Month: October 2022

Huang, Zhiliang; Guan, Renpeng; Shanmugam, Muralidharan; Bennett, Elliot L.; Robertson, Craig M.; Brookfield, Adam; McInnes, Eric J. L.; Xiao, Jianliang published the artcile< Oxidative Cleavage of Alkenes by O2 with a Non-Heme Manganese Catalyst>, Application of C21H22BrP, the main research area is alkene oxygen light manganese oxidation catalyst; ketone preparation.

The oxidative cleavage of C=C double bonds with mol. oxygen to produce carbonyl compounds is an important transformation in chem. and pharmaceutical synthesis. In nature, enzymes containing the first-row transition metals, particularly heme and non-heme iron-dependent enzymes, readily activate O2 and oxidatively cleave C=C bonds with exquisite precision under ambient conditions. The reaction remains challenging for synthetic chemists, however. There are only a small number of known synthetic metal catalysts that allow for the oxidative cleavage of alkenes at an atm. pressure of O2, with very few known to catalyze the cleavage of nonactivated alkenes. In this work, we describe a light-driven, Mn-catalyzed protocol for the selective oxidation of alkenes to carbonyls under 1 atm of O2. For the first time, aromatic as well as various nonactivated aliphatic alkenes could be oxidized to afford ketones and aldehydes under clean, mild conditions with a first row, biorelevant metal catalyst. Moreover, the protocol shows a very good functional group tolerance. Mechanistic investigation suggests that Mn-oxo species, including an asym., mixed-valent bis(μ-oxo)-Mn(III,IV) complex, are involved in the oxidation, and the solvent methanol participates in O2 activation that leads to the formation of the oxo species.

Journal of the American Chemical Society published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Application of C21H22BrP.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hong, Liang; Sun, Wangsheng; Liu, Chunxia; Wang, Lei; Wang, Rui published the artcile< Asymmetric organocatalytic N-alkylation of indole-2-carbaldehydes with α,β-unsaturated aldehydes: one-pot synthesis of chiral pyrrolo[1,2-a]indole-2-carbaldehydes>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is pyrroloindolecarbaldehyde asym preparation; indolecarbaldehyde unsaturated aldehyde Michael addition cyclization diphenylsilyloxymethylpyrrolidine.

Diphenylprolinol trimethylsilyl ether-catalyzed asym. aza-Michael addition/aldol addition of indole-2-carboxaldehyde with unsaturated aldehydes is described. A series of chiral pyrrolo[1,2-a]indole-2-carbaldehydes were obtained in good yields with excellent stereoselectivities.

Chemistry – A European Journal published new progress about Cyclization. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Jinglei; Hu, Hang; Ye, Kai; Wang, Wei; Xu, Defeng published the artcile< Synthesis of Novel Pyrimidinylselenium Compounds as Acetolactate Synthase-Inhibiting Herbicides>, Category: bromides-buliding-blocks, the main research area is Eleusine Amaranthus Portulaca pyrimidinylselenium acetolactate synthase herbicide.

A series of pyrimidinylselenosalicylic acid derivatives (5 a-5 l) and 4-selenopyrimidine derivatives (6 a-6 f) were synthesized and evaluated as potential acetylactate synthase (ALS)-inhibiting herbicides. All synthesized new compounds were characterized by 1H NMR, 13C NMR, and high-resolution mass spectrometry (HRMS). The compounds were subjected to herbicidal activity, in vitro ALS enzyme inhibitory activity, and crop safety studies. The herbicidal activity study shows that 4-chloro (5 b), 5-chloro (5 c), 5-methoxy (5 e), 4,5-dimethoxy (5 f), 5-fluoro (5 h), and 4,5-difluoro (5 i) substituted 2-[(4,6-dimethoxy-2-pyrimidinyl)selanyl]benzoic acid exhibit significantly enhanced weed control effect than other new compounds and Pyrithiobac. Most of compounds exhibit enhanced inhibition effect on Cyperus difformis Linn than those on barnyard grass, Portulaca oleracea, Eleusine indica, and Amaranthus retroflexus. Importantly, 5 c, 5 f, and 5 i also exhibit more potent inhibition effect on Escherichia coli ALS enzyme than other new compounds and Pyrithiobac in in vitro ALS enzyme inhibitory activity study. The possible binding modes of 5 c, 5 f, and 5 i with ALS enzyme were studied on Discovery Studio. To test the possibility of 5 c, 5 f, and 5 i as potential herbicides in paddy fields, we performed the crop safety study. The results show that 5 f and 5 i are safer to rice than 5 c. The present work indicates that 5 f and 5 i may serve as new herbicide candidates for weed control in paddy fields.

ChemistrySelect published new progress about Affinity (binding). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Lucy; Turner, Lewis D.; Silhar, Peter; Pellett, Sabine; Johnson, Eric A.; Janda, Kim D. published the artcile< Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A>, Recommanded Product: 4-Bromobenzylamine, the main research area is hydroxy dimethylpyridine dione botulinum neurotoxin inhibitor.

Botulinum neurotoxin serotype A (BoNT/A) is an important therapeutic target owing to its extremely potent nature, but also has potential use as a biowarfare agent. Currently, no therapeutic exists to reverse the long-lasting paralysis caused by BoNT/A. Herein, we describe the identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione (3,4-HOPTO) as a metal binding warhead for the inhibition of BoNT/A1. An initial screen of 96 metal binding fragments identified three derivatives containing the 3,4-HOPTO scaffold to inhibit the BoNT/A1 light chain (LC) at >95% at 1 mM. Addnl. screening of a 3,4-HOPTO sub-library identified structure-activity relationships (SARs) between N-substituted 3,4-HOPTO derivatives and the BoNT/A1 LC. Subsequent synthesis was conducted to improve on inhibitory potency – achieving low μM biochem. IC50 values. Representative compounds were evaluated in a cellular-based assay and showed promising μM activity.

RSC Medicinal Chemistry published new progress about Enzyme inhibitors (botulinum neurotoxin type A). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sunden, Henrik; Rios, Ramon; Ibrahem, Ismail; Zhao, Gui-Ling; Eriksson, Lars; Cordova, Armando published the artcile< A highly enantioselective catalytic domino aza-Michael/aldol reaction: one-pot organocatalytic asymmetric synthesis of 1,2-dihydroquinolines>, Application of C9H7BrO, the main research area is stereoselective Michael aldol aminobenzaldehyde unsaturated aldehyde catalyst.

The highly enantioselective organocatalytic domino aza-Michael/aldol reaction is presented. The unprecedented, chiral amine-catalyzed asym. domino reactions between 2-aminobenzaldehydes and α,β-unsaturated aldehydes proceed with excellent chemo- and enantioselectivity to give the corresponding pharmaceutically valuable 1,2-dihydroquinolines in high yields with 90 to > 99 % ee.

Advanced Synthesis & Catalysis published new progress about Aldol condensation catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Zhao-Zhao; Zhao, Jia-Hui; Gou, Xue-Ya; Chen, Xi-Meng; Liang, Yong-Min published the artcile< Visible-light-mediated hydrodehalogenation and Br/D exchange of inactivated aryl and alkyl halides with a palladium complex>, Product Details of C9H11Br, the main research area is aryl alkyl halide amine free radical reductive dehalogenation; dehalogenative deuteration reductive cyclization addition cycloaddition arylation.

Herein, a novel photo-induced amine-free radical reductive dehalogenation of inactivated aryl/alkyl bromides and chlorides with a palladium complex is described,. Which reveals excellent functional group compatibility and broad substrate scope. Extensional transformations for reductive cyclization, dehalogenative deuteration, and intra- and intermol. radical addition can be achieved smoothly. Mechanistic studies indicate a single-electron photoredox catalytic system with inactivated solvent as the hydrogen atom donor.

Organic Chemistry Frontiers published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Product Details of C9H11Br.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lu, Dehua; Qu, Lailiang; Wang, Cheng; Luo, Heng; Li, Shang; Yin, Fucheng; Liu, Xingchen; Chen, Xinye; Luo, Zhongwen; Cui, Ningjie; Peng, Wan; Ji, Limei; Kong, Lingyi; Wang, Xiaobing published the artcile< Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy>, SDS of cas: 85070-57-1, the main research area is cancer therapy histone deacetylase harmine DNA damage; Cancer; DNA; DNA damage; HDAC; Harmine.

Overexpression of histone deacetylases (HDACs) are observed in different types of cancers, but histone deacetylase inhibitors (HDACIs) have not shown significant efficacy as monotherapy against solid tumors. Recently, studies demonstrated that it is promising to combine HDACIs with DNA damage agents to improve DNA damage level to gain better effect on treating solid tumor. Harmine has been demonstrated to cause DNA damage by intercalating DNA. Therefore, we designed a series of harmine-based inhibitors targeting HDAC and DNA with multi-target strategy, the most potential compound 27 could bind to DNA and cause DNA damage. Furthermore 27 caused cells apoptosis through p53 signaling pathway, and exhibited significant anti-proliferation effects against HCT-116 cells (IC50 = 1.41 μM). As a DNA damage agent, 27 displayed low toxicity in normal cells. Compound 27 was demonstrated as a dual inhibitor targeting HDAC (HDAC1 IC50 = 0.022 μM and HDAC6 IC50 = 0.45 μM) and DNA, and had the potential in the treatment of solid tumor.

Bioorganic Chemistry published new progress about Acetylation. 85070-57-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, SDS of cas: 85070-57-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bookser, Brett C.; Kasibhatla, Srinivas Rao; Appleman, James R.; Erion, Mark D. published the artcile< AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series>, SDS of cas: 14062-30-7, the main research area is coformycin aglycon analog preparation AMPDA inhibitor; adenylate adenosine deaminase inhibitor coformycin analog.

A series of N3-substituted coformycin aglycon analogs are described that inhibit AMP deaminase (AMPDA) or adenosine deaminase (ADA). The key steps involved in the preparation of these compounds are treating the sodium salt of 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one with an alkyl bromide or an alkyl mesylate to generate the N3-alkylated compound, and (2) reducing the N3-alkylated compound with NaBH4. Selective inhibition of AMPDA was realized when the N3-substituent contained a carboxylic acid moiety. For example, the compound which has a hexanoic acid side chain inhibited AMPDA with a Ki = 4.2 μM and ADA with a Ki = 280 μM. Substitution of large lipophilic groups α to the carboxylate provided a moderate potency increase with maintained selectivity as exemplified by the α-benzyl analog (AMPDA Ki = 0.41 μM and ADA Ki > 1000 μM). These compounds, as well as others described in this series of papers, are the first compounds suitable for testing whether selective inhibition of AMPDA can protect tissue from ischemic damage by increasing local adenosine concentrations at the site of injury and/or by minimizing adenylate loss.

Journal of Medicinal Chemistry published new progress about Structure-activity relationship, enzyme-inhibiting. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, SDS of cas: 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pal, Ritesh; Chakraborty, Jeet; Mukhopadhyay, Titas Kumar; Kanungo, Ajay; Saha, Rimita; Chakraborty, Amit; Patra, Dipendu; Datta, Ayan; Dutta, Sanjay published the artcile< Substituent effect of benzyl moiety in nitroquinoxaline small molecules upon DNA binding: Cumulative destacking of DNA nucleobases leading to histone eviction>, Name: 4-Bromobenzylamine, the main research area is nitroquinoxaline preparation antitumor hydrophobicity SAR DNA binding destacking; Entropically favored; Hydrogen bond disruption; Hydrophobic interaction; In-vitro nucleosome disassembly; Mammalian cell cytotoxicity; Nucleobase destacking.

Cooperative disruption of Watson-Crick hydrogen bonds, as well as base-destacking, was shown to be triggered by a quinoxaline-based small mol. consisting of an N,N-dimethylaminopropyl tether, and a para-substituted benzyl moiety. This events led to superstructure formation and DNA condensation as evident from biophys. experiments and classical mol. dynamics simulations. The DNA superstructure formation by mono-quinoxaline derivatives I [R = 1-piperidyl, [3-(dimethylamino)propylamino]; R1 = benzyl, 2-thienylmethyl, (4-iodophenyl)methyl, etc.] was highly entropically favored and predominantly driven by hydrophobic interactions. Furthermore, oversupercoiling of DNA and base-destacking cumulatively induced histone eviction from in-vitro assembled nucleosomes at lower micromolar concentrations implicating biol. relevance. The DNA structural modulation and histone eviction capacity of the benzyl para-substituents were in the order: -I > -CF3> -Br > -Me > -OMe > -OH, which was largely guided by the polarity of benzyl para-substituent and the resulting mol. topol. The most hydrophobic derivative I [R = [3-(dimethylamino)propylamino], R1 = (4-iodophenyl)methyl] with para-iodo benzyl moiety caused maximal disruption of base pairing and generation of superstructures. Both these events gradually diminished as the polarity of the benzyl para-substituent increases. On the other hand, quinoxaline derivatives I having heterocyclic ring instead of benzyl ring, or in the absence of N,N-dimethylamino head-group, was incapable of inducing any DNA structural change and histone eviction. Further, the quinoxaline compounds I displayed potent anticancer activities against different cancer cell lines which directly correlates with the hydrophobic effects of the benzyl para-substituents. Overall, the study provided new insights into the mechanistic approach of DNA structural modulation driven histone eviction guided by the hydrophobicity of synthesized compounds leading to cellular cytotoxicity towards cancer cells.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wan, Lin-Xi; Zhen, Yong-Qi; He, Zhen-Xiang; Zhang, Yang; Zhang, Lan; Li, Xiaohuan; Gao, Feng; Zhou, Xian-Li published the artcile< Late-Stage Modification of Medicine: Pd-Catalyzed Direct Synthesis and Biological Evaluation of N-Aryltacrine Derivatives>, Application In Synthesis of 401-78-5, the main research area is tacrine aryl preparation Buchwald Hartwig cross coupling palladium catalyst; cholinesterase inhibitor aryltacrine; hepatotoxicity aryltacrine; neuroprotective aryltacrine; mol docking methoxypyridinyl tacrine acetylcholinesterase butyrylcholinesterase; blood brain barrier permeability aryltacrine.

A new series of N-aryltacrine derivatives was designed and synthesized as cholinesterase inhibitors by the late-stage modification of tacrine, using the palladium-catalyzed Buchwald-Hartwig cross-coupling reaction. In vitro inhibition assay against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) demonstrated that most of the synthesized compounds had potent AChE inhibitory activity with neg. inhibition of BuChE. Among them, N-(4-(trifluoromethyl)phenyl)-tacrine (I) and N-(4-methoxypyridin-2-yl)-tacrine (II) showed the most potent activity against AChE (IC50 values of 1.77 and 1.48μM, resp.). The anti-AChE activity of I and II was 3.5 times more than that of tacrine (IC50 value of 5.16μM). Compound II also displayed anti-BuChE activity with an IC50 value of 19.00μM. Cell-based assays against HepG2 and SH-SY5Y cell lines revealed that II had significantly lower hepatotoxicity compared to tacrine, with addnl. neuroprotective activity against H2O2-induced damage in SH-SY5Y cells. The advantages including synthetic accessibility, high potency, low toxicity, and adjunctive neuroprotective activity make compound II a new promising multifunctional candidate for the treatment of Alzheimer’s disease.

ACS Omega published new progress about Alzheimer disease. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary