Month: October 2022

Shen, Yanling; Lei, Ning; Lu, Cong; Xi, Dailin; Geng, Xinxin; Tao, Pan; Su, Zhishan; Zheng, Ke published the artcile< Construction of sterically congested oxindole derivatives via visible-light-induced radical-coupling>, Related Products of 401-78-5, the main research area is oxindole preparation antitumor photochem; alkene enyne oxindole radical coupling reaction.

A visible-light-induced modular methodol. for the synthesis of complex 3,3′-disubstituted oxindole derivatives, e.g. I, is reported. A library of valuable fluoroalkyl-containing highly sterically congested oxindole derivatives can be synthesized by a catalytic three-component radical coupling reaction under mild conditions (metal and photocatalyst free, >80 examples). This strategy shows high functional group tolerance and broad substrate compatibility. Substrates include a wide variety of terminal or non-terminal alkenes, conjugated dienes (e.g. prop-1-en-2-ylbenzene), and enynes RC(:CH2)CCR1 (R = Me, Ph, R1 = H, Ph, cyclopropyl, 3-chloropropyl), and a broad array of polyfluoroalkyl iodide and oxindoles II (R2 = 7-Cl, 5-Br, 4,6-F2, etc., R3 = Ph, 5-methylthiophen-2-yl, 6-methoxynaphthalen-1-yl, etc.), which enables modular modification of complex drug-like compounds in one chem. step. The success of solar-driven transformation, large-scale synthesis, and the late-stage functionalization of bioactive mols., as well as promising tumor-suppressing biol. activities, highlights the potential for practical applications of this strategy. Mechanistic investigations, including a series of control experiments, UV-vis spectroscopy and DFT calculations, suggest that the reaction underwent a sequential two-step radical-coupling process and the photosensitive perfluoroalkyl benzyl iodides are key intermediates in the transformation.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Related Products of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Pinyi; Jia, Xiuwen; Ma, Xiaoli; Ma, Wenbo; Sheng, Yilin; Zhao, Jingwei; Zhao, Fei published the artcile< A Catalyst-Free Cascade Reaction for the Selective Assembly of 3-Hydroxyisoindolinones on Water>, Related Products of 3959-07-7, the main research area is hydroxyisoindolinone green preparation; alkynylbenzoic acid nitrogen nucleophile cascade.

A catalyst- and additive-free cascade reaction between 2-alkynylbenzoic acids and nitrogen-containing nucleophiles for the selective assembly of 3-hydroxyisoindolinones I [R1 = H, 4-Me, 6-F, etc.; R2 = H, n-Bu, Ph, etc.; R3 = n-Bu, Ph, Bn, etc.] under water was developed. This protocol featured readily available starting materials, an environmentally benign solvent, simple operation, extraordinarily broad substrate scope, good functional group tolerance, excellent selectivity, good to excellent yields, high atom- and step-economy, and high bond-forming efficiency, thus provided a convenient and highly efficient access to 3-hydroxyisoindolinones I.

Asian Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schmidt, Jurema; Rotter, Marco; Weiser, Tim; Wittmann, Sandra; Weizel, Lilia; Kaiser, Astrid; Heering, Jan; Goebel, Tamara; Angioni, Carlo; Wurglics, Mario; Paulke, Alexander; Geisslinger, Gerd; Kahnt, Astrid; Steinhilber, Dieter; Proschak, Ewgenij; Merk, Daniel published the artcile< A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis>, Application of C9H8BrFO2, the main research area is benzylbenzamide dual modulator analog preparation nonalcoholic steatohepatitis; dual modulator analog FXR sEH benzylbenzamide analog pharmacokinetics.

Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health burden with alarming incidence, but there is no satisfying pharmacol. therapy to date. Considering the disease’s multifactorial nature, modulation of multiple targets might provide superior therapeutic efficacy. In particular, farnesoid X receptor (FXR) activation that revealed antisteatotic and antifibrotic effects in clin. trials combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy promises synergies. To exploit this dual concept, we developed agents exerting partial FXR agonism and sEH inhibitory activity. Merging known pharmacophores and systematic exploration of the structure-activity relationship on both targets produced dual modulators with low nanomolar potency. Extensive in vitro characterization confirmed high dual efficacy in cellular context combined with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics as well as engagement on both targets in vivo.

Journal of Medicinal Chemistry published new progress about Antifibrotic agents. 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Application of C9H8BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ariano, R. published the artcile< Determining the proportion of cement in finished concrete>, COA of Formula: C8H3BrO3, the main research area is .

The methods of Kriege (cf. C. A. 25, 4680) and Florentin (cf. C. A. 21, 3440) consist in solubilizing the SiO2 of the cement (which is present as Ca silicates) by treating with HCl and then determining it by the usual methods. In Scheibe’s method (cf. C. A. 29, 8273.5) the coarse aggregate is eliminated, the residue (sand and cement) is pulverized and the portions soluble and insoluble in HCl are determined after calcination; it is assumed arbitrarily that the sum of the loss on ignition and the insoluble matter in the cement = 3%. It is then easy to calculate the amount of cement. None of these methods gives reliable results, and the same is true of indirect methods based only on the finished concrete and on samples of the sand and gravel entering into its composition There always remains a certain degree of uncertainty if the complete composition of the cement and the loss on ignition are not known. It should be noted that in all cases where the concrete itself is analyzed, the results give the composition of the finished concrete, and not that of the original mix. For the water also, it is possible to establish only the quantity which is actually combined in the concrete.

Ricerche studi ist. sper. stradale published new progress about Cement. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, COA of Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Wei-Wei; Zhang, Chi; Ye, Ji-Jie; Liu, Zi-Kun; Chen, Kai; Wu, Chuan-De published the artcile< Suspending Ion Electrocatalysts in Charged Metal-Organic Frameworks to Improve the Conductivity and Selectivity in Electroorganic Synthesis>, Recommanded Product: 4-Bromobenzylamine, the main research area is suspended ion electrochem oxidation catalyst metal organic framework dehydrogenation; conductivity; electrocatalysis; electroselectivity; metal-organic frameworks; suspended ion catalysts.

Electroorg. synthesis is an environmentally friendly alternative to traditional synthetic methods; however, the application of this strategy is heavily hindered by low product selectivity. Metal-organic frameworks (MOFs) exhibit high selectivity in numerous catalytic reactions; however, poor conductivity heavily limits the application of MOFs in electroorg. synthesis. To realize the electrocatalytic application of MOFs in selective electroorg. synthesis, a practically applicable strategy by suspending ion electrocatalysts in charged MOFs is herein reported. This approach could markedly improve the product selectivity in electroorg. synthesis. In the electrocatalytic oxidative self-coupling of benzylamine experiments, the imine product selectivity is markedly improved from 61.3 to 94.9 %, when the MOF-based electrocatalyst is used instead of the corresponding homogeneous electrocatalyst under the identical conditions. Therefore, this work opens a new route to improve the product selectivity in electroorg. synthesis.

Chemistry – An Asian Journal published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Qin; Li, Jin; Tu, Xianjun; Liu, Hongbo; Shu, Miao; Si, Rui; Ferguson, Calum T. J.; Zhang, Kai. A. I.; Li, Run published the artcile< Single Atomically Anchored Cobalt on Carbon Quantum Dots as Efficient Photocatalysts for Visible Light-Promoted Oxidation Reactions>, Product Details of C7H8BrN, the main research area is single atom cobalt carbon quantum dot photocatalyst coupling amine.

Generation of efficient light-induced charge separation inside the photocatalyst is an essential factor for a high catalytic efficiency. The usual immobilization of metal or metal oxide particles on semiconductor photocatalysts offers an uncontrolled assembly of active sites during the reaction. The introduction of single metal atoms on photocatalysts can lead to extremely high at. utilization and precise active sites. However, this approach is limited because of the lack of suitable photosensitizers for single atom immobilization. Here, we have designed photocatalytic carbon quantum dots with anchoring sites for single cobalt atoms in a defined Co-N4 structure via facile pyrolysis of vitamin B12. Carbon dots functioned as both light-harvesting antenna and support for the cobalt atom with high atom loadings up to 3.27 wt %. This new photocatalytic material demonstrated enhanced visible light absorption, efficient charge separation, and reduced electrochem. impedance, while single Co atoms acted as the active site with strong oxidative ability. As a result, the photocatalysts showed excellent visible light-promoted photocatalytic efficiency with oxygen evolution rates up to 168μmol h-1 g-1 via water oxidation, imine formation with high conversion (∼90%) and selectivity (>99%), and complete photodegradation of organic dyes.

Chemistry of Materials published new progress about Aromatic amines Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koishi, Hideo published the artcile< A critical examination of Folin's method for determination of creatinine concentration in the urine>, Formula: C8H3BrO3, the main research area is .

A critical examination of Folin’s method (CA 8,2735) showed that the intensity of the color is sensitive to temperature with an increase in values of 0.5 to 1.1% per degree within 10 to 30 °.

Osaka City Medical Journal published new progress about Esters. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fouque, Amelie; Delalande, Olivier; Jean, Mickael; Castellano, Remy; Josselin, Emmanuelle; Malleter, Marine; Shoji, Kenji F.; Hung, Mac Dinh; Rampanarivo, Hariniaina; Collette, Yves; Weghe, Pierre van de; Legembre, Patrick published the artcile< A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells>, Electric Literature of 3893-18-3, the main research area is covalent mTOR inhibitor DHM25 antitumor breast cancer.

Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers. From a chromene backbone reported to inhibit class I PI3K catalytic subunits, several rounds of chem. syntheses led to the generation of a new collection of chromologues that showed enhanced ability to kill PI3K-addicted cancer cells and to inhibit Akt phosphorylation at serine 473, a hallmark of PI3K/mTOR activation. This initial screen uncovered a chromene designated DHM25 that exerted potent antitumor activity against breast tumor cell lines. Strikingly, DHM25 was shown to be a selective and covalent inhibitor of mTOR using biochem. and cellular analyses, modeling, and a large panel of kinase activity assays spanning the human kinome (243 kinases). Finally, in vivo, this novel drug was an efficient inhibitor of growth and metastasis of triple-neg. breast cancer cells, paving the way for its clin. application in oncol.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sinai, Adam; Simko, Daniel Cs.; Szabo, Fruzsina; Paczal, Attila; Gati, Tamas; Benyei, Attila; Novak, Zoltan; Kotschy, Andras published the artcile< Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is aryl diadamantyl phosphine ligand palladium catalyst preparation coupling; Buchwald Hartwig tosyl hydrazone coupling.

Synthesis, temperature-dependent NMR structure study and use of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In the authors’ study, the authors demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

European Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Domaradzki, Maciej E.; Liu, Xiaochen; Ong, Jiye; Yu, Gyeongah; Zhang, Gan; Simantov, Ariel; Perl, Eliyahu; Chen, Yu published the artcile< Triflic acid mediated sequential cyclization of ortho-alkynylarylesters with ammonium acetate>, Quality Control of 17100-65-1, the main research area is isoquinolinone isochromenone preparation; alkynylarylester intramol cyclization triflic acid ammonium acetate.

A triflic acid (TfOH) mediated sequential cyclization of ortho-alkynylarylesters and ammonium acetate (NH4OAc) was reported. The reaction took place via a Bronsted acid-mediated intramol. cyclization of ortho-alkynylarylesters followed by an ammonium acetate participated substitution reaction, forming isoquinolin-1-ones as the major products. Different from most of the known synthetic methods of isoquinolin-1-ones, no metal catalyst was required in the reported reaction. The regioisomers – isoindolin-1-ones were obtained together with isoquinolin-1-ones in a few cases. The intermediate compounds – isochromen-1-ones and isobenzofuran-1-ones were also isolated. The interconversion experiments showed that the regioisomers formed during the Bronsted acid induced intramol. cyclization of ortho-alkynylarylesters. A natural product – ruprechstyril was prepared in a moderate yield employing the new method.

Tetrahedron published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation) (isochromenones). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary