Month: October 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Product Details of C2H7Br2N.

Miller, David C.;Lal, Ravi G.;Marchetti, Luca A.;Arnold, Frances H. research published 《 Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement》, the research content is summarized as follows. Enantioselective one-carbon ring expansion of aziridines was reported to make azetidines I [R = Bn, 2-FBn, CH₂(2-thienyl), etc.; EWG = CO₂Me, CO₂Et, CO₂n-Pr, CO₂i-Pr] as a new-to-nature activity of engineered “carbene transferase” enzymes. A laboratory-evolved variant of cytochrome P 450BM3, P411-AzetS, not only exerts unparalleled stereocontrol (99:1 er) over a [1,2]-Stevens rearrangement, but also override the inherent reactivity of aziridinium ylides, cheletropic extrusion of olefins, to perform a [1,2]-Stevens rearrangement. By controlling the fate of the highly reactive aziridinium ylide intermediates, these evolvable biocatalysts promote a transformation which cannot currently be performed using other catalyst classes.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Product Details of C2H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 3,5-Dibromo-2-hydroxybenzaldehyde.

Mikuriya, Masahiro;Tsuchimoto, Nagisa;Koyama, Yoshiki;Mitsuhashi, Ryoji;Tsuboi, Motohiro research published 《 Crystal Structure of 1,3-Bis(3,5-dibromosalicylideneamino)-2-propanol》, the research content is summarized as follows. The crystal structure of 1,3-bis(3,5-dibromosalicylideneamino)-2-propanol was determined by the single-crystal X-ray diffraction method at 90 K. It crystallizes in the monoclinic space group P2₁/n with a = 16.5374(17)Å, b = 18.1164(19)Å, c = 19.330(2)Å, β = 93.608(3)°, V = 5779.9(10)ų, D_x = 2.117 g/cm³, and Z = 12. The R1 [I > 2σ(I)] and wR2 (all data) values are 0.0743 and 0.1541, resp., for all 13203 independent reflections. The crystal contains three crystallog. independent Schiff-base mols. Each mol. takes a bended structure at the central carbon atom with a dihedral angle of between the two 3,5-dibromosalicylideneaminomethyl planes of 79.68, 84.52, or 89.72°. The three Schiff-base mols. are connected one another by intermol. hydrogen bonds between an alc.-oxygen atom and a phenolato-oxygen atom of a neighboring Schiff-base mol.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Name: 3,5-Dibromo-2-hydroxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5445-17-0, formula is C4H7BrO2, The most pervasive is the naturally produced bromomethane. COA of Formula: C4H7BrO2

Migliore, Nicola;Araya-Hermosilla, Esteban;Scheutz, Georg M.;Sumerlin, Brent S.;Pucci, Andrea;Raffa, Patrizio research published 《 Synthesis of poly(1-vinylimidazole)- block-poly(9-vinylcarbazole) copolymers via RAFT and their use in chemically responsive graphitic composites》, the research content is summarized as follows. This study reports the synthesis of novel poly(1-vinylimidazole)-b-poly(9-vinylcarbazole) (PVI-b-PVK) block copolymers with varying monomer ratios using reversible addition-fragmentation chain-transfer (RAFT) polymerization and their incorporation in responsive composite materials. Specifically, non-covalent exfoliation of two different conductive fillers, multi-walled carbon nanotubes (MWCNTs) or reduced graphene oxide (rGO), was studied. The percolation threshold of the synthesized nanocomposites was dependent on the polymer used for dispersion, showing a better affinity of the fillers for block copolymers with higher relative carbazole content. Resistivity measurements showed selective variation in the resistance signal when the materials were exposed to various organic solvents and acids, providing a good basis for the design of sensing devices.

COA of Formula: C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Formula: C4H7BrO2.

Migliore, N.;Van Kooten, T. G.;Ruggeri, G.;Picchioni, F.;Raffa, P. research published 《 Synthesis and solution properties of poly(p,α dimethylstyrene-co-maleic anhydride): The use of a monomer potentially obtained from renewable sources as a substitute of styrene in amphiphilic copolymers》, the research content is summarized as follows. The use of p,α-dimethylstyrene, potentially obtainable from renewable sources, as a substitute for styrene in the synthesis of amphiphilic copolymers is reported in this work. A series of novel poly(p,α-dimethylstyrene-co-maleic anhydride) (SMA) copolymers was synthesized, characterized, and studied as potential polymeric surfactants. After hydrolysis, the copolymers solution properties were compared to the similar and very well-known styrene-maleic acid copolymers. Both series of copolymers were synthesized using reversible addition-fragmentation chain transfer-mediated polymerization (RAFT), and a sample of poly(p,α-dimethylstyrene-co-maleic anhydride) was synthesized via classical free radical polymerization The synthesized copolymers were studied from the point of view of their solution properties, with particular attention to the influence of the macromol. and chem. structure on the surface tension of their aqueous solutions Our results suggest that p,α-dimethylstyrene can be employed in copolymers with maleic anhydride, the resulting material being a valid alternative to SMA copolymers for various applications, such as emulsifiers and dispersants. Furthermore, the DMSMA series seems to be slightly more surface active than SMA.

Formula: C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Application of C7H5BrO2.

Miao, Yu-Qi;Kang, Jia-Xin;Ma, Yan-Na;Chen, Xuenian research published 《 Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes》, the research content is summarized as follows. Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes RNH(R¹)BH₃ (R = H, Me, Et; R¹ = H, Me, Bn, 4-fluorophenyl, etc.; RR¹ = -(CH₂)₅, -(CH₂)₂O(CH₂)₂-) and carboxylic acids R²C(O)OH (R² = 4-methoxyphenyl, 3,5-dichlorophenyl, 1-benzofuran-5-yl, 4-(dipropylsulfamoyl)phenyl, etc.) is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides R²C(O)NRR¹ with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical mols.

Application of C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C5H9BrO2.

Miao, Yupeng;Qian, Naixin;Shi, Lixue;Hu, Fanghao;Min, Wei research published 《 9-Cyanopyronin probe palette for super-multiplexed vibrational imaging》, the research content is summarized as follows. Multiplexed optical imaging provides holistic visualization on a vast number of mol. targets, which has become increasingly essential for understanding complex biol. processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017, we demonstrated the coupling between electronic pre-resonant stimulated Raman scattering (epr-SRS) microscopy with a proposed library of 9-cyanopyronin-based dyes, named Manhattan Raman Scattering (MARS). Herein, we develop robust synthetic methodol. to build MARS probes with different core atoms, expansion ring numbers, and stable isotope substitutions. We discover a predictive model to correlate their vibrational frequencies with structures, which guides rational design of MARS dyes with desirable Raman shifts. An expanded library of MARS probes with diverse functionalities is constructed. When coupled with epr-SRS microscopy, these MARS probes allow us to demonstrate not only many versatile labeling modalities but also increased multiplexing capacity. Hence, this work opens up next-generation vibrational imaging with greater utilities.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Application of C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 5392-10-9.

Miao, Chun-Bao;Qiang, Xiao-Qi;Xu, Xiaoli;Song, Xiao-Qing;Zhou, Su-Qing;Lyu, Xinyu;Yang, Hai-Tao research published 《 Synthesis of Stable N-H Imines with a Benzo[7,8]indolizine Core and Benzo[7,8]indolizino[1,2-c]quinolines via Copper-Catalyzed Annulation of α,β-Unsaturated O-Acyl Ketoximes with Isoquinolinium N-Ylides》, the research content is summarized as follows. A copper-catalyzed annulation of α,β-unsaturated O-acyl ketoximes, e.g., O-acetyl 1,3-di(p-tolyl)prop-2-en-1-one oxime with isoquinolinium N-ylides has been developed for the concise synthesis of stable N-H imines with a benzo[7,8]indolizine core. When β-(2-bromoaryl)-α,β-unsaturated O-acyl ketoximes, e.g., O-acetyl 3-(2-bromophenyl)-1-(p-tolyl)prop-2-en-1-oxime are used as the starting materials, a cascade cyclization occurs to afford the benzo[7,8]indolizino[1,2-c]quinolines.

Synthetic Route of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Product Details of C5H9BrO2

Messmer, Daniel;Bertran, Oscar;Kissner, Reinhard;Aleman, Carlos;Schluter, A. Dieter research published 《 Main-chain scission of individual macromolecules induced by solvent swelling》, the research content is summarized as follows. We present a comprehensive investigation of main-chain scission processes affecting peripherally charged and neutral members of a class of dendronized polymers (DPs) studied in our laboratory In these thick, sterically highly congested macromols., scission occurs by exposure to solvents, in some cases at room temperature, in others requiring modest heating. Our investigations rely on gel permeation chromatog. and at. force microscopy and are supported by mol. dynamics simulations as well as by ESR spectroscopy. Strikingly, DP main-chain scission depends strongly on two factors: first the solvent, which must be highly polar to induce scission of the DPs, and second the dendritic generation g. In DPs of generations 1 ≤ g ≤ 8, scission occurs readily only for g = 5, no matter whether the polymer is charged or neutral. Much more forcing conditions are required to induce degradation in DPs of g ≠ 5. We propose solvent swelling as the cause for the main-chain scission in these individual polymer mols., explaining in particular the strong dependence on g: g < 5 DPs resemble classical polymers and are accessible to the strongly interacting, polar solvents, whereas g > 5 DPs are essentially closed off to solvent due to their more closely colloidal character. g = 5 DPs mark the transition between these two regimes, bearing strongly sterically congested side chains which are still solvent accessible to some degree. Our results suggest that, even in the absence of structural elements which favor scission such as cross-links, solvent swelling may be a generally applicable mechanochem. trigger. This may be relevant not only for DPs, but also for other types of sterically strongly congested macromols.

Product Details of C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Safety of 2-Bromoethylamine hydrobromide.

Meng, Xiangyue;Wang, Yanbo;Lin, Jianbo;Liu, Xiao;He, Xin;Barbaud, Julien;Wu, Tianhao;Noda, Takeshi;Yang, Xudong;Han, Liyuan research published 《 Surface-Controlled Oriented Growth of FASnI₃ Crystals for Efficient Lead-free Perovskite Solar Cells》, the research content is summarized as follows. Tin-based perovskites with narrow band gap and high carrier mobility are promising candidates for the preparation of efficient lead-free perovskite solar cells (PSCs). However, the poor crystallization of tin-based perovskite films with unfavorable defects and rough morphol. is still the biggest challenge to achieve high power conversion efficiency. In this work, we reveal the surface-controlled growth of FASnI₃ perovskite films, and then precisely control the crystallization process by reducing the surface energy of the solution-air surface with a tailor-made pentafluorophen-oxyethylammonium iodide (FOEI). The demonstrated strategy enabled us to achieve highly oriented and smooth FASnI₃-FOEI films with lower defect d. and longer lifetime of charge carriers. A certificated efficiency of 10.16% for tin-based PSCs was obtained from an accredited institute.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Safety of 2-Bromoethylamine hydrobromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4224-70-8, formula is C6H11BrO2, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 4224-70-8

Mendez, Diego;Donoso-Bustamante, Viviana;Pablo Millas-Vargas, Juan;Pessoa-Mahana, Hernan;Araya-Maturana, Ramiro;Fuentes, Eduardo research published 《 Synthesis and pharmacological evaluation of acylhydroquinone derivatives as potent antiplatelet agents》, the research content is summarized as follows. Platelets are the smallest blood cells, and their activation (platelet cohesion or aggregation) at sites of vascular injury is essential for thrombus formation. Since the use of antiplatelet therapy is an unsolved problem, there are now focused and innovative efforts to develop novel antiplatelet compounds In this context, we assessed the antiplatelet effect of an acylhydroquinone series, synthesized by Fries rearrangement under microwave irradiation, evaluating the effect of diverse acyl chain lengths, their chlorinated derivatives, and their dimethylated derivatives both in the aromatic ring and also the effect of the introduction of a bromine atom at the terminus of the acyl chain. Findings from a primary screening of cytotoxic activity on platelets by lactate dehydrogenase assay identified 19 non-toxic compounds from the 27 acylhydroquinones evaluated. A large number of them showed IC₅₀ values less than 10μM acting against specific pathways of platelet aggregation. The highest activity was obtained with compound 38, it exhibited sub-micromolar IC₅₀ of 0.98 ± 0.40, 1.10 ± 0.26, 3.98 ± 0.46, 6.79 ± 3.02 and 42.01 ± 3.48μM against convulxin-, collagen-, TRAP-6-, PMA- and arachidonic acid-induced platelet aggregation, resp. It also inhibited P-selectin and granulophysin expression. We demonstrated that the antiplatelet mechanism of compound 38 was through a decrease in a central target in human platelet activation as in mitochondrial function, and this could modulate a lower response of platelets to activating agonists. The results of this study show that the chem. space around ortho-carbonyl hydroquinone moiety is a rich source of biol. active compounds, signaling that the acylhydroquinone scaffold has a promising role in antiplatelet drug research.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., HPLC of Formula: 4224-70-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary