Month: October 2022

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Electric Literature of 402-49-3

O’ Sullivan, Michael J.;Hatley, Richard J. D.;Wellaway, Christopher R.;Bew, Sean P.;Richards, Christopher J. research published 《 Synthetic approaches to N- and 4-substituted 1,4-dihydro-3(2H)-isoquinolinone derivatives》, the research content is summarized as follows. Reaction of methyl-2-(2-formylphenyl)acetate with primary amines in a reductive amination/cyclisation process resulted in N-substituted 1,4-dihydro-3(2H)-isoquinolinones I [R¹ = allyl, propynyl, 2,2-dimethoxyethyl; R²= H, benzyl, 4-trifluoromethylbenzyl, etc]. With H₂NCH₂R sodium borohydride was a suitable reductant (11 examples), but H₂NCHR¹R² required a transfer hydrogenation using ammonium formate catalyzed by palladium on carbon (9 examples). 4-Substituted-1,4-dihydro-3(2H)-isoquinolinones were synthesized by deprotonation (n-butyllithium) and addition of R³CH²Br (12 examples with R³ = alkyl, Ar, CH=CH₂, CCH). Modest diastereoselectivity was achieved with 1,4-dihydro-3(2H)-isoquinolinones derived from H₂NCHMeR² [R² = (η⁵-C₅H₄)Co(η⁴-C₄Ph₄) – maximum dr = 1.9 : 1], but use of H₂NCHMeFc (Fc = ferrocenyl) provided a new method of 1,4-dihydro-3(2H)-isoquinolinone N-deprotection with formic acid.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Electric Literature of 402-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Category: bromides-buliding-blocks.

Nova, Nabila Nabi;Zarzar, Lauren D. research published 《 Direct laser writing of graphitic carbon from liquid precursors》, the research content is summarized as follows. One-step synthesis and micropatterning of different types of carbon nanomaterials, such as amorphous carbon or three-dimensional graphene which have versatile electrochem., thermal, and mech. properties, are advantageous for the fabrication of microelectronics, sensors, and wearable devices. Here, we report a direct laser writing method to simultaneously synthesize and pattern graphitic carbon from liquid organic precursors. We have tested a wide range of liquid organic precursors and identified the chem. characteristics that are beneficial for successful laser-induced solvothermal deposition. The laser-deposited carbon exhibits a paracryst.-to-polycrystalline structure and has elec. resistivities on the order of 10^-3 to 10^-4 Ω m which is tunable through variations in the laser power. Such properties of the laser-deposited carbon, coupled with the ability to direct-write custom patterns with microscale resolution, make these carbon materials exciting candidates for use in applications such as energy storage and sensing.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of Ethyl 3-bromo-2-oxopropanoate.

Noushin, Annataj;Sayyed-Alangi, S. Zahra;Varasteh-Moradi, Ali;Hossaini, Zinatossadat;Arshadi, Sattar research published 《 KF Impregnated Natrolite Zeolite as a New Heterogeneous Nanocatalyst Promoted One-Pot Synthesis of Benzo[1,4]-Diazepin-5-One Derivatives》, the research content is summarized as follows. In this study, KF impregnated natural natrolite zeolite nanoparticle was reported as a new and economical heterogeneous catalyst. The KF/Natrolite NPs as a high performance catalyst was employed for the preparation of a new family of substituted benzo[e][1,4]-diazepin-5-ones I (R = Et, Ph, 4-O₂NC₆H₄, etc.; R′ = 4-BrC₆H₄, 4-MeOC₆H₄, CO₂Et, etc.) using the one-pot condensation reactions of isatoic anhydride, primary amines and α-haloketones at 50 °C under solvent free condition. The some advantages of this procedure are the short time of reaction, high yields of product, easy separation of catalyst and products. Due to having benzazepine core, authors investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping experiment It was observed that the compounds I (R = Ph; R′ = 4-BrC₆H₄) and I (R = Ph; R′ = 4-MeOC₆H₄) had good DPPH· radical scavenging.

Safety of Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 70-23-5.

Noushin, Annataj;Varasteh-Moradi, Ali;Sayyed-Alangi, S. Zahra;Hossaini, Zinatossadat research published 《 Green synthesis and evaluation of antioxidant and antimicrobial activity of new dihydropyrroloazepines: Using bio-Ag/CdO/ZnO@MWCNTs nanocomposites as a reusable organometallic catalyst》, the research content is summarized as follows. In this study a new, economical and green method was reported for the synthesis of Ag/CdO/ZnO@MWCNTs nanocomposites (Ag/CdO/ZnO@MWCNTs NCs) as a new heterogeneous catalyst. For confirming the structure of synthesized nanocatalyst, XRD, FESEM, EDX and TEM anal. were utilized. The Ag/CdO/ZnO@MWCNTs NCs as a high performance catalyst was employed for the preparation of a new family of substituted dihydropyrroloazepines I [R = CO₂Et, Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄; R¹ = CO₂Et, 4-BrC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄] using the one-pot condensation reactions of isatin, ammonium acetate, α-haloketones and activated acetylenic compounds in water at room temperature Another work in this research was investigation of antioxidant property of some synthesized compounds I by diphenyl-picrylhydrazine (DPPH) radical trapping experiment Addnl., for confirming the antibacterial activity of some dihydropyrroloazepines, disk diffusion test was used on two kinds of bacteria.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Quality Control of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Synthetic Route of 402-49-3.

Njeri, Dancan K.;Valenzuela, Erik Alvarez;Ragains, Justin R. research published 《 Leveraging Trifluoromethylated Benzyl Groups toward the Highly 1,2-Cis-Selective Glucosylation of Reactive Alcohols》, the research content is summarized as follows. Here, we demonstrate that substitution of the benzyl groups of glucosyl imidate donors with trifluoromethyl results in a substantial increase in 1,2-cis-selectivity when activated with TMS-I in the presence of triphenylphosphine oxide. Stereoselectivity is dependent on the number of trifluoromethyl groups (4-trifluoromethylbenzyl vs 3,5-bis-trifluoromethylbenzyl). Particularly encouraging is that we observe high 1,2-cis-selectivity with reactive alc. acceptors.

Synthetic Route of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid, COA of Formula: C6H6BBrO2

Niu, Wenhui;Fu, Yubin;Komber, Hartmut;Ma, Ji;Feng, Xinliang;Mai, Yiyong;Liu, Junzhi research published 《 Sulfur-Doped Nanographenes Containing Multiple Subhelicenes》, the research content is summarized as follows. In this work, we describe the synthesis and characterization of three novel sulfur-doped nanographenes (NGs) (1-3) containing multiple subhelicenes, including carbo[4]helicenes, thieno[4]helicenes, carbo[5]helicenes, and thieno[5]helicenes. D. functional theory calculations reveal that the helicene substructures in 1-3 possess dihedral angles from 15° to 34°. The optical energy gaps of 1-3 are estimated to be 2.67, 2.45, and 2.30 eV, resp. These three sulfur-doped NGs show enlarged energy gaps compared to those of their pristine carbon analogs.

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., COA of Formula: C6H6BBrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: Methyl 4-bromobutanoate.

Niu, Shengtong;Zhang, Hao;Xu, Weici;Bagdi, Prasanta Ray;Zhang, Guoxiang;Liu, Jinggong;Yang, Shuang;Fang, Xinqiang research published 《 Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols》, the research content is summarized as follows. Contemporary asym. catalysis faces huge challenges when prochiral substrates bear electronically and sterically unbiased substituents and when substrates show low reactivities. One of the inherent limitations of chiral catalysts and ligands is their incapability in recognizing prochiral substrates bearing similar groups. This has rendered many enantiopure substances bearing several similar substituents inaccessible. Here authors report the rationale, scope, and applications of the strategy of kinetic resolution of auxiliary adjacent alcs. (KRA*) that can be used to solve the above troubles. Using this method, a large variety of optically enriched tertiary alcs., epoxides, esters, ketones, hydroxy ketones, epoxy ketones, β-ketoesters, and tetrasubstituted methane analogs with two, three, and four spatially and electronically similar groups can be readily obtained (totally 96 examples). At the current stage, the strategy serves as the optimal solution that can complement the inability caused by direct asym. catalysis in getting chiral mols. with challenging fully substituted stereocenters.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Recommanded Product: Methyl 4-bromobutanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Name: 4-Bromobenzene-1,2-diamine.

Niu, Kaikai;Ding, Ling;Zhou, Pan;Hao, Yanke;Liu, Yuxiu;Song, Hongjian;Wang, Qingmin research published 《 Electro-oxidative C-H azolation of quinoxalin-2(1H)-ones》, the research content is summarized as follows. A practical, general protocol for direct C-H amination reactions of quinoxalin-2(1H)-ones with azoles by electro-oxidative cross-coupling has been developed. These mild reactions proceed under metal-, oxidant-, and reagent-free conditions to provide synthetically useful azolated quinoxalin-2(1H)-ones. Furthermore, the reactions can be carried out with a pencil lead as an electrode and a 3 V battery as a power source, revealing the remarkable flexibility of this protocol.

Name: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 1575-37-7.

Niu, Kaikai;Zhou, Pan;Ding, Ling;Hao, Yanke;Liu, Yuxiu;Song, Hongjian;Wang, Qingmin research published 《 Photoelectrochemical Decarboxylative C-H Alkylation of Quinoxalin-2(1H)-ones》, the research content is summarized as follows. Herein, a protocol for the photoelectrochem. decarboxylative C-H alkylation of quinoxalin-2(1H)-ones with good reactivity and selectivity is reported. This protocol involves the use of iron, an earth-abundant metal, to catalyze decarboxylation via ligand-to-metal charge transfer. Furthermore, the reactions can be carried out with a 3 V battery as a power supply, revealing the remarkable simplicity and flexibility of this photoelectrochem. protocol. It offers a new paradigm for a convenient, green synthesis of valuable compounds from versatile carboxylic acid building blocks.

HPLC of Formula: 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Name: Methyl 4-bromobutanoate

Ning, Xiangxue;Tan, Guiyu;Chen, Xiaojiao;Wang, Mian;Wang, Baomin;Cui, Liwang research published 《 Development of a lateral flow dipstick for simultaneous and semi-quantitative analysis of dihydroartemisinin and piperaquine in an artemisinin combination therapy》, the research content is summarized as follows. Dihydroartemisinin (DHA) and piperaquine (PPQ) are two drugs used in an artemisinin-based combination therapy (ACT). The circulation of counterfeit antimalarial drugs demands the development of simple, point-of-care (POC) tests for monitoring drug quality. Here we aimed to design an antibody-based lateral flow dipstick assay for simultaneous quality control of DHA and PPQ. To obtain a monoclonal antibody (mAb) for PPQ, one structural unit of the sym. PPQ mol. was used to derive a carboxylic acid for linkage to a carrier protein as immunogen. Screening of hybridoma cells identified an mAb 4D112B2 that reacted with the PPQ-based immunogen. A highly-sensitive icELISA was designed based on this mAb, which showed 50% inhibition concentration of PPQ at 1.66 ng/mL and a working range of 0.35 – 7.40 ng/mL. The mAb showed 10.2, 15.9 and 30.4% cross reactivity to hydroxychloroquine sulfate, chloroquine and amodiaquine, resp. No cross reactivity was observed to lumefantrine, mefloquine artemisinin and its derivatives Using our previous DHA dipstick design, a lateral flow dipstick for simultaneous anal. of PPQ and DHA was developed. The indicator ranges for PPQ and DHA were 2 – 5μg/mL and 250 – 500 ng/mL, resp. The dipstick was used to semi-quant. analyze PPQ and DHA content in com. ACT drugs, which produced agreeable results to those determined by high-performance liquid chromatog. This combination dipstick makes it a potential POC device for quality control of the two active ingredients in a commonly used ACT.

Name: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary