Month: October 2022

Elliott, Michael; Janes, Norman F.; Pearson, B. C. published the artcile< Pyrethrins and related compounds. IX. Alkenylbenzyl and benzylbenzyl chrysanthemates>, HPLC of Formula: 17100-65-1, the main research area is CHRYSANTHEMATES BENZYL; BENZYL CHRYSANTHEMATES; PYRETHRINS.

The syntheses of 4-allylbenzyl, 4-benzylbenzyl and other related benzyl chrysanthemates are described. The benzyl alcs. were made by reduction of benzoic esters if these were readily available; otherwise they were made either by Grignard reactions of appropriately substituted bromobenzenes with HCHO, or by reactions of alkenyl halides with Grignard derivatives of bromobenzyl alcs. in which the hydroxyl group was protected as its tetrahydropyranyl ether. 32 references.

Journal of the Science of Food and Agriculture published new progress about 17100-65-1. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, HPLC of Formula: 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Chenglong; Shi, Yafei; Li, Pengfei; Zhang, Niu; Wang, Nan; Yin, Xiaodong; Chen, Pangkuan published the artcile< Access to Highly Luminescent N-Doped Diazaborepins with Penta-, Hexa-, and Heptagon Substructures>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is luminescent N doped diazaborepin.

Two diazaborepins (BNN1 and BNN2) have been accomplished via a highly efficient pathway in the step-economic transformation. Oxidative dimerization of carbazole derivatives followed by borylation reaction gave heterocyclic diazaborepin as the key building block. Replacement of carbon moiety in traditional borepins with N-N functionality led to a significant red shift of their emissions up to 585 nm with strong red color as solids. This work offered an approach to diazaborepin-based materials for applications in light-emitting field.

Organic Letters published new progress about Borylation. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhen, Cian-Jhe; Lu, Shu-Feng; Lin, Min-Hwa; Wu, Jay-Tai; Chao, Ito; Lin, Chih-Hsiu published the artcile< Singlet Biradical Versus Triplet Biradical/Zwitterion Characteristics in Isomers of C6-C5-C6-C7-C6-Fused Pentacyclic Aromatic Hydrocarbons Revealed through Reactivity Patterns>, Category: bromides-buliding-blocks, the main research area is fused pentacyclic aromatic hydrocarbon biradical zwitterion structure property relationship; biradical; polycyclic aromatic hydrocarbons; structure property relationship; zwitterion.

Among various polycyclic aromatic hydrocarbons, C6-C5-C6-C7-C6 fused pentacyclic aromatic hydrocarbons have the unique potential to adopt quinonoid, zwitterion, singlet, or triplet biradical electronic configurations. Two such hybrid structures between pentacene and azulene were synthesized and their ground state electronic configurations were deduced from the reactivity patterns they exhibit resp. Compound I, where the radicaloid carbons are linked through a para-phenylene, forms a head-to-head dimer like a singlet biradical. In contrast, isomer II, where the para-linkage was switched to meta, reacts readily with oxygen which resembles the reactivity of a triplet state. The oxidized intermediate(s) then underwent rearrangement to furnish the C6-C5-C6-C6-C6 ring contraction product 11,13-Dimesityl-13H-indeno[1,2-b]anthracene-6-carbaldehyde. Cation 12,14-Dimesityl-12,14-dihydrobenzo[5,6]cyclohepta[1,2-b]fluoren-12-ylium tetrafluoroborate, the protonated form of compound II, was synthesized, which implies compound II also reacts like a zwitterion. It was revealed the oxidative rearrangement takes place even with mesityl dibenzotropylium cation despite its perceived aromaticity. DFT calculations confirm the most stable forms of compound I and compound II are singlet and triplet diradical, which is consistent with the observed reactivity of resp. mols.

Chemistry – A European Journal published new progress about Biradicals Role: FMU (Formation, Unclassified), FORM (Formation, Nonpreparative). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thorve, Pradip Ramdas; Maji, Biplab published the artcile< Deaminative Olefination of Methyl N-Heteroarenes by an Amine Oxidase Inspired Catalyst>, Reference of 3959-07-7, the main research area is diaryl olefin preparation diastereoselective; methyl heteroarene primary amine deaminative olefination phenanthrolinedione catalyst.

The bioinspired o-quinone cofactor catalyzed aerobic primary amine ArCH2NH2 (Ar = Ph, 2-chlorophenyl, furan-2-yl, etc.) dehydrogenation for a cascade olefination reaction with nine different Me N-heteroarenes, including pyrimidines such as 4-Me pyrimidine, N-benzyl-4-methylpyrimidin-2-amine and N,N-dibenzyl-4-methylpyrimidin-2-amine, 2-methylpyrazine, pyridines such as 4-methylpyridine, 5-bromo-2-methylpyridine, 2-methylpyridine, etc.; quinolines such as 2-methylquinoline, 2,6-dimethylquinoline, 6-methoxy-2-methylquinoline and 4-methylquinoline, 2-methylquinoxaline, benzimidazoles such as 1-benzyl-2-methyl-1H-1,3-benzodiazole and 1-benzyl-5,6-dichloro-2-methyl-1H-1,3-benzodiazole, 2-methyl-1,3-benzoxazole, 2-methyl-1,3-benzothiazole and 2,4,6-trimethyl-1,3,5-triazine were explored. An o-quinone catalyst phd (1,10-phenanthroline-5,6-dione) combined with a Bronsted acid such as TfOH catalyzed the reaction. N-Heteroaryl stilbenoids RCH=CHAr (R = pyridin-2-yl, pyrimidin-4-yl, 1,3-benzoxazol-2-yl, etc.) were synthesized in high yields and (E)-selectivities under mild conditions using oxygen (1 atm) as the sole oxidant without the need of transition-metal salt, ligand, stoichiometric base, or oxidant.

Organic Letters published new progress about Aryl alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Mingkai; Zou, Yong; Zhang, Sai; Qu, Yongquan published the artcile< In situ Re-construction of Pt Nanoparticles Interface for Highly Selective Synthesis of Primary Amines>, Category: bromides-buliding-blocks, the main research area is platinum nanoparticle primary amine selective synthesis.

Regulation of the catalyst interface by adsorbates has been demonstrated as an efficacious methodol. to enhance the catalytic selectivity. Herein, we demonstrated an in situ modifications induced by reactants to re-construct the local interface of Pt nanoparticles anchored on the CoFe layered double hydroxides (CoFe-LDH) supports for a highly selective synthesis of primary amines from reductive amination of aldehydes and ammonia. The strong metal-support interaction between Pt metals and CoFe-LDH supports results in the highly electron-enriched surface of Pt and thereby makes the surface of Pt nanoparticles favor the enrichment of NH4+ species and adsorption of NH3. Such a tailored interface can create an interfacial stereo-hindrance effect and effectively slug the reaction kinetics of side-reactions, further preventing the formation of side-products. We anticipate that such an in situ re-construction of metal interface by reactants and afterwards the constructed local environment of active sites may provide a new approach for the optimization of metal catalysts.

ChemCatChem published new progress about Adsorbed substances. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Varga, Bence; Szemesi, Peter; Nagy, Petra; Herbay, Reka; Holczbauer, Tamas; Fogassy, Elemer; Keglevich, Gyorgy; Bagi, Peter published the artcile< Enantioseparation of P-Stereogenic Secondary Phosphine Oxides and Their Stereospecific Transformation to Various Tertiary Phosphine Oxides and a Thiophosphinate>, Computed Properties of 401-78-5, the main research area is phosphorus stereogenic secondary phosphine oxide preparation enantioseparation transformation; tertiary thiophosphinate phosphine oxide preparation; crystal mol phenylhydroxymethyl methylphenyl phosphine oxide TADDOL.

Secondary phosphine oxides incorporating various aryl and alkyl groups were synthesized in racemic form, and these products formed the library reported in this study. TADDOL derivatives were used to obtain the optical resolution of these P-stereogenic secondary phosphine oxides. The developed resolution method showed a good scope under the optimized reaction conditions, as 9 out of 14 derivatives could be prepared with an enantiomeric excess (ee) ≥ 79% and 5 of these derivatives were practically enantiopure >P(O)H compounds (ee ≥ 98%). The scalability of this resolution method was also demonstrated. Noncovalent interactions responsible for the formation of diastereomeric complexes were elucidated by single-crystal XRD measurements. (S)-(2-Methylphenyl)phenylphosphine oxide was transformed to a variety of P-stereogenic tertiary phosphine oxides and a thiophosphinate in stereospecific Michaelis-Becker, Hirao, or Pudovik reactions.

Journal of Organic Chemistry published new progress about Addition reaction (Pudovik). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Chuang; Xu, Rong; Song, Qingming; Mao, Zhipeng; Li, Junfeng; Yang, Hongjun; Chen, Jian published the artcile< Highly efficient photocatalytic oxidation of C-H bond based on microchannel reactor>, Computed Properties of 2725-82-8, the main research area is alkyl arene oxygen methylanthraquinone photooxidation green chem; aryl ketone preparation.

A mild photocatalytic C-H bond selective oxidation mediated by metal-free photocatalyst 2-Methylanthraquinone was reported. Glass microchannel reactor enhanced the absorption of photon energy and oxygen by the reaction mixture, so as to greatly improve the reaction efficiency of photocatalytic reaction in glass microchannel reactor. This reaction method can quickly oxidize alkyl aromatics into corresponding oxidation products to obtain aromatic ketones in high yield.

Tetrahedron Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Computed Properties of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Xiang; Hou, Wenjuan; Zhang-Negrerie, Daisy; Zhao, Kang; Du, Yunfei published the artcile< Correction to ""Hypervalent Iodine-Mediated Intramolecular trans-Aminocarboxylation and Oxoaminocarboxylation of Alkynes: Divergent Cascade Annulations of Isocoumarins under Metal-Free Conditions"" [Erratum to document cited in CA163:585666]>, Related Products of 6942-39-8, the main research area is indoloisocoumarin spiroindolone preparation cyclization amino carboxy diarylalkyne hypervalent iodine; aminocarboxylation intramol heterocyclization aminoaryl carboxyaryl alkyne erratum; hypervalent iodine oxidation heterocyclization aminocarboxylation diarylalkyne preparation indoloisocoumarin spiroindolone; erratum.

In Scheme 4, the structure of Compound 2m was drawn incorrectly due to the position of Cl. Similarly, in the Supporting Information (Page S8), the structure of 2m was also wrong. The correct structural drawing is given.

Organic Letters published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Related Products of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Ningwei; Su, Kaixin; Zhou, Ziwei; Wang, Daming; Fery, Andreas; Lissel, Franziska; Zhao, Xiaogang; Chen, Chunhai published the artcile< ""Colorless-to-Black"" electrochromic and AIE-active polyamides: an effective strategy for the highest-contrast electrofluorochromism>, Application In Synthesis of 184239-35-8, the main research area is Colorless Black electrochromic AIE active polyamides effective strategy.

Electrofluorochromic (EFC) materials have gained extensive attention owing to their interesting modulations of fluorescence by an elec. stimulus. However, the limited performances, especially the low fluorescence on/off contrast, significantly hampered their further applications. Herein, we design a new strategy to achieve high-contrast electrofluorochromism by combinations of “”colorless-to-black”” electrochromism and highly fluorescent AIE activity. Given the effective fluorescence quenching effect and high solid-state fluorescence, a fluorescence contrast of 838 is realized, to the best of our knowledge, the highest reported so far. Furthermore, to explore the structure-property relationships, we also separated the E/Z isomers of tetraphenylethylene (TPE) and studied the properties of the three electroactive/fluorescent polymers (11TPE-PA, E-12TPE-PA, and Z-12TPE-PA) derived from different TPE derivatives and isomers. The three branches of polymers all exhibited AIE-active and “”colorless-to-black”” electrochromic (EC) properties. In addition to the ultrahigh fluorescence contrast, Z-12TPE-PA also integrated high electrochromic contrast (Δ% T = 92%), short response time (0.6 s/0.3 s), and excellent switching stability (300 cycles), paving the way for the applications in various electronic applications. The study will provide novel insights into the future design and development of high-performance EC/EFC materials.

Macromolecules (Washington, DC, United States) published new progress about Electrochromic materials. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Application In Synthesis of 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bae, Eun Jung; Choi, Won Gun; Pagire, Haushabhau S.; Pagire, Suvarna H.; Parameswaran, Saravanan; Choi, Jun-Ho; Yoon, Jihyeon; Choi, Won-il; Lee, Ji Hun; Song, Jin Sook; Bae, Myung Ae; Kim, Mijin; Jeon, Jae-Han; Lee, In-Kyu; Kim, Hail; Ahn, Jin Hee published the artcile< Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease>, Quality Control of 17100-65-1, the main research area is oxadiazolylphenyl alanine derivative preparation TPH1 inhibitor obesity fatty liver.

Tryptophan hydroxylase 1 (TPH1) has been recently suggested as a promising therapeutic target for treating obesity and fatty liver disease. A new series of 1,2,4-oxadiazolylphenyl alanine derivatives were identified as TPH1 inhibitors. Among them, compound 23a was the most active in vitro, with an IC50 (half-maximal inhibitory concentration) value of 42 nM, showed good liver microsomal stability, and showed no significant inhibition of CYP and hERG. Compound 23a inhibited TPH1 in the peripheral tissue with limited BBB penetration. In high-fat diet-fed mice, 23a reduced body weight gain, body fat, and hepatic lipid accumulation. Also, 23a improved glucose intolerance and energy expenditure. Taken together, compound 23a shows promise as a therapeutic agent for the treatment of obesity and fatty liver diseases.

Journal of Medicinal Chemistry published new progress about Adipose tissue. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary