Month: October 2022

Wang, Kai; Lin, Xiangfeng; Liu, Yan; Li, Can published the artcile< Palladium-Catalyzed Asymmetric Allylic C-H Functionalization for the Synthesis of Hydroquinolines through Intermolecular [4+2] Cycloadditions>, Quality Control of 51605-97-1, the main research area is hydroquinoline preparation stereoselective; ortho allyl aniline alkene allylic alkylation intermol cycloaddition palladium.

Catalytic asym. [4+2] cycloadditions via allylic C-H functionalization are of great interest and importance but remain unexplored. Herein, an intermol. [4+2] cycloaddition involving the direct Pd(0)-catalyzed allylic C-H functionalization with readily accessible olefin substrates is reported. Key to the success of this reaction is a chiral alkylphosphine ligand, which enables the asym. allylic C-H alkylation to deliver a broad range of hydroquinolines in high diastereoselectivities (up to >20:1) and enantioselectivities (up to 98% ee). Control experiments show that allylic C-H functionalization takes place possibly via the concerted proton and two-electron transfer process. This strategy opens a route for synthesizing chiral heterocycles in a straightforward way with readily accessible substrates and minimal functional-group manipulation.

ACS Catalysis published new progress about [4+2] Cycloaddition reaction. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Quality Control of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Matharu, Daljit S.; Flaherty, Daniel P.; Simpson, Denise S.; Schroeder, Chad E.; Chung, Donghoon; Yan, Dan; Noah, James W.; Jonsson, Colleen B.; White, E. Lucile; Aube, Jeffrey; Plemper, Richard K.; Severson, William E.; Golden, Jennifer E. published the artcile< Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity>, SDS of cas: 14062-30-7, the main research area is quinazolinedione inhibitor respiration syncytial virus RNA polymerase.

A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability (selectivity index, SI ∼ 24). Scaffold optimization delivered analogs with improved potency and selectivity profiles. Most notable were compounds 15 and 19 (EC50 = 300-500 nM, CC50 > 50 μM, SI > 100), which significantly reduced viral titer (>400,000-fold), and several analogs were shown to block the activity of the RNA-dependent RNA-polymerase complex of RSV.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, SDS of cas: 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chang-An; Li, Yan-Wei; Han, Yin-Feng; Zhang, Jian-Ping; Wu, Ren-Tao; He, Guo-Fang published the artcile< The ""bottom-up"" construction of chiral porous organic polymers for heterogeneous asymmetric organocatalysis: MacMillan catalyst built-in nanoporous organic frameworks>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is chiral porous polymer organocatalyst enantioselectivity.

Although many porous organic polymers (POPs) embedded with chiral ligand-metal catalytic activities have been examined as heterogeneous asym. catalysts, examples of metal-free stereoselective POP catalysts are very scarce. Herein, we report a “”bottom-up”” strategy used to construct a MacMillan catalyst-embedded chiral porous organic polymer, Mac-CPOPs. The porosity of the Mac-CPOPs frameworks could be adjusted by varying the mol. length of the rigid structural monomers. Due to the high Brunauer-Emmett-Teller sp. surface area and the built-in character of the covalently linked MacMillan catalyst, the Mac-CPOP-2 polymer can be applied as a highly efficient and recoverable heterogeneous organocatalyst in the asym. Diels-Alder reaction, which gives products in good yields and with good enantioselectivity. Moreover, the Mac-CPOP-2 polymer can be reused 6 times for the asym. Diels-Alder reaction without any significant loss of catalytic activity and enantioselectivity.

Polymer Chemistry published new progress about Adsorption. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Plunkett, Shane; DeRatt, Lindsey G.; Kuduk, Scott D.; Balsells, Jaume published the artcile< Synthesis of 4-Alkylated Isocoumarins via Pd-Catalyzed α-Arylation Reaction>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is isocoumarin preparation; palladium catalyst cyclocondensation aldehyde halobenzoate.

A convergent method for the rapid preparation of substituted isocoumarins such as I is reported. The transformation takes advantage of a spontaneous intramol. cyclization that follows the Pd-catalyzed α-arylation of aldehydes such as butyraldehyde and ketones (cyclohexanone and 2,3-dihydro-4-benzopyranone) with 2-halobenzoic esters such as Me 2-bromo-5-methoxybenzoate. The reaction uses an air-stable, single-component palladium catalyst (Xantphos Pd G3) and provides access to 4-alkylated isocoumarins in one step from com. starting materials. The applicability of the method using both cyclic and linear ketones as well as transformations of the isocoumarin core is also demonstrated.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Mukesh; Chauhan, Pankaj; Valkonen, Arto; Rissanen, Kari; Enders, Dieter published the artcile< Asymmetric Synthesis of Functionalized Tricyclic Chromanes via an Organocatalytic Triple Domino Reaction>, Electric Literature of 3893-18-3, the main research area is asym synthesis functionalized tricyclic chromane organocatalysis triple domino; secondary amine catalyzed domino Michael aldol condensation aldehyde nitrochromene; alpha beta unsaturated aldehyde Michael aldol condensation nitrochromene; crystal mol structure tricyclic chromane.

A highly stereoselective triple domino reaction for the synthesis of functionalized tricyclic chromane scaffolds has been developed. A secondary amine-catalyzed domino Michael/Michael/aldol condensation reaction between aliphatic aldehydes, nitro-chromenes, and α,β-unsaturated aldehydes leads to the formation of synthetically important tricyclic chromanes bearing four contiguous stereogenic centers including a tetrasubstituted carbon in good yields (20-66%) and excellent stereoselectivities (>20:1 dr and >99% ee).

Organic Letters published new progress about Aldol condensation. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sevgili, Omer; Lafzi, Ferruh; Karabulut, Abdulkerim; Orak, Ikram; Bayindir, Sinan published the artcile< The synthesis of new bola-amphiphile TPEs and the comparison of current transformer mechanism and structural properties for Al/Bis(HCTA)-TPE/p-Si and Al/Bis(HCOA)-TPE/p-Si heterojunctions>, Recommanded Product: 1,2-Bis(4-bromophenyl)-1,2-diphenylethene, the main research area is bola amphiphile tetraphenylethylene silicon heterojunction current transformer.

In this study, the new bola-amphiphile tetraphenylethylene derivatives Bis(HCTA)-TPE and Bis(HCOA)-TPE were synthesized to use in device application by a green approach. Al/organic layer/p-Si heterojunctions were fabricated by the usage of Bis(HCTA)-TPE and Bis(HCOA)-TPE organic interfacial layers. The mentioned organic layers were coated on the polished side of silicon wafer using the spin coating method. The surface and morphol. analyses of materials coated on silicon substrate were investigated by using at. force microscopy (AFM) and SEM (SEM) images. Besides, the elec. characteristics of fabricated heterojunctions were examined by the use of current-voltage (I-V) and current-time (I-t) measurements and compared with each other. I-V characteristics were investigated under various illumination conditions, and also the behavior of these characteristics against changing temperature conditions has been determined At the same time, transient photocurrent measurements were performed to determine the photoresponse behaviors. The results show that the fabricated device with Bis(HCTA)-TPE organic interfacial layer exhibits better elec. characteristics than the Bis(HCOA)-TPE organic layer. The other result of this experiment is that the fabricated devices could be used in optoelectronic and photovoltaic applications.

Composites, Part B: Engineering published new progress about Electric contacts. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Recommanded Product: 1,2-Bis(4-bromophenyl)-1,2-diphenylethene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Breuers, Christian B. J.; Daniliuc, Constantin G.; Studer, Armido published the artcile< Dearomatizing Cyclization of 2-Iodoindoles by Oxidative NHC Catalysis to Access Spirocyclic Indolenines and Oxindoles Bearing an All Carbon Quaternary Stereocenter>, Related Products of 337536-14-8, the main research area is spirooxindole enantioselective preparation; iodoindolylmethylbenzaldehye NHC catalyst oxidative cyclization.

An intramol. dearomatizing spirocyclization of indoles by oxidative N-heterocyclic carbene catalysis was reported. C2-iodinated indoles are used as substrates in combination with aroyl azolium ions as acceptors, which provides C2-iodinated indolenines containing an all carbon quaternary stereocenter. The products are readily further C2-functionalized and give access to valuable oxindoles by simple hydrolysis in very good overall yields and excellent enantioselectivities.

Organic Letters published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, Related Products of 337536-14-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chu, Duc; Ellman, Jonathan A. published the artcile< Three-Component Friedel-Crafts Transformations: Synthesis of Alkyl and Alkenyl Trifluoromethyl Sulfides and Alkenyl Iodides>, Reference of 576-83-0, the main research area is trifluoromethyl arylalkenyl sulfide diastereoselective preparation; arene alkyne trifluoromethyl benzenesulfonamide regioselective three component Friedel Crafts; trifluoromethylthio alkylarene diastereoselective preparation; alkene arene trifluoromethyl benzenesulfonamide regioselective three component Friedel Crafts; iodoalkenyl arene preparation; iodosuccinamide alkyne arene regioselective three component Friedel Crafts reaction.

Straightforward and mild hexafluoroisopropanol (HFIP)-mediated, metal-free, three-component Friedel-Crafts approaches were reported for the synthesis of alkenyl and alkyl trifluoromethyl sulfides from arenes, (PhSO2)2NSCF3 and alkynes or alkenes, resp. The transformations proceeded with high regio- and stereochem. control via the initial formation of cationic thiirenium and thiiranium intermediates, resp., followed by Friedel-Crafts reactions with the arene. A mechanistically related three-component synthesis of alkenyl iodides from arenes, alkenes and N-iodosuccinimide was reported.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Reference of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary