Month: October 2022

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 70-23-5.

Haroon, Muhammad;de Barros Dias, Mabilly Cox Holanda;Santos, Aline Caroline da Silva;Pereira, Valeria Rego Alves;Barros Freitas, Luiz Alberto;Balbinot, Rodolfo Bento;Kaplum, Vanessa;Nakamura, Celso Vataru;Alves, Luiz Carlos;Brayner, Fabio Andre;Leite, Ana Cristina Lima;Akhtar, Tashfeen research published ã€?The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivativesã€? the research content is summarized as follows. Given this, novel 1,3-thiazoles I (Ar = Ph, 3-chlorophenyl, furan-2-yl, etc.; R = H, Me) and 4-thiazolidinones II (R¹ = (phenylmethylidene)aminyl, [(4-hydroxy-3-methoxyphenyl)methylidene]aminyl, 1,2,3,4-tetrahydronaphthalen-1-iminyl, etc.; R² = Me, Et) using bioisosteric and esterification strategies to develop improved and safer drug candidates were synthesized. Then, in vitro assays were performed, against Leishmania infantum and Leishmania amazonensis promastigotes, Trypanosoma cruzi trypomastigotes and amastigotes, for selected compounds I and II to determine IC₅₀ and SI, with cytotoxicity on LLC-MK2 cell lines. Overall, 1,3-thiazoles I exhibited better trypanocidal activity than 4-thiazolidinones II. The compound I[Ar = 2-bromophenyl, R = H] (III), an ortho-bromobenzylidene-substituted 1,3-thiazole (IC₅₀ = 0.83μM), is the most potent of them all. In addition, compounds I and II had negligible cytotoxicity in mammalian cells (CC₅₀ values > 50μM). Also noteworthy is the examination of the cell death mechanism of T. cruzi, which showed that compound III induced necrosis and apoptosis in the parasite. SEM anal. demonstrated that the treatment of Trypanosoma cruzi trypomastigote cells with the compound III at different IC₅₀ concentrations promoted alterations in the shape, flagella and body surface, inducing parasite death. Together, the data revealed a novel series of 1,3-thiazole structure-based compounds I with promising activity against Trypanosoma cruzi and Leishmania spp., broadening ways for scaffold optimization.

Application In Synthesis of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Application In Synthesis of 70-23-5

Haroon, Muhammad;Akhtar, Tashfeen;Yousuf, Muhammad;Tahir, Muhammad Nawaz;Rasheed, Lubna;Zahra, Syeda Saniya;Haq, Ihsan ul;Ashfaq, Muhammad research published �Synthesis, crystal structure, Hirshfeld surface investigation and comparative DFT studies of ethyl 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate� the research content is summarized as follows. The Et 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate, a thiazole ester, was synthesized by refluxing 1-(2-nitrobenzylidene)thiosemicarbazide and Et bromopyruvate. The compound is characterized by spectrometric, spectroscopic and single crystal (SC-XRD) techniques. Non-covalent interactions that are responsible for crystal packing are explored by Hirshfeld surface anal. All theor. calculations were performed by DFT quantum chem. methods using 6-311G(d,p) and cc-pVTZ basis sets and compared. Theor. harmonic frequencies of Et 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate were optimized. Confirmation of hydrogen bonding sites was analyzed by mol. electrostatic potential (MEP) and Mulliken population anal. The vibrational frequencies of characteristic functional groups and chem. shifts were found in good agreement with exptl. assignments. Frontier MO (FMO) revealed relatively small HOMO-LUMO (HOMO-LUMO) gape, which speaks off the nearly planar geometry and extended conjugation, as compared to the substituents with no conjugation possible. It has also been observed that -NO2 substituent plays a vital role for this relatively small HOMO-LUMO gape and overall electronic properties when compared with similar thiazole carboxylates. Et 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate was also evaluated for its anti-oxidant and anti-microbial activities.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Application In Synthesis of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Reference of 70-23-5

Hao, Zesheng;Yu, Bin;Gao, Wei;Chen, Haoyin;Yang, Dongyan;Lv, You;Zhang, Yue;Chen, Lei;Fan, Zhijin research published ã€?Design, synthesis and fungicidal activity of pyrazole-thiazole carboxamide derivativesã€? the research content is summarized as follows. Twenty-one novel pyrazole-thiazole carboxamide derivatives were rationally designed and synthesized I [R = 2-(p-tolyl)ethyl, 2-(2-chlorophenyl)ethyl, 2-[4-(trifluoromethoxy)phenyl]ethyl, etc.] and II. Bioassay results indicated that I [R = 2-(p-tolyl)ethyl, 2-(2-chlorophenyl)ethyl] (EC₅₀ = 5.11μg/mL), (EC₅₀ = 8.14μg/mL) resp. exhibited better in-vitro activities than fluxapyroxad (EC₅₀ = 11.93μg/mL) and thifluzamide (EC₅₀ = 22.12μg/mL) against Rhizoctonia cerealis. Particularly, compound I [R = 2-(2-chlorophenyl)ethyl] showed promising in-vivo protective activity against Rhizoctonia solani and Puccinia sorghi Schw. with 80% and 90% inhibition at 10μg/mL, resp. Pyrazole-thiazole I was a promising fungicide lead deserving for further derivation.

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 402-49-3.

Han, Xue;Shan, Li-Xin;Zhu, Jin-Xin;Zhang, Chang-Sheng;Zhang, Xiao-Ming;Zhang, Fu-Min;Wang, Hong;Tu, Yong-Qiang;Yang, Ming;Zhang, Wen-Shuo research published �Copper-Nitrene-Catalyzed Desymmetric Oxaziridination/1,2-Alkyl Rearrangement of 1,3-Diketones toward Bicyclic Lactams� the research content is summarized as follows. The novel copper-nitrene-catalyzed desym. oxaziridination reaction of cyclic diketones with alkyl azides and the subsequent rearrangement of the resulting highly active intermediate, which produces a synthetically challenging chiral bicyclic lactam containing a quaternary carbon center were reported. This procedure not only enriches the copper-nitrene-catalyzed asym. reactions, but also provides an alternative strategy to address the inherent challenges of catalytic asym. Schmidt reactions. This unique reaction could inspire the investigation of novel copper-nitrene-catalyzed asym. transformations and their reaction mechanisms.

HPLC of Formula: 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Electric Literature of 402-49-3

Han, Ming-Liang;Chen, Jun-Jie;Xu, Hui;Huang, Zhi-Cong;Huang, Wei;Liu, Yu-Wen;Wang, Xing;Liu, Min;Guo, Zi-Qiong;Dai, Hui-Xiong research published �Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters� the research content is summarized as follows. Herein, a novel decarbonylative Catellani reaction via palladium-catalyzed, norbornene (NBE)-mediated polyfunctionalization of aromatic thioesters, which served as readily available carboxylic acid derivs was reported. A variety of alkenyl, alkyl, aryl and sulfur moieties was conveniently introduced into the ipso-positions of the aromatic thioesters. By combining carboxyl-directed C-H functionalization and the classical Catellani reaction, this protocol allows for the construction of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted arenes from simple aromatic acids. Furthermore, the late-stage functionalization of a series of drug mols. highlights the potential utility of the reaction.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Electric Literature of 402-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4224-70-8, formula is C6H11BrO2, The most pervasive is the naturally produced bromomethane. Application In Synthesis of 4224-70-8

Han, Jingjing;Li, Haidong;Zhao, Luyang;Kim, Gyoungmi;Chen, Yahui;Yan, Xuehai;Yoon, Juyoung research published ã€?Albumin-mediated “Unlocking” of supramolecular prodrug-like nanozymes toward selective imaging-guided phototherapyã€? the research content is summarized as follows. Construction of an activatable photosensitizer and integration into an adaptive nanozyme during phototherapy without producing off-target toxicity remains a challenge. Herein, we have fabricated a prodrug-like supramol. nanozyme based on a metallic-curcumin and cyanine co-assembly. The albumin-mediated phenol AOH group transformation of nanozyme changes its adjustable oxygen stress from neg. superoxide dismutase-like activity of ROS-scavenging to pos. photo oxidase activity with an ROS-amplifying capacity. It further increases the depth penetration of a nanozyme in a tumor spheroid, selectively targeting tumorous phototherapy. It also triggers a signal in targeted tumor cells and helps increase cancer cell ablation. This work suggests new options for development of activatable supramol. nanozymes and provides a synergetic prodrug-like nanozyme strategy for early diagnosis and preclin. phototherapeutics.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Application In Synthesis of 4224-70-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Recommanded Product: Methyl 4-bromobutanoate

Han, Hae Ji;Lee, Sung-Sik;Kang, Seok Min;Kim, Yerin;Park, Chanho;Yoo, Suah;Kim, Chul Hee;Oh, Young-Ho;Lee, Sungyul;Kim, Dong Wook research published ã€?The Effects of Structural Modifications of Bis-tert-alcohol-Functionalized Crown-Calix[4]arenes as Nucleophilic Fluorination Promotors and Relations with Computational Predictionsã€? the research content is summarized as follows. The authors prepared four structurally modified bis-tert-alc. functionalized crown ether-strapped calix[4]arene promoters, i.e., bis-tert-alc. functionalized crown-5-calix[4]arene (BA5C), bis-tert-alc. functionalized crown-7-calix[4]arene (BA7C), bis-1,1-dimethylbutanol functionalized crown 6-calix[4]arene (B3A6C), and bis-1,1-dimethylhexanol functionalized crown 6-calix[4]arene (B5AC6C). Nucleophilic fluorinations were conducted using alkali metal fluorides to study phase-transfer catalytic activities with respect to the sizes of crown ether-strapped calix[4]arene (CEC) subunits and lengths of alkyl chain spacers between tert-alc. and CEC subunits. The reactivity of potassium fluoride was significantly enhanced by BA5C promoter because its crown-5-calix[4]arene subunit had cavity size appropriate for K⁺ capture. In contrast, BA7C did not efficiently enhance cesium fluoride S_N2 fluorination because its crown-7-calix[4]arene cavity was too large to capture Cs⁺. The alkyl spacer of bis-tert-alc. functionalized CEC provided sufficient distance between F^– and Cs⁺. In particular, the three-component alkyl carbon chain of B3A6C was optimal in terms of increasing CsF reactivity. Systematic quantum chem. anal. predicted that fluorination reactions facilitated by bis-tert-alc.-substituted crown-6-calix[4]arene (BACCA) and B3A6C might proceed via separated ion-pair type pre-reaction complexes, which suggested that these two promotors act as Lewis bases that essentially sep. CsF ion-pairs. The lower (by 0.4 kcal/mol) Gibbs free energy of activation for the reaction promoted by B3A6C than that facilitated by BACCA concurred with the exptl. observed slightly greater efficiency of B3A6C than BACCA.

Recommanded Product: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Formula: C5H9BrO2

Han, Guiyan;Liu, Na;Li, Chenglan;Tu, Jie;Li, Zhuang;Sheng, Chunquan research published ã€?Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasisã€? the research content is summarized as follows. Invasive fungal infections (particularly candidiasis) are emerging as severe infectious diseases worldwide. Because of serious antifungal drug resistance, therapeutic efficacy of the current treatment for candidiasis is limited and associated with high mortality. However, it is highly challenging to develop novel strategies and effective therapeutic agents to combat drug resistance. Herein, the first generation of lanosterol 14α-demethylase (CYP51)-histone deacetylase (HDAC) dual inhibitors was designed, which exhibited potent antifungal activity against azole-resistant clin. isolates. In particular, compounds 12h(II) and 15j(I) were highly active both in vitro and in vivo to treat azole-resistant candidiasis. Antifungal mechanism studies revealed that they acted by blocking ergosterol biosynthesis and HDAC catalytic activity in fungus, suppressing the function of efflux pump, yeast-to-hypha morphol. transition, and biofilm formation. Therefore, CYP51-HDAC dual inhibitors represent a promising strategy to develop novel antifungal agents against azole-resistant candidiasis.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C5H7BrO3.

Hamedani, Naghmeh Faal;Ghazvini, Maryam;Sheikholeslami-Farahani, Fatemeh;Bagherian-Jamnani, Mohammad Taghi research published ã€?ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activityã€? the research content is summarized as follows. In this work, thiophene derivatives I [R = 4-H₃CC₆H₄, 4-H₃COC₆H₄, 4-O₂NC₆H₄, CH₃CH₂OC(O); R¹ = Me, Et; R² = 4-H₃CC₆H₄, 4-H₃COC₆H₄] were synthesized in good yields via multicomponent reaction of isoquinoline, alkyl bromides BrCH₂C(O)R, activated acetylenic compounds R¹OC(O)CCC(O)OR¹, isothiocyanates R²N=C=S, and catalytic amounts of ZnO nanorods (NRs) at room temperature under solvent-free conditions. This procedure for the synthesis of thiophene derivatives I is green, easy, and simple with excellent yield. In addition, DPPH radical scavenging and ferric reduction power experiment has been studied for the evaluation of the antioxidant activity of some prepared thiophenes, for example, I [R = CH₃CH₂OC(O), R¹ = Me, R² = 4-H₃COC₆H₄ (A); R = 4-O₂NC₆H₄, R¹ = Me, R² = 4-H₃CC₆H₄ (B); R = CH₃CH₂OC(O), R¹ = Me, R² = 4-H₃CC₆H₄ (C); R = CH₃CH₂OC(O), R¹ = Et, R² = 4-H₃COC₆H₄ (D)]. As outcome, the compound (B) exhibited a noteworthy radical trapping activity and excellent reducing ability than synthetic antioxidants such as butylated hydroxytoluene (BHT) and 2-tertbutylhydroquinone (TBHQ). Moreover, the antimicrobial activity of some synthesized thiophenes was confirmed by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. The obtained results of disk diffusion test showed that compounds (A), (B), (C), and (D) prevented bacterial growth.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 70-23-5.

Hamedani, Naghmeh Faal;Azad, Leila;Shafiee, Shahin;Noushin, Annataj research published ã€?Green Synthesis of Thiazole Derivatives using Multi-component Reaction of Aldehydes, Isothiocyanate and Alkyl Bromides: Investigation of Antioxidant and Antimicrobial Activityã€? the research content is summarized as follows. The multicomponent reaction of aldehydes, benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide and a catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in the water at 100°C was investigated. In these reactions, thiazole I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] were produced in good to excellent yields and short time. Also, the antioxidant activity was studied for some newly synthesized compounds using the DPPH radical trapping and reducing of ferric ion experiments and compared the results with synthetic antioxidants (TBHQ and BHT). As a result, the compounds I [R= i-Pr; R¹ = ethoxycarbonyl] showed excellent DPPH radical trapping and reducing the strength of ferric ion. These compounds I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] have biol. potential because of the thiazole core. For this reason, the antimicrobial activity of some synthesized compounds I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] was studied by employing the disk diffusion test on Gram-pos. bacteria and Gram-neg. bacteria. The results of the disk diffusion test showed that these compounds I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] prevented bacterial growth.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., HPLC of Formula: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary