Month: October 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 19111-87-6, formula is C18H11Br, Name is 2-Bromotriphenylene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 19111-87-6.

Kyushin, Soichiro;Fujii, Hidetoshi;Negishi, Keisuke;Matsumoto, Hideyuki research published 《 Improvement of the fluorescence quantum yield of triphenylene by the rotational effect of 4-(trimethylsilyl)phenyl groups》, the research content is summarized as follows. The fluorescence quantum yield of triphenylene is low because the transition moment between the HOMOs and the LUMOs is negligibly small. To improve the fluorescence quantum yield, break of the sym. structure of triphenylene is necessary. We found that the rotational effect of the 4-(trimethylsilyl)phenyl groups of 2,3,6,7,10,11-hexakis[4-(trimethylsilyl)phenyl]triphenylene is effective to break the symmetry in spite of the sym. structure, leading to improvement of the fluorescence quantum yield.

SDS of cas: 19111-87-6, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., 19111-87-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C7H5BrO2.

Kushawaha, Ajay Kishor;Jaiswal, Arvind Kumar;Pandey, Shubham;Sashidhara, Koneni V. research published 《 A simple and efficient oxidation of primary and secondary benzylamines to acids using table salt in aqueous medium》, the research content is summarized as follows. A novel, simple, efficient method for the oxidation of aromatic benzylamines RCH₂NH₂ (R = C₆H₅, 4-FC₆H₄, 2-thienyl, etc.), R¹CH₂NHCH₂R¹ (R¹ = C₆H₅, 4-ClC₆H₄, 2-thienyl, etc.) and 4-OCH₃C₆H₄CH₂NHR₂ (R₂ = Me, Et, Pr, n-octyl, t-butyl) to corresponding acids RC(O)OH, R¹C(O)OH and 4-methoxybenzoic acid using common table salt in aqueous medium has been described. Oxidation of benzylamine was achieved by using NaCl (20 mol%) as a catalyst, NaOH (4 equiv) and TBHP (5 equiv) as oxidant, in moderate to good yields (34-84%). Control experiments revealed that in situ generated ClO₂^– ion is the active form of the catalyst. This methodol. can also be scaled up for easy accessibility to the industrially important terephthalic acid as well. This investigation provided a facile entry of various primary as well as secondary benzylamines with wide range of functional group tolerance.

Formula: C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 244205-40-1, formula is C6H6BBrO2, The most pervasive is the naturally produced bromomethane. SDS of cas: 244205-40-1

Kurnia, Kiki Adi;Setyaningsih, Widiastuti;Darmawan, Noviyan;Yuliarto, Brian research published 《 A comprehensive study on the impact of the substituent on pK_a of phenylboronic acid in aqueous and non-aqueous solutions: A computational approach》, the research content is summarized as follows. The acid dissociation constant (pK_a) is the fundamental physicochem. properties required to understand the structure and reactivity of boronic acid-based material as a sensor that identifies carbohydrates. However, there is a lack of comprehensive study on the impact of the substituent on the pK_a of monosubstituted phenylboronic acid in aqueous and non-aqueous solutions In this work, extensive exptl. data on the pK_a of monosubstituted phenylboronic acid in an aqueous solution was reviewed and compared in terms of accuracy. In addition, computational, were used to predict and investigate the impact of the substituent on the pK_a for a series of monosubstituted phenylboronic acid in an aqueous solution at the mol. level. Good agreement was observed between predicted and literature pK_a values of monosubstituted phenylboronic acid in the aqueous solution While some deviations exist, predominantly with fluorine-containing phenylboronic acid, the COSMO-RS model is proficient at predicting the pK_a of boronic acid in an aqueous solution with the accuracy of ±1.5 pK_a. Subsequently, the model was used to predict the pK_a of boronic acid in the non-aqueous solution, which data is not available in the literature. Furthermore, an excellent relationship is observed between the acidity of para-substituted, and to some extent, meta-substituted phenylboronic acid with the at. charge of acidic hydrogen calculated using Natural Bond Orbital (NBO) Population Anal. In contrast, the steric hindrance and the existence of other mol. forces might influence the acidity of ortho-substituted phenylboronic acid. The gathered information in this work could be of benefit for the understanding of the acidity of the boronic acid-based materials not only as a sensor but also in many diverse areas.

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., SDS of cas: 244205-40-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde.

Kurma, Siva Hariprasad;Kolla, Sai Teja;Sridhar, Balasubramanian;Bhimapaka, China Raju research published 《 Ruthenium-Catalyzed Intermolecular Cyclization and N-Methylation of Salicyl N-Tosylhydrazones》, the research content is summarized as follows. Synthesis of 3-(2,2-dichloroacetyl)-2H-chromen-2-ones I [R = H, 6-Me, 7-MeO, etc.] by treating salicyl N-tosylhydrazones II [R¹ = H, 3-Me, 4-MeO, etc.; R² = H] with Et 4,4,4-trichloro-3-oxobutanoate in presence of catalytic amount of La(OTf)₃ and RuCl₃ · 3H₂O was reported. The chromenones I were formed through C-C, C-O bond formations, detosylation and more importantly dechlorination protocol. One of the compound I [R = 6-Me] structure was confirmed by single-crystal X-ray anal. Further, salicyl N-tosylhydrazones when treated with di-Me (1-diazo-2-oxopropyl)-phosphonate (Bestmann-Ohira reagent) in presence of potassium carbonate and RuCl₃ · 3H₂O provided (E)-N’-(2-hydroxybenzylidene)-N,4-dimethylbenzenesulfono hydrazide II [R¹ = H, 3-Me, 4-MeO, etc.; R² = Me].

Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Kung, Pei-Pei;Bingham, Patrick;Burke, Benjamin J.;Chen, Qiuxia;Cheng, Xuemin;Deng, Ya-Li;Dou, Dengfeng;Feng, Junli;Gallego, Gary M.;Gehring, Michael R.;Grant, Stephan K.;Greasley, Samantha;Harris, Anthony R.;Maegley, Karen A.;Meier, Jordan;Meng, Xiaoyun;Montano, Jose L.;Morgan, Barry A.;Naughton, Brigitte S.;Palde, Prakash B.;Paul, Thomas A.;Richardson, Paul;Sakata, Sylvie;Shaginian, Alex;Sonnenburg, William K.;Subramanyam, Chakrapani;Timofeevski, Sergei;Wan, Jinqiao;Yan, Wen;Stewart, Albert E. research published 《 Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library》, the research content is summarized as follows. Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technol. screening. Biophys. and biochem. data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand their mechanism of action. These data were also used to rationalize the binding affinity differences observed between the two compounds and a MLGP peptide-containing substrate. Cellular target engagement experiments further confirm the Naa50 binding of 4a and demonstrate its selectivity toward related enzymes (Naa10 and Naa60). Addnl. analogs of inhibitor 4a were also evaluated to study the binding mode observed in the cocrystal structures.

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Kumari, Annu;Dehaen, Wim;Chopra, Deepak;Dey, Swapan research published 《 Imidazopyridine-fluoride interaction: solvent-switched AIE effects via S···O conformational locking》, the research content is summarized as follows. Convenient and straightforward methods have been developed for the detection and quant. estimation of fluoride anions by two novel imidazopyridine-based carboxamides (C1 and C2) in organic and aqueous media. The synthesized mols. exhibit high selectivity and enhanced sensitivity towards recognizing fluoride ions through the ‘turn on’ fluorogenic mode. The fluoride ion-driven deprotonation of the N-H proton and the subsequent spectral changes have been characterized by ¹H and ¹⁹F NMR spectroscopic techniques. Single-crystal XRD elucidates the structural evidence for deprotonation upon the addition of fluoride anions, wherein C1.S (C1-.2H₂O.TBA⁺) and C2.S (C2-.2H₂O.TBA⁺) salts were generated. Accordingly, C1 unveiled broad absorption bands at λ_max 340 nm, whereas C2 displayed similar bands at λ_max 308 nm in UV-vis spectra. The peaks shift to λ_max 350 nm and λ_max 341 nm after deprotonation. C1 itself exhibits the aggregation induced emission (AIE) phenomenon in water-DMSO (1 : 1). This is the first report of an imidazopyridine moiety being involved in a solvent-switched AIE effect via S···O conformational locking. UV-vis and fluorescence spectra of the compounds were obtained to predict the stoichiometry, binding constant, and the limit of detection (LOD). The actual structures of carboxamides and the resulting deprotonated carboxamide salts have been confirmed by single-crystal X-ray diffraction data. Different intra- and intermol. H-bonds, namely O-H···N, O-H···O, N-H···O, C-H···N and C-H···O, play a significant role in the crystal packing of these compounds

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Reference of 402-49-3.

Kumar, Sourav;Kumar, Manoj;Bhalla, Vandana research published 《 Pyrazine Based Type-I Sensitizing Assemblies for Photoreduction of Cu(II) in ‘One-Pot Three-Component’ CuAAC Reaction Under Aerial Conditions》, the research content is summarized as follows. Photosensitizing assemblies of pyrazine derivative PDA have been developed which exhibit a high photostability, ‘lighted’ excited state, balanced redox potential, high transportation potential and activate oxygen via type-I pathway only. These PDA assemblies in combination with Cu(II) ions catalyze the CuAAC reaction via in situ reduction of Cu(II) ions without any reducing or stabilizing agent. The present protocol has wide substrate scope with recyclability of the catalytic system up to six catalytic cycles and is applicable to gram-scale synthesis.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Reference of 402-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. SDS of cas: 4897-84-1.

Kumar, Kunal;Wang, Peng;Swartz, Ethan A.;Khamrui, Susmita;Secor, Cody;Lazarus, Michael B.;Sanchez, Roberto;Stewart, Andrew F.;DeVita, Robert J. research published 《 Structure-activity relationships and biological evaluation of 7-substituted harmine analogs for human β-cell proliferation》, the research content is summarized as follows. Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure-activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell proliferation based on our related previous structure-activity relationship studies of harmine in the context of diabetes and β-cell specific targeting strategies. Thirty three harmine analogs of the 7-position substituent were synthesized and evaluated for biol. activity. Two novel inhibitors were identified which showed DYRK1A inhibition and human β-cell proliferation capability. The DYRK1A inhibitor, compound 3-(7-oxy-1-methyl-9-H-b-carbolin)propionic acid Me ester, induced β-cell proliferation half that of harmine at three times higher concentration From these studies we can draw the inference that 7-position modification is limited for further harmine optimization focused on β-cell proliferation and cell-specific targeting approach for diabetes therapeutics.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., SDS of cas: 4897-84-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Electric Literature of 4897-84-1.

Kumar, Kunal;Wang, Peng;Wilson, Jessica;Zlatanic, Viktor;Berrouet, Cecilia;Khamrui, Susmita;Secor, Cody;Swartz, Ethan A.;Lazarus, Michael;Sanchez, Roberto;Stewart, Andrew F.;Garcia-Ocana, Adolfo;DeVita, Robert J. research published 《 Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor》, the research content is summarized as follows. Recently, our group identified that harmine is able to induce β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. Since, harmine suffers from a lack of selectivity, both against other kinases and CNS off-targets, we therefore sought to expand structure-activity relationships for harmine’s DYRK1A activity, to enhance selectivity for off-targets while retaining human β-cell proliferation activity. We carried out optimization of the 9-N-position of harmine to synthesize 29 harmine-based analogs. Several novel inhibitors showed excellent DYRK1A inhibition and human β-cell proliferation capability. An optimized DYRK1A inhibitor, compound I, was identified as a novel, efficacious in vivo lead candidate. Compound I also demonstrates improved selectivity for kinases and CNS off-targets, as well as in vivo efficacy for β-cell proliferation and regeneration at lower doses than harmine. Collectively, these findings demonstrate that compound I is a much improved in vivo lead candidate as compared to harmine for the treatment of diabetes.

Electric Literature of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde, COA of Formula: C7H4Br2O2

Kumar, Amit;Mahiya, Kuldeep;Prasad, Ashok K.;Singh, Sunil K. research published 《 Multicomponent Synthesis of 4-Aryl-1,4-Dihydro-Oxochromeno[3,2-b] Oxoindeno[6,5-e]Pyridine》, the research content is summarized as follows. One pot multi-component strategy has been developed for the synthesis of a small library of nineteen 4-aryl-1,4-dihydro-oxochromeno[3,2-b]oxoindeno[6,5-e]pyridine by the condensation of 4-aminocoumarin, aromatic aldehyde and indane-1,3-dione in acetic acid:ethylene glycol (5:1) in good yields along with the formation of di-(4-aminocoumarin-3-yl)arylmethane as by product in three cases. The use of microwave irradiation for the condensation of 4-aminocoumarin, aromatic aldehyde and indane-1,3-dione in acetic acid and ethylene glycol at 200 W and at 120°C led to the selective formation of 4-aryl-1,4-dihydro-oxochromeno[3,2-b]oxoindeno[6,5-e] pyridine in excellent yields. Interestingly, the side product di-(4-aminocoumarin-3-yl)arylmethane could be converted exclusively to 4-(4′-nitrophenyl)-1,4-dihydro-di(oxochromeno[3,2-b:5,6-e])pyridine on microwave irradiation under identical condition.

COA of Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary