Month: October 2022

Stull, Savannah M.; Mei, Liangyong; Gianetti, Thomas L. published the artcile< Red-Light-Induced N,N'-Dipropyl-1,13-dimethoxyquinacridinium-Catalyzed [3+2] Cycloaddition of Cyclopropylamines with Alkenes or Alkynes>, Formula: C7H4BrF3, the main research area is cyclopropylamine alkene dipropyl dimethoxyquinacridinium catalyst photochem diastereoselective cycloaddition; cyclopentanamine preparation; alkyne cyclopropylamine dipropyl dimethoxyquinacridinium photochem diastereoselective cycloaddition; cyclopentenamine preparation.

A red-light-mediated [3+2] annulation of cyclopropylamines with akenes or alkynes in the presence of N, N’-dipropyl-1,13-dimethoxyquinacridinium was reported. An array of cyclopentane or cyclopentene derivatives with diverse functional groups were obtained in moderate to excellent yields under mild conditions.

Synlett published new progress about [3+2] Cycloaddition reaction catalysts (stereoselective, photochem.). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Formula: C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shan, Chao; Cao, Liming; Yang, Jiasheng; Cheng, Ruihua; Yao, Xiantong; Liang, Chaoming; Sun, Maolin; Ye, Jinxing published the artcile< Construction of an α-chiral pyrrolidine library with a rapid and scalable continuous flow protocol>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is chloro tert butanesulfinyl imine grignard reagent continuous flow heterocyclization; tert butylsulfinyl pyrrolidine preparation enantioselective diastereoselective.

An α-chiral pyrrolidine library was established via a highly diastereoselective continuous flow protocol under mild conditions. Various functionalized pyrrolidines was obtained in generally high yields (up to 87%) and with superior diastereocontrol within 150 s. The utility of this flow methodol. was further demonstrated by the gram-scale preparation of a κ-opioid receptor selective antagonist Aticaprant intermediate. Moreover, the scale-up in a self-designed microfluidic reactor provided a throughput of 7.45 g h-1, suggesting its potential large-scale applications. The flow procedure afforded rapid, cost-efficient and scalable access to obtain chiral α-substituted pyrrolidines in the compound library.

Reaction Chemistry & Engineering published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Lei; Zhang, Wangqin; Xu, Chao; He, Jiaying; Xu, Zhenhui; Yang, Zehui; Ling, Fei; Zhong, Weihui published the artcile< Electrosynthesis of CF3-Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene>, HPLC of Formula: 20776-50-5, the main research area is alkenyl quinazolinone sodium triflinate electrochem tandem trifluoromethylation cyclization; trifluoroethyl fused quinazolinone preparation.

An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkenes with Langlois reagent as a CF3 source was described. A variety of polycyclic quinazolinones were successfully synthesized in 52-81% yields under transition metal- and oxidant-free conditions. The Langlois reagent used in this strategy as a CF3 reagent possessed the advantages of bench-stablity, cost-effectivity and high-efficiency. Addnl., gram-scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol.

Advanced Synthesis & Catalysis published new progress about Electrochemical cyclization. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, HPLC of Formula: 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bhaumik, Asish; Eswaraiah, M. Chinna; Chakraborty, Raja published the artcile< Evaluation of antimicrobial profile of some novel 1, 3, 4-oxadiazole derivatives followed by molecular docking against 3G7E bacterial DNA gyrase>, Electric Literature of 16426-64-5, the main research area is oxadiazole derivative preparation mol docking 3G7E bacterial DNA gyrase; physicochem property antibacterial antifungal oxadiazole derivative preparation.

Design, synthesis, spectral characterization and evaluation of in vitro antimicrobial profile of some novel oxadiazole derivatives I [R = 4-NH2, 2-Br, 4-NO2, etc.] followed by mol. docking studies against bacterial DNA gyrase. The mol. structures of the synthesized compounds were assigned by IR, NMR and mass spectral anal. Mol. docking studies were carried out by AUTO DOCK program. The in vitro antibacterial and antifungal activities of compounds I were done by paper disk diffusion and agar streak dilution technique. In silico mol. docking studies the binding energy of synthesized compounds I were found to be -7.66, -7.67, -7.12, – 7.12, -6.59, -6.46, -7.35, -5.09 which indicated that the compounds had the high binding affinity toward the bacterial DNA gyrase with PDB id 3G7E and inhibit the function topoisomerase in comparison with standard drug ciprofloxacin (-7.44). The preliminary antimicrobial screening displayed that most of the synthesized compounds I were executed moderate to good antimicrobial activity against following bacteria: S. aureus (ATCC 9144), B. subtilis (ATCC 6633), S. epidermidis (ATCC 12228), P. Aeruginosa (ATCC27853), E.coli (ATCC25922), V. cholerrae (ATCC14035) and fungi: A. Niger (ATCC 9029), A.flavus (ATCC204304), C. albicans (ATCC10231) and B. dermatitis (ATCC 26199) etc. All the synthesized compounds I exhibited moderate to good antibacterial and antifungal activity with an MIC range of 12-37μg/mL. Among these eight synthesized oxadiazole derivatives, compound I [R = 4-NH2, 2,4-Cl2, 3,5-(NO2)2] were found to be very good antibacterial as well as antifungal potentiality with an MIC range of 13-12μg/mL; 7-10μg/mL and 15-18μg/mL.

Journal of Drug Delivery and Therapeutics published new progress about Acids Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Electric Literature of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gugulothu, Venkanna; Ahemed, Jakeer; Subburu, Mahesh; Yadagiri, Bhongiri; Mittal, Ritu; Prabhakar, Chetti; Pola, Someshwar published the artcile< Evolution of physical and photocatalytic properties of new Zn(II) and Ru(II) complexes>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is zinc ruthenium macrocyclic Schiff base complex preparation photocatalytic activity; methylstyrene carbon hydrogen bond activation zinc ruthenium macrocyclic Schiff; aromatic hydrocarbon photooxidation zinc ruthenium macrocyclic Schiff base catalyzed.

Synthesis of Zn(II) and Ru(II) complexes were reported by using N4-macrocyclic Schiff base ligands under solvothermal conditions. The newly synthesized Zn(II) and Ru(II) complexes have been characterized by various physico-chem. techniques such as elemental anal., molar conductance, HRMS, TGA, FESEM, UV-Vis, FT-IR, 1H NMR, and cyclic voltammetry. By using molar conductance studies, the complexes are formulated as [Zn(TPTTP)]Cl2 and [Ru(TPTTP)Cl2]. C-H bond activation of an sp3 group of methylstyrenes (converted into cinnamaldehydes) and C-H bond activation of the sp2 bond of polycyclic aromatic hydrocarbons through photooxidation was examined in the presence of Zn(II) and Ru(II) complexes. Reusable activity studies and photostability of catalyst are investigated by using UV-Vis spectra. Based on the results, higher catalytic activity of [Ru(TPTTP)Cl2] complex than [Zn(TPTTP)]Cl2 complex in both C-H bond activation and photooxidation of aromatic hydrocarbons has been reported.

Polyhedron published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (cinnamaldehydes). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Amano, Katsushi; Leung, Patrick S. C.; Rieger, Roman; Quan, Chao; Wang, Xiaobing; Marik, Jan; Suen, Yat Fan; Kurth, Mark J.; Nantz, Michael H.; Ansari, Aftab A.; Lam, Kit S.; Zeniya, Mikio; Matsuura, Eiji; Coppel, Ross L.; Gershwin, M. Eric published the artcile< Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis: Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid>, HPLC of Formula: 16426-64-5, the main research area is xenobiotic mitochondria autoantigen primary biliary cirrhosis antibody.

Emerging evidence has suggested environmental factors as causative agents in the pathogenesis of primary biliary cirrhosis (PBC). The authors have hypothesized that in PBC the lipoyl domain of the immunodominant E2 component of pyruvate dehydrogenase (PDC-E2) is replaced by a chem. xenobiotic mimic, which is sufficient to break self-tolerance. To address this hypothesis, based upon the quant. structure-activity relationship data, a total of 107 potential xenobiotic mimics were coupled to the lysine residue of the immunodominant 15 amino acid peptide of the PDC-E2 inner lipoyl domain and spotted on microarray slides. Sera from patients with PBC (n = 47), primary sclerosing cholangitis (n = 15), and healthy volunteers (n = 20) were assayed for Ig reactivity. PBC sera were subsequently absorbed with native lipoylated PDC-E2 peptide or a xenobiotically modified PDC-E2 peptide, and the remaining reactivity analyzed. Of the 107 xenobiotics, 33 had a significantly higher IgG reactivity against PBC sera compared with control sera. In addition, 9 of those 33 compounds were more reactive than the native lipoylated peptide. Following absorption, 8 of the 9 compounds demonstrated cross-reactivity with lipoic acid. One compound, 2-octynoic acid, was unique in both its quant. structure-activity relationship anal. and reactivity. PBC patient sera demonstrated high Ig reactivity against 2-octynoic acid-PDC-E2 peptide. Not only does 2-octynoic acid have the potential to modify PDC-E2 in vivo but importantly it was/is widely used in the environment including perfumes, lipstick, and many common food flavorings.

Journal of Immunology published new progress about Autoantibodies Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, HPLC of Formula: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Binder, Jorg T.; Cordier, Christopher J.; Fu, Gregory C. published the artcile< Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents>, Reference of 405931-46-6, the main research area is secondary benzylic bromide cycloalkylzinc reagent nickel catalyzed Negishi coupling; chiral isoquinoline oxazoline ligand stereoselective Negishi coupling; acyclic alkylzinc reagent Negishi cross coupling isomerization.

The authors have developed a nickel-catalyzed method for the asym. cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline-oxazoline ligand I furnishes excellent ee’s and good yields. Ent-I is also used to provide products of opposite configuration with excellent ee’s and good yields. The use of acyclic alkylzinc reagents as coupling partners led to the discovery of a highly unusual isomerization that generates a significant quantity of a branched cross-coupling product from an unbranched nucleophile.

Journal of the American Chemical Society published new progress about Aralkyl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (secondary). 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Reference of 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary