Month: October 2022

Singh, Sudhir K.; Ruchelman, Alexander L.; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. published the artcile< Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity>, Application of C7H4BrNO4, the main research area is methylenedioxydibenzonaphthyridinone preparation topoisomerase inhibiting activity cytotoxicity; structure methylenedioxydibenzonaphthyridinone topoisomerase inhibiting activity cytotoxicity; nitro amino substitution methylenedioxydibenzonaphthyridinone topoisomerase targeting activity cytotoxicity.

Methylenedioxydibenzo[c,h][1,6]naphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et) are prepared as potential inhibitors of human topoisomerase I. Coupling of 2-bromobenzoic acids to amino(methylenedioxy)quinolines [prepared by displacement of 4-chloro-6,7-(methylenedioxy)quinoline] followed by palladium-catalyzed intramol. Heck arylation reactions and reduction of the pendant nitro groups (if present) yields methylenedioxydibenzonaphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et). I (R = H; R1 = H, O2N; R2 = O2N, H; R3 = Me2N) inhibit topoisomerase I-mediated DNA cleavage more effectively and are more cytotoxic than camptothecin; I have topoisomerase I inhibiting activities comparable to dimethoxydibenzonaphthyridinone I (R = H; R1 = R2 = MeO; R3 = Me2N).

Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitrea, Daiana G.; Circu, Viorel published the artcile< Synthesis and characterization of novel acylthiourea compounds used in ions recognition and sensing in organic media>, Reference of 3959-07-7, the main research area is synthesis characterization acylthiourea ion recognition colorimetric sensing; Acyl thiourea; Anion recognition; Cation recognition; Colorimetric sensors; Copper (II) detection; Fluoride detection; Organic media.

A series of novel N-acyl-N’-aryl thiourea derivatives were designed and prepared with the aim to develop dual responsive receptors for anions and cations. The structure of the new products was confirmed by NMR spectroscopy (13C and 1H), elemental anal., and IR spectroscopy. Their thermal stability was studied by thermogravimetric anal. (TG) and it was found that these acyl thiourea derivatives are stable up to 160°C. The ion recognition and sensing properties of the acyl thiourea compounds were investigated by UV-VIS absorption spectroscopy in organic media upon the addition of various salts. The UV-VIS studies revealed that these acyl thiourea derivatives are able to sense biol. important ions such as fluoride and copper (II) ions.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetric sensors. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Wenyi; Shrestha, Mohini; Wang, Chenchen; Fang, Ke; Teng, Yaxin; Qu, Jingping; Chen, Yifeng published the artcile< Asymmetric synthesis of 3-benzyl and allyl isoindolinones by Pd-catalyzed dicarbofunctionalization of 1,1-disubstituted enamides>, Application of C7H4BrNO4, the main research area is disubstituted isoindolinone enantioselective preparation; boronic acid disubstituted enamide tandem Heck Suzuki palladium catalyst.

A palladium-catalyzed asym. synthesis of 3,3-disubstituted isoindolinones I [R = (E)-n-BuCH=CH, 3-thienyl, PMB, etc.; R1 = Bn, (CH2)2Ph, PMB; R2 = Me, iPr; R3 = H, 6-Cl, 5-NO2; etc.] via tandem Heck/Suzuki coupling of 1,1-disubstituted enamides with aryl/alkenyl boronic acids under mild reaction conditions was reported. This reaction exhibited both broad functional group tolerance and high enantioselectivity. The first dicarbo-functionalization of 1,1-disubstituted enamides to generate amide derivatives bearing quaternary stereocenters was reported. Finally, synthetic utility of this protocol was demonstrated by expedient synthesis of PI3K-delta inhibitor precursor.

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (enamides). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Ya-Wei; Zheng, Hong-Xing; Yang, Bo; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< tBuOK-Promoted Cyclization of Imines with Aryl Halides>, COA of Formula: C7H4Br2O2, the main research area is imine aryl halide aminyl radical potassium tert butoxide cyclization; indole preparation.

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramol. coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Organic Letters published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, COA of Formula: C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wolff, Oliver; Waldvogel, Siegfried R. published the artcile< 3-substituted phthalic acid derivatives by Sonogashira coupling reaction>, Computed Properties of 82-73-5, the main research area is phthalic acid substituted preparation Sonogashira coupling reaction.

Phthalic acid derivatives with carbon substituents in position 3 are easily accessible by Sonogashira coupling reaction of the corresponding bromo derivative For reasonable conversions the phthaloyl moiety is masked as the N-phenylphthalimide, which can smoothly be converted into other phthalic acid derivatives For example, stirring 3-bromo-N-phenylphthalimide with oct-1-yne in DMF in the presence of Et3N, CuI, and bis(triphenylphosphine)palladium dichloride at 80° for 16 h gave 91% 3-(oct-1-ynyl)-N-phthalimide.

Synthesis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Fenghua; Chen, Cheng; Yang, Kailin; Xu, Yang; Liu, Xiaomei; Gao, Fan; Liu, He; Chen, Xia; Zhao, Qi; Liu, Xiang; Cai, Yan; Yang, Haitao published the artcile< Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus>, HPLC of Formula: 405931-46-6, the main research area is preparation Michael acceptor peptidomimetic porcine epidemic diarrhea virus protease.

Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication. We solved the structure of PEDV Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing at. level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV Mpro. These compounds have potential as future therapeutics to combat PEDV infection.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, HPLC of Formula: 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yao; Liu, Yun-Qi; Hu, Le’an; Zhang, Xumu; Yin, Qin published the artcile< Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is keto ester enantioselective ruthenium reductive amination ring closing cascade; chiral benzazepinone preparation.

We report here a Ru-catalyzed enantioselective synthesis of biaryl-bridged NH lactams through asym. reductive amination and a spontaneous ring-closing cascade from keto esters and NH4OAc with H2 as reductant. The reaction features broad substrate generality and high enantioselectivities (up to >99% ee). To showcase the practical utility, a highly enantioselective synthesis of 5-ethylindolobenzazepinone C, a promising antimitotic agent, has been rapidly completed. Furthermore, the amide group in the products enables versatile elaborations through directed C-H functionalization.

Organic Letters published new progress about Benzazepines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Hengchao; Chen, Hang; Zhou, Yang; Huang, Jin; Yi, Jundan; Zhao, Hongcai; Wang, Wei; Jing, Linhai published the artcile< Selective Synthesis of Z-Cinnamyl Ethers and Cinnamyl Alcohols through Visible Light-Promoted Photocatalytic E to Z Isomerization>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is cinnamyl ether alc diastereoselective photoisomerization iridium catalyst; allylic alcohols; cinnamyl ethers; iridium; isomerization; photocatalysis.

A photocatalytic E to Z isomerization of alkenes using an iridium photosensitizer under mild reaction conditions is disclosed. This method provides scalable and efficient access to Z-cinnamyl ethers and allylic alcs. in high yields with excellent stereoselectivity. Importantly, this method also provides a powerful strategy for the selective synthesis of Z-magnolol and honokiol derivatives possessing potential biol. activity.

Chemistry – An Asian Journal published new progress about Allyl ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rotbergs, J.; Oskaja, V. published the artcile< Condensation of 3-bromophthalic anhydride with β-dicarbonyl compounds>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is phthalic anhydride condensation; bromo indandionecarboxylic acid; dicarbonyl compound condensation.

3-Bromophthalic anhydride (I) condensed with AcCH2CO2Et in Ac2O-Et3N gave 85.9% II. Ir spectra of condensation products of I with AcCH2Ac, BzCH2Ac, BzCH2Bz, and CH2(CO2Et)2 were compared.

Uch. Zap. Latv. Univ. published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Zhaofeng; Zhao, Kun; Fu, Junkai; Zhang, Junlin; Yin, Weiyu; Tang, Yefeng published the artcile< Organocatalytic 1,4-conjugate addition of ascorbic acid to α,β-unsaturated aldehydes: bio-inspired total syntheses of leucodrin, leudrin and proposed structure of dilaspirolactone>, Quality Control of 3893-18-3, the main research area is crystal mol structure spirodilactone core ascorbylated natural product; leucodrin leudrin preparation ascorbylated natural product.

The organocatalytic additions of ascorbic acid to various α,β-unsaturated aldehydes via tandem 1,4-conjugate addition/hemiacetalization/hemiketalization were developed, which provided a rapid entry into the 5-5-5 spirodilactone cores of a family of ascorbylated natural products. Based on the described chem., total syntheses of leucodrin, leudrin and the proposed structure of dilaspirolactone were achieved.

Organic & Biomolecular Chemistry published new progress about Acetalization (hemi). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Quality Control of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary