Month: October 2022

In 2019,Acta Crystallographica, Section E: Crystallographic Communications included an article by Anitha, Azhagan Ganapathi; Arunagiri, Chidambaram; Subashini, Annamalai. Category: bromides-buliding-blocks. The article was titled 《Synthesis, X-ray crystal structure, Hirshfeld surface analysis and DFT studies of (E)-N’-(2-bromobenzylidene)-4-methylbenzohydrazide》. The information in the text is summarized as follows:

The title mol., C15H13BrN2O, displays a trans configuration with respect to the C=N double bond. The dihedral angle between the bromo- and methyl-substituted benzene rings is 16.1 (3)°. In the crystal, mols. are connected by N-H·-O and weak C-H-O hydrogen bonds, forming R21(6) ring motifs and generating chains along the a-axis direction. The optimized structure generated theor. via d. functional theory (DFT) using standard B3LYP functional and 6-311 G(d,p) basis-set calculations renders good support to the exptl. data. The HOMO-LUMO behavior was elucidated to determine the energy gap. The intermol. interactions were quantified and analyzed using Hirshfeld surface anal. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Category: bromides-buliding-blocks)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Category: bromides-buliding-blocksSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Enzyme activity of thiophene-fluorene based-copolymer blended with urease in thin films》 was published in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2020. These research results belong to Rodrigues, Rebeca da Rocha; de Aquino, Tamires Pedrali; Caseli, Luciano; Peres, Laura Oliveira. Name: 2,5-Dibromothiophene The article mentions the following:

Enzyme activity can be boosted if the mol. architecture of films is manipulated. In this paper, we show an alternative way to immobilize the enzyme urease in a matrix composed of the copolymer poly[(9,9-dioctylfluorene)-co-thiophene] by using the spin coating method. The films were characterized with Fluorescence, UV-vis, and IR spectroscopies, confirming not only the adsorption of the enzyme, but also the maintenance of its secondary structure. Enzyme activity of the blended films was evaluated in terms of hydrolysis of urea as a heterogeneous catalyst. As measured with UV-vis spectroscopy, the blended films presented substrate-enzyme affinity in relation to the Langmuir-Blodgett method, which may be important for the production of enzymic sensors with enhanced performance. This increase was related to the configurational disorder in the copolymer/enzyme blend with their chains being intertwined, facilitating the access of urea to the catalytic site of the enzyme. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromothiophene(cas: 3141-27-3Name: 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Name: 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wan, Pui-Ki; Tong, Ka-Chung; Lok, Chun-Nam; Zhang, Chunlei; Chang, Xiao-Yong; Sze, Kong-Hung; Tsai Wong, Alice Sze; Che, Chi-Ming published an article in 2021. The article was titled 《Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth》, and you may find the article in Proceedings of the National Academy of Sciences of the United States of America.Electric Literature of C13H17BrO9 The information in the text is summarized as follows:

Platinum cationic arylbipyridine cyclometalated NHC complexes, substituted with hydroxyalkyl and carbohydrate groups, were prepared as antitumor agents effective against metastatic and cisplatin-resistant cancers. Vimentin is a cytoskeletal intermediate filament protein that plays pivotal roles in tumor initiation, progression, and metastasis, and its overexpression in aggressive cancers predicted poor prognosis. Herein described is a highly effective antitumor and antimetastatic metal complex [Pt(C-N-N)(NHC)][PF6] (1a; HC-N-N = 6-phenyl-2,2′-bipyridine; NHC = 1,3-dibutyl-2-imidazolylidene) that engages vimentin via noncovalent binding interactions with a distinct orthogonal structural scaffold. The complex 1a displays vimentin-binding affinity with a dissociation constant of 1.06μM from surface plasmon resonance measurements and fits into a pocket between the coiled coils of the rod domain of vimentin with multiple hydrophobic interactions. It engages vimentin in cellulo, disrupts vimentin cytoskeleton, reduces vimentin expression in tumors, suppresses xenograft growth and metastasis in different mouse models, and is well tolerated, attributable to biotransformation to less toxic and renal-clearable platinum(II) species. Our studies uncovered the practical therapeutic potential of platinum(II)-NHC complexes as effective targeted chemotherapy for combating metastatic and cisplatin-resistant cancers.(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Electric Literature of C13H17BrO9) was used in this study.

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Electric Literature of C13H17BrO9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Conjugation-extended viologens with thiophene derivative bridges: near-infrared electrochromism, electrofluorochromism, and smart window applications》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020. These research results belong to Chang, Meijuan; Chen, Weinan; Xue, Haodong; Liang, Dingli; Lu, Xuefeng; Zhou, Gang. Recommanded Product: 2,5-Dibromothiophene The article mentions the following:

Two types of thiophene derivatives, i.e., thiophene (T) and 3,4-ethylenedioxylthiophene (ET) with a single thiophene ring, and thieno[3,2-b]thiophene (TT) and 2,2′-bithiophene (BT) with double thiophene rings, have been inserted between the two pyridinium units of an octyl viologen (V). The effective conjugation lengths of the resulting thienoviologens TV, ETV, TTV, and BTV have been successfully extended. Unlike a traditional alkyl viologen, which always serves as a fluorescence quencher, all four thienoviologens exhibit intense photoluminescence (PL). The bathochromic shifts in both absorption and PL spectra are more pronounced in TTV and BTV with double thiophene rings as compared with TV and ETV with a single thiophene bridge. Moreover, upon applying a neg. potential, all four thienoviologens display significant changes in both absorption and PL spectra, indicating their electrochromic (EC) and electrofluorochromic (EFC) properties. Addnl., the EC response can be found not only in the visible but also in the near-IR (NIR) region. Although TTV and BTV with longer conjugated bridges exhibit more extended effective conjugation lengths and higher PL quantum yields, the EC and EFC devices based on TV and ETV gels display better performance than that for TTV and BTV owing to the faster charge and mass transport for smaller mols. Consequently, a better comprehensive property is achieved by the ETV-based gel, which demonstrates fast coloration (1.9 s), high color contrast (87%), and high coloration efficiency (521 cm2 C-1) in the EC device with high fluorescence contrast ratio (Ion/Ioff = 221) in the EFC device. Furthermore, two smart windows have been fabricated to utilize their different driving potentials. Upon increasing the potential, the “”window flower”” in the first device blossoms out with gradually changing petal colors, while the other dual-functional smart window can be adjusted between flower decoration and light blocking functions. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Recommanded Product: 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Recommanded Product: 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Dinker, Manish Kumar; Zhao, Kan; Liu, Song; Qi, Shi-Chao; Li, Yu-Xia; Liu, Gong-Ping; Ding, Lifeng; Liu, Xiao-Qin; Sun, Lin-Bing published an article in Journal of Materials Chemistry A: Materials for Energy and Sustainability. The title of the article was 《Permanent cavities in ionic liquids created by metal-organic polyhedra》.Recommanded Product: 626-40-4 The author mentioned the following in the article:

As an emerging type of material, porous liquids combine the fluidity of liquids with the permanent porosity of porous solids, which makes them promising for various applications. Despite several significant attempts earlier, the porous liquid system still requires the novel entries of porous hosts and bulky liquids Here, we report a new porous liquid system based on the coalition of metal-organic polyhedra and well-designed bulky ionic liquids As a proof of concept, the typical metal-organic polyhedra, Pd12L24 where L represents the ligands, are employed as porous hosts. Also, a polyethylene glycol-linked bis-imidazolium-based bulky ionic liquid with a mol. size larger than the pore aperture of Pd12L24 is designed as a solvent, yielding type II porous ionic liquids These liquid materials possessing permanent cavities, good thermal stability and long-term durability have captured high CO2 compared to neat ionic liquids Besides, they are found separating CO2 from N2 and CH4 mols. not only as an entity but also as supported porous liquid membranes. We expect that the present strategy can be used to construct other porous liquids with specific functionality for addnl. applications.3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenylOn September 30, 2006 ,《Synthesis and characterization of shape persistent polyphenylene dendrimers》 was published in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry). The article was written by Brown, Gemma L.; Gardiner, John M.; D’Emanuele, Antony; Attwood, David; Gibb, Ryan. The article contains the following contents:

Dendrimers are a class of polymeric macromol. that are unique in that they have well defined, globular structures with high symmetry and low polydispersity. There has been recent interest in the synthesis of polyphenylene dendrimers due to their well defined, shape persistent architectures. In this study we have synthesized G0 and G1 polyphenylene dendrimers with shape persistent cores via a series of Suzuki cross coupling reactions and conversion of aryl bromides to boronic acid derivatives The dendrimers have been characterized by 1H and 13C NMR spectroscopy, mass spectrometry and elemental analyses. A crystal structure of the G0 methoxy-terminated dendrimer was obtained. We are currently using mol. modeling to investigate dendrimer topol. In conclusion a new set of rigid dendrimers with triphenylbenzene cores were successfully synthesized in high yields. In order to investigate a variety of topologies different cores are being synthesized, for example tetraphenylmethane and hexaphenylbenzene. The experimental process involved the reaction of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8Safety of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl)

3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl(cas: 29102-67-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Safety of 3,3”,5,5”-Tetrabromo-5′-(3,5-dibromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Original synthesis and spectroscopic study of thiophene triazine derivatives with enhanced luminescence properties》 was written by Rodrigues, Alysson Duarte; Marcotte, Nathalie; Quignard, Francoise; Deabate, Stefano; Robitzer, Mike; Lerner, Dan A.. Synthetic Route of C4H2Br2SThis research focused onthiophene triazine preparation arylation palladium catalyst fluorescence quantum yield; Fluorescence; Fluorescent label; Oligothiophene; Palladium catalyzed C–H arylation; Thiophene; Triazine. The article conveys some information:

A straightforward access to π-conjugated oligothiophenes bearing amino-rich groups was developed. Palladium-catalyzed C-H arylation applied in the main step of the synthesis allowed to couple 2-thiophenecarbonitriles and aryl bromides with moderate to excellent yields (35-93%). Then, to improve their basic fluorescence properties, these compounds were transformed into their 2,4-diamino-1,3,5-triazine derivatives, also with good to excellent yields (74-98%). UV-Visible absorption and fluorescence studies identified a strongly emissive mol. (fluorescence quantum yield: ΦF = 0.78 ± 0.05), which could find use in sensors for applications in biol. and in material chem. We observed an antagonistic effect in the spectroscopic properties of oligothiophenes bearing 2,4-diamino-1,3,5-triazine, resulting in improved absorptive and emissive properties for more constrained structures having shorter oligothiophenes chains. After reading the article, we found that the author used 2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Solvent mediated thermodynamically favorable helical supramolecular self-assembly: recognition behavior towards achiral and chiral analytes》 was written by Kataria, Meenal; Kim, Youngseo; Chau, Hong Diem; Kwon, Na Yeon; Hong, Yongju; Kim, Taekyung; Ko, Jaewan; Son, Myung Kook; Bang, Joona; Park, Sungnam; Kim, Hugh I.; Lee, Kwangyeol; Choi, Dong Hoon. HPLC of Formula: 4316-58-9This research focused ontriphenylamine urea preparation mol recognition self assembly. The article conveys some information:

Herein, we successfully developed an entropically favored helical supramol. self-assembly from a triphenylamine-based derivative 4 in a green solvent in order to mimic the structural transformations that occur during the self-assembly of proteins/peptides which may cause various neurodegenerative diseases. Its structural transformation from helical supramol. self-assembly to a random coil and then achiral nanorods was studied by varying the concentration of achiral stimuli (i.e., Fe2+ ions). The driving force of this transformation is the strong binding affinity of chiral supramol. assemblies and Fe2+ ions. Furthermore, the “”metal-free”” helical supramol. self-assembly exhibited enantioselectivity for differentiating between L- and D-proline; this was achieved through a chiral stimuli-induced structural modulation methodol. Our evaluation of the effects of achiral/chiral stimuli is also novel. The results came from multiple reactions, including the reaction of Tris(4-bromophenyl)amine(cas: 4316-58-9HPLC of Formula: 4316-58-9)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)HPLC of Formula: 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and mesomorphic properties of laterally fluorinated alkyl 4”-alkylterphenyl-4-yl carbonate liquid crystals》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2014. These research results belong to Choluj, Artur; Kula, Przemyslaw; Dabrowski, Roman; Tykarska, Marzena; Jaroszewicz, Leszek. Reference of 1-Bromo-4-ethoxy-2-fluorobenzene The article mentions the following:

Fifteen series of homologues of a variety of mono-, di- and trifluorosubstituted alkyl 4”-alkylterphenyl-4-yl carbonates have been synthesized and their mesomorphic properties have been determined From among 95 prepared compounds, 40 pure nematogens have been found, as well as 55 mesogens with orthogonal and tilted smectic phases in broad temperature ranges. The type and combination of the LC phase strongly depend on the position and number of the fluorine atoms. Phys. properties and correlations between the mol. core fluorosubstitution, the length of the terminal chains and the type and sequence of the liquid crystalline phases, have been determined The compounds are useful for the formulation of nematic mixtures as well as ferroelec. ones. After reading the article, we found that the author used 1-Bromo-4-ethoxy-2-fluorobenzene(cas: 107713-66-6Reference of 1-Bromo-4-ethoxy-2-fluorobenzene)

1-Bromo-4-ethoxy-2-fluorobenzene(cas: 107713-66-6) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 1-Bromo-4-ethoxy-2-fluorobenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The liquid crystal Click procedure for oligothiophene-tethered phthalocyanines – self-assembly, alignment and photocurrent》 was written by Dechant, Moritz; Lehmann, Matthias; Uzurano, Genya; Fujii, Akihiko; Ozaki, Masanori. Synthetic Route of C9H11BrO3This research focused onzinc phthalocyanine oligothiophene tether preparation photocurrent property; fluorescence thermotropic liquid crystal zinc phthalocyanine oligothiophene tether. The article conveys some information:

A series of star-shaped liquid crystals (LCs) with a phthalocyanine donor core, oligothiophene antennae and fullerene acceptors have been successfully prepared This hierarchical self-assembly results in a nanosegregated helical donor-acceptor-antennae LC-system promoted by the recently discovered Click procedure. This model system reveals all photophys. prerequisites for energy conversion, charge generation and transport. Uniform amorphous thin films of 150 nm could be produced by bar-coating. Annealing did not only induce the formation of columns via the Click procedure but also partially homeotropically aligned the non-clearing sample in a sandwich geometry (ITO and Ag/MoO3). This has been confirmed by microscopic studies and the measurement of photocurrent, which increased by a factor of 300 after the annealing step. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Synthetic Route of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Synthetic Route of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary