Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organic compounds having carbon bonded to bromine are called organic bromides. Synthetic Route of 1575-37-7.
Yang, Chun;Song, Lili;Miao, Zhong;Jiang, Lingyun;Li, Ting;Zhi, Xiaoyan;Hao, Xiaojuan;Cao, Hui research published 《 Discovery of novel obovatol-based phenazine analogs as potential antifungal agents: synthesis and biological evaluation in vitro》, the research content is summarized as follows. To explore candidate fungicides from plant secondary metabolites, 16 novel obovatol-type phenazine derivatives were semi-synthesized from obovatol isolated from the leaves of Magnolia obovata Thunb. The antifungal activity of synthesized compounds was investigated in vitro against four phytopathogenic fungi using the spore germination method. The bioassay results showed that eight derivatives exhibited better antifungal activity against Fusarium solani than two pos. controls, especially compounds 3-allyl-1-(4-allylphenoxy)-7,8-difluorophenazine (IC50 = 64.61μg mL-1) and 3-allyl-1-(4-allylphenoxy)-8-chlorophenazine (IC50 = 79.97μg mL-1) showed pronounced inhibition of spore germination activity against F. solani. They could be used as lead compounds for further structural optimization. Addnl., the preliminary structure-activity relationships (SARs) illustrated that the introduction of a benzene ring monosubstituted with electron-withdrawing groups into the obovatol scaffold could lead to potentially antifungal compounds
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Synthetic Route of 1575-37-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary