October 2022 - Page 321 of 343 - Bromides-buliding-blocks

Huang, Shuaishuai’s team published research in Youji Huaxue in 2020 | 401-78-5

Youji Huaxue published new progress about Alkyl aryl ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Electric Literature of 401-78-5.

Huang, Shuaishuai; Nie, Yixue; Yang, Jingjing; Zheng, Zhanjiang; Cao, Jian; Xu, Zheng; Xu, Liwen published the artcile< Copper-catalyzed arylated etherification of 2,2-difluoroethanol and its mechanistic study>, Electric Literature of 401-78-5, the main research area is haloarene difluoroethanol copper catalyst Ullmann type arylated etherification; difluoroethoxy arene preparation.

A mild and efficient method for the preparation of difluoroethyl aryl ethers was developed by the copper-catalyzed Ullmann-type arylated etherification reaction of aryl bromides or iodides with 2,2-difluoroethanol. This reaction proceeded smoothly in the presence of CuI and 8-hydroxyquinoline/t-BuOK and has a broad substrate scope. ESI-MS anal. supported the existence of LCu(III)Ar(OR) species during this catalytic reaction. Further d. functional theory (DFT) calculations suggested a proposed mechanism of arylated etherification reaction involving oxidative addition, followed by nucleophile substitution and reductive elimination would be rational.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Bryan’s team published research in Journal of Organic Chemistry in 2013-02-01 | 6942-39-8

Journal of Organic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.

Li, Bryan; Samp, Lacey; Sagal, John; Hayward, Cheryl M.; Yang, Christine; Zhang, Zhijun published the artcile< Synthesis of Quinazolin-4(3H)-ones via Amidine N-Arylation>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is trifluoromethyliodonicotinic acid amidine palladium catalyst arylation; pyridopyrimidinone preparation; amindine halobenzoate palladium catalyst arylation; quinazolinone preparation.

Pyrido[4,3-d]pyrimidin-4(3H)-one was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid with amidine I catalyzed by Pd2(dba)3 and Xantphos, followed by cyclization effected with HBTU and subsequent demethylation using PhBCl2. The amidine arylation method was found applicable for the syntheses of quinazolin-4(3H)-ones. Thus, reaction of 2-bromo or 2-iodo benzoate esters with amidines afforded substituted quinazolin-4(3H)-ones, e.g. II, in 44-89% yields.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lafzi, Ferruh’s team published research in Journal of Luminescence in 2019-04-30 | 184239-35-8

Journal of Luminescence published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Formula: C26H18Br2.

Lafzi, Ferruh; Kilic, Haydar; Ertugrul, Berrak; Arik, Mustafa; Saracoglu, Nurullah published the artcile< Bis(indolyl)methane substituted tetraphenylethylene derivatives as AIE active materials>, Formula: C26H18Br2, the main research area is tetraphenylethylene derivative aggregation induced emission.

A series of nonplanar tetraphenylethene (TPE)-bis(indolyl)methane (BIM) conjugates were designed and prepared and characterized by standard spectroscopic techniques. The properties of TPE-BIM derivatives were investigated by UV/Vis and fluorescence spectroscopy, and DFT calculations All of the TPE-BIM showed aggregation-induced emission (AIE) features. However, DFT calculations confirmed the nonplanar structures or propeller structures.

Journal of Luminescence published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Formula: C26H18Br2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oh, Soo-Jin’s team published research in Molecular Pharmacology in 2013-11-30 | 16426-64-5

Molecular Pharmacology published new progress about Anoctamins, Ano1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Quality Control of 16426-64-5.

Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Lee, C. Justin published the artcile< MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1>, Quality Control of 16426-64-5, the main research area is oocyte structure activity relationship plasma membrane; MONNA ANO1 protein blocker anthranilic acid derivative screening Xenopus.

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiol. functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiol. functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established. We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biol. activity and the nature and position of substituents in these derived compounds A structure-activity relationship revealed novel chem. classes of xANO1 blockers. The derivatives contain a -NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC50 < 10 μM. The most potent blocker, N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid (MONNA), had an IC50 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10∼30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacol. dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia. Molecular Pharmacology published new progress about Anoctamins, Ano1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Quality Control of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hao, Huimin’s team published research in Applied Catalysis, B: Environmental in 2019-06-05 | 3959-07-7

Applied Catalysis, B: Environmental published new progress about Attenuated-total-reflectance IR spectra. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Hao, Huimin; Shi, Ji-Long; Xu, Hui; Li, Xia; Lang, Xianjun published the artcile< N-hydroxyphthalimide-TiO2 complex visible light photocatalysis>, COA of Formula: C7H8BrN, the main research area is hydroxyphthalimide titania visible light photocatalysis.

TiO2 is the most established semiconductor photocatalyst. The prominence of TiO2 is becoming increasingly obvious because its interfacial redox reactions have implication on a wide range processes such as energy conversion and environmental remediation. Herein, we exploited the surface complex created by the interaction between organic mols. with binding sites and accommodating surface of TiO2 for visible light-driven selective aerobic oxidation reactions. A novel surface complex formed between N-hydroxyphthalimide (NHPI) and TiO2 was discovered. The NHPI-TiO2 complex turned out to be an outstanding visible light photocatalyst and was successfully used in the selective oxidation of amines into imines with atm. O2 under blue LED irradiation The stability of the NHPI-TiO2 complex was preserved by 3 mol.% of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) acting as a cooperative catalyst. Moreover, selectivities for the imine products were also promoted by TEMPO. Superoxide anion radical (O·2-) were evidenced to be the primary reactive oxygen species (ROS) to execute the oxidative conversions. This work suggests that TiO2 surface complexes can be robust photocatalysts for visible light-driven selective aerobic reactions, provided that an appropriate cooperative redox catalyst exists to channel the photocatalytic electron transfer.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kadu, Vikas D’s team published research in Asian Journal of Organic Chemistry in 2022-08-31 | 3959-07-7

Asian Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Kadu, Vikas D.; Khadul, Siddheshwar P.; Kothe, Gokul J.; Mali, Ganesh A. published the artcile< Rapid One-Pot Aerobic Oxidative N-α-C(sp3)-H Functionalization of Arylmethylamines to Access Tetrasubstituted Imidazoles>, SDS of cas: 3959-07-7, the main research area is tetrasubstituted Imidazole preparation green chem; arylmethylamine one pot aerobic oxidative functionalization copper.

A simple copper catalyzed “”one-pot”” process has been developed for synthesis of polysubstituted imidazoles via direct oxidative N-α-C(sp3)-H functionalization of arylmethylamines. The readily available arylmethylamines as substrates have afforded tetrasubstituted imidazoles products up to 94% yields under mild and environmentally benign conditions. The explored substrates scope with 1,2-diketones and α-hydroxyketones have shown great utility for synthesis of tetrasubstituted imidazoles.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Qian, Yimin’s team published research in Bioorganic & Medicinal Chemistry in 1999-12-31 | 16426-64-5

Bioorganic & Medicinal Chemistry published new progress about Peptidomimetics. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Safety of 2-Bromo-4-nitrobenzoic acid.

Qian, Yimin; Marugan, Juan Jose; Fossum, Renae D.; Vogt, Andreas; Sebti, Said M.; Hamilton, Andrew D. published the artcile< Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors>, Safety of 2-Bromo-4-nitrobenzoic acid, the main research area is methionine CAAX peptidomimetic preparation potent inhibitor farnesyltransferase; structure activity relationship farnesyltransferase inhibitor methionine CAAX peptidomimetic.

The authors report here the design, synthesis and biol. characterization of a series of CAAX (C = cysteine, AA = aromatic amino acid, X = methionine) peptidomimetics as farnesyltransferase inhibitors. For example, peptidomimetics I (R = Ph, 2-thienyl, 1-naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl) are extremely potent towards farnesyltransferase with IC50 values ranging from subnanomolar to low nanomolar concentrations They have a high selectivity for farnesyltransferase over the closely related geranylgeranyltransferase-I. Structure-activity relationship studies demonstrated that a properly positioned hydrophobic group significantly enhanced inhibition potency, reflecting an improved complementarity to the large hydrophobic pocket in the CAAX binding site.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Giles, Robin G F’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1991-06-30 | 135999-16-5

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Cycloaddition reaction. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Product Details of C7H7BrO2.

Giles, Robin G. F.; Sargent, Melvyn V.; Sianipar, Hercules published the artcile< Regioselectivity in the reactions of methoxydehydrobenzenes with furans. Part 1. Reactions of 3-methoxydehydrobenzene and 3-(methoxycarbonyl)dehydrobenzene with 2-substituted furans>, Product Details of C7H7BrO2, the main research area is cycloaddition furan methoxydehydrobenzene regiochem; dehydrobenzene methoxy cycloaddition furan regiochem; ring cleavage dihydroepoxynaphthalene; naphthol alkoxy.

The isomer ratios for the cycloadducts obtained for the reaction of 3-methoxydehydrobenzene, generated from 2-amino-6-methoxybenzoic acid by aprotic diazotization, or from 2,3-BrMeOC6H3OSO2C6H4Me-4 by treatment with BuLi, and for the reaction of 3-(methoxycarbonyl)dehydrobenzene, generated from 2,6-(H2N)(MeO2C)C6H3CO2H by aprotic diazotization, with seven 2-substituted furans were obtained. These results are discussed in terms of an asynchronous, concerted, biradicaloid reaction pathway.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Guanchao’s team published research in ACS Catalysis in 2020-05-15 | 3959-07-7

ACS Catalysis published new progress about Imines Role: FMU (Formation, Unclassified), NUU (Other Use, Unclassified), FORM (Formation, Nonpreparative), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.

Wang, Guanchao; Zhang, Ting; Yu, Weiwei; Si, Rui; Liu, Yuefeng; Zhao, Zhongkui published the artcile< Modulating Location of Single Copper Atoms in Polymeric Carbon Nitride for Enhanced Photoredox Catalysis>, Application of C7H8BrN, the main research area is copper atom polymeric carbon nitride photocatalyst photoredox benzylamine.

Introducing single-atom metals (SAMs) is a promising strategy to improve photocatalysis of polymeric carbon nitride (PCN), but current studies are limited to loading SAMs on the surface of PCN to serve as active sites. Herein, we report an intercalation-structured hollow carbon nitride sphere composed of carbon nitride nanosheets (HCNS) with atomically dispersed Cu1N3 moieties embedded within nanosheets (Cu1@HCNS) prepared by a facile mol. assembly approach. It exhibits far superior photoredox catalysis to the pristine HCNS and the modified HCNS with Cu1N3 moieties anchored on the surface of nanosheets (Cu1/HCNS) for solar hydrogen production (3261μmol g-1 h-1 rate with 7.1% of apparent quantum yield), in which the embedded single-atom Cu acts as a modifier to effectively modulate the electron structure and remarkably promote interfacial charge transfer of PCN rather than act as active sites to facilitate surface reaction. It can be extended to the nonoxygen coupling of benzylamine and derivants to corresponding imines, and the unexpectedly high reaction rate is achieved. The promoting effect strongly depends on the location of single-atom Cu in the PCN, and the coordination method is a very effective strategy to introduce single-atom metals in terms of the improvement in photocatalysis of PCN owing to the intensified metal-PCN interaction. This work opens up a window for further improving the photocatalytic efficiency of carbon nitride in terms of solar fuel production and clean organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jabeen, Amara’s team published research in International Journal of Molecular Sciences in 2021 | 14062-30-7

International Journal of Molecular Sciences published new progress about Medicine (ectopic olfactory receptor agonist). 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Quality Control of 14062-30-7.

Jabeen, Amara; de March, Claire A.; Matsunami, Hiroaki; Ranganathan, Shoba published the artcile< Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors>, Quality Control of 14062-30-7, the main research area is ectopic olfactory receptor agonist machine learning based model; G protein-coupled receptors; luciferase assay; machine learning; molecular descriptors; olfactory receptor; random forest; virtual ligand screening.

Olfactory receptors (ORs) constitute the largest superfamily of G protein-coupled receptors (GPCRs). ORs are involved in sensing odorants as well as in other ectopic roles in non-nasal tissues. Matching of an enormous number of the olfactory stimulation repertoire to its counterpart OR through machine learning (ML) will enable understanding of olfactory system, receptor characterization, and exploitation of their therapeutic potential. In the current study, we have selected two broadly tuned ectopic human OR proteins, OR1A1 and OR2W1, for expanding their known chem. space by using mol. descriptors. We present a scheme for selecting the optimal features required to train an ML-based model, based on which we selected the random forest (RF) as the best performer. High activity agonist prediction involved screening five databases comprising ∼23 M compounds, using the trained RF classifier. To evaluate the effectiveness of the machine learning based virtual screening and check receptor binding site compatibility, we used docking of the top target ligands to carefully develop receptor model structures. Finally, exptl. validation of selected compounds with significant docking scores through in vitro assays revealed two high activity novel agonists for OR1A1 and one for OR2W1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary