Month: October 2022

Rahaman, S. M. Wahidur; Pandey, Dilip K.; Rivada-Wheelaghan, Orestes; Dubey, Abhishek; Fayzullin, Robert R.; Khusnutdinova, Julia R. published the artcile< Hydrogenation of Alkenes Catalyzed by a Non-pincer Mn Complex>, Related Products of 2725-82-8, the main research area is alkane preparation; alkene hydrogenation manganese catalyst.

Hydrogenation of substituted styrenes and unactivated aliphatic alkenes by mol. hydrogen has been achieved using a Mn catalyst with a non-pincer, picolylphosphine ligand. This is the second reported example of alkene hydrogenation catalyzed by a Mn complex. Mechanistic studies showed that a Mn hydride formed by H2 activation in the presence of a base is the catalytically active species. Based on exptl. and DFT studies, H2 splitting is proposed to occur via a metal-ligand cooperative pathway involving deprotonation of the CH2 arm of the ligand, leading to pyridine dearomatization.

ChemCatChem published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Related Products of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Michael, William R.; King, William R.; Wakim, J. M. published the artcile< Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog, and monkey>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is etidronate disodium metabolism; absorption etidronate disodium.

After administration by intragastric cannula, the absorption of disodium etidronate [7414-83-7] (10-20 mg/kg) from the gastrointestinal tract of adult rats, weanling rats, rabbits, monkeys, adult dogs, and young dogs was 3, 10.5, 3.8, 6, 14, and 21% resp. Absorption was primarily from the stomach. I was not metabolized by the rat or dog, and there was virtually no enterohepatic circulation of I in the rat. Approx. half of the absorbed I was excreted in the urine, while the remaining half was deposited in the skeleton. The half-life of I the skeleton of the rat was 12 days.

Toxicology and Applied Pharmacology published new progress about Bone. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

MacNeil, Connor S.; Hsiang, Shou-Jen; Hayes, Paul G. published the artcile< Reversible dehydrogenation of a primary aryl borane>, Application In Synthesis of 576-83-0, the main research area is mesitylborane cleavage boron hydrogen bond phosphiniminepyrrolyl rhodium pincer complex; crystal structure phosphiniminepyrrolyl rhodium aminoborylene pincer complex; mol structure phosphiniminepyrrolyl rhodium aminoborylene pincer complex.

The consecutive activation of B-H bonds in mesitylborane (H2BMes; Mes = 2,4,6-Me3C6H2) by a 16-electron Rh(I) monocarbonyl complex, (iPrNNN)Rh(CO) (1-CO; iPrNNN = 2,5-[iPr2P:N(4-iPrC6H4)]2N(C4H2)-) is described. Dehydrogenative extrusion of the {BMes} fragment gave (iPrNNN)(CO)RhBMes (1-BMes). Addition of H2 gas to 1-BMes regenerated 1-CO and H2BMes, highlighting the ability of 1-CO to facilitate interconversion of {BMes} with dihydrogen. Reactivity studies revealed that 1-BMes promotes formal group transfer and that {BAr} fragments accessed by dehydrogenation are reactive entities.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bond cleavage (boron-hydrogen). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Application In Synthesis of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dong, Kui; Jin, Xiao-Ling; Chen, Shihao; Wu, Li-Zhu; Liu, Qiang published the artcile< Controllable synthesis of 2- and 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols>, Category: bromides-buliding-blocks, the main research area is aryl benzomorpholine preparation diastereoselective chemoselective regioselective; aminophenol vinylphenol cross coupling heterocyclization rose bengal photocatalyst.

Herein, a method for the controllable synthesis of 3-aryl-benzomorpholine and 2-aryl-benzomorpholine cycloadducts I (R1 = H, 5-Me, 6-t-Bu, 6-Br, etc.; R2 = H, Me, Ph, Bn; R3 = H, Me, OMe, t-Bu; R4 = Me, OMe, OEt, t-Bu; R5 = Me, Et, OMe, CH1OH; R6 = H, Me) and II (R7 = H, 5-Me, 6-Br, 7-Cl, etc.; R8 = H, OMe, OEt, t-Bu) via cross-coupling/annulation between electron-rich 2-aminophenols 2-NH(R2)R1C6H3OH/2-NH2-R7C6H3OH and 4-vinylphenols 3-R3-4-OH-5-R4C6H2CH=CH(R5)R6/ 3-R3-4-OH-5-R8C6H2CH=CH(R5)R6 was presented. Mol. oxygen was successfully used in the reaction as the terminal oxidant and the complete inversion of chemoselectivity was achieved by the adjustment of the solvents and bases at room temperature

Chemical Communications (Cambridge, United Kingdom) published new progress about Chemoselectivity. 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Sida; Picci, Cristina; Ustinova, Kseniya; Benoy, Veronick; Kutil, Zsofia; Zhang, Guiping; Tavares, Mauricio T.; Pavlicek, Jiri; Zimprich, Chad A.; Robers, Matthew B.; Van Den Bosch, Ludo; Barinka, Cyril; Langley, Brett; Kozikowski, Alan P. published the artcile< Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model>, Computed Properties of 128577-47-9, the main research area is tetrahydroquinoline phenylhydroxamate synthesis SW101 HDAC6 neurodegenerative disorder; Charcot Marie Tooth disease tetrahydroquinoline Structure activity.

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and selective HDAC6i that was shown to be effective in mouse models of Fragile X syndrome and Charcot-Marie-Tooth disease type 2A (CMT2A). In this study, we report the discovery of a new THQ-capped HDAC6i, termed SW-101 (1s), that possesses excellent HDAC6 potency and selectivity, together with markedly improved metabolic stability and druglike properties compared to SW-100 (1a). X-ray crystallog. data reveal the mol. basis of HDAC6 inhibition by SW-101 (1s). Importantly, we demonstrate that SW-101 (1s) treatment elevates the impaired level of acetylated α-tubulin in the distal sciatic nerve, counteracts progressive motor dysfunction, and ameliorates neuropathic symptoms in a CMT2A mouse model bearing mutant MFN2. Taken together, these results bode well for the further development of SW-101 (1s) as a disease-modifying HDAC6i.

Journal of Medicinal Chemistry published new progress about Charcot-Marie-Tooth disease. 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Computed Properties of 128577-47-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nakamura, Shinji; Kamaura, Masahiro; Akao, Yuichiro; Nakamura, Natsuko; Mizukami, Atsushi; Goto, Akihiko; Furuyama, Naoki; Cho, Nobuo; Kasai, Shizuo published the artcile< Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is trifluoromethyl phenyl oxazolyl propanoic acid preparation RBP4 reducer SAR; pyrrolidinyloxy acetic acid trifluoromethyl phenyl preparation RBP4 reducer SAR; Age-related macular degeneration (AMD); Diabetes; Protein–protein interaction (PPI); Retinol-binding protein 4 (RBP4); Transthyretin (TTR).

Retinol-binding protein 4 (RBP4) is a potential drug target for metabolic and ophthalmol. diseases. A high-throughput screening of compound library has identified a small-mol. RBP4 reducer compound I, as a hit compound Aiming to provide a suitable tool for investigating the pharmacol. effects of RBP4 reducers, we conducted a structure-activity relationship study of compound I. Exploration of the aryl head, oxazole core, and propanoic acid tail of compound I resulted in the discovery of novel, potent, and orally available phenylpyrrolidine derivatives ({(3S)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid and ({(3R)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid. Compound ({(3S)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid had a potent and long-lasting blood RBP4-level-reducing effect when orally administered to mice at a dose as low as 0.3 mg/kg.

Bioorganic & Medicinal Chemistry published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Human RBP4 Gene). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, Atul K.; Chawla, Ruchi; Rai, Ankita; Yadav, Lal Dhar S. published the artcile< NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones>, Category: bromides-buliding-blocks, the main research area is NHC catalyst enal azalactone ring opening piperidine closing reaction; diastereoselective preparation multifunctionalized piperidine.

NHC-catalyzed azalactone ring-opening and piperidine ring-closing cascade with α,β-unsaturated aldehydes (enals) in a one-pot operation is reported. The present reaction cascade offers a convenient method for a highly diastereoselective synthesis of multifunctionalised piperidines, e.g. I, in excellent yields under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Azlactones Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rao, Changqing; Mai, Shaoyu; Song, Qiuling published the artcile< Rh(II)/phosphine-cocatalyzed synthesis of dithioketal derivatives from diazo compounds through simultaneous construction of two different C-S bonds>, Application In Synthesis of 14062-30-7, the main research area is dithioketal preparation rhodium phosphine catalyst diazo carbon sulfur bond.

Rhodium(II)/phosphine-cocatalyzed bis-sulfuration of α-diazocarbonyl compounds using thiosulfonates as the sulfenylating agent, which provided two sulfur-containing moieties, was developed via simultaneous inter- and intra-mol. C-S bond formation. This novel protocol provides a rapid synthetic route to dithioketal derivatives in moderate to good yields in an atom-economic process. The transformation is proposed to proceed through phosphine ylide formation followed by S(O2)-S bond cleavage and rearrangement.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-S bond formation. 14062-30-7 belongs to class bromides-buliding-blocks, and the molecular formula is C10H11BrO2, Application In Synthesis of 14062-30-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Elguero, Jose; Jacquier, Robert; Marzin, Claude published the artcile< Synthesis of azines from α,β-unsaturated β-(p-bromophenyl) carbonyl compounds>, Formula: C9H7BrO, the main research area is azines alkenyl; cinnamaldehydes azines; phenyl oxoalkenes; alkenones Ph; alkenals Ph.

Reduction of p-BrC6H4Ac with LiAlH4 gave 82% p-BrC6H4CHMeOH, b16 135-6°, which was dehydrated over K pyrosulfate to p-BrC6H4CH:CH2, b15 90°, and converted to p-BrC6H4CH:CHCHO (I), m. 79-80°, by known methods. p-BrC6H4CHO and acetone yielded 30% p-BrC6H4CH:CHAc (II), m. 78-80° (2,4-dinitrophenylhydrazone m. 246-7°), and 15% (p-BrC6H4CH:CH)2CO, m. 205-7° (2,4-dinitrophenylhydrazone m. 225-7°), even with excess acetone. 1-(p-Bromophenyl)-2-methyl-3-chloro-2-propen-1-one, m. 63-5°, with MeOH and NaOH gave 77% mixture containing 65% p-BrC6H4-COCHMeCH(OMe)2 and 35% 1-(p-bromophenyl)-2-methyl-3-methoxy-2-propen-1-one. Reduction of the mixture with LiAlH4 gave, after preparative gas chromatog., p-bromo-α-methylcinnamal-dehyde (III) along with p-bromobenzaldehyde, 3-(p-bromophenyl)-2-methyl-1-penten-3-ol, and 1-(p-bromophenyl)-2-methyl-3,3-dimethoxypropan-1-ol. By the method of Knoepfer (CA 3: 1535), I gave 40% (p-BrC6H4CH:CHCH:N)2, m. 229-31°. II similarly gave 45% (p-BrC6H4CH:CHCMe:N)2, m. 203-5°, and 10% II hydrazone, m. 143-5°. III (0.005 mole), 0.0025 mole N2H4, and a small amount of p-MeC6H4SO3H yielded 85% (p-BrC6H4CH:CMeCH:N)2, m. 189-91°. N.M.R., ir, and uv data for the azines were tabulated.

Bulletin de la Societe Chimique de France published new progress about Azines Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary