Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of (2-Bromophenyl)boronic acid.
Trzepizur, Damian;Brodzka, Anna;Koszelewski, Dominik;Wilk, Monika;Ostaszewski, Ryszard research published 《 Selective Palladium-Catalyzed α,β-Homodiarylation of Vinyl Esters in Aqueous Medium》, the research content is summarized as follows. A palladium-catalyzed 1,2-diarylation of vinyl esters RC(O)OCH=CH2 (R = Me, Ph, CH2Cl, etc.) with arylboronic acids R1B(OH)2 (R1 = Ph, 3,4-dimethoxyphenyl, 2-bromophenyl, etc.) in water has been developed. This newly elaborated protocol features a good functional group tolerance and provides one-step access to 1,2-diarylethanol derivatives R1CH2CH(R1)OC(O)R under mild reaction conditions. The presented reaction can be carried out in the water at ambient temperature without the addition of any ligands, making this procedure environmentally benign. The transformation occurs within a single catalytic cycle and is feasible due to the modification of transition metal catalytic activity through the influence of π-acceptor olefin (benzoquinone) as well as water as a medium. Moreover, this protocol allows to generate entire compound libraries (highly profitable in medicinal chem.) and utilizes sustainable arylboronic acids as coupling partners under mild conditions. It is also noted that the structure of boron moiety has a great impact on the reaction selectivity, the usage of sterically hindered esters of arylboronic acids influence the reaction course towards stilbenes.
Safety of (2-Bromophenyl)boronic acid, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary