Month: October 2022

Chacon-Huete, Franklin; Lasso, Juan David; Szavay, Paul; Covone, Jason; Forgione, Pat published the artcile< Synthesis of 2,5-diaryl nonsymmetric furans C6-platform chemicals via catalytic conversion of biomass and the formal synthesis of dantrolene>, Application In Synthesis of 2725-82-8, the main research area is diarylfuran preparation biomass furancarboxylic acid decarboxylation arylation aryl bromide.

Biomass-derived commodity chem. 5-hydroxymethyl furfural is an underutilized C6-platform chem. derived from cellulose that is ideal to prepare next-generation value-added products. We have developed an efficient synthetic strategy to access 2,5-diaryl nonsym. furans from 5-hydroxymethyl furfural utilizing decarboxylative cross-couplings. A key finding was that the presence of the hydroxymethyl handle enhances the yields of the palladium-catalyzed decarboxylative cross-coupling reaction. The method provides access to a broad-range nonsym. 2,5-diaryl furans where each arene can be systematically introduced as required. Addnl., this green synthetic strategy was employed for a formal synthesis of the muscle relaxant Dantrolene in excellent yields.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application In Synthesis of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Garcia-Rodriguez, Jose; Mendiratta, Saurabh; White, Michael A.; Xie, Xiao-Song; De Brabander, Jef K. published the artcile< Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs>, HPLC of Formula: 6942-39-8, the main research area is salicylihalamide synthesis anticancer antiviral structure activity relationship; VATPase inhibitor salicylihalamide analog preparation; Anticancer; Antiviral; Benzolactone; Salicylihalamide; V-ATPase.

An efficient total synthesis of the potent V-ATPase inhibitor saliphenylhalamide (SaliPhe), a synthetic variant of the natural product salicylihalamide A (SaliA), has been accomplished aimed at facilitating the development of SaliPhe as an anticancer and antiviral agent. This new approach enabled facile access to derivatives for structure-activity relationship studies, leading to simplified analogs that maintain SaliPhe’s biol. properties. These studies will provide a solid foundation for the continued evaluation of SaliPhe and analogs as potential anticancer and antiviral agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Albano, Gianluigi; Colli, Tony; Biver, Tarita; Aronica, Laura Antonella; Pucci, Andrea published the artcile< Photophysical properties of new p-phenylene- and benzodithiophene-based fluorophores for luminescent solar concentrators (LSCs)>, COA of Formula: C8H5BrS2, the main research area is photophys property phenylene benzodithiophene based fluorophore luminescent solar concentrator.

In this study, we report on the synthesis of new organic fluorophores containing either the p-phenylene or the benzodithiophene cyclic nucleus connected to thiophene units via triple bonds and carbonyl group, and on their application for the fabrication of luminescent solar concentrators (LSCs). Their optical properties were evaluated. Independent of the core, dyes containing the CO-thiophene residues seem to be the most promising for LSCs applications. In fact, carbonyl groups slightly enhance the quantum yield but significantly increase the red-shift of the emission so that the superimposition between the absorbance spectrum and the emission one is diminished. In the case of the benzodithiophene center, light emission in the yellow-red portion of the spectrum is achieved. The latter dye is then selected for tests in a poly(Me methacrylate) (PMMA) matrix. It showed good compatibility and homogenous distribution, no auto-absorption phenomena, and optical efficiencies of about 8% at 1 weight %, i.e. comparable with those PMMA/Lumogen Red films in the same range of concentration

Dyes and Pigments published new progress about Fluorescent substances. 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, COA of Formula: C8H5BrS2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Garcia, Kevin J.; Gilbert, Michael M.; Weix, Daniel J. published the artcile< Nickel-Catalyzed Addition of Aryl Bromides to Aldehydes To Form Hindered Secondary Alcohols>, Formula: C9H11Br, the main research area is aryl halide aldehyde nickel catalyst zinc reducing agent addition; hindered secondary alc preparation.

Transition-metal-catalyzed addition of aryl halides across carbonyls remains poorly developed, especially for aliphatic aldehydes and hindered substrate combinations. We report here that simple nickel complexes of bipyridine and PyBox can catalyze the addition of aryl halides to both aromatic and aliphatic aldehydes using zinc metal as the reducing agent. This convenient approach tolerates acidic functional groups that are not compatible with Grignard reactions, yet sterically hindered substrates still couple in high yield (33 examples, 70% average yield). Mechanistic studies show that an arylnickel, and not an arylzinc, adds efficiently to cyclohexanecarboxaldehyde, but only in the presence of a Lewis acid co-catalyst (ZnBr2).

Journal of the American Chemical Society published new progress about Addition reaction. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Formula: C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moon, Patrick J.; Yin, Shengkang; Lundgren, Rylan J. published the artcile< Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis>, Related Products of 14062-30-7, the main research area is monoaryl acetate preparation; decarboxylative arylation coupling arylboron nucleophile malonic acid.

We report decarboxylative carbonyl α-arylation by coupling of arylboron nucleophiles with malonic acid derivatives This process is enabled by the merger of aerobic oxidative Cu catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method enables the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization.

Journal of the American Chemical Society published new progress about Arylation. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Related Products of 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chidananda, N.; Poojary, Boja; Sumangala, V.; Kumari, N. Suchetha; Shetty, Prashanth; Arulmoli, T. published the artcile< Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles>, Category: bromides-buliding-blocks, the main research area is disubstituted triazolothiadiazole dihydrodisubstituted triazolothiadiazole synthesis antiinflammatory analgesic antioxidant antimicrobial; amino bromo methoxyphenyl dihydro triazolethione cyclocondensation carboxylic acid aldehyde; bromomethoxy benzoic acid cyclization hydrazone Mannich reaction condensation.

Two new series of compounds namely, 3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (I) (R1 = 4-methoxy Ph, 4-Me Ph, Ph, 3,5-dichlorophenyl, 4-aminophenyl, 3,5 -dimethyl Ph, 4-nitro Ph, 3,5 -dinitro Ph, 2-hydroxy-4-Me Ph, 2,4 -diiodo phenyl) and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (II) (R1 = 2-chloro Ph, Ph, 4-chloro Ph, 3-chlorophenyl, 2,4-dimethoxy Ph, 4-methoxy Ph, 2-methoxy Ph, 4-nitro Ph, biphenyl, 4-Me phenyl) were prepared In continuation of a previously reported study, the first series I were synthesized by the cyclocondensation of 4-amino-5-(2-bromo-5-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (III) with various substituted aromatic carboxylic acids in phosphorus oxychloride and the second series I by the reaction of III with various substituted aromatic aldehydes in the presence of p-Toluene sulfonic acid. Reaction of III with the aldehyde (IV) afforded the Schiff’s base (V) and not the cyclized product on treatment with p-Toluene sulfonic acid. Synthesized compounds were structurally confirmed by spectral anal. and studied for their anti-inflammatory, analgesic, anti-oxidant and antimicrobial activities. Some of the tested compounds showed significant pharmacol. activities.

European Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Dejiang; Tang, Ting; Zhang, Zhao; Le, Liyuan; Xu, Zhi; Lu, Hao; Tong, Zhou; Zeng, Dishu; Wong, Wai-Yeung; Yin, Shuang-Feng; Ghaderi, Arash; Kambe, Nobuaki; Qiu, Renhua published the artcile< Nickel- and Palladium-Catalyzed Cross-Coupling of Stibines with Organic Halides: Site-Selective Sequential Reactions with Polyhalogenated Arenes>, Application In Synthesis of 401-78-5, the main research area is chloro fluorophenyl tetrahydrodibenzoazastibocine preparation arylation aryl halide; crystal structure chloro fluorophenyl tetrahydrodibenzoazastibocine; mol structure chloro fluorophenyl tetrahydrodibenzoazastibocine; biphenyl preparation; arylstibine preparation coupling reaction aryl halide palladium nickel catalyst.

Herein, the authors disclose a general and efficient method for the synthesis of Sb-aryl and Sb-alkyl stibines by the Ni-catalyzed cross-coupling of halostibines with organic halides. The synthesized Sb-aryl stibines couple with aryl halides to give biaryls efficiently via Pd catalysis. Sequential reactions of stibines with polyhalogenated arenes bearing active C-I/C-Br sites and inactive C-Cl sites successfully proceeded, giving a variety of complex mols. with good site selectivity. Drugs such as diflunisal and fenbufen, as well as a fenofibrate derivative, were synthesized on gram scales in good yields, together with the high recovery of chlorostibine. Also, catalytic mechanisms are proposed based on the results of control experiments

ACS Catalysis published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Setati, Boitumelo; Moshapo, Paseka Thendo; Holzapfel, Cedric Wahl; Maumela, Munaka Christopher published the artcile< Palladium-catalyzed Heck reactions promoted by limonene-derived bicyclic phosphines>, Related Products of 576-83-0, the main research area is halobenzene aryl alkene palladium catalyst Heck reaction; aryl ester preparation; aromatic ketone preparation.

Tertiary bicyclic phosphines derived from (R)-(+)-limonene provided efficient palladium catalysts for Heck cross-coupling reactions. Overall, high yields of the desired aryl alkenes products were obtained for cross-coupling of sterically and electronically diverse substrates. The efficiency of the catalysts was further demonstrated in the synthesis of com. ketones, such as raspberry ketone and its derivatives

Synthetic Communications published new progress about Aromatic esters Role: SPN (Synthetic Preparation), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Related Products of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Wenxing; Zhang, Shuo; Shi, Guang; Chen, Zhiwei published the artcile< Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines>, Related Products of 3959-07-7, the main research area is imidazole preparation green chem; enamine benzylamine electrochem amination.

An electrochem. method for synthesizing 1,2,4,5-tetrasubstituted imidazoles I (R = Me, Et, Ph, i-Pr; R1 = n-Bu, Bn, cyclohexyl, 4-chlorophenyl, naphthalen-1-yl, etc.; R2 = Me, OMe, OEt, Ot-Bu; R3 = Ph, 2,3-dichlorophenyl, thiophen-2-yl, etc.) was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochem. C(sp3)-H amination via enamines (Z)-RC(NHR1)=C(O)R2 and amines R3NH2. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAA receptor analogs I (R = Me; R1 = 2,4-dichlorophenyl; R2 = OEt; R3 = 4-bromophenyl).

Organic & Biomolecular Chemistry published new progress about Amination. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jagot, Fatema; Ntsimango, Songeziwe; Ngwira, Kennedy J.; Fernandes, Manuel A.; de Koning, Charles B. published the artcile< Synthesis of Angucycline/Tetrangulol Derivatives Using Suzuki-Miyaura Cross-Coupling and Ring-Closing Carbonyl-Olefin Metathesis Reactions>, Electric Literature of 1530-33-2, the main research area is angucycline tetrangulol preparation.

Key steps in the synthesis of derivatives of the angucycline, tetrangulol include the use of a palladium catalyzed Suzuki-Miyaura cross-coupling reaction for the assembly of I from 2-iodo-3-methoxy-5-methylbenzaldehyde and II. The biaryl product I was then subjected to an iron-catalyzed ring-closing carbonyl-olefin metathesis reaction to afford 1,7,12-trimethoxy-3-methyltetraphene, which was oxidized to the corresponding quinone III. Late stage oxidation of the quinone III with Ru[Cl2(p-cymene)]2 and an oxidant unexpectedly afforded the chlorinated compounds IV (R = H, OH).

European Journal of Organic Chemistry published new progress about Anthracyclines Role: SPN (Synthetic Preparation), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Electric Literature of 1530-33-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary