Month: October 2022

Kumar, Inder; Kumar, Rakesh; Gupta, Shiv Shankar; Sharma, Upendra published the artcile< C70 Fullerene Catalyzed Photoinduced Aerobic Oxidation of Benzylamines to Imines and Aldehydes>, Recommanded Product: 4-Bromobenzylamine, the main research area is C70 fullerene catalyzed photoinduced aerobic oxidation; benzylamine oxidation imine aldehyde preparation radical formation.

C70 fullerene catalyzed photoinduced oxidation of benzylic amines at ambient conditions has been explored here. The developed strategy’s main feature includes the additive/oxidant-free conversion of benzylic amine to corresponding imine and aldehydes. The reaction manifests broad substrate scope with excellent function group leniency and is applicable up to the gram scale. Further, sym. secondary amines can also be synthesized from benzylic amine in a one-pot two-step process. Various experiments and d. functional theory studies revealed that the current reaction involves the generation of reactive oxygen species, single electron transfer reaction, and benzyl radical formation as key steps under photocatalytic conditions.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Smith, Bradley D.; Goodenough-Lashua, DeeAnne M.; D’Souza, Carlisle J. E.; Norton, Kieran J.; Schmidt, Leslie M.; Tung, James C. published the artcile< Substituent effects on the barrier to carbamate C-N rotation>, Formula: C12H16BrNO2, the main research area is substituent effect barrier carbamate carbon nitrogen rotation.

Seven aryl-substituted t-Bu N-methyl-N-aryl carbamates were prepared, and in each case, the barrier to C-N bond rotation, ΔG‡, was determined in CDCl3 solution using variable temperature NMR. A linear free energy relationship is observed between ΔG‡ and the electronic stabilization effect of the substituent on the N-aryl ring. More specifically, electron donating groups increase ΔG‡, whereas withdrawing groups decrease ΔG‡. A plot against σ- was more linear (r2=0.96), than a plot against σ (r2 = 0.90) or σ+ (r2 = 0.88) and a value of ρ = 1.76 was obtained at 243 K. Thus, rotation about the carbamate C-N bond in weakly polar chloroform involves a decrease in pos. charge on the nitrogen.

Tetrahedron Letters published new progress about C-N bond. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Formula: C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oi, Miku; Takita, Ryo; Kanazawa, Junichiro; Muranaka, Atsuya; Wang, Chao; Uchiyama, Masanobu published the artcile< Organocopper cross-coupling reaction for C-C bond formation on highly sterically hindered structures>, Product Details of C7H7BrO2S, the main research area is organocopper compound aryl iodide cross coupling reaction mechanism.

A powerful, broadly applicable cross-coupling protocol that enabled carbon-carbon bond formation at highly sterically hindered carbon centers (both sp2 and sp3) by employing organocopper reagents under palladium catalysis was described. Exptl. studies and theor. calculations indicated that the key to the unique reactivity of copper was the relatively low activation energy of the compact transmetalation transition state, due to Cu(I)-Pd(II) interaction, which was associated with small values of deformation energy of the reactants. This reaction was applicable to a variety of bulky substrates, including compounds inert to previous cross-coupling chem. and has high functional group tolerance.

Chemical Science published new progress about Aryl bromides Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 5751-83-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2S, Product Details of C7H7BrO2S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shang, Le-Le; Feng, Yun; Gao, Xing-Lian; Chen, Zi-Ren; Xia, Yu; Jin, Wei-Wei; Liu, Chen-Jiang published the artcile< DMAP-Catalyzed C-N Bond formation for Diverse synthesis of Imidazo[1,2-a]pyrimidine and Pyrimido[1,2-a]benzimidazole Derivatives.>, Synthetic Route of 3893-18-3, the main research area is haloalkenyl carbonyl compound aminobenzimidazole DMAP catalyst cyclocondensation reaction; imidazopyrimidine preparation green chem; aminoimidazole haloalkenyl carbonyl compound DMAP catalyst cyclocondensation reaction; pyrimidobenzimidazole preparation green chem.

A DMAP (2-dimethylaminopyridine)-catalyzed condensation reactions for the successful direct construction of pyrimido[1,2-a]benzimidazole or imidazo[1,2-a]pyrimidine was developed. The method utilized readily available α-bromocinnamaldehydes with 2-aminobenzimidazole or 2-aminoimidazole as starting materials in the presence of 2-DMAP/TBHP. In the process, two C-N bonds were successfully constructed to synthesize target compounds

Chinese Journal of Chemistry published new progress about Benzimidazoles Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Synthetic Route of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Han, Liuqing; Li, Ke; Xu, Haitong; Mei, Tao; Sun, Yali; Qu, Jingping; Song, Yuming published the artcile< N-TFA-Gly-Bt-Based Stereoselective Synthesis of Substituted 3-Amino Tetrahydro-2H-pyran-2-ones via an Organocatalyzed Cascade Process>, COA of Formula: C9H7BrO, the main research area is organocatalyst cascade unsaturated aldehyde trifluoroacetamidoacetylbenzotriazole; stereoselective synthesis aminotetrahydropyranone.

Chiral-substituted 3-amino tetrahydro-2H-pyran-2-ones were prepared in excellent enantioselectivities (up to 99% ee) via an organo-catalyzed cascade procedure with N-TFA-Gly-Bt and α,β-unsaturated aldehydes as the substrates. The corresponding tetrahydro-2H-pyran-2-ones can be used for further synthetic transformations that furnish chiral-substituted 3-aminopiperidin-2-ones with high levels of stereoselectivity.

Journal of Organic Chemistry published new progress about Diastereoselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, COA of Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pocinho, Alexandre; Mallet-Ladeira, Sonia; Hureau, Christelle; Gras, Emmanuel published the artcile< N,N′-Bis(4-bromophenyl)-N,N′-dimethylurea>, Quality Control of 639520-70-0, the main research area is bisbromophenyl dimethylurea preparation crystal structure.

The structure of the title compound, C15H14Br2N2O, at 180 K has monoclinic (P21/n) symmetry. It was obtained unexpectedly from the decomposition of the parent 4-bromo-N-tert-butoxycarbonyl-N-methyl-aniline. It exhibits an ′endo′ conformation with angles between the two aromatic rings slightly lower than the average values found for similar compounds on the Cambridge Structural Database. In the crystal, C-H···O hydrogen bonds and short Br···Br halogen bonds [3.444 (1) Å] are observed

IUCrData published new progress about Crystal structure. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Quality Control of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Song, Jing-Ru; Li, Na; Li, Dian-Peng published the artcile< Synthesis and anti-proliferation activity of Mogrol derivatives bearing quinoline and triazole moieties>, Related Products of 29124-57-0, the main research area is Mogrol quinolinyl triazolyl synthesis antitumor agent; Lung cancer; Mogrol; Quinoline; Structural modification; Triazole.

A series of novel derivatives based on Mogrol were designed and synthesized in attempt to improve anti-lung cancer activity. The cytotoxicity against human lung cancer cells including A549 and NCI-H460 were performed by Cell Counting Kit-8 (CCK8) assay in vitro. The screening result showed that compound 8f exhibited the strongest activity with an IC50 value of 4.47μM against A549 cell, and could induce the cell apoptosis in a dose-dependent manner and arrest cell cycle at G0/G1 phase. Besides, compound 8f displayed anti-proliferation effect on A549 cell through inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3). Furthermore, compared with Mogrol, compound 10a significantly improved the cytotoxicity against NCI-H460 with the IC50 value of 17.13μM. The research stimulated the development of potential therapeutic agent for lung cancer from the natural Mogrol.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Related Products of 29124-57-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Matsui, Y; Figi, A; Horikawa, M; Jahangiri Noudeh, Y; Tomozawa, Y; Hashimoto, K; Kaufman, J A; Farsad, K published the artcile< Erratum to ""Arteriopathy after transarterial chemo-lipiodolization for hepatocellular carcinoma"" [Diagn. Interv. Imaging 98 (12) (2017) 827-35].>, Name: 4-Bromoisobenzofuran-1,3-dione, the main research area is .

There is no abstract available for this document.

Diagnostic and interventional imaging published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Name: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mondal, B.; Bendikov, M.; Kanti Roy, U. published the artcile< Oligoselenophenes (n and p Type): Synthesis and Properties>, Category: bromides-buliding-blocks, the main research area is oligoselenophene preparation semiconductor thermal property.

An array of semiconducting oligoselenophenes (n and p types), up to hexamer units, e.g., I were synthesized by the double Stille coupling methods using tetrakis(triphenylphosphine)palladium(0) as a catalyst. A series of semiconducting oligomers (n and p types) containing mixed hetero-units (hexamers of thiophene and selenophene), e.g., II were also synthesized using the Stille coupling reaction. Their thermal properties were systematically studied and compared with those of π-conjugated thiophene based oligomers using DSC and TGA. The field-effect mobility of synthesized n and p type oligomers was analyzed.

Russian Journal of General Chemistry published new progress about Selenides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cyclic). 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Xia; Fang, Chengtao; Huang, Xiaolei; Xiao, Xiaohui published the artcile< 1,1,2-Tribromoethyl arenes: novel and highly efficient precursors for the synthesis of 1-bromoalkynes and α-bromoketones>, Computed Properties of 2725-82-8, the main research area is bromoalkyne bromoketone preparation; tribromoethyl arene preparation elimination reaction; ethylbenzene bromination.

Herein, a novel method to synthesize 1,1,2-tribromoethyl arenes, which can be easily transformed to 1-bromoalkynes via base-mediated elimination reaction is reported. The bromination reagent was in situ generated from the reaction of NaBr/NaBrO3/H2SO4, resulting in high reactivity, excellent chem. selectivity and outstanding functional group tolerance. Moreover, 1,1,2-tribromoethyl arenes encounter a selectivity switch to afford α-bromoketones under strong acidic conditions.

Organic Chemistry Frontiers published new progress about Alkynes, bromo Role: SPN (Synthetic Preparation), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Computed Properties of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary