Month: October 2022

Dong, Xiaoyun; Hao, Huimin; Wang, Ningning; Yuan, Hong; Lang, Xianjun published the artcile< Cadmium sulfide/titanate hybrid green light photocatalysis for selective aerobic oxidative homocoupling of amines>, Application In Synthesis of 3959-07-7, the main research area is cadmium sulfide green light photocatalysis amines aerobic oxidative homocoupling; CdS/titanate hybrid; Green light; Homocoupling of amines; Selective oxidation; Semiconductor photocatalysis.

Semiconductor photocatalysis can carry out selective chem. transformations under ambient conditions, mitigating the associated environmental consequences. However, a single semiconductor photocatalyst usually cannot perform the transformations satisfactorily from the aspects of light-absorption, efficiency, and selectivity, etc. To address these challenges, cadmium sulfide (CdS)/titanate hybrid was fabricated by simultaneously growing titanate and CdS and had been comprehensively characterized. The optimized CdS/titanate hybrid can power the highly selective oxidative homocoupling of amines under the irradiation of green light-emitting diodes (LEDs). Specifically, CdS with a narrow bandgap captures green light; the conduction band of titanate activates mol. oxygen (O2). The valence band of CdS could ensure the selective oxidative homocoupling of amines in methanol (CH3OH). The hybridization between CdS and titanate accounts for the expeditious oxidative homocoupling of amines into imines and the improved stability. Reactive oxygen species (ROS) quenching experiments and in situ ESR (EPR) tests suggest that superoxide anion (O·-2) and benzylamine radical are intermediates en route to imines. This work highlights the viability of hybridization of dual semiconductor nanostructures in implementing visible light-powered selective conversions.

Journal of Colloid and Interface Science published new progress about Absorption spectra. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Biping; Su, Weiping published the artcile< A Tandem Dehydrogenation-Driven Cross-Coupling between Cyclohexanones and Primary Amines for Construction of Benzoxazoles>, Application of C7H8BrN, the main research area is substituted benzoxazole tandem dehydrogenation driven cross coupling; cyclohexanone primary amine; Aromatization; Heterocycles; Radical; Reaction Mechanisms; Synthetic Methods.

Herein, authors report a transition metal-free, operationally simple, general method for straightforward syntheses of 2-substituted benzoxazoles from readily available cyclohexanones and aliphatic primary amines by an imine α-oxygenation-initiated cascade reaction sequence. The key to achieving high selectivity and excellent functional-group tolerance is the use of TEMPO as a mild oxidant that selectively oxidizes the reaction intermediates through its multiple reactivity modes, thus facilitating the individual steps to proceed in succession. More than 70 substrate combinations are disclosed, demonstrating the reliability of this protocol to synthesize structurally diverse products, including marketed drugs, drug candidate, and natural products that are unattainable by the existing methods.

Angewandte Chemie, International Edition published new progress about Aralkyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xia, Mengxin; Moussa, Ziad; Judeh, Zaher M. A. published the artcile< Acetic Acid-Catalyzed Selective Synthesis of N-Substituted 2-Amino-3-Cyanopyrroles via a Three-Component Reaction Between Carbohydrates, Primary Amines and Malononitrile>, Product Details of C7H8BrN, the main research area is carbohydrate amine malononitrile acetic acid catalyst cascade cyclization; acetoxyaminocyanopyrrole preparation.

Direct conversion of unprotected carbohydrates to N-heterocycles was challenging and highly desirable. A simple three-component synthesis of N-substituted 2-amino-3-cyanopyrrole key framework was developed from the reaction between unprotected carbohydrates, malononitrile and primary amines. The reaction proceeded under mild reaction conditions (AcOH catalyst, EtOH, 60 °C, 2 h), tolerated a wide substrate scope, worked smoothly on a 4 g scale and gave the pyrroles in up to 86% yield. The pyrroles were also converted into functional intermediates to demonstrated their versatility. NMR and LC-MS experiments supported a proposed cascade reaction mechanism. The approach demonstrated a robust upcycling process for the challenging synthesis of highly functionalized N-heterocyclic compounds from unprotected carbohydrates.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Yiwei; Shi, Haoyu; Lei, Shengshu; Shi, Lei; Li, Hao published the artcile< Cu catalyzed [4 + 2] cycloaddition for the synthesis of highly substituted 3-fluoropyridines>, SDS of cas: 3959-07-7, the main research area is fluoro aryl nicotinoyl preparation; trifluoro aryl ethanimine acryloyloxazolidinone cycloaddition aromatization catalyst copper; propenoylimidazolidinone trifluoro aryl ethanimine cycloaddition aromatization catalyst copper.

A copper catalyzed annulation-aromatization of benzyl trifluoromethyl ketimines with 3-acryloyloxazolidin-2-ones for the synthesis of 3-fluoropyridines I [R = H, 3-Cl, 3-Me, etc.; R1 = H, 4-Cl, 4-MeO, etc.; R2 = 2-oxopyrrolidin-1-yl, 2-oxooxazolidin-3-yl, 2-oxo-3-phenyl-imidazolidin-1-yl, etc.] through double C-F bond cleavages had been developed. In this approach, the annulation occurred between the in situ formed dienes from trifluoromethyl ketimines via the first C-F bond cleavage and 3-acryloyloxazolidin-2-ones. Then the aromatization afforded 3-fluoropyridines I in moderate yields through the second C-F bond cleavage. The 3-fluoropyridine products I [R = R1 = H; R2 = 2-oxooxazolidin-3-yl] could be further hydrolyzed to multi-substituted 3-pyridinecarboxylic acids.

Organic & Biomolecular Chemistry published new progress about [4+2] Cycloaddition reaction. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peng, Ting; He, Yujiao; Wang, Tao; Yu, Jialing; Ma, Xiaofang; Zhou, Zongyuan; Sheng, Yuwen; Li, Lingyu; Peng, Huipan; Li, Sheng; Zou, Jiawei; Yuan, Yi; Zhao, Yongyun; Shi, Hailong; Li, Fu; Liu, Wanli; Hu, Kaifeng; Lu, Xiaoxia; Zhang, Guolin; Wang, Fei published the artcile< Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis>, Reference of 3959-07-7, the main research area is hepatocellular carcinoma miRNA biogenesis TRBP SAR proliferation cancer therapy.

MicroRNAs (miRNAs) are key players in human hepatocellular carcinoma (HCC) tumorigenesis. Therefore, small mols. targeting components of miRNA biogenesis may provide new therapeutic means for HCC treatment. By a high-throughput screening and structural simplification, we identified a small mol., CIB-3b (I), which suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells. Mechanistically, CIB-3b phys. binds to transactivation response (TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction, thereby altering the activity of Dicer and mature miRNA production Structure-activity relationship study via the synthesis of 45 CIB-3b derivatives showed that some compounds exhibited a similar inhibitory effect on miRNA biogenesis to CIB-3b. These results support TRBP as a potential therapeutic target in HCC and warrant further development of CIB-3b along with its analogs as a novel therapeutic strategy for the treatment of HCC.

Journal of Medicinal Chemistry published new progress about A-kinase anchor protein 10 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary