Month: October 2022

Abt, Arthur F.; Hardy, J. Martin; Farmer, Chester J.; Maaske, Jessie D. published the artcile< Relation of vitamin C to scarlet fever, rheumatic infections and diphtheria in children>, HPLC of Formula: 82-73-5, the main research area is .

The ascorbic acid content of the blood plasma was significantly lowered in 76 patients with scarlet fever. Oral administration of ascorbic acid in large doses did not influence the course of the disease. The plasma ascorbic acid was not significantly altered in 17 patients with rheumatic fever, in 26 with acute rheumatic heart disease, in 2 with chorea or in 8 with acute pharyngeal diphtheria. High temperatures per se did not significantly lower the plasma ascorbic acid or increase its utilization in the body. Fever, accompanied by active infection, may cause an increased ascorbic acid utilization, which is reflected in a decrease in the plasma level and in urinary excretion.

American Journal of Diseases of Children published new progress about Blood plasma. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, HPLC of Formula: 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Yujuan; Huang, Liliang; Feng, Huihui; Qi, Yayu; Van der Eycken, Erik V.; Feng, Huangdi published the artcile< Regio- and Chemoselective Copper-Catalyzed Formal [2+2+2] Cycloaddition of Primary Amines with Arylacetylenes to 2,4,5-Trisubstituted Pyridines>, Application In Synthesis of 3959-07-7, the main research area is pyridine preparation chemoselective regioselective; primary amine alkyne cycloaddition copper catalyst.

Synthesis of 2,4,5-trisubstituted pyridines I (R1 = Ph, 3,4-dimethoxyphenyl, furan-2-yl, etc.; R2 = Ph, 2-bromophenyl, 3-methylphenyl, etc.) via CuI/NBS-catalyzed formal intermol. [2+2+2] cycloaddition of easily available primary amines R1CH2NH2 and nonactivated terminal alkynes R2CCH is described. Moreover, this given reaction features a new mode of cycloaddition with high regio- and chemoselectivity, good atom- and step-economy, broad substrate scope, and wide functional group compatibility. Further mechanism studies indicate that this transformation starts with oxidative alkynation of the amine to form propargylamine intermediate, followed by radical addition to the alkyne and intramol. cycloaddition, delivering the pharmacol. interesting 2,4,5-trisubstituted pyridinesI.

Organic Letters published new progress about [2+2+2] Cycloaddition reaction (regio- and chemoselective). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lux, Michaelyn C.; Boby, Melissa L.; Brooks, Joshua L.; Tan, Derek S. published the artcile< Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction>, Application In Synthesis of 81107-97-3, the main research area is diastereoselective synthesis bicyclic ether; palladium catalyzed oxidative cyclization cascade bicyclic ether synthesis.

Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient access to these scaffolds from readily available linear diene-diol substrates [e.g., I → II, (60% isolated) with complete cis-diastereoselectivity at ring junction and 4:1 dr (α/β) at vinyl side chain]. A Pd redox-relay process is used strategically to transmit reactivity between an initial oxypalladative cyclization and a subsequent π-allyl-Pd cyclization at remote sites. The reaction affords variety of bicyclic ether scaffolds with complete diastereoselectivity for cis-ring fusion.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Application In Synthesis of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Darrah, Kristie; Wang, Ting; Cook, Ian; Cacace, Mary; Deiters, Alexander; Leyh, Thomas S. published the artcile< Allosteres to regulate neurotransmitter sulfonation>, Formula: C7H6BrNO, the main research area is SULT1A3 allosteric inhibitor catecholamine sulfonation; SULT1A3; allosteric regulation; allostery; catecholamine; dopamine; enzyme inhibitor; enzyme kinetics; enzyme mechanism; enzyme structure; epinephrine; inhibition; mechanism; neurotransmitter; norepinephrine; nuclear magnetic resonance (NMR); serotonin; spin label; sulfotransferase.

Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition – cognitive flexibility, aggression, depression, and reward seeking – and manipulating these levels is a major objective of the pharmaceutical industry. Certain neurotransmitters are extensively sulfonated and inactivated by human sulfotransferase 1A3 (SULT1A3). To our knowledge, sulfonation as a therapeutic means of regulating transmitter activity has not been explored. Here, we describe the discovery of a SULT1A3 allosteric site that can be used to inhibit the enzyme. The structure of the new site is determined using spin-label-triangulation NMR. The site forms a cleft at the edge of a conserved ∼30-residue active-site cap that must open and close during the catalytic cycle. Allosteres anchor into the site via π-stacking interactions with two residues that sandwich the planar core of the allostere and inhibit the enzyme through cap-stabilizing interactions with substituents attached to the core. Changes in cap free energy were calculated ab initio as a function of core substituents and used to design and synthesize a series of inhibitors intended to progressively stabilize the cap and slow turnover. The inhibitors bound tightly (34 nm to 7.4μm) and exhibited progressive inhibition. The cap-stabilizing effects of the inhibitors were exptl. determined and agreed remarkably well with the theor. predictions. These studies establish a reliable heuristic for the design of SULT1A3 allosteric inhibitors and demonstrate that the free-energy changes of a small, dynamic loop that is critical for SULT substrate selection and turnover can be calculated accurately.

Journal of Biological Chemistry published new progress about Allosterism. 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Formula: C7H6BrNO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tarnowicz, Stanislawa; Alsalahi, Waleed; Mieczynska, Ewa; Trzeciak, Anna M. published the artcile< Heck arylation of allyl alcohol catalyzed by Pd(0) nanoparticle>, Reference of 3893-18-3, the main research area is Heck arylation allyl alc palladium nanoparticle catalyzed; palladium nanoparticle preparation catalyst allyl alc Heck arylation.

Pd(0) nanoparticle ca. 2 nm in diameter were obtained by the reduction of PdCl2 and Pd(OAc)2 in water at 80° in the presence of a PVP-stabilizing polymer. Pd(0) NPs were successfully used in the Heck coupling of allyl alc. with iodo- and bromobenzenes. Iodobenzenes reacted under solventless conditions or in DMF solution producing 3-arylpropanals and 2-arylpropanals as the main products. The same products were obtained in the reaction of bromobenzene in TBAB as the reaction medium. The stability of Pd(0) NPs was evidenced in recycling experiments Similar Heck coupling results were also obtained with the palladium compounds PdCl2(cod) and Pd(OAc)2 under the same conditions.

Tetrahedron published new progress about Heck reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Boykin, David W.; Baumstark, Alfons L.; Kayser, Margaret M.; Soucy, Chantal M. published the artcile< Oxygen-17 nuclear magnetic resonance spectroscopic study of substituted phthalic anhydrides and phthalides>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is NMR oxygen phthalic anhydride phthalide.

17O chem. shift data (natural abundance) for 3-substituted phthalic anhydrides and 4- and 7-substituted phthalides in acetonitrile at 75° are reported. Steric interactions of substituents ortho to the carbonyl groups result in deshielding effects (9-22 ppm) relative to parent compounds regardless of the electronic character of the substituents. Factors contributing to the deshielding effects are discussed. The relationship between 17O chem. shifts and regiochem. of the phthalic anhydrides is discussed.

Canadian Journal of Chemistry published new progress about NMR (nuclear magnetic resonance). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Krishanmoorthy, Sankarganesh; Schnell, Simon D.; Dang, Huong; Fu, Fang; Prakash, G. K. Surya published the artcile< Fluorodecarboxylation: Synthesis of aryl trifluoromethyl ethers (ArOCF3) and thioethers (ArSCF3)>, Reference of 2252-45-1, the main research area is aryl trifluoromethyl ether preparation; aryloxydifluoroacetic acid selectfluor fluorodecarboxylation; aryltrifluoromethyl thioether preparation; arylmercaptodifluoroacetic acid selectfluor fluorodecarboxylation.

Fluorodecarboxylation of aryloxydifluoroacetic acid (ArOCF2CO2H) [Ar = C6H5, 4-(CH3)3CC6H4, naphthalen-1-yl, etc.] and arylmercaptodifluoroacetic acid (RSCF2CO2H) [R = C6H5, 4-ClC6H4, 3,5-(CF3)2C6H3, etc.] towards RSCF3 and ArOCF3 using silver (I) salts in the presence of Selectfluor in a biphasic system with trifluoroacetic acid additive is discussed.

Journal of Fluorine Chemistry published new progress about Aromatic carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Reference of 2252-45-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Jitao; Li, Zhilong; Xu, Yumin; Shu, Xiaomin; Huo, Haohua published the artcile< Stereodivergent Synthesis of Both Z- and E-Alkenes by Photoinduced, Ni-Catalyzed Enantioselective C(sp3)-H Alkenylation>, Name: 1-Bromo-3-ethylbenzene, the main research area is alkylarene vinyl bromide nickel catalyst photoredox enantioselective diastereoselective alkenylation; aryl alkyl alkene preparation.

An enantioselective benzylic C(sp3)-H alkenylation of simple alkylarenes with vinyl bromides via photoinduced nickel catalysis was reported, which allowed the stereodivergent synthesis of both enantioenriched Z- and E-alkenes bearing aryl-substituted, allylic tertiary stereogenic centers. Interestingly, the tunable Z/E-selectivity was achieved by energy transfer catalysis via a judicious choice of the photocatalyst counteranion. This versatile strategy featured simple starting materials, mild reaction conditions, broad substrate scope, divergent Z- and E-selectivity and high enantioselectivities. Moreover, a formal asym. benzylic C(sp3)-H alkylation was also be achieved via a one-pot alkenylation/reduction sequence, providing a complementary strategy to address the notoriously challenging stereochem. control in C(sp3)-C(sp3) bond construction.

ACS Catalysis published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Name: 1-Bromo-3-ethylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Ming-Hui; Tu, Yong-Qiang; Tian, Jin-Miao; Zhang, Fu-Min; Wang, Shao-Hua; Zhang, Shi-Heng; Zhang, Xiao-Ming published the artcile< Asymmetric epoxidation of α,β-unsaturated aldehydes catalyzed by a spiro-pyrrolidine-derived organocatalyst>, COA of Formula: C9H7BrO, the main research area is epoxide preparation diastereoselective enantioselective; aldehyde unsaturated asym epoxidation spiro pyrrolidine organocatalyst.

The asym. epoxidation of α,β-unsaturated aldehydes R1R2C=CHCHO [R1 = CH3CH2, 4-ClC6H4, naphthalen-2-yl, etc.; R2 = H, CH3; R1R2 = -(CH2)4-], catalyzed by a spiro-pyrrolidine (SPD)-derived organocatalyst, has been accomplished with good diastereoselectivities (up to dr >20:1) and with high to excellent enantioselectivities (up to 99% ee).

Tetrahedron: Asymmetry published new progress about Alcohols, epoxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Osyanin, V. A.; Korzhenko, K. S.; Rashchepkina, D. A.; Osipov, D. V.; Klimochkin, Yu. N. published the artcile< Nucleophilic Vinylic Substitution in Perfluoroacylchromenes. Diastereoselective Synthesis of Push-Pull Enamino Ketones>, Related Products of 3959-07-7, the main research area is enamino ketone diastereoselective preparation; perfluoroacylchromene nucleophilic vinylic substitution.

The reactions of 2-perfluoroacyl-1H-benzo[f]chromenes and 6,7-dimethyl-3-trifluoroacetyl-4H-chromene with primary aliphatic amines and ammonia afforded a series of enamino ketones containing a (2-hydroxynaphthalen-1-yl)methyl or 2-hydroxybenzyl substituent in the α-position with respect to the carbonyl group, e.g., I [R = H, cyclopropyl, Bn, etc.; X = CF3, C2F5, ]. These reactions involved opening of the pyran ring, which followed aza-Michael addition as the initial step. The obtained enamino ketones were found to exist in DMSO solution as single E isomers.

Russian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary