Month: October 2022

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 4-Bromo-N-methylaniline.

Kuanr, Nirmalendu;Gilmour, Damon J.;Gildenast, Hans;Perry, Mitchell R.;Schafer, Laurel L. research published 《 Amine-Containing Monomers for Ring-Opening Metathesis Polymerization: Understanding Chelate Effects in Aryl- and Alkylamine-Functionalized Polyolefins》, the research content is summarized as follows. Ring-opening metathesis polymerization (ROMP) of two different types of amine-functionalized monomers, aminonorbornenes (ANs) and aminocyclooctenes (ACs), has been studied using [(H2IMes)(PCy3)(Cl)2Ru = CHPh] Grubbs second generation catalyst, G2, and [(H2IMes)(pyr)2(Cl)2Ru = CHPh] Grubbs third generation catalyst, G3. Despite the known detrimental effects of unprotected amine functionalities on Ru-based ROMP catalysts, amino polyolefins can be readily prepared using G2 and G3. The influence of the amine substituent of the monomer on the polymerization process, as probed by monitoring reaction kinetics, confirmed that the basicity/nucleophilicity of the amine group has a detrimental influence on the ROMP process. Reaction kinetics of homopolymerization of both these classes of monomers revealed faster polymerization of ACs than the more strained AN counterpart, which was attributed to the favored chelated catalyst resting states in the case of ANs. Hammett studies show increased polymerization rates in the presence of electron-withdrawing aryl amine-containing monomers. These observed kinetic effects were used to benefit copolymerization of AN and AC monomers to access a gradient polymer with different reactivity profiles than their homopolymerization trends. Polyolefins with unprotected secondary alkyl amines could be synthesized by leveraging the unfavorable chelate formation in the case of AC monomers. The strategic selection of cyclic alkene and relative positioning of amine substitution allows for the diverse incorporation of secondary amines into polymers by ROMP.

Name: 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 1575-37-7.

Kozlova, Arina;Thabault, Leopold;Liberelle, Maxime;Klaessens, Simon;Prevost, Julien R. C.;Mathieu, Caroline;Pilotte, Luc;Stroobant, Vincent;Van den Eynde, Benoit;Frederick, Raphael research published 《 Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase》, the research content is summarized as follows. Tryptophan 2,3-dioxygenase (TDO2) is a heme-containing enzyme constitutively expressed at high concentrations in the liver and responsible for L-tryptophan (L-Trp) homeostasis. Expression of TDO2 in cancer cells results in the inhibition of immune-mediated tumor rejection due to an enhancement of L-Trp catabolism via the kynurenine pathway. In the study herein, we disclose a new 6-(1H-indol-3-yl)-benzotriazole scaffold of TDO2 inhibitors developed through rational design, starting from existing inhibitors. Rigidification of the initial scaffold led to the synthesis of stable compounds displaying a nanomolar cellular potency and a better understanding of the structural modulations that can be accommodated inside the active site of hTDO2.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Application In Synthesis of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Related Products of 1575-37-7

Kozlova, Arina;Thabault, Leopold;Dauguet, Nicolas;Deskeuvre, Marine;Stroobant, Vincent;Pilotte, Luc;Liberelle, Maxime;Van den Eynde, Benoit;Frederick, Raphael research published 《 Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase》, the research content is summarized as follows. Selenium is an underexplored element that can be used for bioisosteric replacement of lower mol. weight chalcogens such as oxygen and sulfur. More studies regarding the impact of selenium substitution in different chem. scaffolds are needed to fully grasp this element′s potential. Herein, we decided to evaluate the impact of selenium incorporation in a series of tryptophan 2,3-dioxygenase (TDO2) inhibitors, a target of interest in cancer immunotherapy. First, we synthesized the different chalcogen isosteres through Suzuki-Miyaura type coupling. Next, we evaluated the isosteres′ affinity and selectivity for TDO2, as well as their lipophilicity, microsomal stability and cellular toxicity on TDO2-expressing cell lines. Overall, chalcogen isosteric replacements did not disturb the on-target activity but allowed for a modulation of the compounds′ lipophilicity, toxicity and stability profiles. The present work contributes to our understanding of oxygen/sulfur/selenium isostery towards increasing structural options in medicinal chem. for the development of novel and distinctive drug candidates.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Related Products of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 19111-87-6, formula is C18H11Br, Name is 2-Bromotriphenylene, Application In Synthesis of 19111-87-6

Kovalev, Igor S.;Kopchuk, Dmitry S.;Khasanov, Albert F.;Zyryanov, Grigory V.;Rusinov, Vladimir L.;Chupakhin, Oleg N. research published 《 The synthesis of polyarene-modified 5-phenyl-2,2′-bipyridines via the S_N^H methodology and aza-Diels-Alder reaction》, the research content is summarized as follows. Nucleophilic substitution of hydrogen (S_N^H) in 6-phenyl-3-(2-pyridyl)-1,2,4-triazine under the action of Li derivatives of polynuclear arenes followed by aza-Diels-Alder reaction with norbornadiene or 1-morpholinocyclopentene gives novel polyarene-modified photoluminescent 5-phenyl-2,2′-bipyridine ligands I (n = 0, R = 1-pyrenyl, 9-phenanthrenyl, 2-triphenylenyl; n = 3, R = 1-pyrenyl).

Application In Synthesis of 19111-87-6, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., 19111-87-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 244205-40-1.

Koszelewski, Dominik;Paprocki, Daniel;Brodzka, Anna;Keciek, Aleksandra;Wilk, Monika;Ostaszewski, Ryszard research published 《 The sustainable copper-catalyzed direct formation of highly functionalized p-quinols in water》, the research content is summarized as follows. The straightforward copper-catalyzed formation of p-quinols in water under air has been accomplished employing arylboronic acids. Various substituted p-benzoquinol derivatives of biol. importance were obtained in good yield. Furthermore, the synthesis of target p-quinols under physiol. conditions in serum and carbonate buffer is demonstrated. The essential features of this method are the high functional group tolerance and scalable one-pot preparation of p-quinols from corresponding arylboronic acid. Very mild reaction conditions, an absence of the heavy toxic metals, simple procedure as well as high chemoselectivity makes the established protocol desirable for academia and pharmaceutical industry laboratories

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., Quality Control of 244205-40-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Quality Control of 70-23-5

Kordmahalleh, Mohaddeseh Yahyanezhad;Moradi, Ali Varasteh;Hossaini, Zinatossadat;Golsefidi, Maziar Ahmadi research published 《 Synthesis and evaluation of antioxidant and antimicrobial activity of new spiropyrrolopyrrolizine compounds: Using Fe₃O₄/TiO₂/Multiwall carbon nanotubes (MWCNTs) magnetic nanocomposites》, the research content is summarized as follows. The Fe₃O₄/TiO₂/multiwall carbon nanotubes (MWCNTs) magnetic nanocomposites was synthesized using water extract of Spinacia oleracea leaves, and the high performance of synthesized catalyst was confirmed by employing of it in the multicomponent reaction of reaction of isatoic anhydride, tert-butylisocyanide, diamines, or hydroxyamines, electron-deficient acetylenic ester, α-haloketones and Et₃N in water at ambient temperature for the production of new spiropyrrolopyrrolizine compounds in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized compounds have NH and OH group in their structure and for this reason have good antioxidant activity. Also, employing Gram-pos. and Gram-neg. bacteria in the disk diffusion procedure confirmed the some spiropyrrolopyrrolizine derivatives antimicrobial effect. The results showed that synthesized compounds prevented the bacterial growth. This used procedure for preparation of spiropyrrolopyrrolizine derivatives have some advantages such as low reaction time, product with high yields and simple separation of catalyst and products.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Quality Control of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde, Computed Properties of 90-59-5

Kordestani, Nazanin;Amiri Rudbari, Hadi;Correia, Isabel;Valente, Andreia;Corte-Real, Leonor;Islam, Mohammad Khairul;Micale, Nicola;Braun, Jason D.;Herbert, David E.;Tumanov, Nikolay;Wouters, Johan;Enamullah, Mohammed research published 《 Heteroleptic enantiopure Pd(II)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity》, the research content is summarized as follows. Seven enantiomeric pairs of palladium complexes, [Pd(pic)(R or S)-N-1-(phenyl)ethyl-2,4-X₁,X₂-salicylaldiminate]NO₃, [Pd(pic)(R or S)]NO₃ (X₁ = X₂ = Cl, Br, I, H; X₁/X₂ = Br/Cl), were synthesized by the reaction of enantiopure halogen-substituted Schiff bases (R or S)-N-1-(phenyl)ethyl-2,4-X₁,X₂-salicylaldimine with [Pd(pic)Cl₂] (pic = 2-picolylamine). The composition and structure of the complexes were confirmed by FT-IR, ¹H NMR and ¹³C NMR spectroscopy, elemental anal. and x-ray crystallog. The electronic structure of the reported complexes was investigated using UV-vis absorption and electronic CD (ECD) spectroscopy, complemented by DFT/TDDFT modeling. To investigate the effect of chirality and different halogen substituents on the anticancer activity of the complexes, the cytotoxic activity of all fourteen complexes was tested in the human breast cancer cell lines MDA-MB-231 and MCF-7 at 24 h using the colorimetric MTT assay. Also, the cell death mechanism was assessed using the annexin V/propidium iodide (AV/PI) cytometry-based assay.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Computed Properties of 90-59-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 90-59-5, formula is C7H4Br2O2, The most pervasive is the naturally produced bromomethane. Product Details of C7H4Br2O2

Kordestani, Nazanin;Rudbari, Hadi Amiri;Fateminia, Zohreh;Caljon, Guy;Maes, Louis;Mineo, Placido G.;Cordaro, Annalaura;Mazzaglia, Antonino;Scala, Angela;Micale, Nicola research published 《 Antimicrobial and antiprotozoal activities of silver coordination polymers derived from the asymmetric halogenated Schiff base ligands》, the research content is summarized as follows. A series of polymeric silver(I) complexes with Schiff base ligands containing pyridine and 3,5-halogen substituted phenol moieties were synthesized and characterized by spectroscopic methods and in the case of Ag6 also by X-ray crystallog. All silver(I) complexes (Ag1-Ag8) were evaluated for their biol. activity against a panel of pathogens including the protozoa Trypanosoma cruzi, T. brucei, T. rhodesiense and Leishmania infantum; the bacteria Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis H37Ra and the yeast Candida albicans. Cytotoxicity evaluation was carried out on human lung fibroblasts (MRC-5) and on primary peritoneal mouse macrophages. The most relevant result reveals antileishmanial activity potential with all complexes demonstrating higher potency than the reference drug miltefosine. Complexes with the best antiprotozoal profile (i.e., Ag2 and Ag7) were selected for incorporation into poly(lactic acid) nanoparticles (PLA NPs) with the aim to enhance selectivity. PLA/Ag2 NPs and PLA/Ag7 NPs exhibited adequate physicochem. properties, i.e., average size of 263 ± 60 nm and 225 ± 6 nm, resp., good entrapment efficiency (69% and 63%), loading content (6.2% and 5.7%) and stability. The cytotoxicity of PLA/Ag2 NPs and PLA/Ag7 NPs on MRC-5 cells was reduced with respect to the “free” metal complexes by ∼2-fold and ∼6-fold, resp.

Product Details of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 5392-10-9.

Korch, Katerina M.;Watson, Donald A. research published 《 Total Synthesis of (±)-Impatien A via Aza-Heck Cyclization》, the research content is summarized as follows. The first total synthesis of the natural product impatien A is described. This concise synthesis features an aza-Heck cyclization to construct the complex spirocyclic ring system and provides a rare example of the use of aza-Heck cyclizations in complex mol. synthesis. To enable this key cyclization of an electrophilic nitrogen atom with a tetrasubstituted alkene, we utilized high-throughput experimentation to identify a new ligand and ultimately deliver impatien A in seven steps from known compounds

Reference of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. COA of Formula: C7H6Br2.

Kong, Haiyan;Meng, Xianshe;Hou, Rui;Yang, Xiaoxiao;Han, Jihong;Xie, Zhouling;Duan, Yajun;Liao, Chenzhong research published 《 Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation》, the research content is summarized as follows. Successes have been achieved in developing human monoamine oxidase B (hMAO-B) inhibitors as anti-Parkinson’s disease (PD) drugs. However, low efficiency and unwanted side effects of the marketed hMAO-B inhibitors hamper their medical applications, therefore, novel potent selective hMAO-B inhibitors are still of great interest. Herein we report 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as hMAO-B inhibitors, which were designed by employing a fragment-based drug design strategy to link rasagiline to hydrophobic fragments. Among the synthesized 31 compounds, I and II demonstrated very encouraging hMAO-B inhibitory activities and selectivity over hMAO-A, better than rasagiline and safinamide. In vitro studies indicated that K8 and K24 are nontoxic to nervous tissue cells and they have considerable effects against ROS formation and potential neuroprotective activity. Further mice behavioral tests demonstrated these two compounds have good therapeutic effects on MPTP-induced PD model mice. All these experiment results suggest that compounds K8 and K24 can be promising candidates for further research for treatment of PD.

COA of Formula: C7H6Br2, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary