Month: October 2022

Nguyen, Julia; Chong, Andrea; Lalic, Gojko published the artcile< Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes>, HPLC of Formula: 639520-70-0, the main research area is alkene aryl halide anti Markovnikov hydroarylation regioselective nickel catalyst.

We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, HPLC of Formula: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mochalov, S. S.; Fedotov, A. N.; Trofimova, E. V.; Gazzaeva, R. A.; Zefirov, N. S. published the artcile< Isomerization of 3-unsubstituted 4,5-dihydroisoxazoles over alumina. A new synthesis of β-hydroxy nitriles>, Application In Synthesis of 3893-18-3, the main research area is aryl hydroxypropane nitrile one pot synthesis; arylcyclopropane nitrosation dihydroisoxazole isomerization alumina catalyst chromatog.

3-Unsubstituted 4,5-dihydroisoxazoles obtained by nitrosation of arylcyclopropanes are capable of undergoing efficient isomerization into 3-aryl-3-hydroxypropanenitriles during chromatog. on alumina.

Russian Journal of Organic Chemistry published new progress about Hydroxynitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Tian-Yuan; Xiao, Li-Jun; Zhou, Qi-Lin published the artcile< Nickel-Catalyzed Desymmetric Reductive Cyclization/Coupling of 1,6-Dienes: An Enantioselective Approach to Chiral Tertiary Alcohol>, Name: Methyl 2-bromo-4-methoxybenzoate, the main research area is chiral tertiary alc preparation enantioselective; diene desym reductive cyclization coupling nickel catalyst; 1,6-Dienes; Asymmetric Reductive Coupling; Desymmetric Catalysis; Nickel Catalysis; Tertiary Alcohols.

Authors have developed a nickel-catalyzed desym. reductive cyclization/coupling of 1,6-dienes. The reaction provides an efficient method for constructing a chiral tertiary alc. and a quaternary stereocenter by a single operation. The method has excellent diastereoselectivity and high enantioselectivity, a broad substrate scope, as well as good tolerance of functional groups. Preliminary mechanism studies show that alkyl nickel(I) species are involved in the reaction.

Angewandte Chemie, International Edition published new progress about Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Name: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xing, Qiaoyan; Xiao, Fuhong; Mao, Guojiang; Deng, Guo-Jun published the artcile< A Four-Component Reaction for the Synthesis of Thienopyrrolediones under Transition Metal Free Conditions>, Related Products of 188813-04-9, the main research area is thienopyrrole dione preparation green chem; aldehyde ketoamide multicomponent reaction.

A three-starting-material four-component reaction strategy is described to construct thienopyrrolediones (TPDs) I (R = H, Me, Et, Ph, Cy; R1 = Ph, naphthalen-2-yl, furan-2-yl, quinolin-8-yl, etc.; R2 = Ph, 4-(benzyloxy)phenyl, thiophen-2-yl, pyridin-3-yl, etc.) from the simplest raw materials, elemental sulfur, aldehydes R1CHO and R2CHO, and β-ketoamides e.g., 1-methylpyrrolidin-2-one, under transition metal free conditions. Compared with traditional multistep reaction sequences, this process is simple, efficient, environmentally friendly, and atom-economic and has laid the foundation for further development of an easily synthesized TPD unit.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Related Products of 188813-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mal, Abhijit; Wani, Imtiyaz Ahmad; Goswami, Gaurav; Ghorai, Manas K. published the artcile< Synthesis of Nonracemic 1,4-Benzoxazines via Ring Opening/Cyclization of Activated Aziridines with 2-Halophenols: Formal Synthesis of Levofloxacin>, Formula: C7H4BrF3O, the main research area is benzoxazine preparation; aziridine halophenol ring opening cyclization.

Novel 3,4-dihydro-1,4-benzoxazine derivatives have been synthesized by an efficient and simple method in excellent enantio- and diastereospecificity (ee > 99%, de > 99%). The reaction proceeds via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with 2-halophenols followed by Cu(I)-catalyzed intramol. C-N cyclization in a stepwise fashion under one-pot conditions to furnish the 3,4-dihydro-1,4-benzoxazine derivatives in excellent yields (up to 95%). The strategy offers a short and efficient synthesis to (S)-3-methyl-1,4-benzoxazine (S)-3v, a late stage intermediate in the synthesis of levofloxacin.

Journal of Organic Chemistry published new progress about Aziridines Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Formula: C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitsudo, Koichi; Kobashi, Yoshiaki; Nakata, Kaito; Kurimoto, Yuji; Sato, Eisuke; Mandai, Hiroki; Suga, Seiji published the artcile< Cu-Catalyzed Dehydrogenative C-O Cyclization for the Synthesis of Furan-Fused Thienoacenes>, HPLC of Formula: 81107-97-3, the main research area is thiophenyl phenol copper catalyst dehydrogenative cyclization coupling; furan fused thienoacene preparation.

The first Cu-catalyzed dehydrogenative C-O cyclization for the synthesis of furan-fused thienoacenes is described. A variety of heteroacenes including a thieno[3,2-b]furan or a thieno[2,3-b]furan skeleton were synthesized by intramol. C-H/O-H coupling. The use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and efficiently promoting the reaction. Double C-O cyclization was also conducted to afford highly π-expanded furan-fused thienoacenes.

Organic Letters published new progress about Bond cleavage. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, HPLC of Formula: 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Jufeng; Ambrus, Joey I.; Baker, Jennifer R.; Russell, Cecilia C.; Cossar, Peter J.; Sakoff, Jennette A.; Scarlett, Christopher J.; McCluskey, Adam published the artcile< 3,5-Bis(trifluoromethyl)phenylsulfonamides, a novel pancreatic cancer active lead. Investigation of the terminal aromatic moiety>, Reference of 3959-07-7, the main research area is pancreatic cancer anticancer agent virtual screening.

Virtual screening identified N-(6-((4-bromobenzyl)amino)hexyl)-3,5-bis(trifluoromethyl)benzenesulfonamide (1) a lead compound that bound to the S100A2-p53 binding groove. S100A2 is a Ca2+ binding protein with implications in cell signaling and is known to be upregulated in pancreatic cancer. It is a validated pancreatic cancer drug target. Lead 1, inhibited the growth of the MiaPaCa-2 pancreatic cancer cell line (GI50 = 2.97 μM). Focused compound libraries were developed to explore the SAR of this compound class with 4 libraries and 43 compounds total. Focused library (Library 1) development identified lipophillic sulfonamides as preferred for MiaPaCa-2 activity, with -CF3 and -C(CH3)3 substituents well tolerated (MiaPaCa-2 GI50 < 6 μM). Contraction of the hexylamino spacer to Et (Library 2) and Pr (Library 3) proved beneficial to activity against a broad spectrum panel of cancer cell lines: HT29 (lung), MCF-7 (breast), A2780 (ovarian), H460 (colon), A431 (skin), Du145 (prostate), BE2-C (neuroblastoma), U87 and SJ-G2 (glioblastoma) (cohort-1); and a pancreatic cancer cell line panel: MiaPaCa-2, BxPC-3, AsPC-1, Capan-2, HPAC and PANC-1 (cohort-2). With a marked preference for a Pr linker the observed GI50 values ranged from 1.4 to 30 μM against cohort-1 and 1.4-30 μM against cohort-2 cell lines. In Library 4 the terminal aromatic moiety was explored with 4-substituted analogs preferred (with activity of 48 (4-Cl) > 47 (3-Cl) > 46 (2-Cl)) against the cell lines examined The introduction of bulky aromatic moieties was well tolerated, e.g. dihydrobenzo[b][1,4]dioxine (51) returned cohort-2 GI50 values of 1.2-3.4 μM. In all instances the observed docked binding poses and binding scores were consistent with the observed cytotoxicity. This in turn supports, but does not prove, that these analogs function via S100A2-p53 binding groove inhibition.

Bioorganic & Medicinal Chemistry Letters published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jia, Xiuquan; Ma, Jiping; Xia, Fei; Gao, Mingxia; Gao, Jin; Xu, Jie published the artcile< Switching acidity on manganese oxide catalyst with acetylacetones for selectivity-tunable amines oxidation>, Recommanded Product: 4-Bromobenzylamine, the main research area is manganese oxide acetylacetone switching acidity selectivity tunable amine oxidation.

The design of metal oxide catalysts predominantly focuses on the composition or geometry engineering to enable optimized reactivity on the surface. Despite the numerous reports investigating the surface chemisorption of organic mols. on metal oxides, insights into how adsorption of organic modifiers can be exploited to optimize the catalytic properties of metal oxides are lacking. Herein, we describe the use of enolic acetylacetones to modify the surface Lewis acid properties of manganese oxide catalysts. The acetylacetone modification is stable under the reaction conditions and strongly influences the redox-acid cooperative catalysis of manganese oxides. This enables a rational control of the oxidation selectivity of structurally diverse arylmethyl amines to become switchable from nitriles to imines.

Nature Communications published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kocen, Andrew L.; Cui, Shilin; Lin, Ting-Wei; LaPointe, Anne M.; Coates, Geoffrey W. published the artcile< Chemically Recyclable Ester-Linked Polypropylene>, Application of C9H11Br, the main research area is recyclable ester polypropylene.

Polyolefins represent the largest class of commodity materials due to their excellent material properties; however, they have limited pathways to chem. recycling and are often difficult to mech. recycle. Here we demonstrate a new catalyst for the isoselective copolymerization of propylene and butadiene capable of favoring 1,4-insertion over 1,2-insertion while maintaining good mol. weights and turnover frequencies. This isotactic propylene copolymer with main-chain unsaturation was depolymerized to a telechelic macromonomer using an olefin metathesis catalyst and 2-hydroxyethyl acrylate. After hydrogenation, the telechelic macromonomer was repolymd. to form an ester-linked polypropylene material. This polymer shows thermal and mech. properties comparable to linear low-d. polyethylene. Finally, the telechelic macromonomer could be regenerated through the depolymerization of the ester-linked polypropylene material, which allows for the chem. recycling to macromonomer. This process provides a route to transform partially unsaturated polyolefins to chem. recyclable materials with similar properties to their parent polymers.

Journal of the American Chemical Society published new progress about Aluminoxanes, Me Role: CAT (Catalyst Use), USES (Uses) (Methylaluminoxane). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Application of C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shon, Jong-Hwa; Sittel, Steven; Teets, Thomas S. published the artcile< Synthesis and characterization of strong cyclometalated iridium photoreductants for application in photocatalytic aryl bromide hydrodebromination>, Computed Properties of 576-83-0, the main research area is iridium photoredox catalyst hydrodebromination.

A series of potent bis-cyclometalated iridium photoreductants with electron-rich β-diketiminate (NacNac) ancillary ligands is described. Structure-property anal. reveals that substituent modification of the NacNac ligands has a large effect on the ground-state IrIV/IrIII potential, which shifts cathodically as the NacNac is made more electron-rich. In addition, the excited-state IrIV/*IrIII potentials are ca. 300-500 mV more neg. than that of fac-Ir(ppy)3 (ppy = 2-phenylpyridine), indicating that these compounds have much more reducing excited states. Rate constants for excited-state electron transfer between these photosensitizers and benzophenone are ∼2-3 times faster than fac-Ir(ppy)3, demonstrating that these complexes are both kinetically and thermodynamically more potent for excited-state electron transfer. We use these photosensitizers to optimize a simple reaction procedure for photocatalytic debromination of aryl bromide substrates, which requires only the photosensitizer, blue light, and an amine base, without silanes or other additives that are used in previously reported methods.

ACS Catalysis published new progress about Aromatic nitrogen heterocycles, aromatic nitrogen heterocycle transition metal complexes Role: CAT (Catalyst Use), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Computed Properties of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary