Month: October 2022

Wu, Wei; Wang, Biyun; Ji, Xinfei; Cao, Song published the artcile< Direct copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3>, Application of C7H4BrF3S, the main research area is arylboronic acid silver trifluoromethylthiolate copper catalyst trifluoromethylthiolation; aryl trifluoromethyl thioether preparation.

A copper-catalyzed direct oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3 was developed. This approach provided straightforward and efficient access to a variety of aryl trifluoromethyl sulfides from an easily prepared and stable nucleophilic trifluoromethylthiolation reagent AgSCF3, and readily available nucleophilic arylboronic acids, thus avoiding the preparation of electrophilic trifluoromethylthiolating reagents in advance. Preliminary mechanistic experiments indicated that AgSCF3 served as both a source of SCF3 and an oxidant.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Application of C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carullo, Gabriele; Mazzotta, Sarah; Giordano, Francesca; Aiello, Francesca published the artcile< Green synthesis of new pyrrolo [1,2-a] quinoxalines as antiproliferative agents in GPER-expressing breast cancer cells>, Computed Properties of 51605-97-1, the main research area is pyrroloquinoxaline GPER breast cancer antiproliferative activity.

4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biol. properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, the synthesis and preliminary antiproliferative activity of a small set of new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) and pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known antiproliferative agents (G-1, G-15, and G-36). The synthesis of the pyrroloquinoxalinic core was employed following the Pictet-Spengler reaction, using the surfactant p-dodecylbenzene sulfonic acid (p-DBSA), as catalyst. It demonstrated efficiency in the catalysis of the 4-phenylpyrrole [1,2-a] quinoxaline type compound formation in mild solvents such as water, ethanol, and hydroalcoholic solutions In addition, the reactions proceeded in a short time (between 15 and 120 min) at room temperature and with high yields. The in vitro MTT assays showed that the presence of iso-Pr groups furnished promising antiproliferative compounds Although, the acetyl group provided also antiproliferative effects, breaking down its responsibility in the GPER transactivation. Nevertheless, it is possible to conclude that the 4,5-dihydropyrrolo[1,2-a]quinoxalines remain a feasible scaffold to develop anticancer agents against GPER-expressing cells.

Journal of Chemistry published new progress about Antiproliferative agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Computed Properties of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Long, Solida; Loureiro, Joana B.; Carvalho, Carla; Gales, Lu Is; Saraiva, Lucilia; Pinto, Madalena M. M.; Puthongking, Ploenthip; Sousa, Emilia published the artcile< Semi-synthesis of small molecules of aminocarbazoles: tumor growth inhibition and potential impact on p53>, Recommanded Product: 4-Bromobenzylamine, the main research area is aminocarbazole derivative preparation antitumor p53 activator; alkaloids; aminocarbazoles; heptaphylline; mutant; p53; tumor.

The tumor cell growth inhibitory activity of aminocarbazole derivatives, I [R = H, OMe; R1 = H, CH2CHC(Me)2; R2 = NH(CH2)3N(Me)2, pipridin-1-yl, 4-ClC6H4NH, etc.] as well as their potential activation of p53 was reported. Compounds I was synthesized from naturally-occurring carbazoles II [R3 = H, OMe; R4 = H, CH2CHC(Me)2] with amine precursors and isolated from Clausena harmandiana, using a reductive amination protocol. Compounds I and II were evaluated for their potential effect on wild-type and mutant p53 activity using a yeast screening assay and on human tumor cell lines. Naturally-occurring carbazoles II showed the most potent growth inhibitory effects on wild-type p53-expressing cells, being heptaphylline II [R3 = H; R4 = CH2CHC(Me)2] the most promising in all the investigated cell lines. However, compound II [R3 = H; R4 = CH2CHC(Me)2] also showed growth inhibition against non-tumor cells. Conversely, semi-synthetic aminocarbazole I [R = H; R1 = CH2CHC(Me)2; R2 = 4-FC6H4NH] showed an interesting growth inhibitory activity in tumor cells expressing both wild-type and mutant p53, exhibiting low growth inhibition on non-tumor cells. The yeast assay showed a potential reactivation of mutant p53 by heptaphylline derivatives, including compound I [R = H; R1 = CH2CHC(Me)2; R2 = 4-FC6H4NH].

Molecules published new progress about Amines Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ke, Da; Zhou, Shaodong published the artcile< General Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters>, Quality Control of 3959-07-7, the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, Avineesh; Patel, Vijay K.; Rajak, Harish published the artcile< Appraisal of pyrrole as connecting unit in hydroxamic acid based histone deacetylase inhibitors: Synthesis, anticancer evaluation and molecular docking studies>, Reference of 3893-18-3, the main research area is pyrrole hydroxamic acid preparation SAR antitumor mol docking human; histone deacetylase inhibitor.

SAHA and its synthetic analogs has demonstrated potent antitumor activity against numerous human cancer lines and different classes of HDACs. The objective of present studies was to incorporate pyrrole as connecting unit in hydroxamic acid based HDAC inhibitors for their anticancer evaluation and mol. docking studies. A series of novel 4-substituted Me 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)hexanoate I (R = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and 4-substituted 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)-N-hydroxyhexanamide II were synthesized and were evaluated for their anticancer activity using in-vitro method against leukemia (K-562), lung (A-549), breast (MCF-7), and cervical (HeLa) human cancer cell lines using Sulforhodamine B (SRB) assay method, HDAC1 and HDAC6 inhibitory assay and binding mode anal. using mol. docking studies. Interestingly, p-nitro-substituted mol. produced a most active derivative in the series. The in-vitro anticancer study of synthesized compounds indicated that the unsubstituted Ph derivative, II (R = Ph) have moderate antitumor activity against K-562 human leukemia cell line. Substitution at 4-Ph ring with weak and moderate electron withdrawing groups, such as fluoro, chloro, and bromo potentiated the cytotoxic activity. Compounds II were docked against different HDAC proteins to determine the exact binding mode and orientation. These studies can be further employed for the design and development of novel SAHA analogs with promising anticancer activity.

Journal of Molecular Structure published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mao, Weizhong; Liu, Junhua; Yin, Bingqian; Miao, Shiwen; Li, Yafei; Kong, Deyu; Wang, Fang published the artcile< Co-Cr composite oxides efficiently catalyzed transfer hydrogenation of α, β-unsaturated aldehydes via N-doped carbon and interfacial electron migration>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is chromium copper oxide carbon catalyst cinnamaldehyde catalytic hydrogen transfer.

We present a simple catalyst preparation route, that is spinel-structured CoCrOx (1:2) loaded on N-doped carbon (CoCrOx (1:2)-CN). The as-synthesized CoCrOx (1:2)-CN catalyst promoted catalytic hydrogen transfer (CTH) of cinnamaldehyde (CMA), affording cinnamyl alc. (CMO) yield as high as 95.3% under mild reaction conditions. There are several reasons for the high yield of CMA: (a) Through interfacial electron migration and N-doped carbon, the acidity and basicity of mesoporous CoCrOx (1:2)-CN catalyst were enhanced, thereby achieving optimal acid-base synergy. (b) Kinetic studies indicated that spinel-structure and N-doped carbon could increase the reaction rate and achieve a low activation energy (69.2 kJ/mol). (c) DFT calculations revealed that both pyridyl-N and pyrrolyl-N doping lowered the energy barrier for adsorption and desorption of reactants resulting in improved catalytic activity. In addition, the CoCrOx (1:2)-CN catalyst showed good reusability.

Molecular Catalysis published new progress about Activation energy. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Davies, David L.; Singh, Kuldip; Tamosiunaite, Neringa published the artcile< Steric effects on acetate-assisted cyclometallation of meta-substituted N-phenyl and N-benzyl imidazolium salts at [MCl2Cp*]2 (M = Ir, Rh)>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is aryl benzyl meta substituted imidazolium cyclometalation preparation half sandwich; iridium rhodium half sandwich cyclometalated aryl benzyl imidazolylidene preparation; crystal mol structure iridium rhodium cyclometalated aryl benzyl imidazolylidene.

Meta-Substituted aryl and benzyl imidazolium salts [3-MeIm-1-(3-RC6H4)][OTf] (H2L-Ar) and [3-MeIm-1-(CH2-3-RC6H4)][OTf] (H2L-CH2Ar) undergo acetate-assisted cyclometalation to provide mixtures of ortho and para substituted cyclometalated complexes [(L-C2,C2′)ClMCp*] and [(L-C2,C6′)ClMCp*], resp. (L = LAr, L-CH2Ar). The effect of the substituents on the isomer ratios is discussed; steric effects are more important in the 6-membered rings derived from the N-benzyl imidazolium salts than 5-membered rings from the N-Ph salts. Comparisons are made to steric effects with some other common directing groups.

Dalton Transactions published new progress about Carbene complexes, N-heterocyclic, transition metal complexes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cyclometalated). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hung, Vu Thai; Tran, Cong Chi; Yamamoto, Yuki; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya published the artcile< Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light>, HPLC of Formula: 401-78-5, the main research area is aryl cyclohexyl selenide preparation; diaryl diselenide hexacyclohexyldilead light irradation; diaryl dichalcogenides; hexacyclohexyldilead; homolytic substitution; photoirradiation.

In this study, the reactivity of organochalcogen compounds toward a representative alkyl-lead bond compound under light was investigated in detail. Under light irradiation, the Cy-Pb bond of Cy6Pb2 (Cy = cyclohexyl) undergoes homolytic cleavage to generate a cyclohexyl radical (Cy·). This radical can be successfully captured by di-Ph diselenide, which exhibits excellent carbon-radical-capturing ability. In the case of (PhS)2 and (PhTe)2, the yields of the corresponding cyclohexyl sulfides and tellurides were lower than that of (PhSe)2. This probably occurred due to the low carbon-radical-capturing ability of (PhS)2 and the high photosensitivity of the cyclohexyl-tellurium bond.

Molecules published new progress about Diselenides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, HPLC of Formula: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Wei; Zeng, Qiang; Chen, Weiming published the artcile< Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329>, COA of Formula: C7H4BrF3O, the main research area is protein tyrosine phosphatase receptor allosteric inhibitor preparation antitumor activity.

NAZ2329 is the first cell-permeable small mol. allosteric inhibitor of protein tyrosine phosphatase receptor-type Z (PTPRZ), which was considered as a new potential mol. target for drug development in glioblastoma. A facile and high-efficient synthesis of NAZ2329 was developed by a straight-forward strategy starting from key ethoxy benzyl bromide intermediate obtained from com. available 4-(trifluoromethyl)phenol.

Russian Journal of General Chemistry published new progress about Antitumor agents. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, COA of Formula: C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alba, Andrea-Nekane; Companyo, Xavier; Moyano, Albert; Rios, Ramon published the artcile< Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β-Unsaturated Aldehydes>, Safety of 3-(4-Bromophenyl)acrylaldehyde, the main research area is unsaturated aldehyde fluorobisphenylsulfonyl methane chiral diphenylprolinol TMS ether; enantioselective nucleophilic addition fluorobisphenylsulfonylmethyl aldehyde stereoselective preparation reduction oxidation; reductive amination alc carboxylic acid amine stereoselective preparation; esterification reductive desulfonylation ester fluoroalc stereoselective preparation; oxidation fluoroaldehyde stereoselective preparation DEAD amination reduction aminoalc; nucleophilic addition enantioselective catalyst chiral diphenylprolinol TMS ether.

The first organocatalytic enantioselective fluoro(bisphenylsulfonyl)methylation od α,β-unsaturated aldehydes in high yields and enantioselectivities was described. The resulting compounds were converted into a wide range of derivatives to show the applicability of this new methodol. Moreover, valuable 4-fluoro-2-amino-1-alkanol that can be easily transformed to fluoroaminoacids or fluoroaminoalcs. by know procedures was synthesized.

Chemistry – A European Journal published new progress about Aldehydes, halo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Safety of 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary