Month: October 2022

Cha, Mi Young; Lee, Kwang-Ok; Kim, Jong Woo; Lee, Chang Gon; Song, Ji Yeon; Kim, Young Hoon; Lee, Gwan Sun; Park, Seung Bum; Kim, Maeng Sup published the artcile< Discovery of A Novel Her-1/Her-2 Dual Tyrosine Kinase Inhibitor for the Treatment of Her-1 Selective Inhibitor-Resistant Non-Small Cell Lung Cancer>, SDS of cas: 115843-99-7, the main research area is tyrosine kinase inhibitor quinazolinyl pyrrolidine preparation SAR.

A novel series of (S)-1-acryloyl-N-[4-(arylamino)-7-(alkoxy)quinazolin-6-yl]pyrrolidine-2-carboxamides were synthesized and evaluated as Her-1/Her-2 dual inhibitors. In contrast to the Her-1 selective inhibitors, our novel compounds are irreversible inhibitors of Her-1 and Her-2 tyrosine kinases with the potential to overcome clin. relevant, mutation-induced drug resistance. The selected compounds, 19c and 19d (I), showed excellent EGFR inhibition activity even toward the T790M mutation of Her-1 tyrosine kinase with excellent selectivity. The excellent pharmacokinetic profiles of these compounds in rats and their robust in vivo efficacy in an A431 xenograft model clearly demonstrate that they merit further investigation as novel therapeutic agents for EGFR-targeting treatment of solid tumors, especially Her-1 selective inhibitor-resistant non-small cell lung cancer.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, SDS of cas: 115843-99-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Taherinia, Zahra published the artcile< (ZrO)2Fe2O5 as an efficient and recoverable nanocatalyst in C-C bond formation>, Computed Properties of 401-78-5, the main research area is zirconium ferrite recoverable nanocatalyst carbon bond formation.

In this paper, the synthesis and characterization of zirconium ferrite ((ZrO)2Fe2O5) magnetic nanoparticles (MNPs) and their application as a catalyst in C-C cross-coupling reaction will be described. The structure of the catalyst was studied by Fourier transform IR spectroscopy (FT-IR), SEM, energy dispersive spectrometry (EDS), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), vibrating sample magnetometer (VSM) and ICP-OES anal. The resulting zirconium ferrite [(ZrO)2Fe2O5] was efficient for C-C coupling reactions, affording the desired products in good to excellent yields. Moreover, the catalyst could be easily recovered by magnetic separation and recycled for four times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zhong-Yuan; Lakmal, Hetti Handi Chaminda; Qian, Xiaolin; Zhu, Zhenyu; Donnadieu, Bruno; McClain, Sarah J.; Xu, Xue; Cui, Xin published the artcile< Ruthenium-Catalyzed Enantioselective C-H Functionalization: A Practical Access to Optically Active Indoline Derivatives>, Application In Synthesis of 188813-04-9, the main research area is hydroindolecarboxaldehyde regioselective enantioselective preparation; ruthenium catalyst enantioselective cyclization alkenylaminobenzaldehyde transient imine directing group; study mechanism ruthenium catalyzed directed enantioselective cyclization alkenylaminobenzaldehyde.

In the presence of [Ru(p-cymene)Cl2]2, nonracemic 1-(1-naphthyl)ethylamine as a transient directing group, and N-phthaloyl-L-tert-leucine, 3-(alkenylamino)benzaldehydes such as I underwent enantioselective cyclization mediated by AgBF4 and KH2PO4 in chlorobenzene/hexafluoroisopropanol to yield nonracemic dihydroindolecarboxaldehydes such as II in up to 92% yield with 96% ee. A benzindolecarboxaldehyde potentially useful for the synthesis of lysergic acid analogs was prepared using this method. The reaction mechanism was studied using the preparation of ruthenacycles related to potential reaction intermediates, mass spectrometric detection of reaction intermediates, and deuterium labeling experiments

Journal of the American Chemical Society published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (m-alkenylamino). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Application In Synthesis of 188813-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Barros, Helio Lopes; Esteves, Maria Alexandra; Brites, Maria Joao published the artcile< Synthesis and photophysical properties of tetraphenylethylene derivatives as luminescent downshifting materials for organic photovoltaic applications>, HPLC of Formula: 184239-35-8, the main research area is tetraphenylethylene luminescent organic solar cell.

Luminescent Down-Shifting (LDS) is an optical approach applied in several photovoltaic (PV) technologies in which high energy solar radiation is converted to a wavelength region where the response of the photovoltaic devices is better. The use of LDS layers on organic photovoltaics (OPV) could serve two purposes: to prevent cell degradation by filtering the incident UV radiation and to improve the spectral response of PV cells at short-wavelength. This work reports, the design and synthesis of a series of tetraphenylethylene (TPE) derivatives based on TPE-A or A-π-TPE-π-A mol. structure featuring various electron-acceptor (A) groups. The photophys. properties of the new LDS compounds were systematically studied in 1,4-dioxane solution and film (Zeonex) by UV-visible absorption and fluorescence spectroscopy, and electrochem. properties studied by cyclic voltammetry. Thermal stability of the new LDS compounds was evaluated by Thermogravimetric anal. (TGA). Theor. computational studies provided evidence of existence of intramol. charge-transfer (ICT) between frontier orbitals of donor and acceptor moieties. The good photophys. and thermal properties of the synthesized TPE derivatives, associated with high molar absorption coefficients in UV spectrum and emission maximum in the range of 476-531 nm, make them promising candidates for LDS layers in OPV application.

Dyes and Pigments published new progress about Electric current-potential relationship. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, HPLC of Formula: 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hansa, Raj KC.; Khan, M. M. K.; Frangie, M. M.; Gilmore, D. F.; Shelton, R. S.; Savenka, A. V.; Basnakian, A. G.; Shuttleworth, S. L.; Smeltzer, M. S.; Alam, M. A. published the artcile< 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents>, Application of C6H4BrClFN, the main research area is anilinomethyl phenyl pyrazolyl benzoic acid preparation antibacterial cytotoxicity SAR; Antibiotics; Antimicrobial; Enterococcus; MRSA; Pyrazole; Staphylococcus aureus; Toxicity.

A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl Ph derived pyrazoles I [R = HO(O)C, F3C; R1 = Ph, 3-bromophenyl, 5-iodopyridin-2-yl, etc.] was synthesized and tested for antibacterial activity. The majority of trifluoromethyl Ph derivatives are highly potent growth inhibitors of Gram-pos. bacteria and showed low toxicity to human cultured cells. In particular, two compounds I [R = F3C; R1 = 3-fluoro-5-(trifluoromethyl)phenyl, 3,5-dichloro-4-fluorophenyl] were selected for addnl. studies. These compounds were highly effective against Staphylococcus aureus as shown by a low min. inhibitory concentration (MIC), a bactericidal effect in time-kill assays, moderate inhibition of biofilm formation as well as biofilm destruction and a bactericidal effect against stationary phase cells representing non-growing persister cells. Multistep resistance assays showed a very low tendency for S. aureus and Enterococcus faecalis to develop resistance through mutation. Addnl., in vivo mouse model studies showed no harmful effects at doses up to 50 mg/kg using 14 blood plasma organ toxicity markers or TUNEL assay in liver and kidney. Investigations into the mode of action by performing macromol. synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, Application of C6H4BrClFN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vogt, David B.; Seath, Ciaran P.; Wang, Hengbin; Jui, Nathan T. published the artcile< Selective C-F Functionalization of Unactivated Trifluoromethylarenes>, Reference of 401-78-5, the main research area is difluoroalkylarene preparation; trifluoromethylarene alkene photocatalytic alkylation.

Fluorinated organic mols. are pervasive within the pharmaceutical and agrochem. industries due to the range of structural and physicochem. properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of the corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaroms.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Reference of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jensen, Kim L.; Poulsen, Pernille H.; Donslund, Bjarke S.; Morana, Fabio; Joergensen, Karl Anker published the artcile< Asymmetric Synthesis of γ-Nitroesters by an Organocatalytic One-Pot Strategy>, Reference of 3893-18-3, the main research area is unsaturated aldehyde nitroalkane diphenyltrimethylsilyloxymethylpyrrolidine enantioselective Michael addition oxidative esterification; gamma arylnitroester Baclofen piperidone stereoselective preparation; enantioselective Michael addition oxidative esterification catalyst diphenyl trimethylsilyloxymethyl pyrrolidine.

An enantioselective synthesis of γ-nitroesters by a one-pot asym. Michael addition/oxidative esterification of α,β-unsaturated aldehydes is presented. The procedure is based on merging the enantioselective organocatalytic nitroalkane addition with an N-bromosuccinimide-based oxidation The γ-nitroesters are obtained in good yields and enantioselectivities, and the method provides an attractive entry to optically active γ-aminoesters, 2-piperidones, and 2-pyrrolidones.

Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Siddiqui, I. R.; Rahila; Rai, Pragati; Sagir, Hozeyfa; Waseem, Malik A. published the artcile< Molecular iodine catalysed domino cyclization in aqueous medium: a simple and efficient synthetic route to 1,4-dihydropyridazines>, Formula: C9H7BrO, the main research area is dihydropyridazine preparation green chem; benzylidene phenylhydrazine unsaturated aldehyde cyclization iodine catalyst.

A facile, efficient and environmentally friendly approach has been developed for the diverse synthesis of 1,4-dihydropyridazines I (R = Ph, 4-ClC6H4, 4-MeOC6H4, 1-naphthyl, 4-bromonaphthyl; R1 = Me, Ph, 4-NCC6H4, 3-O2NC6H4, etc.) from (E)-2-benzylidene-1-phenylhydrazines and α,β-unsaturated aldehydes under aqueous condition using mol. iodine as a green and recoverable catalyst. This procedure features low cost and easily available starting materials, an inexpensive and recoverable catalyst, short reaction time, reliable scalability, excellent yield and mild reaction conditions, as well as use of aqueous medium. The scope of this method was thoroughly explored under three different reaction conditions resulting in the generation of a library of title compounds In view of the various advantages of the present investigation, this methodol. gives a convenient and straightforward pathway to construct 1,4-dihydropyridazines in an eco-friendly fashion.

RSC Advances published new progress about Cyclization. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Moon, Patrick J.; Fahandej-Sadi, Anis; Qian, Wenyu; Lundgren, Rylan J. published the artcile< Decarboxylative Benzylation of Aryl and Alkenyl Boronic Esters>, Application of C10H11BrO2, the main research area is aryl boronic ester arylacetate potassium copper decarboxylative benzylation catalyst; alkenyl boronic ester arylacetate potassium copper decarboxylative benzylation catalyst; copper arylacetate aryl boronic ester potassium acetate decarboxylative benzylation; diarylmethane preparation; aerobic catalysis; boron; copper; cross-coupling; decarboxylation.

The copper-catalyzed decarboxylative benzylation of aryl and alkenyl boronic esters with electron-deficient aryl acetates is reported. The oxidative coupling proceeds under mild, aerobic conditions and tolerates a host of potentially reactive electrophilic functional groups that would be problematic with traditional benzylation methods (aryl iodides and bromides, protic heteroatoms, aldehydes, Michael acceptors). A reaction pathway in which a benzylic nucleophile is generated by aryl acetate decarboxylation and in turn is intercepted by the catalyst to form diarylmethane products is supported by mechanistic studies.

Angewandte Chemie, International Edition published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (diarylmethane). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Application of C10H11BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ozols, J.; Vanags, G. published the artcile< Bromo-3-ethylidenephthalide and its transformations>, Reference of 82-73-5, the main research area is phthalides bromo; bromo phthalides; ketone aromatic.

A mixture of 7 g. 4-bromophthalic anhydride, 4.4 g. (EtCO)2O and 1.6 g. dry EtCO2Na was heated 3 hrs. at 170-80° and poured into 75 ml. H2O to yield 61% bromo-3-ethylidenephthalide (I), m. 115-16° (CCl4). With alkalis, I did not isomerize, but formed bromopropiophenone-o-carboxylic acid (II) which appeared in a tautomer form as 3-hydroxy-3-ethylbromophthalide (III). To 0.85 g. I in 20 ml. MeOH was added MeONa prepared from 0.08 g. Na and 2 ml. MeOH, and the mixture heated on a water bath 0.5 hr. and worked up to give 0.5 g. III m. 114-15° (EtOH). Similarly, III was obtained from I and 10% KOH. 10 references.

Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Reference of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary