One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Reference of 4224-70-8
Walker, Rebecca;Pociecha, Damian;Faidutti, Camilla;Perkovic, Eva;Storey, John M. D.;Gorecka, Ewa;Imrie, Corrie T. research published 《 Remarkable stabilisation of the intercalated smectic phases of nonsymmetric dimers by tert-butyl groups》, the research content is summarized as follows. The synthesis and characterization of two groups of nonsym. dimers, the 1-(4-cyanobiphenyl-4′-yloxy)-ω-(4-alkylbenzylidene-4′-oxy)alkanes and the 1-(4-cyanobiphenyl-4′-yl)-ω-(4-alkylbenzylidene-4′-oxy)alkanes, are reported. The length and parity of the flexible spacer are varied. The tert-Bu homologues show higher m.ps. than the corresponding sec-Bu or Bu substituted dimers and suggesting that chain branching improves packing efficiency within the crystalline structure. The branched chain homologues have a stronger tendency to exhibit smectic phases than the n-butyl-substituted dimers and are exclusively smectic for longer spacers. A comparison of the nematic-isotropic transition temperatures (TNI) for the dimers and containing the different terminal chains is possible for one set of materials, and reveals a large reduction in TNI on passing from the Bu to sec-butyl-substituted, but a much smaller decrease on changing sec-Bu for tert-Bu. A different trend is observed for the smectic A-isotropic transition temperatures for which the tert-Bu substituted dimers and show a higher value than the corresponding sec-Bu homolog, and only marginally lower than that of the n-butyl-substituted dimers. This surprising behavior is interpreted in terms of the ability of the tert-Bu group to pack more efficiently into the intercalated smectic A phase as the spacer length increases.
Reference of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary