Month: October 2022

On December 1, 2020, Serran- Aguilera, Lucia; Mariotto, Elena; Rubbini, Gianluca; Castro Navas, Francisco Fermin; Marco, Carmen; Carrasco-Jimenez, Maria Paz; Ballarotto, Marco; Macchiarulo, Antonio; Hurtado-Guerrero, Ramon; Viola, Giampietro; Lopez-Cara, Luisa Carlota published an article.Computed Properties of 2567-29-5 The title of the article was Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism. And the article contained the following:

Seeking for new anticancer drugs with strong antiproliferative activity and simple mol. structure, we designed a novel series of compounds based on our previous reported pharmacophore model composed of five moieties. Antiproliferative assays on four tumoral cell lines and evaluation of human choline kinase CKα1 enzymic activity was performed for these compounds Among tested mols., those ones with biphenylmethyl groups showed better enzymic and antiproliferative activities. Docking and crystallization studies validate the hypothesis and confirm the results. The most active compound, the biphenylmethylquinolinium bromide I·Br-, induced significant arrest of the cell cycle in G0/G1 phase that ultimately lead to apoptosis, following the mitochondrial pathway, as demonstrated for other choline kinase inhibitors. However, addnl. assays reveal that the inhibition of choline uptake could also be involved in the antiproliferative activity of this class of compounds The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Computed Properties of 2567-29-5

The Article related to benzylquinolinium benzylpyridinium benzylquinuclidinium preparation choline kinase inhibition, structure benzylpyridinium benzylquinolinium benzylquinuclidinium inhibition choline kinase antitumor activity, benzylpyridinium bromide complex choline kinase mol crystal structure and other aspects.Computed Properties of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 31, 2020, Liang, Xiao; Fu, Huansheng; Xiao, Peng; Fang, Hao; Hou, Xuben published an article.Category: bromides-buliding-blocks The title of the article was Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors. And the article contained the following:

Synthesized imidazolidine-2,4-dione derivatives I [R = carboxymethyl, Ph, benzyl, (4-carboxyphenyl)methyl, (4-phenylphenyl)methyl] and 2-thioxothiazolidin-4-one derivatives II (R1 = Bu, cyclohexyl, 2-chlorophenyl, thiazol-2-yl, etc.; R2 = carboxy, 4-carboxyphenyl, 2-carboxyeth-1-en-1-yl, etc.) as new LYP inhibitors were designed. Among them, the cinnamic acids-based inhibitors II [R1 = 2-methoxyphenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl; R1 = 4-chlorophenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl (III)] displayed good LYP inhibitory activities (IC50 = 2.85-6.95μM). Especially, the most potent inhibitor III was identified as competitive inhibitor (Ki = 1.09μM) and bind LYP reversibly. Meanwhile, III exhibited better selectivity over other phosphatases than known LYP inhibitor A15. Furthermore, compound III could regulate TCR associated signaling pathway in Jurkat T cell. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to thioxothiazolidinone preparation docking lymphoid tyrosine phosphatase inhibitor autoimmunity, imidazolidinedione preparation diastereoselective docking lymphoid tyrosine phosphatase inhibitor autoimmunity, autoimmune diseases, inhibitor, lymphoid-specific tyrosine phosphatase and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 28, 2019, de O. Assis, Shalom P.; da Silva, Moara T.; da Silva, Filipe Torres; Sant’Anna, Mirella P.; de Albuquerque Tenorio, Carolina M. B.; dos Santos, Caroline F. Brito; da Fonseca, Caique S. M.; Seabra, Gustavo; Lima, Vera L. M.; de Oliveira, Ronaldo N. published an article.Category: bromides-buliding-blocks The title of the article was Design and synthesis of triazole-phthalimide hybrids with anti-inflammatory activity. And the article contained the following:

Phthalimido-alkyl-1H-1,2,3-triazole derivatives were efficiently synthesized using 1,3-dipolar cycloaddition reaction. Anti-inflammatory activity and toxicity studies were performed. The results demonstrated that all the tested compounds reduced carrageenan-induced paw edema and indicated no lethality for toxicity against Artemia salina and acute toxicity in vivo (LD50 up to 1 g kg-1). Furthermore, the structure of phthalimide linked to Ph group proved to be more active than the compounds containing benzothiazole moiety. Structural modifications such as removal of the phthalimide group and subsequent acetylation, to exemplify a non-cyclic amide, demonstrate that the phthalimide and triazole moieties were important for design of potent candidates with anti-inflammatory drug proprieties. Docking into the cyclooxygenase-2 (COX-2) confirmed the importance of the phthalimide and triazole groups in the anti-inflammatory activity. The histopathol. studies showed that the compounds did not cause serious pathol. lesions liver or kidneys. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks

The Article related to benzothiazolyl sulfanyl methyl phthalimidoylalkyl triazole regioselective preparation, phenyl phthalimido alkyl triazole regioselective preparation, antiinflammatory activity sar acute toxicity lipophilicity mol docking, anti-inflammatory activity, phthalimide, toxicity, triazole and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 17, 2021, Li, Wangbing; Lu, Zhichao; Hammond, Gerald B.; Xu, Bo published an article.Electric Literature of 2567-29-5 The title of the article was Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride. And the article contained the following:

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerated nucleophilic fluorinations using easy handling KF. An inexpensive and com. available ion-exchange resin was successfully converted to the polymer-supported ion pair promoter (A26-SO42-), which could be reused after filtration. Moreover, A26-SO42- could be used in continuous flow conditions. Water was well-tolerated. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to alkyl fluoride preparation, methanesulfonate alkyl nucleophilic fluorination unbalanced ion pair catalyst, bromide alkyl nucleophilic fluorination unbalanced ion pair catalyst, sulfonyl fluoride preparation, chloride sulfonyl nucleophilic fluorination unbalanced ion pair catalyst and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gong, Lingzhen; Zhao, He; Yang, Jian; Jiang, Huanfeng; Zhang, Min published an article in 2021, the title of the article was Selective construction of fused heterocycles by an iridium-catalyzed reductive three-component annulation reaction.Computed Properties of 2567-29-5 And the article contains the following content:

Here, through an initial pretreatment of N-heteroarenes with alkyl bromide, a syn-selective construction of functional fused heterocycles, chromenoquinolinones I [R1 = H, 7-Br, 10-NO2, etc.; R2 = CH2CH=CH2, Ph, 4-MeC6H4, etc.; R3 = H, Me; R4 = Me, Ph, 2-furyl] and chromenopyranoquinolinones II [R5 = H, 10-Me, 7-Br, etc.; R6 = H, 3-MeO, 2-Br, etc.] via iridium catalyzed reductive annulation of N-heteroarenium salts with formaldehyde and cyclic 1,3-diketones or 4-hydroxycoumarins, proceeding with broad substrate scope, good functional group compatibility, readily available feedstocks, and high step and atom efficiency was described. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Computed Properties of 2567-29-5

The Article related to chromenoquinolinone preparation diastereoselective, cyclohexanedione quinolinium bromide selective reductive annulation iridium catalyzed, chromenopyranoquinolinone preparation diastereoselective, hydroxycoumarin quinolinium bromide selective reductive annulation iridium catalyzed and other aspects.Computed Properties of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 15, 2015, Dominique, Romyr; Lopez-Tapia, Francisco Javier; Mertz, Eric; So, Sung-Sau published a patent.Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid The title of the patent was Inhibitors of bruton’s tyrosine kinase. And the patent contained the following:

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient. The experimental process involved the reaction of 2-Bromo-4-fluoro-5-methylbenzoic acid(cas: 1003709-39-4).Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid

The Article related to pyridinone phthalazinone preparation brutons tyrosine kinase btk inhibitor antiinflammatory, phthalazinone oxopyridinylbenzyl preparation auto immune disease aberrant bcell proliferation, rheumatoid arthritis treatment antirheumatic pyridinone phthalazinone preparation btk inhibitor and other aspects.Application In Synthesis of 2-Bromo-4-fluoro-5-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 22, 2014, Dominique, Romyr; Lopez-Tapia, Francisco Javier; Mertz, Eric; So, Sung-Sau published a patent.Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid The title of the patent was Preparation of substituted pyridinones as inhibitors of bruton’s tyrosine kinase. And the patent contained the following:

The title compounds I [A = (un)substituted unsaturated or partially saturated monocyclic or bicyclic heteroaryl or phenyl; R1 = halo, hydroxyalkyl, alkyl; m = 0-2; R2 = Me, pyrazolyl; n = 0-1; X = a bond, CH2, NHC(O)], useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity, were prepared E.g., a multi-step synthesis of II, starting from 6-tert-butyl-8-fluoro-2H-phthalazin-1-one and 1-bromo-4-chloromethylbenzene, was described. Exemplified compounds I were evaluated for their Btk inhibitory activity (data given). The compounds I are useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds I and at least one carrier, diluent or excipient. The experimental process involved the reaction of 2-Bromo-4-fluoro-5-methylbenzoic acid(cas: 1003709-39-4).Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid

The Article related to pyridinone phthalazinone preparation bruton’s tyrosine kinase btk inhibitor antiinflammatory, phthalazinone oxopyridinylbenzyl preparation auto immune disease aberrant bcell proliferation, rheumatoid arthritis treatment antirheumatic pyridinone phthalazinone preparation btk inhibitor and other aspects.Recommanded Product: 2-Bromo-4-fluoro-5-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mumtaz, Saira; Robertson, Mark J.; Oelgemoller, Michael published an article in 2019, the title of the article was Continuous flow photochemical and thermal multi-step synthesis of bioactive 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

An effective multi-step continuous flow approach towards N-(diamino)alkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones I [R = H, Me, OMe, F, R1 = Me, Et, X = (CH2)n, n = 2, 3], including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochem.-thermal-thermal flow setup rapidly provides the desired target compounds I in superior yields and significantly shorter reaction times. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to arylmethylene isoindolinone preparation continuous flow photochem thermal, bromoalkyl phthalimide arylactetate continuous flow photochem thermal reaction, arylmethylene isoindolinones, continuous-flow photochemistry, multi-step synthesis, photochemistry, photodecarboxylation, phthalimide and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 10, 2022, Chen, Chen published a patent.Related Products of 111010-07-2 The title of the patent was Preparation of cyclic iminopyridimdine compounds and their bicyclic derivatives as kinase inhibitors and uses thereof. And the patent contained the following:

Provided are the title compounds I [G1 = N or CRa; G2 = N or CRb; n = 1 or 2; m = 0-3; Ra and Rb = (independently) H, halo, CN, etc.; each R1 = (independently) halo, (un)substituted alkyl, alkoxy; or two R1 groups with the carbon atom they connect to form (un)substituted 4-7 membered carbocyclic or heterocyclic ring; R2 = H, (un)substituted alkyl, alkoxy, etc.; R3 = H, halo, (un)substituted alkyl, alkoxy; R4 = H, (un)substituted alkyl, heterocyclyl, etc.; and R5 = H, alkyl, or heterocyclyl; or NR4R5 = (un)substituted heterocyclyl or heteroaryl; with the provisos] or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to kinases such as MAPK, PDGFR, Src, PAKs, c-Kit, EphA2, EphB4, FGFR, Axl, and c-Met. E.g., a multi-step synthesis of II, starting from 4-amino-2-(methylthio)pyrimidine-5-carboxaldehyde and Me 2-(2,4-dichlorophenyl)acetate, was described. The effect of the exemplified compounds I on the activity of various kinases were assessed (data given for representative compounds I). The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Related Products of 111010-07-2

The Article related to cyclic iminopyrimidine bicyclic derivative preparation kinase inhibitor antitumor, mapk pdgfr src pak kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation, ckit epha2 ephb4 kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation antitumor and other aspects.Related Products of 111010-07-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 1, 2018, Erokhina, Svetlana A.; Stogniy, Marina Yu.; Suponitsky, Kyrill Yu.; Kosenko, Irina D.; Sivaev, Igor B.; Bregadze, Vladimir I. published an article.COA of Formula: C10H8BrNO2 The title of the article was Synthesis of new nido-carborane based carboxylic acids and amines. And the article contained the following:

New nido-carborane based carboxylic acids 10-HOOC(CH2)n(Me)S-7,8-C2B9H11 (n = 1-4) were prepared by alkylation of Bu4N salt of 10-methylthio-7,8-dicarba-nido-borane with ω-haloalkyl esters or nitriles followed by acid hydrolysis. Likewise nido-carborane based amines 10-H2N(CH2)n(Me)S-7,8-C2B9H11 (n = 2, 3) were obtained using ω-bromoalkylphthalimides as alkylating agents followed by removal of the protecting group with hydrazine. Structure of 10-C6H4(CO)2NCH2CH2(Me)S-7,8-C2B9H11 was determined by single crystal x-ray diffraction. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2

The Article related to amine carboranylthioalkyl derivative preparation, carboxylic acid carboranylthioalkyl derivative preparation, carboranyl thioalkylphthalimide preparation crystal structure reaction hydrazine, mol structure carboranyl thioalkylphthalimide, alkylation thiodicarbaborane haloalkyl ester nitrile and other aspects.COA of Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary