Organic compounds having carbon bonded to bromine are called organic bromides. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 1-Bromoheptane.
Wahid, Sana;Jahangir, Sajid;Ali Versiani, Muhammad;Mohammed Khan, Khalid;Yik Sung, Yeong;Iqbal, Jamshed;Wadood, Abdul;Kanwal;Ur Rehman, Ashfaq;Arshia;Uzair, Muhammad;Ali Khan, Imtiaz;Taha, Muhammad;Perveen, Shahnaz research published 《 Biology-oriented drug synthesis of nitrofurazone derivatives: Their α-glucosidase inhibitory activity and molecular docking studies》, the research content is summarized as follows. In the present study, twenty (20) structural variants of nitrofurazone were synthesized based on BIODS (Biol.-oriented drug synthesis) approach. The structure elucidation of the synthetic mols. (1-20) was carried out using different spectroscopic techniques, and their α-glucosidase inhibitory activity was also determined The synthetic mols. 1-20 exhibited good α-glucosidase inhibition than the parent, nitrofurazone. Four compounds 2, 4, 6, and 7 showed potential inhibition against α-glucosidase with IC50 values ranging between 0.63 ± 0.25-1.29 ± 0.46 μM as compared to the standard acarbose (IC50 = 2.05 ± 0.41 μM). Nevertheless, compounds 15 (IC50 = 0.74 ± 0.12 μM), and 19 (IC50 = 0.54 ± 0.3 μM) also displayed good α-glucosidase inhibition and compound 19 was the most active compound of the series. Kinetic study of the active compounds 7 and 19 was also carried out to confirm the mode of inhibition. The binding interactions of the most active compounds within the active site of enzyme were determined by mol. docking. Moreover, mol. dynamic simulation of compound 19 was also performed in order to determine the stability of the overall complex (α-glucosidase + c19) in an explicit watery environment. The synthetic mols. were predicted as non-cytotoxic, however, seven compounds 1, 3, 4, 9, 10, 11, and 12 were predicted as carcinogenic.
629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Name: 1-Bromoheptane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary