SDS of cas: 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Klett, Johannes; Wozniak, Lukasz; Cramer, Nicolai published the artcile< 1,3,2-Diazaphospholene-Catalyzed Reductive Cyclizations of Organohalides>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is dihydrobenzofurane pyrrolidine preparation photochem; aryl alkyl halide reductive cyclization diazaphospholene hydride catalyst; Cyclizations; Diazaphospholenes; Homogeneous Catalysis; Photocatalysis; Radical Reactions.

1,3,2-Diazaphospholene hydrides (DAP-Hs) are highly nucleophilic organic hydrides serving as main-group catalysts for a range of attractive transformations. DAP hydrides can act as stoichiometric hydrogen atom transfer agents in radical reactions. Herein, authors report a DAP-catalyzed reductive radical cyclization of a broad range of aryl and alkyl halides under mild conditions. The pivotal DAP catalyst turnover was achieved by a DBU-assisted σ-bond metathesis between the formed DAP halide and HBpin, which rapidly regenerates DAP-H. The transformation is significantly accelerated by irradiation with visible light. Mechanistic investigations indicate that visible light irradiation leads to the formation of DAP dimers, which are in equilibrium with DAP radicals and accelerate the cyclization. The direct use of (DAP)2 enabled a catalytic protocol in the absence of light.

Angewandte Chemie, International Edition published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary