A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.
Wang, Ao;Wang, Yawan;Meng, Xin;Yang, Yushe research published 《 Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer》, the research content is summarized as follows. Two series of novel thiohydantoin derivatives of enzalutamide I (X = C, N, S; R = Br, Ph, 3-pyridyl) and II (M = C, N; A = di-Me, cyclobutyl, oxetanyl, etc.; X = C, N; Y = O, N-methyl; n = 0, 1) as potent androgen receptor (AR) antagonists were designed and synthesized. Among them, compound II (M = C; A = dimethyl; X = C; Y = O; n =1) was identified as an AR antagonist which was 2.3-fold more potent than enzalutamide. Mol. docking studies were performed to explain the improved potency of II (M = C; A = dimethyl; X = C; Y = O; n =1) at AR. In cell proliferation assays, II (M = C; A = dimethyl; X = C; Y = O; n =1) exhibited similar anti-proliferative activities with enzalutamide against hormone sensitive LNCaP cells and AR-overexpressing LNCaP/AR cells. These data indicated that II (M = C; A = dimethyl; X = C; Y = O; n =1) can be a good lead compound for further structure optimization for the treatment of prostate cancer.
70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary