Month: October 2022

Wang, Na; Zhang, Wei; Zhou, Long-Hua; Deng, Qing-Feng; Xie, Zong-Bo; Yu, Xiao-Qi published the artcile< One-Pot Lipase-Catalyzed Aldol Reaction Combination of In Situ Formed Acetaldehyde>, Category: bromides-buliding-blocks, the main research area is lipase aldol condensation addition acetaldehyde aldehyde.

A facile tandem route to α,β-unsaturated aldehydes was developed by combining the two catalytic activities of the same enzyme in a one-pot strategy for the aldol reaction and in situ generation of acetaldehyde. Lipase from Mucor miehei was found to have conventional and promiscuous catalytic activities for the hydrolysis of vinyl acetate and aldol condensation with in situ formed acetaldehyde. The first reaction continuously provided material for the second reaction, which effectively reduced the volatilization loss, oxidation, and polymerization of acetaldehyde, as well as avoided a neg. effect on the enzyme of excessive amounts of acetaldehyde. After optimizing the process, several substrates participated in the reaction and provided the target products in moderate to high yields using this single lipase-catalyzed one-pot biotransformation.

Applied Biochemistry and Biotechnology published new progress about Aldol addition. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Jun; Ma, Xiaoming; Wang, Yuexin; Li, Xia; Lang, Xianjun published the artcile< Visible light-initiated aerobic oxidation of amines to imines over TiO2 microspheres with TEMPO+PF6->, COA of Formula: C7H8BrN, the main research area is amine preparation photochem; imine aerobic oxidation; titanium dioxide microsphere tetramethylpiperidine oxoammonium hexafluorophosphate cooperative photocatalysis.

Semiconductor photocatalysis holds great promise to drive vital chem. reactions utilizing sunlight. Amongst semiconductors, TiO2-related materials are one of the most viable to achieve enhanced photocatalytic performances because of their intrinsic merits. Here TiO2 microspheres assembled from nanocrystals with a distinct hierarchical architecture and a high sp. surface area were fabricated using a simple template-free solvothermal process. Assembling amines on TiO2 microspheres initiated by visible light can lead to a surface complex that captures visible light for further oxidation of amines. Moreover, the selective oxidation of amines could be boosted by fully exploring the surface polarity of TiO2 microspheres with more polar 2,2,6,6-tetramethylpiperidine-1-oxoammonium hexafluorophosphate (TEMPO+PF6-) instead of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) as the redox mediator. As such, cooperative photocatalysis with TEMPO+PF6- was framed over TiO2 microspheres to initiate the efficient and selective aerobic oxidation of benzyl amines into imines. Significantly, the activity of TEMPO+PF6- surpassed that of TEMPO in aiding the visible light-initiated selective oxidation of amines over TiO2 microspheres, reaching more than about 3 times in some cases. This work suggests that the surface properties of a semiconductor could be maneuvered to enable coupling with a suitable redox mediator to ameliorate selective organic conversions in an unprecedented manner.

Sustainable Energy & Fuels published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Barker, Joshua E.; Dressler, Justin J.; Cardenas Valdivia, Abel; Kishi, Ryohei; Strand, Eric T.; Zakharov, Lev N.; MacMillan, Samantha N.; Gomez-Garcia, Carlos J.; Nakano, Masayoshi; Casado, Juan; Haley, Michael M. published the artcile< Molecule Isomerism Modulates the Diradical Properties of Stable Singlet Diradicaloids>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is stable open shell singlet diradicaloid isomer.

Inclusion of quinoidal cores in conjugated hydrocarbons is a common strategy to modulate the properties of diradicaloids formed by aromaticity recovery within the quinoidal unit. Here we describe an alternative approach of tuning of diradical properties in indenoindenodibenzothiophenes upon anti → syn isomerism of the benzothiophene motif. This alters the relationship of the S atom with the radical center from linear to cross conjugation yet retains the same 2,6-naphtho conjugation pattern of the rearomatized core. We conduct a full comparison between the anti and syn derivatives based on structural, spectroscopic, theor., and magnetic measurements, showing that these systems are stable open-shell singlet diradicaloids that only access their triplet state at elevated temperatures

Journal of the American Chemical Society published new progress about Benzothiophenes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (indenoindenodibenzothiophenes). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pave, Gregoire; Leger, Jean-Michel; Jarry, Christian; Viaud-Massuard, Marie-Claude; Guillaumet, Gerald published the artcile< Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy>, COA of Formula: C7H7BrO2, the main research area is asym synthesis spirocyclic aminochroman derivative cyano phenyl oxazolopiperidine substitution; crystal structure absolute configuration aminochroman derivative benzopyran piperidine.

Enantiomerically pure (3’R)- and (3’S)-3′,4′-dihydrospiro[piperidine-2,3′(2’H)-benzopyran]s I (R = H) and II (R = H) were successfully synthesized according to the CN(R,S) methodol. with the aim of serving as a pattern for the generation of related spirocyclic compounds Two different synthetic pathways were studied starting from 2-cyano-6-phenyloxazolopiperidine III. One of them was selected and used for the preparation of amines I (R = OMe) and II (R = OMe) starting from III and IV, resp. The enantiomeric purity of all final aminochroman derivatives was determined by capillary electrophoresis using β-cyclodextrin as the chiral selector.

Journal of Organic Chemistry published new progress about Absolute configuration. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ibrahem, Ismail; Breistein, Palle; Cordova, Armando published the artcile< One-Pot Three-Component Catalytic Enantioselective Synthesis of Homoallylboronates>, Application of C9H7BrO, the main research area is copper catalyzed asym reaction diboron unsaturated aldehyde triphenylphosphoranylidene ester; enantioselective synthesis homo allyl boronate.

Authors have developed an efficient, novel one-pot three-component enantioselective reaction between a diboron reagent, α,β-unsaturated aldehydes, and 2-(triphenylphosphoranylidene)acetate esters. The asym. multicomponent reaction proceeds through a β-boration/Wittig sequence to give the corresponding homoallylboronates with high enantiomeric ratios using simple bench-stable chiral amines and copper catalysts. In addition, the study shows that it is possible to merge the catalytic cycles of transition-metal-catalyzed nucleophilic activation of diboron reagents with amine-catalyzed iminium activation of enals to achieve a highly 1,4- and enantioselective β boration of enals. The one-pot expansion of the cocatalytic three-component reaction to the asym. synthesis of homoallylic alcs. was also disclosed. Further development of this type of one-pot multicomponent cocatalytic asym. reaction and its application in total synthesis is ongoing in authors laboratories Thus, three-component trimethylsilyl substituted pyrrolidine amine/PPh3/Cu(OTf)2-catalyzed reaction of cinnamaldehyde with B2pin2 and Ph3P:CHCO2Et in MeOH/Et2O followed by treatment with 2-fluorobenzoic acid gave 65% (S,E)-Et 5-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pent-2-enolate stereoselectively.

Angewandte Chemie, International Edition published new progress about Amines, chiral Role: CAT (Catalyst Use), USES (Uses). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thorve, Pradip Ramdas; Maji, Biplab published the artcile< Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst>, Electric Literature of 3959-07-7, the main research area is quinazolinone preparation kinetic mechanistic study; amine aminobenzamide cascade aerobic oxidative coupling copper catalyst.

Herein, a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and an in situ generated non-native secondary amine is reported. The catalyst consists of an o-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Catalysis Science & Technology published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Electric Literature of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jorgensen, P. Fischer published the artcile< A mathematical-statistical analysis of titration errors in the determination of ascorbic acid of serum by use of the 2,6-dichlorophenolindophenol method>, Computed Properties of 82-73-5, the main research area is .

373 determinations of ascorbic acid in serum were made, using a slight modification of the method of Farmer and Abt (cf. C.A. 30, 8273.5). The results are divided into 6 groups and the standard deviation determined for each group. The possible sources of error are investigated. Two types of errors can be distinguished: Group (a) comprises the exptl. errors. In this group the standard deviation is constant Group (b) is associated with the chemistry of the analytical method, and the standard deviation is found to be directly proportional to the ascorbic acid concentration The chem. significance of these errors is discussed.

Dansk Tidsskrift for Farmaci published new progress about Blood. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nazarahari, Maryam; Azizian, Javad published the artcile< FeCl2-PPh3 as an efficient catalytic system for the acceptorless dehydrogenation of amines into imines>, Product Details of C7H8BrN, the main research area is benzylamine iron chloride triphenylphosphine catalyst diastereoselective dehydrogenative coupling; phenylmethanimine preparation.

A novel and simple catalytic system including FeCl2, PPh3 and potassium tert-butoxide were employed for the synthesis of imines from amines. In order to prove the catalytic acceptorless dehydrogenation pathway for this transformation, the liberated H2 gas was detected by NMR spectroscopy. By utilizing this protocol, a variety of arylamines were used successfully for the preparation of corresponding imines in good to excellent yields (on a 1 mmol scale, 73-91% yield for homocoupling, 71 and 91% for heterocoupling).

Chemical Papers published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Wanqiao; Zhang, Ruzhong; Zhang, Ruxue; Yu, Jianxin; Wang, Mang published the artcile< Radical hydrotrifluoromethylation of ynamides: a route toward β-CF3 enamides>, Synthetic Route of 3959-07-7, the main research area is aryl trifluoromethyl amine preparation; trifluoromethyl enamide preparation diastereoselective deprotection reduction reaction; ynamide chlorophenyl trifluoromethyliodane radical hydrotrifluoromethylation reaction.

Radical hydrotrifluoromethylation of ynamides RNR2CCR1 (R = Ph, 3-chlorophenyl, benzodioxol-5-yl, etc.; R1 = H, cyclopropyl, Ph, etc.; R2 = Boc, Ac, Cbz) to provide an alternative route toward (E)-β-CF3 enamides RNR2CH=C(CF3)R1 was reported. By using PhICF3Cl as the CF3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature Further reduction of the resulting β-CF3 enamides efficiently delivered β-CF3 amines RNHCH2CH(CF3)R1. Gram-scale synthesis was conducted to demonstrate the practicability of the method.

Organic Chemistry Frontiers published new progress about Diastereoselective synthesis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Martinelli, Joseph R.; Freckmann, Dominique M. M.; Buchwald, Stephen L. published the artcile< Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure>, SDS of cas: 639520-70-0, the main research area is Weinreb amide preparation; palladium catalyst aminocarbonylation aryl bromide; phosphine ligand palladium catalyst aminocarbonylation; benzamide methoxymethyl preparation.

The direct transformation of aryl bromides into the corresponding Weinreb amides via Pd-catalyzed aminocarbonylation at atm. pressure was reported. Thus, reaction of 3-BrC6H4CN and MeNHOMe.HCl with CO in toluene containing Pd(OAc)2, the bidentate P ligand Xantphos, and Na2Co3 at 80° gave 88% 3-BrC6H4CONMeOMe.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, SDS of cas: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary