Month: October 2022

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organic compounds having carbon bonded to bromine are called organic bromides. Related Products of 6911-87-1.

Shinohara, Koichi;Tsurugi, Hayato;Mashima, Kazushi research published 《 N-Methylation of Aniline Derivatives with CO₂ and Phenylsilane Catalyzed by Lanthanum Hydridotriarylborate Complexes bearing a Nitrogen Tridentate Ligand》, the research content is summarized as follows. A lanthanum amide complex, La(L)[N(SiHMe₂)₂](thf) (L = N,N”-bis(pentafluorophenyl)diethylenetriamine dianion), upon activation with B(3,4,5-F₂C₆H₂)₃, showed excellent catalytic activity for N-methylation of N-alkylaniline derivatives with CO₂ in the presence of PhSiH₃. A catalytically active lanthanum hydridotriarylborate complex, [La(L)(thf)₂][HB(3,4,5-F₃C₆H₂)₃], was generated via hydride abstraction from the Si-H moiety by moderate Lewis acid B(3,4,5-F₂C₆H₂)₃ in THF. DFT studies of the CO₂ hydrosilylation step clarified the following multiple noncovalent interactions as key factors for locating the HB(3,4,5-F₂C₆H₂)₃ anion and B(3,4,5-F₃C₆H₂)₃ near the lanthanum center in the transition states of CO₂ reduction and Si-O bond formation: (1) π-π interaction between the electron-deficient C₆F₅ ring on ligand L and the 3,4,5-F₃C₆H₂ ring of the HB(3,4,5-F₃C₆H₂)₃ anion and (2) C-H···F hydrogen bonds between the ortho-C-H bond of B(3,4,5-F₃C₆H₂)₃ and the fluorine atoms of L.

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Related Products of 6911-87-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Safety of 6-Bromohexanoic acid.

Shinohara, Akira;Shao, Guang;Nakanishi, Takashi;Shinmori, Hideyuki research published 《 Porphyrin photoabsorption and fluorescence variation with adsorptive loading on gold nanoparticles》, the research content is summarized as follows. Here, we report the photophys. structure-property relationship of porphyrins adsorbed on gold nanoparticles. The number of porphyrin-alkanethiolate adsorbates per particle was adjusted by a post-synthetic thiol/thiolate exchange reaction on 1-dodecanethiolate-protected gold nanoparticles. Even with a low loading level of adsorbates (<10% of all thiolate sites on gold nanoparticles), the shoulder absorption at the Soret band was intensified, indicating the formation of aggregates of porphyrin adsorbates on the nanoparticles. Steady-state fluorescence quantum yields could be adjusted by the bulkiness of substituents at the meso-positions of the porphyrin or the methylene linker chain length, regardless of the porphyrin loading level and the nanoparticle diameter

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Safety of 6-Bromohexanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application of C8H6BrF3.

Shin, Young-Hee;Jeong, Kiyoung;Lee, Jihye;Lee, Hyo Jung;Yim, Junhyeong;Kim, Jonghoon;Kim, Seungtaek;Park, Seung Bum research published 《 Inhibition of ACE2-Spike Interaction by an ACE2 Binder Suppresses SARS-CoV-2 Entry》, the research content is summarized as follows. The emergence of SARS-CoV-2 variants is a significant concern in developing effective therapeutics and vaccines in the middle of the ongoing COVID-19 pandemic. Here, we have identified a novel small mol. that inhibited the interactions between SARS-CoV-2 spike RBDs and ACE2 by modulating ACE2 without impairing its enzymic activity necessary for normal physiol. functions. Furthermore, the identified compounds suppressed viral infection in cultured cells by inhibiting the entry of ancestral and variant SARS-CoV-2. Our study suggests that targeting ACE2 could be a novel therapeutic strategy to inhibit SARS-CoV-2 entry into host cells and prevent the development of COVID-19.

Application of C8H6BrF3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., HPLC of Formula: 4224-70-8.

Shimomura, Takashi;Seino, Ryo;Umezaki, Kaori;Shimoda, Asako;Ezoe, Takatoshi;Ishiyama, Munetaka;Akiyoshi, Kazunari research published 《 New Lipophilic Fluorescent Dyes for Labeling Extracellular Vesicles: Characterization and Monitoring of Cellular Uptake》, the research content is summarized as follows. PKH dyes, which are currently the most widely used fluorescent probes for extracellular vesicle (EV) labeling, have some limitations. For example, these dyes tend to aggregate, leading to formation of EV-like nanoparticles that can be taken up by cells. Moreover, it has been suggested that PKH dyes trigger an enlargement of EVs because of membrane fusion or intercalation. To overcome these limitations, we developed three novel extracellular vesicular-membrane-binding fluorescent probes-Mem dye-Green, Mem dye-Red, and Mem dye-Deep Red with general formula I wherein X is selected from O and C(CH₃)₂ and n is an integer selected from 1 and 2-for monitoring EV uptake into cells. The dyes contain a cyanine group as a fluorescent scaffold and amphiphilic moieties on the cyanine. The three dyes have different photophys. characteristics. To investigate the characteristics of the Mem dyes for EV labeling, we performed nanoparticle tracking, zeta potential measurements, and confocal microscopy. The dyes enable highly sensitive fluorescence imaging of EVs. They can also be used to observe EV dynamics in live cells. The Mem dyes show excellent EV labeling with no aggregation and less particle enlargement.

HPLC of Formula: 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 244205-40-1.

Shi, Zhaojiang;Lu, Hao-Kuan;Li, Nan;Yuan, Yaofeng;Li, Zhen;Ye, Ke-Yin research published 《 Electrochemical oxidative dearomatization of 2-arylthiophenes》, the research content is summarized as follows. A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC₆H₄, 2-pyridyl, etc.; R¹ = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity.

244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., Electric Literature of 244205-40-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 5445-17-0.

Shi, Yanlin;Mudugamuwa, Chanaka J.;Abeysinghe, Thidas N.;Alotaibi, Yasser S. M.;Monteiro, Michael J.;Chalker, Justin M.;Lutkenhaus, Jodie L.;Jia, Zhongfan research published 《 Ionic Effect on Electrochemical Behavior of Water-Soluble Radical Polyelectrolytes》, the research content is summarized as follows. Water-soluble redox-active polymers (RAPs) have emerged as attractive electroactive materials for aqueous redox flow batteries because these systems rely on readily available size-exclusion membranes rather than expensive ion-selective membranes. While incorporating ionic units is the most effective strategy for forming water-soluble redox polyelectrolytes, little is known about how charges dictate their electrochem. behavior. Here, we design a series of water-soluble TEMPO (2,2,6,6-tetramethylpiperidyl-1-oxy) radical polyelectrolytes with identical radical distribution but various ionic groups through a sequential postmodification method. Phys. and electrochem. characterizations show disparate diffusion coefficients (D) and charge transfer kinetics (k⁰) of these radical polyelectrolytes at various pH. Particularly, pH exerts a strong impact on k⁰ of the neg. charged polymer (i.e., with carboxylic acid groups). The bimol. reaction rate k_ex determined from redox-induced polymer films shows electrostatic interactions between charged segments can enhance the electron self-exchange reaction rate by ten folds. The results suggest that charge effects are of great importance when designing water-soluble redox polymers for electrochem. applications.

Synthetic Route of 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organic compounds having carbon bonded to bromine are called organic bromides. Application of C2H7Br2N.

Shi, Xiaoyu;Chu, Yiyue;Wang, Ya;Fang, Zhiqiang;Liu, Zixuan;Deng, Yijia;Dong, Qingsong;Hao, Zhaomin research published 《 Nanohybridization of Keggin polyoxometalate clusters and reduced graphene oxide for lithium-ion batteries》, the research content is summarized as follows. The nanocomposites of reduced graphene oxide (RGO) and polyoxometalates (POMs) have been considered to be effective to boost more Li⁺ to participate in intercalation/deintercalation process of lithium-ion batteries (LIBs). In this paper, a nanocomposite (PMo₁₂@RGO-AIL) with electrostatic interaction of RGO and Keggin-type [PMo₁₂O₄₀]^3- has been fabricated and characterized by XRD, XPS, SEM, and TEM. To prepare PMo₁₂@RGO-AIL, a strategy of covalent modification is developed between amino-based ionic liquid and RGO, helping to achieve the uniform dispersion of [PMo₁₂O₄₀]^3-. When the PMo₁₂@RGO-AIL was used as a cathode for LIBs, it could exhibit more excellent reversible capacity, cycle stability, and rate capability than those of samples without modifying by ionic liquids

Application of C2H7Br2N, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Organic compounds having carbon bonded to bromine are called organic bromides. Name: 1-Bromoheptane.

Shi, Xiang;Xia, TianTian;McKamey, Brooke E.;Wu, Xian;Sun, Yue;Zhou, Weifeng;Zhang, Guangyan research published 《 Concise and Efficient Synthesis of [6]-Paradol》, the research content is summarized as follows. An efficient synthesis of [6]-paradol (I) has been performed in four steps with a 72.0% overall yield. The present method highlights com. available materials, convenient isolation with multiple crystallization without involving column chromatog., and a high-purity product (more than 99.2%), and it is amenable to large-scale synthesis.

Name: 1-Bromoheptane, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4224-70-8, formula is C6H11BrO2, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 4224-70-8

Shi, Mingwan;Fu, Zhongliang;Pan, Wei;Chen, Yuanyuan;Wang, Kaiye;Zhou, Ping;Li, Na;Tang, Bo research published 《 A Protein-Binding Molecular Photothermal Agent for Tumor Ablation》, the research content is summarized as follows. Photothermal therapy usually requires a high power d. to activate photothermal agent for effective treatment, which inevitably leads to damage to normal tissues and inflammation in tumor tissues. Herein, we rationally design a protein-binding strategy to build a mol. photothermal agent for photothermal ablation of tumor. The synthesized photothermal agent can covalently bind to the thiol groups on the intracellular proteins. The heat generated by the photothermal agent directly destroyed the bioactive proteins in the cells, effectively reducing the heat loss and the mol. leakage. Under a low power d. of 0.2 W cm^-2, the temperature produced by the photothermal agent was sufficient to induce apoptosis. In vitro and in vivo experiments showed that the therapeutic effect of photothermal therapy can be efficiently improved with the protein-binding strategy.

HPLC of Formula: 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C7H8BrN.

Shi, Junbin;Wang, Yubin;Bu, Qingqing;Liu, Binyuan;Dai, Bin;Liu, Ning research published 《 Cr-Catalyzed Direct ortho-Aminomethylation of Phenols》, the research content is summarized as follows. A Cr-catalyzed strategy for the regioselective formation of Csp²-Csp³ bonds through the direct and efficient ortho-aminomethylation of N,N-dimethylanilines with phenols is reported. The approach showed excellent site selectivity at the ortho-position of phenols and accommodated broad substrate scope and functional group compatibility for both N,N-dimethylanilines and phenols. Mechanistic studies revealed that the direct ortho-aminomethylation between N,N-dimethylanilines and phenols occurred via an ionic mechanism.

Formula: C7H8BrN, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary