Month: October 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organobromine compounds have fallen under increased scrutiny for their environmental impact., HPLC of Formula: 2576-47-8.

Maegawa, Koshiro;Tanimoto, Hiroki;Onishi, Seiji;Tomohiro, Takenori;Morimoto, Tsumoru;Kakiuchi, Kiyomi research published 《 Taming the reactivity of alkyl azides by intramolecular hydrogen bonding: site-selective conjugation of unhindered diazides》, the research content is summarized as follows. Organic azides are still in the center of click chem. connecting two mols. However, taming the conjugation selectivity of azides is difficult without the help of bulky groups. Herein the unique reactivities of α-azido secondary acetamides (α-AzSAs) as minimal and unhindered azide structures is reported. The NH-azide interaction in the α-AzSAs, supposed by DFT calculations, allowed selective conjugation in the presence of other azido moieties, even without steric hindrance. With Staudinger-Bertozzi ligation, α-AzSAs underwent conjugation prior to the other primary alkyl azides. On the other hand, in propargyl cation-mediated triazole synthesis, other alkyl azides, including tertiary alkyl azides, underwent the conjugation faster than α-AzSAs. Authors also demonstrated site-selective integration of the functional components onto the diazide modular hubs.

HPLC of Formula: 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H15Br.

Mach, Mateusz;Bazydlo-Guzenda, Katarzyna;Buda, Pawel;Matloka, Mikolaj;Dzida, Radoslaw;Stelmach, Filip;Galazka, Kinga;Wasinska-Kalwa, Malgorzata;Smuga, Damian;Holowinska, Dagmara;Dawid, Urszula;Gurba-Bryskiewicz, Lidia;Wisniewski, Krzysztof;Dubiel, Krzysztof;Pieczykolan, Jerzy;Wieczorek, Maciej research published 《 Discovery and development of CPL207280 as new GPR40/FFA1 agonist》, the research content is summarized as follows. Due to a unique mechanism that limits the possibility of hypoglycemia, the free fatty acid receptor (FFA1) is an attractive target for the treatment of type 2 diabetes. So far, however, none of the promising agonists have been able to enter the market. The most advanced clin. candidate, TAK-875, was withdrawn from phase III clin. trials due to liver safety issues. In this article, we describe the key aspects leading to the discovery of CPL207280 (13), the design of which focused on long-term safety. The introduction of small, nature-inspired acyclic structural fragments resulted in compounds with retained high potency and a satisfactory pharmacokinetic profile. Optimized synthesis and upscaling provided a stable, solid form of CPL207280-51 (45) with the properties required for the toxicol. studies and ongoing clin. trials.

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Application of C7H15Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 244205-40-1, formula is C6H6BBrO2, The most pervasive is the naturally produced bromomethane. Computed Properties of 244205-40-1

Ma, Yang-Tong;Lin, Chao;Huang, Xiao-Bo;Liu, Miao-Chang;Zhou, Yun-Bing;Wu, Hua-Yue research published 《 An (NH₄)₂S₂O₈-promoted cross-coupling of thiols/diselenides and sulfoxides for the synthesis of unsymmetrical disulfides/selenosulfides》, the research content is summarized as follows. An (NH₄)₂S₂O₈-promoted cross-coupling of thiols/diselenides and sulfoxides to construct unsym. disulfides/selenosulfides was disclosed. Control experiments demonstrate that (NH₄)₂S₂O₈ acts as an acid and an oxidant, while both ionic and radical routes were involved in the reaction. The KIE experiments reveal that C-H bond cleavage of sulfoxides was involved in the turnover-limiting step.

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., Computed Properties of 244205-40-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Quality Control of 402-49-3.

Ma, Xiaojun;Sun, Nannan;Li, Xinwei;Fu, Wei research published 《 Discovery of novel N-sulfonamide-tetrahydroisoquinolines as potent retinoic acid receptor-related orphan receptor γt agonists》, the research content is summarized as follows. Cancer immunotherapy has become a research hotspot in recent years. A variety of targets were developed for small mol. immuno-oncol. agents, including retinoic acid-related orphan receptor gamma t (RORγt), chemokine receptor, stimulator of interferon genes (Sting), indoleamine 2,3-dioxygenase (IDO), toll-like receptors (TLR), etc. Among them, the retinoic acid receptor-related orphan receptor γt (RORγt) has gradually attracted more attention in these years. In particular, LYC-55716 (cintirorgon), a small mol. RORγt agonist developed by Lycera, has entered the phase II clin. study. In this work, starting from compound 7, compound 28 was obtained after 4 rounds of compound design, synthesis and SAR studies, which had an EC50 of 0.021 ± 0.002 μM in dual Fluorescence Resonance Energy Transfer (dual-FRET) assay and an EC50 of 0.021 ± 0.002 μM in mouse Th17 cell differentiation assay. It indicated that compound 28 had excellent RORγt agonistic activity and was expected to be developed as a new type of small mol. drug for cancer immunotherapy. The mol. dynamic simulation revealed that the agonist 28 formed a strong HYF triplet intramol. interaction to stabilize H12, which helped RORγt to form the protein-binding site and therefore made the receptor ready to recruit coactivator. When the inverse agonist s27 bound with RORγt, the steric hindrance between s27 and H479 caused the destruction of the HYF triplet, leading to the collapse of H12, thus the transcription function of RORγt was interrupted due to the failure of recruiting a coactivator mol. The triplet HYF in RORγt and the rigidity of 28 and s27 were identified to be the structural determinants for the functional switch of RORγt.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Quality Control of 402-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene, Name: 1-Bromo-3,5-dimethoxybenzene

Ma, Teng;Li, Xiao;Ping, Yuanyuan;Kong, Wangqing research published 《 Synthesis of gem-Difluoroalkenes via Ni-Catalyzed Three-Component Defluorinative Reductive Cross-Coupling of Organohalides, Alkenes and Trifluoromethyl Alkenes》, the research content is summarized as follows. Gem-Difluoroalkenes are considered ideal isosteres for metabolically susceptible carbonyl groups in modern drug discovery and medicinal chem. In addition, gem-difluoroalkenes are used as versatile precursors for the synthesis of difluoroalkylated compounds and monofluoroalkenes. Therefore, a great deal of effort has been devoted to developing efficient methods for their preparation The catalytic defluorinative functionalization of trifluoromethyl alkenes represents a useful strategy for the preparation of chiral gem-difluoroalkenes. However, most of these catalytic processes are still essentially limited to two-component defluorinative cross-couplings to form single C-C bonds. Due to the challenge of controlling chemoselectivity in the carbon-carbon bond forming events, three-component defluorinative cross-coupling involving multiple C-C bond formations has rarely been studied. Authors report a nickel-catalyzed three-component defluorinative reductive cross-coupling of organohalides, alkenes and trifluoromethyl alkenes. A variety of electron-rich and electron-deficient alkenes, as well as aryl and alkyl halides can efficiently participate in the formation of three-component cross-coupling products. This reaction proceeds under mild conditions and exhibits excellent functional group compatibility without requiring a pendant chelating group, providing a variety of functionalized gem-difluoroalkenes in good yields with excellent chemoselectivity.

Name: 1-Bromo-3,5-dimethoxybenzene, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 2576-47-8.

Ma, Lie;Zhang, Chi;Lin, Saisai;Chen, Shengfu;Yao, Zhikan;Sun, Zhilin;Gao, Congjie;Zhang, Lin research published 《 Enhancing antifouling property of reverse osmosis membranes via surface tethered with the aminated cation of ionic liquids》, the research content is summarized as follows. The elec. neutrality of ionic liquids (ILs) was exploited to enhance the antifouling property of polyamide (PA) reverse osmosis (RO) membranes in this work. We solely tethered the aminated imidazolium cation of ILs [AVIM] Br onto the top-surface of PA RO membranes via mild amidation. The mol. simulation results confirmed that the tethered imidazolium cation and the dissociated bromine anion were stably existed in the form of ion pairs on PA RO membrane surface. In virtue of the elec. neutrality of these ion pairs, the ionic-solvation induced hydration layer formed in ILs above the modified membrane surface was thick and evenly distributed, similar to that formed in conventionally electroneutral zwitterion antifouling materials. Thereby, the cation-tethered membrane surface intuitively achieved balanced charge and strong hydrophilicity, and stably exhibited low protein adsorption and excellent antifouling behaviors to diverse foulants, even when the imidazolium cation was paired with anions of different mol. size. Meanwhile, the typical ridge-and-valley surface morphol. for PA RO membrane was well preserved due to the mild modification condition, and thereby harvested satisfactory separation performance. The integration of high performance, abundant ILs and mild conditions was expected to expand the application of superb antifouling materials in a variety of biofouling areas.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., HPLC of Formula: 2576-47-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 6911-87-1, formula is C7H8BrN, The most pervasive is the naturally produced bromomethane. Quality Control of 6911-87-1

Ma, Ben;Sun, Rongxia;Yang, Jingya research published 《 Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source》, the research content is summarized as follows. Herein, a cobalt-catalyzed α-hydroxymethylation of amides RCH₂C(O)NR¹R² [R = Ph, 3-methoxyphenyl, thiophen-2-yl, etc.; R¹ = Me, Et, Ph; R² = Me, 2-fluorophenyl, 3-methylphenyl, etc.; R¹R² = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-] and 1-(2,3-dihydro-1H-indol-1-yl)-2-phenylethan-1-one with methanol under mild conditions was reported. Using CoCl₂.6H₂O as an inexpensive and efficient catalyst, some important bioactive β-hydroxyamides RCHCH₂(OH)C(O)NR¹R² and 3-hydroxy-1-(indolin-1-yl)-2-phenylpropan-1-one were obtained in moderate to excellent yields. The developed method features a wide substrate scope and good functional group tolerance. In addition, anticholinergic tropicamide was easily synthesized in this way.

Quality Control of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Category: bromides-buliding-blocks

Lv, Xin-Yang;Abrams, Roman;Martin, Ruben research published 《 Dihydroquinazolinones as adaptative C(sp³) handles in arylations and alkylations via dual catalytic C-C bond-functionalization》, the research content is summarized as follows. C-C bond forming cross-couplings are convenient technologies for the construction of functional mols. Consequently, there is continual interest in approaches that can render traditionally inert functionality as cross-coupling partners, included in this are ketones which are widely-available commodity chems. and easy to install synthetic handles. Herein, a dual catalytic strategy that utilizes dihydroquinazolinones derived from ketone congeners as adaptative one-electron handles for forging C(sp³) architectures via α C-C cleavage with aryl and alkyl bromides is reported. This approach is achieved by combining the flexibility and modularity of nickel catalysis with the propensity of photoredox events for generating open-shell reaction intermediates. This method is distinguished by its wide scope and broad application profile–including chem. diversification of advanced intermediates–, providing a catalytic technique complementary to existing C(sp³) cross-coupling reactions that operates within the C-C bond-functionalization arena.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Application In Synthesis of 1575-37-7

Lv, Guangxin;Jensen, Elynn;Shen, Chengtian;Yang, Kexin;Evans, Christopher M.;Cahill, David G. research published 《 Effect of Amine Hardener Molecular Structure on the Thermal Conductivity of Epoxy Resins》, the research content is summarized as follows. Epoxy resins with enhanced thermal conductivity are in great demand to improve the thermal management of elec. motors. However, the thermal conductivity of epoxy resin is typically low, comparable to 0.2 W/m-K, and a predictive understanding of the connection between mol. structure and thermal conductivity is not yet established. In this work, we present data for the thermal conductivity of seven thermosets synthesized from one com. available diepoxide (resorcinol diglycidyl ether) and seven phenylenediamines to systematically examine the dependence of thermal conductivity on the mol. structure of the phenylenediamine hardener. Variations in the mol. structure of phenylenediamines, e.g., positions of amine groups and the addition of electron withdrawing group, produce up to a factor of 2 change in the thermal conductivity of the cured resins. The highest thermal conductivity of 0.27 W/m-K is obtained with 5-chloro-m-phenylenediamine; the lowest thermal conductivity of 0.14 W/m-K is obtained with o-phenylenediamine. Thermal conductivities of these seven epoxy resins are 10-40% lower than the prediction of the min. thermal conductivity model.

Application In Synthesis of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Related Products of 629-04-9.

Luxenburger, Andreas;Bougen-Zhukov, Nicola;Fraser, Michael G.;Beetham, Henry;Harris, Lawrence D.;Schmidt, Dorian;Cameron, Scott A.;Guilford, Parry J.;Evans, Gary B. research published 《 Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer》, the research content is summarized as follows. Diffuse gastric cancer and lobular breast cancer are aggressive malignancies that are frequently associated with inactivating mutations in the tumor suppressor gene CDH1. Synthetic lethal (SL) vulnerabilities arising from CDH1 dysfunction represent attractive targets for drug development. Recently, SLEC-11 (1) emerged as a SL lead in E-cadherin-deficient cells. Here, we describe our efforts to optimize 1. Overall, 63 analogs were synthesized and tested for their SL activity toward isogenic mammary epithelial CDH1-deficient cells (MCF10A-CDH1^-/-). Among the 26 compounds with greater cytotoxicity, AL-GDa62 (3)(I) was four-times more potent and more selective than 1 with an EC₅₀ ratio of 1.6. Furthermore, 3 preferentially induced apoptosis in CDH1^-/- cells, and Cdh1^-/- mammary and gastric organoids were significantly more sensitive to 3 at low micromolar concentrations Thermal proteome profiling of treated MCF10A-CDH1^-/- cell protein lysates revealed that 3 specifically inhibits TCOF1, ARPC5, and UBC9. In vitro, 3 inhibited SUMOylation at low micromolar concentrations

Related Products of 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary